keyword
https://read.qxmd.com/read/37033604/efficacy-and-safety-of-melaleuca-alternifolia-tea-tree-oil-for-human-health-a-systematic-review-of-randomized-controlled-trials
#1
Lana Kairey, Tamara Agnew, Esther Joy Bowles, Bronwyn J Barkla, Jon Wardle, Romy Lauche
Introduction: Leaves of the Australian tea tree plant Melaleuca alternifolia were used traditionally by First Nations Australians for treating wounds, burns, and insect bites. Tea tree oil, the essential oil steam-distilled from M. alternifolia , is well-known for its medicinal properties, the evidence for most applications however is limited. This review aimed to critically appraise evidence from clinical trials examining the therapeutic efficacy and safety of tea tree oil on outcomes. Methods: Randomized controlled trials with participants of any age, gender, or health status, comparing tea tree oil to any control were included, without limit on publication date...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36348789/dietary-tea-tree-melaleuca-alternifolia-oil-supplementation-enhances-the-expressions-of-amino-acid-transporters-in-goat-ileal-mucosa-and-improves-intestinal-immunity
#2
JOURNAL ARTICLE
Xiaokang Lv, Liang Chen, Chuanshe Zhou, Yibing Guo, Guijie Zhang, Jinhe Kang, Zhiliang Tan, Shaoxun Tang, Zixin Liu
Tea tree oil (TTO) is a plant-derived additive with anti-inflammatory, bactericidal, and growth-promoting properties. However, little is known about the effects of TTO on intestinal amino acid transport and immune function in goats. Twenty-four Ganxi goats (initial body weight of 13.5 ± 0.70 kg) were randomly allotted two treatments and fed either control (CON) or CON+TTO (0.2 ml/kg) diet. The addition of TTO to the diet significantly decreased ( p  < .05) tumor necrosis factor-α content and increased ( p  < ...
November 2022: Food Science & Nutrition
https://read.qxmd.com/read/35668682/cosmetic-formulations-with-melaleuca-alternifolia-essential-oil-for-the-improvement-of-photoaged-skin-a-double-blind-randomized-placebo-controlled-clinical-study
#3
JOURNAL ARTICLE
Victor Hugo Infante, Patricia Maria Maia Campos, Maxim Darvin, Silke Lohan, Johannes Schleusener, Sabine Schanzer, Juergen Lademann, Martina Meinke
This aim of this study was to evaluate the penetration depth, antioxidant capacity and the clinical efficacy of Melaleuca alternifolia pure essential oil and in a nanoemulsion to prevent skin photoaging. For this, 2% of pure essential oil or 2% of this essential oil in a nanoemulsion were vehiculated in a formulation. The skin penetration was evaluated using confocal Raman microspectroscopy. The radical protection factor was evaluated using electron paramagnetic resonance spectroscopy. For a clinical study, 40 male participants, aged 18-28 years, were enrolled, being divided into three groups: vehicle formulation, M...
June 6, 2022: Photochemistry and Photobiology
https://read.qxmd.com/read/35546457/efficacy-of-melaleuca-alternifolia-and-chlorhexidine-mouth-rinses-in-reducing-oral-malodor-and-solobacterium-moorei-levels-a-1-week-randomized-double-blind-parallel-study
#4
JOURNAL ARTICLE
K Prabhu Srikumar, B N Bhagyashree, Sridharan Srirangarajan, Rao J Ravi, Rudresh Vinaya
OBJECTIVES: The objective is to evaluate the association of Solobacterium moorei (S. moorei) to halitosis and to also check for the effects of two different mouth rinses on levels of S. moorei in saliva and tongue coating and its impact on oral halitosis. MATERIALS AND METHODS: This was a placebo-controlled parallel study of 160 individuals who were randomized and the study was performed using double-blinded protocol. Enrolled individuals filled a structured questionnaire regarding demographic data, oral hygiene habits, and dietary habits...
March 2022: Indian Journal of Pharmacology
https://read.qxmd.com/read/35408626/essential-oils-as-in-vitro-ruminal-fermentation-manipulators-to-mitigate-methane-emission-by-beef-cattle-grazing-tropical-grasses
#5
JOURNAL ARTICLE
Gabriela Benetel, Thaysa Dos Santos Silva, Gisele Maria Fagundes, Katiéli Caroline Welter, Flavia Alves Melo, Annelise A G Lobo, James Pierre Muir, Ives C S Bueno
There is increasing pressure to identify natural feed additives to mitigate methane emissions from livestock systems. Our objective was to investigate the effects of essential oils (EO) extracts star anise ( Illicium verum ), citronella ( Cymbopogon winterianus ), clove bud ( Eugenia caryophyllus ), staigeriana eucalyptus ( Eucalyptus staigeriana ), globulus eucalyptus ( Eucalyptus globulus ), ginger ( Zingiber officinale ), ho wood ( Cinnamomum camphora ), melaleuca ( Melaleuca alternifolia ), oregano ( Origanum vulgare ) and white thyme ( Thymus vulgaris ) on in vitro methane emissions from four rumen-cannulated Nellore cattle grazing a tropical grass pasture as inoculum donors...
March 29, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/34416298/efficacy-of-medicinal-plant-extracts-as-dental-and-periodontal-antibiofilm-agents-a-systematic-review-of-randomized-clinical-trials
#6
JOURNAL ARTICLE
Victoria Furquim Dos Santos Cardoso, Ricardo Haack Amaral Roppa, Carolina Antunes, Amanda Naiara Silva Moraes, Lucélia Santi, Eduardo Luis Konrath
ETHNOPHARMACOLOGICAL RELEVANCE: The presence of biofilm in oral cavity is associated with dental plaque and related diseases, including gingivitis, periodontitis and inflammatory responses. Some medicinal plants traditionally used for biofilm-associated pathologies such as Camellia sinensis (L.) Kuntze, Punica granatum L. and Lippia sidoides Cham. are currently incorporated into dosage forms as antiplaque agents. AIMS OF THE STUDY: To present the current application of medicinal plant extracts associated in drug dosages to control microbial biofilms, with emphasis on those present in the oral cavity, especially to treat dental plaque...
December 5, 2021: Journal of Ethnopharmacology
https://read.qxmd.com/read/33952216/intrapocket-application-of-tea-tree-oil-gel-in-the-treatment-of-stage-2-periodontitis
#7
JOURNAL ARTICLE
Maha R Taalab, Sabah Abdelhady Mahmoud, Riham M El Moslemany, Dania M Abdelaziz
BACKGROUND: The gold standard in treatment of periodontitis is mechanical removing of dental biofilm but using local delivery drugs as adjunctive to SRP is widely used to modulate inflammatory host and eradicate microbes. Tea tree oil (TTO) has a broad-spectrum antimicrobial, anti-inflammatory, antifungal, antiviral, antioxidant effect. This study aimed to assess clinically and biochemically the effect of intrapocket application of TTO (Melaleuca alternifolia) gel adjunctive to scaling and root planing (SRP) in the treatment of stage 2 (moderate) periodontitis and to correlate the biochemical levels with clinical response...
May 5, 2021: BMC Oral Health
https://read.qxmd.com/read/33950544/antimicrobial-and-hand-hygiene-effects-of-tea-tree-essential-oil-disinfectant-a-randomised-control-trial
#8
RANDOMIZED CONTROLLED TRIAL
Bock-Hui Youn, Yeon-Suk Kim, Seungmin Yoo, Myung-Haeng Hur
BACKGROUND: Hand hygiene is paramount in preventing healthcare-associated infections in medical environments and the spread of infectious diseases in non-medical environments. AIMS: This study used a randomised controlled trial to investigate the effects of a tea tree (Melaleuca alternifolia) oil disinfectant on hand disinfection and skin condition. METHODS: A tea tree oil group received 5 mL of 10% tea tree oil disinfectant mixed in a ratio of 2:2:1:15 of Melaleuca alternifolia oil, solubiliser, glycerin and sterile distilled water...
August 2021: International Journal of Clinical Practice
https://read.qxmd.com/read/32466117/in-vitro-activity-of-essential-oils-against-planktonic-and-biofilm-cells-of-extended-spectrum-%C3%AE-lactamase-esbl-carbapenamase-producing-gram-negative-bacteria-involved-in-human-nosocomial-infections
#9
JOURNAL ARTICLE
Ramona Iseppi, Alessandro Di Cerbo, Piero Aloisi, Mattia Manelli, Veronica Pellesi, Cinzia Provenzano, Stefania Camellini, Patrizia Messi, Carla Sabia
The aim of this study was to analyze the antibacterial activity of four essential oils (EOs), Melaleuca alternifolia , Eucalyptus globulus , Mentha piperita, and Thymus vulgaris, in preventing the development and spread of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae , metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa and carbapenemase (KPC)-producing Klebsiella pneumoniae . A total of 60 strains were obtained from the stock collection from the Microbiology Laboratory of Hesperia Hospital, Modena, Italy...
May 25, 2020: Antibiotics
https://read.qxmd.com/read/31859706/anti-biofilm-and-anti-inflammatory-effect-of-a-herbal-nanoparticle-mouthwash-a-randomized-crossover-trial
#10
RANDOMIZED CONTROLLED TRIAL
Maísa Casarin, Josiele Pazinatto, Leandro Machado Oliveira, Márcia Ebling de Souza, Roberto Christ Vianna Santos, Fabricio Batistin Zanatta
Laboratory evidence has demonstrated the antimicrobial effect of Melaleuca alternifolia (MEL) against oral microorganisms. This randomized, double-blind, crossover clinical trial, compared the anti-biofilm and anti-inflammatory effects of MEL nanoparticles with 0.12% chlorhexidine gluconate (CHX) on biofilm-free (BF) and biofilm-covered (BC) surfaces. Before each experimental period, the participants refrained from all oral hygiene practices for 72 hours. The 60 participants were randomly assigned to professional prophylaxis in two quadrants (Q1-Q3 or Q2-Q4), and rinsed with MEL or CHX for four days...
2019: Brazilian Oral Research
https://read.qxmd.com/read/31558010/pumpkin-seeds-centella-asiatica-boswellia-helichrysum-acetate-vitamin-e-melaleuca-alternifolia-and-hyaluronic-acid-phytocomplex-monotherapy-effects-in-patients-with-chronic-pelvic-pain-syndrome
#11
JOURNAL ARTICLE
Tommaso Di Vico, Jacopo Durante, Chiara Polito, Alessio Tognarelli, Domenico Canale, Carolina Caglieresi, Girolamo Morelli, Riccardo Bartoletti
BACKGROUND: Proxelan® and antibiotics combined therapy was successfully previously used in the treatment of symptoms of patients with chronic prostatitis. Aim of the present study was to investigate the effects of Proxelan® monotherapy on pain symptoms of patients with chronic prostatitis (CP) or chronic pelvic pain syndrome (CPPS) in a prospective pilot study. METHODS: Thirty consecutive patients with CP/CPPS symptoms younger than 50, without urinary obstruction, total prostate-specific antigen (PSA) <4 ng/mL, negative microbiology testing on prostate fluid and urethral swab, naïve from other treatments during the previous three months were enrolled in a pilot study...
April 2020: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://read.qxmd.com/read/29162482/antimicrobial-activity-of-melaleuca-alternifolia-nanoparticles-in-polymicrobial-biofilm-in-situ
#12
JOURNAL ARTICLE
Márcia Ebling de Souza, Dariane Jornada Clerici, Camila Marina Verdi, Gabriela Fleck, Priscilla Maciel Quatrin, Luana Ebling Spat, Pauline Cordenonsi Bonez, Camilla Fillippi Dos Santos, Raquel Pippi Antoniazzi, Fabrício Batistin Zanatta, André Gundel, Diego Stefani Teodoro Martinez, Rodrigo de Almeida Vaucher, Roberto Christ Vianna Santos
Microbial biofilms represent a challenge in the treatment of infections, due to the low efficacy of the antimicrobials. This study evaluated the antimicrobial effect of nanoparticles of Melaleuca alternifolia (TTO) in dental biofilm. Thirty-eight volunteers used an oral device in situ in situ including four bovine enamel specimens for 07 days. From the fifth day four solutions were applied randomly for each specimen: Physiological Saline Solution (0.85% NaCl) (C+), Chlorhexidine 0.12% (CHX), M. alternifolia oil 0...
December 2017: Microbial Pathogenesis
https://read.qxmd.com/read/24174722/effect-of-local-application-of-tea-tree-melaleuca-alternifolia-oil-gel-on-long-pentraxin-level-used-as-an-adjunctive-treatment-of-chronic-periodontitis-a-randomized-controlled-clinical-study
#13
JOURNAL ARTICLE
Enas Ahmed Elgendy, Shereen Abdel-Moula Ali, Doaa Hussien Zineldeen
BACKGROUND: Conventional non-surgical periodontal therapy has been proven to be an effective treatment for patients with chronic periodontitis. Tea tree oil (TTO) can be used as adjunct to conventional periodontal therapy in patient with chronic periodontitis. The aim of this study was to evaluate the effectiveness of adjunctive treatment of TTO on the clinical parameters and the level of pentraxin-3 (PTX3) in chronic periodontitis. MATERIALS AND METHODS: A total of 40 patients with moderate to severe chronic periodontitis were divided into two groups, Group I received scaling and root planing (SRP) only, Group II received SRP and TTO gel...
July 2013: Journal of Indian Society of Periodontology
https://read.qxmd.com/read/23337964/-antiinflammatory-potential-of-seven-plant-extracts-in-the-ultraviolet-erythema-test-a-randomized-placebo-controlled-study
#14
RANDOMIZED CONTROLLED TRIAL
F C Beikert, B S Schönfeld, U Frank, M Augustin
BACKGROUND: Phytotherapeutics are widely used in medicine. The aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- (UV)-erythema test. PATIENTS AND METHODS: Randomized, placebo-controlled study on 40 healthy subjects. Test areas on the upper back were irradiated with the 1.5 fold UV-B minimal erythema dose (MED). Formulations of Aloe vera, Chamomilla recutita, Hamamelis virginiana, Melissa officinalis, Mentha arvensis, Melaleuca alternifolia, Coriandrum sativum as well as 1% hydrocortisone acetate and 0...
January 2013: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://read.qxmd.com/read/22770512/oral-cancer-awareness-at-chemist-s-and-herbalist-s-shops-new-targets-for-educational-interventions-to-prevent-diagnostic-delay
#15
JOURNAL ARTICLE
P Varela-Centelles, R Pedrosa, J Lopez-Niño, M Sánchez, A Gonzalez-Mosquera, A Mendez, J Seoane
OBJECTIVES: To assess whether chemist's and herbalist's shops were offering appropriate advice for patients seeking guidance on a potentially malignant oral lesion. MATERIAL AND METHODS: A cross-sectional study was undertaken using the standardised patient approach on a representative sample of chemist's and herbalists' shops in Galicia (Spain). The introductory statement was "I have a painful ulceration on the tongue for about a month now. What would you advise?" The study sample was selected by stratified random sampling for a 5% precision, and contacted by telephone...
December 2012: Oral Oncology
https://read.qxmd.com/read/19403294/antifungal-activity-of-tea-tree-oil-from-melaleuca-alternifolia-against-trichophyton-equinum-an-in-vivo-assay
#16
RANDOMIZED CONTROLLED TRIAL
F Pisseri, A Bertoli, S Nardoni, L Pinto, L Pistelli, G Guidi, F Mancianti
Dermatophytes are a group of keratinophilic and keratinolytic molds, some of which are responsible for ringworm. Among them Trichophyton equinum, which mostly infects equids, can cause extensive outbreaks in stud farms. The conventional treatment of equine trichophytosis is topic, based upon medicated shampoos to reduce the spread of infection among the animals. Nevertheless the popularity of phytotherapy is at an all-time peak, and the interest for natural alternatives or complements to conventional drug therapy is challenging both in human and veterinary field...
November 2009: Phytomedicine
https://read.qxmd.com/read/17544340/use-of-deception-to-achieve-double-blinding-in-a-clinical-trial-of-melaleuca-alternifolia-tea-tree-oil-for-the-treatment-of-recurrent-herpes-labialis
#17
JOURNAL ARTICLE
Christine F Carson, David W Smith, Gail J Lampacher, Thomas V Riley
Double-blinding is an important and widely implemented feature of clinical trials although its success is rarely assessed. In a randomized, placebo-controlled trial of tea tree oil, an aromatic essential oil, for the treatment of recurrent herpes labialis (RHL), or cold sores, deception was used to prevent volunteers from identifying their treatment allocation. Volunteers received placebo (n=102) or tea tree oil (n=112) ointment in preparation for their next episode of RHL and were told, falsely, that the aroma of the ointments had been changed to prevent identification of the treatment group...
January 2008: Contemporary Clinical Trials
https://read.qxmd.com/read/16507072/the-effect-of-german-chamomile-marticaria-recutita-l-extract-and-tea-tree-melaleuca-alternifolia-l-oil-used-as-irrigants-on-removal-of-smear-layer-a-scanning-electron-microscopy-study
#18
RANDOMIZED CONTROLLED TRIAL
M S Sadr Lahijani, H R Raoof Kateb, R Heady, D Yazdani
AIM: To compare the cleaning effectiveness of chamomile hydroalcoholic extract and tea tree oil to 2.5% sodium hypochlorite (NaOCl) solution as an intracanal irrigant for the removal of the smear layer. METHODOLOGY: Forty extracted, single-rooted, mature, permanent, human teeth were allocated at random into one of three experimental groups of ten teeth and two control groups of five teeth. For each tooth, the pulp chamber was accessed and the canal prepared using K-type files and Gates-Glidden burs, using a step-back technique; the apical stop was prepared to a size 30...
March 2006: International Endodontic Journal
https://read.qxmd.com/read/16418522/melaleuca-alternifolia-tea-tree-oil-a-review-of-antimicrobial-and-other-medicinal-properties
#19
REVIEW
C F Carson, K A Hammer, T V Riley
Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy...
January 2006: Clinical Microbiology Reviews
https://read.qxmd.com/read/16317652/a-clinical-study-melaleuca-manuka-calendula-and-green-tea-mouth-rinse
#20
RANDOMIZED CONTROLLED TRIAL
Jeffrey D Lauten, Linda Boyd, M Blair Hanson, Dana Lillie, Christina Gullion, Theresa E Madden
A novel mouthrinse (IND 61,164) containing essential oils and extracts from four plant species (Melaleuca alternifolia, Leptospermum scoparium, Calendula officinalis and Camellia sinensis) were tested. This study aimed to evaluate the safety, palatability and preliminary efficacy of the rinse. Fifteen subjects completed the Phase I safety study. Seventeen subjects completed the Phase II randomized placebo-controlled study. Plaque was collected, gingival and plaque indices were recorded (baseline, 6 weeks, and 12 weeks)...
November 2005: Phytotherapy Research: PTR
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