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Endobronchial valve

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https://www.readbyqxmd.com/read/29787288/a-multicenter-rct-of-zephyr%C3%A2-endobronchial-valve-treatment-in-heterogeneous-emphysema-liberate
#1
Gerard J Criner, Richard Sue, Shawn Wright, Mark Dransfield, Hiram Rivas-Perez, Tanya Wiese, Frank C Sciurba, Pallav L Shah, Momen M Wahidi, Hugo Goulart de Oliveira, Brian Morrissey, Paulo F G Cardoso, Steven Hays, Adnan Majid, Nicholas Pastis, Lisa Kopas, Mark Vollenweider, P Michael McFadden, Michael Machuzak, David W Hsia, Arthur Sung, Nabil Jarad, Malgorzata Kornaszewska, Stephen Hazelrigg, Ganesh Krishna, Brian Armstrong, Narinder S Shargill, Dirk-Jan Slebos
RATIONALE: This is the first multicenter RCT to evaluate effectiveness and safety of Zephyr® Endobronchial Valve EBV® out to 12-months. OBJECTIVES: To evaluate the effectiveness and safety of Zephyr EBV in heterogeneous emphysema with little to no collateral ventilation (CV) in the treated lobe. METHODS: Subjects were enrolled with a 2:1 randomization (EBV: Standard-of-Care (SoC)) at 24 sites. Primary outcome at 12-months was the ΔEBV-SoC of subjects with a post-bronchodilator FEV1 improvement from baseline of ≥15%...
May 22, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29657717/closure-of-a-bronchopleural-fistula-complicating-cryoprobe-biopsy-of-the-lung
#2
Rahul H Mehta, Jeffrey Hoag, Amit Borah, Emil Abramian
Cryoprobe biopsies are routinely performed by the interventional pulmonologist. Diagnostic yields are larger, with complication rates that are equal to or lower than that of traditional forceps biopsies. We will specifically evaluate one instance where a cryoprobe biopsy led to an alveolo-pleural fistula that did not resolve with simple tube thoracostomy. An endobronchial valve was placed and successfully resolved the pneumothorax and persistent air leak.
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29622759/endobronchial-valve-for-treatment-of-persistent-air-leak-complicating-spontaneous-pneumothorax
#3
W C Yu, E Lm Yu, H C Kwok, H L She, K K Kwong, Y H Chan, Y L Tsang, Y C Yeung
INTRODUCTION: Endobronchial one-way valves have been proposed as treatment for persistent air leak complicating spontaneous pneumothorax in which surgical intervention is not feasible. However, published data on efficacy, safety, and factors associated with success are scanty. METHODS: This is a retrospective study of 37 patients at a general hospital from 2008 to 2016. The impact of endobronchial valve implantation on the time to air-leak cessation after bronchoscopy was evaluated...
April 4, 2018: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29595651/bronchoscopic-valve-placement-for-the-treatment-of-persistent-air-leaks
#4
Xiaojie Huang, Liren Ding, Hao Xu
Persistent air leaks (PALs) are associated with increased morbidity, prolonged hospital stay, and increased treatment costs. Endobronchial 1-way valves have been recently used as a potential less invasive treatment option. We sought to investigate the effects of valve therapy in treating this condition. The patients with evidence of continuous air leak flow whose chest tubes remained in place for more than 7 days were treated with bronchoscopic closure using 1-way valves. The source of the air leak was identified by the Chartis system...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29575395/cost-effectiveness-of-endobronchial-valve-treatment-in-patients-with-severe-emphysema-compared-to-standard-medical-care
#5
Jorine E Hartman, Karin Klooster, Henk Groen, Nick H T Ten Hacken, Dirk-Jan Slebos
BACKGROUND AND OBJECTIVE: Bronchoscopic lung volume reduction using endobronchial valves (EBV) is an effective new treatment option for severe emphysema patients without interlobar collateral ventilation. The objective of this study was to perform an economic evaluation including the costs and cost-effectiveness of EBV treatment compared with standard medical care (SoC) from the hospital perspective in the short term and long term. METHODS: For the short-term evaluation, incremental cost-effectiveness ratios (ICER) were calculated based on the 6-month end point data from the STELVIO randomized trial...
March 25, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29444521/non-answered-questions-in-patients-with-endobronchial-valve-placement-for-lung-volume-reduction
#6
Iván R Caviedes, Gonzalo Labarca, Hugo G de Oliveira, Felix J F Herth, Sebastián Fernandez-Bussy
Endoscopic lung volume reduction is a minimally invasive procedure performed to reduce the space occupied by the emphysemas' lobes. This procedure has been demonstrated to be beneficial for patients with advanced chronic obstructive pulmonary disease and severe hyperinflation. The use of endobronchial valves is increasing, as well as the number of reports of adverse events. The most common complications after the procedure are a pneumothorax, bleeding, infections, the need for valve removal, and valve expulsion...
2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29433712/bronchoscopic-lung-volume-reduction
#7
REVIEW
Javier Flandes, Francisco J Soto, Rosa Cordovilla, Enrique Cases, Javier Alfayate
Since the publication of the National Emphysema Treatment Trial study, lung volume reduction (LVR) has been considered a therapeutic alternative for patients with advanced obstructive lung disease. The high complication rate of surgical LVR has led to the development of bronchoscopic LVR (BLVR). Of the currently available BLVR alternatives, coils and unidirectional endobronchial valves lead the list. The choice of each device depends on emphysema characteristics and presence of collateral ventilation. Evaluation of these patients at centers with expertise in interventional pulmonology and management of BLVR is strongly recommended...
March 2018: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29296080/microbiological-airway-colonization-in-copd-patients-with-severe-emphysema-undergoing-endoscopic-lung-volume-reduction
#8
Franziska C Trudzinski, Frederik Seiler, Heinrike Wilkens, Carlos Metz, Annegret Kamp, Robert Bals, Barbara Gärtner, Philipp M Lepper, Sören L Becker
Background: Endoscopic lung volume reduction (eLVR) is a therapeutic option for selected patients with COPD and severe emphysema. Infectious exacerbations are serious events in these vulnerable patients; hence, prophylactic antibiotics are often prescribed postinterventionally. However, data on the microbiological airway colonization at the time of eLVR are scarce, and there are no evidence-based recommendations regarding a rational antibiotic regimen. Objective: The aim of this study was to perform a clinical and microbiological analysis of COPD patients with advanced emphysema undergoing eLVR with endobronchial valves at a single German University hospital, 2012-2017...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29261587/endobronchial-valve-migration-secondary-to-changes-in-bronchial-diameter-after-the-initial-treatment
#9
Sebastian Fernandez-Bussy, Gonzalo Labarca, Hugo de Oliveira
No abstract text is available yet for this article.
January 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29214063/bronchoscopic-management-of-prolonged-air-leak
#10
REVIEW
Sevak Keshishyan, Alberto E Revelo, Oleg Epelbaum
Bronchopleural fistula (BPF) with prolonged air leak (PAL) is most often, though not always, a sequela of lung resection. When this complication occurs post-operatively, it is associated with substantial morbidity and mortality. Surgical closure of the defect is considered the definitive approach to controlling the source of the leak, but many patients with this condition are suboptimal operative candidates. Therefore there has been active interest for decades in the development of effective endoscopic management options...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29136621/evaluation-of-nickel-release-from-endobronchial-valves-as-a-possible-cause-of-hypersensitivity-pneumonitis-in-a-patient-treated-with-bronchoscopic-lung-volume-reduction
#11
Daniel P Franzen, Claudia Lang, Nikos Agorastos, Lutz Freitag, Malcolm Kohler, Peter Schmid-Grendelmeier
BACKGROUND: Endobronchial valve (EBV) placement is an established lung volume reduction procedure aiming to improve lung function and exercise capacity in patients with severe emphysema. As EBVs consist of silicone and nitinol (a metal alloy of nickel and titanium), there are concerns that nickel ions might be released and could have a clinical impact in patients with a contact allergy to nickel. Based on a case with hypersensitivity pneumonitis (HP) after treatment with EBVs, we aimed to evaluate the in vitro nickel release from EBVs using inductively coupled plasma mass spectrometry (ICP-MS) and scanning electron microscopy (SEM)...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29110704/endobronchial-one-way-valves-for-treatment-of-persistent-air-leaks-a-systematic-review
#12
REVIEW
Mei Ding, Ya-Dong Gao, Xian-Tao Zeng, Yi Guo, Jiong Yang
Persistent air leak (PAL) is associated with significant morbidity and mortality, prolonged hospitalization and increased health-care costs. It can arise from a number of conditions, including pneumothorax, necrotizing infection, trauma, malignancies, procedural interventions and complications after thoracic surgery. Numerous therapeutic options, including noninvasive and invasive techniques, are available to treat PALs. Recently, endobronchial one-way valves have been used to treat PAL. We conducted a systematic review based on studies retrieved from PubMed, EMbase and Cochrane library...
November 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29105909/endobronchial-valve-placement-in-emphysema-when-is-it-lung-volume-reduction
#13
EDITORIAL
Ralf Eberhardt
No abstract text is available yet for this article.
March 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29100445/efficacy-and-safety-of-bronchoscopic-lung-volume-reduction-therapy-in-patients-with-severe-emphysema-a-meta-analysis-of-randomized-controlled-trials
#14
Yong Wang, Tian-Wen Lai, Feng Xu, Jie-Sen Zhou, Zhou-Yang Li, Xu-Chen Xu, Hai-Pin Chen, Song-Min Ying, Wen Li, Hua-Hao Shen, Zhi-Hua Chen
BACKGROUND: Increasing randomized controlled trials (RCTs) indicate that bronchoscopic lung volume reduction (BLVR) is effective for severe emphysema. In this meta-analysis, we investigated the efficacy and safety of BLVR in patients with severe emphysema. METHODS: PubMed, Embase and the Cochrane Library and reference lists of related articles were searched, and RCTs that evaluated BLVR therapy VS conventional therapy were included. Meta-analysis was performed only when included RCTs ≥ 2 trials...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081655/mesenchymal-stromal-cell-therapy-in-copd-from-bench-to-bedside
#15
REVIEW
Mariana A Antunes, José Roberto Lapa E Silva, Patricia Rm Rocco
COPD is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality. The major risk factor for COPD development is cigarette smoke, and the most efficient treatment for COPD is smoking cessation. However, even after smoking cessation, inflammation, apoptosis, and oxidative stress may persist and continue contributing to disease progression. Although current therapies for COPD (primarily based on anti-inflammatory agents) contribute to the reduction of airway obstruction and minimize COPD exacerbations, none can avoid disease progression or reduce mortality...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29049667/when-can-computed-tomography-fissure-analysis-replace-chartis-collateral-ventilation-assessment-in-the-prediction-of-patients-with-emphysema-who-might-benefit-from-endobronchial-valve-therapy
#16
Alfonso Fiorelli, Mario Santini, Pallav Shah
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was when can computed tomography-fissure analysis replace Chartis collateral ventilation assessment in the prediction of patients with emphysema who might benefit from endobronchial valve therapy? Twelve papers were chosen to answer the question. The authors, date, journal, country of publication and study type; patient group studied; relevant outcomes and results of these papers were tabulated. Five studies retrospectively compared the prognostic value of 2 methods...
February 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29040413/bilateral-cavitary-multidrug-or-extensively-drug-resistant-tuberculosis-role-of-surgery
#17
Galina Yu Marfina, Kirill B Vladimirov, Armen O Avetisian, Anna A Starshinova, Grigorii G Kudriashov, Evgenii G Sokolovich, Piotr K Yablonskii
OBJECTIVES: Cavitary disease and bilateral lesions are among the risk factors for poor outcome of pulmonary tuberculosis (TB). Our aim was to explore the value and limits of surgery in patients with advanced TB. METHODS: A retrospective study of 57 consecutive patients who underwent thoracic surgery for culture-positive bilateral cavitary pulmonary TB was performed. Forty-four (77.2%) patients were men and 13 (22.8%) patients were women; their ages were in the range of 18-61 years...
March 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28977365/hybrid-bilobectomy-for-treatment-of-an-early-stage-lung-cancer-in-a-patient-with-severe-emphysema-using-the-benefits-of-lung-volume-reduction
#18
Periklis Perikleous, Rocco Bilancia, Inger Oey, David A Waller
Patients with resectable lung cancer and concomitant emphysema can fall outside the accepted guidelines for surgery. Lung volume reduction can improve their lung function but involves resecting an emphysematous lobe containing the tumour. Volume reduction can also be achieved by endobronchial one-way valve insertion, causing lobar collapse, but intact fissures are required. A 'hybrid bilobectomy' was performed on a 77-year-old ex-smoker with suspected T2aN0M0 bronchogenic carcinoma and severe pulmonary emphysema...
November 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28957891/reexpansion-pulmonary-edema-as-a-complication-of-endobronchial-valve-placement
#19
Yaniv Dotan, Nathaniel Marchetti, Gerard J Criner
No abstract text is available yet for this article.
October 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28947021/medical-lung-volume-reduction-for-severe-emphysema-a-review
#20
REVIEW
Kalliopi Aggelou, Nikolaos Siafakas
Lung hyperinflation is the main pathophysiological mechanism significantly reducing the Quality of Life (QoL)and contributing to increased morbidity and mortality of the emphysematous patients. Therefore, the prime aim of the management of those patients is the deflation of their lungs. There are a number of treatments proven effective to reduce hyperinflation, such as,pharmacotherapy (bronchodilators/deflators), rehabilitation and surgical volume reduction. Recently, methods to reduce lung volume by a bronchoscopic approach had been developed...
October 2017: Respiratory Medicine
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