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Endobronchial valve

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https://www.readbyqxmd.com/read/28323737/an-unusual-complication-of-long-term-endobronchial-valves-placed-for-persistent-air-leak
#1
Trevor M Taylor, Robert J Lentz, Fabien Maldonado
No abstract text is available yet for this article.
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28267436/management-of-persistent-air-leaks
#2
REVIEW
Karen C Dugan, Balaji Laxmanan, Septimiu Murgu, D Kyle Hogarth
Alveolar-pleural fistulas causing persistent air leaks are associated with prolonged hospital stays and high morbidity. Prior guidelines recommend surgical repair as the gold standard for treatment, albeit a solution with limited success. In patients who have recently undergone thoracic surgery or in which surgery would be contraindicated based on severity of illness, there has been a lack of treatment options. This review describes a brief history of treatment guidelines for persistent air leaks. In the past 20 years, newer and less invasive treatment options have been developed...
March 3, 2017: Chest
https://www.readbyqxmd.com/read/28230230/bronchoscopic-lung-volume-reduction-procedures-for-chronic-obstructive-pulmonary-disease
#3
REVIEW
Joseph Em van Agteren, Khin Hnin, Dion Grosser, Kristin V Carson, Brian J Smith
BACKGROUND: In the recent years, a variety of bronchoscopic lung volume reduction (BLVR) procedures have emerged that may provide a treatment option to participants suffering from moderate to severe chronic obstructive pulmonary disease (COPD). OBJECTIVES: To assess the effects of BLVR on the short- and long-term health outcomes in participants with moderate to severe COPD and determine the effectiveness and cost-effectiveness of each individual technique. SEARCH METHODS: Studies were identified from the Cochrane Airways Group Specialised Register (CAGR) and by handsearching of respiratory journals and meeting abstracts...
February 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28186686/combined-bone-marrow-derived-mesenchymal-stromal-cell-therapy-and-one-way-endobronchial-valve-placement-in-patients-with-pulmonary-emphysema-a-phase-i-clinical-trial
#4
Hugo Goulart de Oliveira, Fernanda Ferreira Cruz, Mariana Alves Antunes, Amarilio Vieira de Macedo Neto, Guilherme Augusto Oliveira, Fabio Munhoz Svartman, Tamara Borgonovo, Carmen Lucia Kuniyoshi Rebelatto, Daniel J Weiss, Paulo Roberto Slud Brofman, Marcelo Marcos Morales, José Roberto Lapa E Silva, Patricia Rieken Macedo Rocco
One-way endobronchial valves (EBV) insertion to reduce pulmonary air trapping has been used as therapy for chronic obstructive pulmonary disease (COPD) patients. However, local inflammation may result and can contribute to worsening of clinical status in these patients. We hypothesized that combined EBV insertion and intrabronchial administration of mesenchymal stromal cells (MSCs) would decrease the inflammatory process, thus mitigating EBV complications in severe COPD patients. This initial study sought to investigate the safety of this approach...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27992862/endobronchial-valves-for-endoscopic-lung-volume-reduction-best-practice-recommendations-from-expert-panel-on-endoscopic-lung-volume-reduction
#5
Dirk-Jan Slebos, Pallav L Shah, Felix J F Herth, Arschang Valipour
Endoscopic lung volume reduction (ELVR) is being adopted as a treatment option for carefully selected patients suffering from severe emphysema. ELVR with the one-way endobronchial Zephyr valves (EBV) has been demonstrated to improve pulmonary function, exercise capacity, and quality of life in patients with both heterogeneous and homogenous emphysema without collateral ventilation. In this "expert best practices" review, we will highlight the practical aspects of this therapy. Key selection criteria for ELVR are hyperinflation with a residual volume >175% of predicted, forced expiratory volume <50% of predicted, and a 6-min walking distance >100 m...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27974713/one-year-follow-up-after-endobronchial-valve-treatment-in-patients-with-emphysema-without-collateral-ventilation-treated-in-the-stelvio-trial
#6
Karin Klooster, Jorine E Hartman, Nick H T Ten Hacken, Dirk-Jan Slebos
BACKGROUND: One-way endobronchial valve (EBV) treatment has shown safety and efficacy at 6 months after treatment in patients with severe emphysema and confirmed absence of interlobar collateral ventilation. Longer follow-up in this subgroup is not available. OBJECTIVES: To investigate the efficacy and safety of EBV treatment of the STELVIO cohort at a 1-year follow-up. METHODS: Emphysema patients who have been treated with EBV in the STELVIO trial were invited for a voluntary 1-year follow-up visit...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27920518/significant-lung-volume-reduction-with-endobronchial-valves-in-a-patient-despite-the-presence-of-microcollaterals-masked-by-low-flow-chartis-phenotype
#7
Yan Yin, Gang Hou, Felix J Herth, Xiao-Bo Wang, Qiu-Yue Wang, Jian Kang
Satisfactory functional outcomes following bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) depend on the absence of collateral ventilation (CV) between the target and adjunct lobes. The Chartis system has proven to be useful for determining whether CV is present or absent, but this system can also erroneously indicate the absence of CV, which can lead to BLVR failure. Here, we describe low-flow Chartis phenotype in the target lobe resulted in difficult judgment of existence of CV...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27814898/endobronchial-valve-therapy-for-a-refractory-air-leak-after-lung-transplantation-in-a-patient-with-multiple-connective-tissue-disorders
#8
John R Spratt, Eitan Podgaetz, Gabriel Loor, Sara J Shumway
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27806368/endobronchial-valves-for-emphysema-time-to-push-the-envelope
#9
Zaid Zoumot, Samuel V Kemp, Pallav L Shah
No abstract text is available yet for this article.
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27806152/bronchoscopic-management-of-prolonged-air-leaks-with-endobronchial-valves-in-a-veteran-population
#10
Lorraine D Cornwell, Ramola Panchal, Faisal G Bakaeen, Shuab Omer, Ourania Preventza, Donald R Lazarus, Roberto F Casal
No abstract text is available yet for this article.
February 1, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/27797610/endobronchial-valves-as-a-treatment-for-emphysema-moving-out-of-the-shadow-of-lung-volume-reduction-surgery
#11
Nicholas S Hopkinson
No abstract text is available yet for this article.
November 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27776598/endobronchial-valve-treatment-of-destructive-multidrug-resistant-tuberculosis
#12
A Levin, S Sklyuev, I Felker, E Tceymach, D Krasnov
BACKGROUND: In accordance with the existing hypothesis, the application of an endobronchial valve (EbV) leads to selective curative atelectasis of the affected part of the lung, contributing to early closure of cavities. OBJECTIVE: To assess the effect of EbV treatment on the course of tuberculosis (TB). METHODS: We compared the efficacy of EbV treatment and complex second-line treatment in treating patients with destructive pulmonary multidrug-resistant TB (MDR-TB)...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27742781/endobronchial-valves-for-bronchopleural-fistula-pitfalls-and-principles
#13
Dany Gaspard, Thaddeus Bartter, Ziad Boujaoude, Haroon Raja, Rohan Arya, Nikhil Meena, Wissam Abouzgheib
BACKGROUND: Placement of endobronchial valves for bronchopleural fistula (BPF) is not always straightforward. A simple guide to the steps for an uncomplicated procedure does not encompass pitfalls that need to be understood and overcome to maximize the efficacy of this modality. OBJECTIVES: The objective of this study was to discuss examples of difficult cases for which the placement of endobronchial valves was not straightforward and required alterations in the usual basic steps...
January 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27739872/the-clinical-significance-of-collateral-ventilation
#14
Peter B Terry, Richard J Traystman
Oxygen delivery and carbon dioxide removal being critical to cell survival, mammals have developed collateral vascular and ventilation systems to ensure tissue viability. Collateral ventilation, defined as ventilation of alveoli via pathways that bypass normal airways, is present in humans and many other species. The presence of collateral ventilation can be beneficial in certain disease states, whereas its relative absence can predispose to other diseases. These well defined anatomical pathways contribute little to ventilation in normal humans, but modulate ventilation perfusion imbalance in a variety of diseases, including obstructive diseases, such as asthma and emphysema...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27728916/lobar-collapse-therapy-using-endobronchial-valves-as-a-new-complementary-approach-to-treat-cavities-in-multidrug-resistant-tuberculosis-and-difficult-to-treat-tuberculosis-a-case-series
#15
Lorenzo Corbetta, Ariela Tofani, Flavio Montinaro, Lucio Michieletto, Loris Ceron, Chiara Moroni, Pier Giorgio Rogasi
BACKGROUND: The poor treatment outcomes of multidrug-resistant tuberculosis (TB) and the emergence of extensively drug-resistant TB and extremely and totally drug-resistant TB highlight the urgent need for new antituberculous drugs and other adjuvant treatment approaches. OBJECTIVES: We have treated cavitary tuberculosis by the application of endobronchial one-way valves (Zephyr®; Pulmonx Inc., Redwood City, Calif., USA) to induce lobar volume reduction as an adjunct to drug treatment...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27701180/bilateral-endoscopic-lung-volume-reduction-in-patients-with-severe-emphysema
#16
Franziska C Trudzinski, Philipp M Lepper, Daniela Leppert, Frank Langer, Christian Lensch, Monika Flaig, Robert Bals, Heinrike Wilkens, Peter Minko, Sebastian Fähndrich
Reducing hyperinflated areas in chronic obstructive pulmonary disease, either surgically or endoscopically, leads to improvement of functional parameters. It is unclear if bilateral treatment with endobronchial valves (EBV) aiming at total lobar occlusion is beneficial. The aim of this study was to assess the results after staged bilateral endoscopic treatment with EBV. This is a retrospective analysis of patients with severe airflow obstruction, who were treated bilaterally with EBV in two stages, aiming at subsequent atelectasis...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27693408/lung-volume-reduction-for-emphysema
#17
REVIEW
Pallav L Shah, Felix J Herth, Wouter H van Geffen, Gaetan Deslee, Dirk-Jan Slebos
Advanced emphysema is a lung disease in which alveolar capillary units are destroyed and supporting tissue is lost. The combined effect of reduced gas exchange and changes in airway dynamics impairs expiratory airflow and leads to progressive air trapping. Pharmacological therapies have limited effects. Surgical resection of the most destroyed sections of the lung can improve pulmonary function and exercise capacity but its benefit is tempered by significant morbidity. This issue stimulated a search for novel approaches to lung volume reduction...
February 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/27647978/management-of-prolonged-pulmonary-air-leaks-with-endobronchial-valve-placement
#18
Charles Bakhos, Peter Doelken, Stevan Pupovac, Ashar Ata, Tom Fabian
BACKGROUND: Prolonged pulmonary air leaks (PALs) are associated with increased morbidity and extended hospital stay. We sought to investigate the role of bronchoscopic placement of 1-way valves in treating this condition. METHODS: We queried a prospectively maintained database of patients with PAL lasting more than 7 days at a tertiary medical center. Main outcome measures included duration of chest tube placement and hospital stay before and after valve deployment...
July 2016: JSLS: Journal of the Society of Laparoendoscopic Surgeons
https://www.readbyqxmd.com/read/27603781/endoscopic-lung-volume-reduction-using-endobronchial-valves-in-patients-with-severe-emphysema-and-very-low-fev1
#19
Franziska C Trudzinski, Anna J Höink, Daniela Leppert, Sebastian Fähndrich, Heinrike Wilkens, Thomas P Graeter, Frank Langer, Robert Bals, Peter Minko, Philipp M Lepper
BACKGROUND: Patients with a forced expiratory volume in 1 s (FEV1) below 20% of the predicted normal values (pred.) and either homogeneous emphysema or low diffusing capacity for carbon monoxide (DLCO) have a high risk for adverse events including death when undergoing surgical lung volume reduction. OBJECTIVES: We hypothesized that selected patients can benefit from endoscopic lung volume reduction (eLVR) despite a very low FEV1. METHODS: This study is a retrospective analysis of consecutive patients with severe airflow obstruction, an FEV1 ≤20% of pred...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27580428/endobronchial-valve-therapy-in-patients-with-homogeneous-emphysema-results-from-the-impact-study
#20
Arschang Valipour, Dirk-Jan Slebos, Felix Herth, Kaid Darwiche, Manfred Wagner, Joachim H Ficker, Christoph Petermann, Ralf-Harto Hubner, Franz Stanzel, Ralf Eberhardt
RATIONALE: Endobronchial valves (EBVs) have been successfully used in patients with severe heterogeneous emphysema to improve lung physiology. Limited available data suggest that EBVs are also effective in homogeneous emphysema. OBJECTIVES: To evaluate the efficacy and safety of EBVs in patients with homogeneous emphysema with absence of collateral ventilation assessed with the Chartis system. METHODS: Prospective, multicenter, 1:1 randomized controlled trial of EBV plus standard of care (SoC) or SoC alone...
November 1, 2016: American Journal of Respiratory and Critical Care Medicine
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