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https://www.readbyqxmd.com/read/29772565/safety-of-iohexol-administration-to-measure-glomerular-filtration-rate-in-different-patient-populations-a-25-year-experience
#1
Flavio Gaspari, Surabhi Thakar, Fabiola Carrara, Annalisa Perna, Matias Trillini, Maria Carolina Aparicio, Olimpia Diadei, Silvia Ferrari, Antonio Cannata, Nadia Stucchi, Piero Ruggenenti, Giuseppe Remuzzi, Norberto Perico
BACKGROUND/AIM: In clinical research setting, accurate and precise measurement of glomerular filtration rate (GFR) is essential to overcome the limitations of GFR estimation with equations, which are often unreliable. In recent decades, a method for measuring GFR by plasma clearance of iohexol, a non-ionic radiocontrast agent, was developed. To evaluate the safety of the procedure, we aimed to review all immediate adverse reactions that could be related to iohexol administration in our group's 25 years worth of experience...
May 17, 2018: Nephron
https://www.readbyqxmd.com/read/29733431/adverse-drug-reactions-reported-by-healthcare-professionals-reaction-characteristics-and-time-to-reporting
#2
Ar Kar Aung, Mei Jie Tang, Nikki Rae Adler, Sara Lee de Menezes, Michelle Sue Yen Goh, Hui Wen Tee, Jason Anthony Trubiano, Robert Puy, Celia Mary Zubrinich, Linda Velta Graudins
We describe adverse drug reaction (ADR) reporting characteristics and factors contributing to length of time to report by healthcare professionals. This is a retrospective study of voluntary reports to an Australian healthcare ADR Review Committee over a 2-year period (2015-2016). Descriptive and univariate models were used for outcomes, employing standardized ADR definitions. Hospital pharmacists reported 84.8% of the 555 ADRs: 70.3% were hospital onset reactions, and 71.7% were at least of moderate severity...
May 7, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29732195/the-feasibility-of-electromagnetic-navigational-bronchoscopic-localization-with-fluorescence-and-radiocontrast-dyes-for-video-assisted-thoracoscopic-surgery-resection
#3
REVIEW
Kook Nam Han, Hyun Koo Kim
Recently, some groups have reported the utilization of electromagnetic navigational bronchoscopy (ENB) for localization of pulmonary lesion. Its application for intraoperative visual localization with dyes to determine the target area has been increasing. In this paper, we reviewed the feasibility of ENB utilization for video-assisted thoracoscopic surgery (VATS) or robotic sublobar resection as a localization tool, and its future application in minimally invasive thoracic surgery.
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29705293/cytotoxicity-of-radiocontrast-dyes-in-human-umbilical-cord-mesenchymal-stem-cells
#4
Christina McKee, Naimisha Beeravolu, Shreeya Bakshi, Bryan Thibodeau, George Wilson, Mick Perez-Cruet, G Rasul Chaudhry
Radiocontrast dyes are used for a wide range of diagnostic procedures for enhancing the image of anatomical structures, pain targets, and vascular uptake. While some of these dyes show toxicity to primary cells, their effect on stem cells, particularly mesenchymal stem cells (MSCs), is unknown. This study investigates the cytotoxic effects of two clinically used radiocontrast dyes, iohexol and iopamidol, on bone marrow and human umbilical cord MSCs. Exposure to these dyes significantly affected morphology of MSCs from both sources, as treated cells appeared transparent and no longer fibroblastoid...
April 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29649334/urinary-cgmp-predicts-major-adverse-renal-events-in-patients-with-mild-renal-impairment-and-or-diabetes-mellitus-before-exposure-to-contrast-medium
#5
Lyubov Chaykovska, Fabian Heunisch, Gina von Einem, Carl-Friedrich Hocher, Oleg Tsuprykov, Mira Pavkovic, Peter Sandner, Axel Kretschmer, Chang Chu, Saban Elitok, Johannes-Peter Stasch, Berthold Hocher
BACKGROUND: The use of iodine-based contrast agents entails the risk of contrast induced nephropathy (CIN). Radiocontrast agents elicit the third most common cause of nephropathy among hospitalized patients, accounting for 11-12% of cases. CIN is connected with clinically significant consequences, including increased morbidity, prolonged hospitalization, increased risk of complications, potential need for dialysis, and increased mortality rate. The number of in-hospital examinations using iodine-based contrast media has been significantly increasing over the last decade...
2018: PloS One
https://www.readbyqxmd.com/read/29616440/distortion-of-the-temporary-cavity-and-its-influence-on-staining-in-firearm-barrels
#6
Christian Schyma, Rolf Müller, Eva Brenčičová, Julia Brünig
After contact shots to the head, biological traces can be found inside the barrel of the firearm. Experimental protocols to generate this sort of staining, using 12 cm gelatin cubes containing thin foil bags filled with acrylic paint, human blood, and radiocontrast agent, have been developed. Previous research on shots fired at a distance has shown the underlay sustaining these gelatin cubes has an influence on experimental results. This study was conducted to investigate the role of the sustaining base of the gelatin blocks during contact shots, and its influence on the staining result inside firearm barrels...
April 3, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29594317/-prevention-of-acute-kidney-injury-in-critically-ill-patients-recommendations-from-the-renal-section-of-the-dgiin-%C3%A3-giain-and-divi
#7
REVIEW
M Joannidis, S J Klein, S John, M Schmitz, D Czock, W Druml, A Jörres, D Kindgen-Milles, J T Kielstein, M Oppert, V Schwenger, C Willam, A Zarbock
BACKGROUND: Acute kidney injury (AKI) has both high mortality and morbidity. OBJECTIVES: To prevent the occurrence of AKI, current recommendations from the renal section of the DGIIN (Deutschen Gesellschaft für Internistische Intensivmedizin und Notfallmedizin), ÖGIAIN (Österreichischen Gesellschaft für Internistische und Allgemeine Intensivmedizin und Notfallmedizin) and DIVI (Deutschen Interdisziplinären Vereinigung für Intensiv- und Notfallmedizin) are stated...
March 28, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29553120/-anaphylaxis-triggered-by-radiocontrast-media-and-local-anesthetics-what-should-be-done-when-they-are-essential
#8
Masao Yamaguchi
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29456202/contrast-induced-nephropathy-pathophysiology-risk-factors-and-prevention
#9
REVIEW
Mohammad A Hossain, Eric Costanzo, James Cosentino, Chirag Patel, Huzaif Qaisar, Vikas Singh, Taimoor Khan, Jennifer S Cheng, Arif Asif, Tushar J Vachharajani
Contrast-induced acute kidney injury is a common iatrogenic complication associated with increased health resource utilization and adverse outcomes, including short- and long-term mortality and accelerated progression of preexisting renal insufficiency. The incidence of contrast-induced nephropathy (CIN) has been reported to range from 0% to 24%. This wide range reported by the studies is due to differences in definition, background risk factors, type and dose of contrast medium used, and the frequency of other coexisting potential causes of acute renal failure...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29411557/electronic-consultation-support-system-for-radiocontrast-media-hypersensitivity-changes-clinicians-behavior
#10
Min Suk Yang, Sang Il Choi, Woo Jung Song, Sae Hoon Kim, Sang Heon Cho, Kyung Up Min, Jae Hyoung Kim, Yoon Seok Chang
PURPOSE: Patients with a history of radiocontrast media (RCM) hypersensitivity can be overlooked, resulting in repeated reactions. Therefore, a consultation support system for RCM hypersensitivity has been in operation at Seoul National University Bundang Hospital since December 2011. We analyzed the effect of this system on physicians' practice. METHODS: A retrospective study was conducted on patients with previous RCM reactions (December 1, 2010 to November 30, 2012)...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29402350/evaluation-of-volume-of-intramuscular-injection-into-the-caudal-thigh-muscles-of-female-and-male-balb-c-mice-mus-musculus
#11
Alicia M Gehling, Kyle Kuszpit, Emily J Bailey, Krystal H Allen-Worthington, David P Fetterer, Pedro J Rico, Thomas M Bocan, Christian C Hofer
This study presents recommendations for intramuscular injection into the caudal thigh muscle of mice according to analysis of in vivo imaging of intramuscularly injected iohexol, a radiocontrast agent commonly used in CT imaging. An experienced laboratory animal technician using a Hamilton syringe intramuscularly injected iohexol into isoflurane-anesthetized female and male BALB/c mice. Injected volumes (25, 50, 100, and 200 μL) underwent CT scanning at 9 time points over a 3-h period. The distribution of the injectate in the muscles of the rear leg was examined over time for each volume group...
January 1, 2018: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/29258724/does-oral-radiocontrast-affect-image-quality-of-abdominal-sonography
#12
Christopher Dang, Eitan Dickman, Mark O Tessaro, Pranjal Patel, Maxim Dzeba, Antonios Likourezos, Illya Pushkar, Peter Homel, Lawrence E Haines
OBJECTIVE: Emergency Department patients with abdominal pain may require both an ultrasound (US) and computed tomography (CT) for an accurate diagnosis. Patients are often asked to drink oral radiocontrast while awaiting ultrasound, in order to better expedite a CT in the case of a non-diagnostic US. The impact of oral radiocontrast on US image quality has not been studied. We compared the quality of US images obtained before and after the ingestion of oral radiocontrast in healthy adult volunteers...
November 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29230707/acute-kidney-injury-after-abdominal-aortic-aneurysm-repair-current-epidemiology-and-potential-prevention
#13
Liesa Zabrocki, Frank Marquardt, Klaus Albrecht, Stefan Herget-Rosenthal
PURPOSE: Acute kidney injury (AKI) is a severe complication after infrarenal abdominal aortic aneurysm (iAAA) repair. Little data are available whether endovascular aneurysm (EVAR) or open aortic repair (OAR) differs with respect to AKI frequency and severity, consecutive development of chronic kidney disease (CKD) and potentially preventable and modifiable risk factors of AKI. PATIENTS AND METHODS: We assessed AKI rates, AKI stages and CKD applying current, complete definitions from the kidney disease improving global outcomes initiative in propensity-score-matched cohorts of all patients with elective and urgent iAAA repair at our institution from 2007 to 2011...
February 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29214792/life-threatening-thrombocytopenia-following-intravenous-contrast-media-infusion
#14
Mihwa Park, Minjeong Kim, Jisun Park, Jinhyun Cho
Radiocontrast media-induced acute severe thrombocytopenia is a very rare complication and potentially life-threatening. Here, we report the case of a 63-year-old male patient with severe acute thrombocytopenia following first exposure to intravenous non-ionic contrast media without immediate allergic reactions. His platelet count dropped from 107000/μL to 2000/μL after six hours of radiocontrast infusion. After administration of corticosteroid and transfusion of platelet concentrates, the platelet count returned gradually to normal within 5 days...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29189343/kinetics-of-urinary-cell-cycle-arrest-markers-for-acute-kidney-injury-following-exposure-to-potential-renal-insults
#15
Marlies Ostermann, Peter A McCullough, Lui G Forni, Sean M Bagshaw, Michael Joannidis, Jing Shi, Kianoush Kashani, Patrick M Honore, Lakhmir S Chawla, John A Kellum
OBJECTIVES: Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology. To aid clinical interpretation, we describe the kinetics of biomarker elevations around an exposure. DESIGN: In an ancillary analysis of the multicenter SAPPHIRE study, we examined the kinetics of the urinary [tissue inhibitor of metalloproteinase-2]•[insulin-like growth factor binding protein 7] in association with exposure to common renal insults (major surgery, IV radiocontrast, vancomycin, nonsteroidal anti-inflammatory drugs, and piperacillin/tazobactam)...
March 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29173356/contrast-induced-nephropathy-after-cardiac-catheterization-culprits-consequences-and-predictors
#16
Yub Raj Sedhai, Reshma Golamari, Santosh Timalsina, Soney Basnyat, Ajay Koirala, Ankush Asija, Tatvam Choksi, Akanksha Kushwah, David Geovorgyan, Tawseef Dar, Madhura Borikar, Waseem Ahangar, Joseph Alukal, Subtain Zia, Jose Missri
BACKGROUND: Contrast-induced nephropathy (CIN) is a common complication after radiocontrast exposure. METHODS: A retrospective medical record review of 513 hospitalized patients who underwent cardiac catheterization from June-December 2014 was done, of which 38 patients with end-stage renal disease and 57 patients without preprocedural creatinine were excluded. Serum creatinine concentration before the procedure and each day for 3 days after the procedure was recorded...
November 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29134518/erector-spinae-plane-block-for-the-management-of-chronic-shoulder-pain-a-case-report
#17
Mauricio Forero, Manikandan Rajarathinam, Sanjib Das Adhikary, Ki Jinn Chin
PURPOSE: The erector spinae plane (ESP) block has been described in the successful management of both thoracic and abdominal pain. Since the erector spinae muscle extends to the cervical spine, the ESP block may be potentially useful in painful conditions of the shoulder girdle. CLINICAL FEATURES: We performed a series of ESP blocks at the T2/T3 level in an elderly male patient with chronic shoulder pain. Immediate and profound analgesia with improved range of motion was consistently observed following the block...
March 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29131024/evaluation-of-anastomotic-leak-after-esophagectomy-for-esophageal-cancer-typical-time-point-of-occurrence-mode-of-diagnosis-value-of-routine-radiocontrast-agent-studies-and-therapeutic-options
#18
Benjamin Struecker, Andreas Andreou, Sascha Chopra, Ann-Christin Heilmann, Johanna Spenke, Christian Denecke, Igor Maximilian Sauer, Marcus Bahra, Johann Pratschke, Matthias Biebl
BACKGROUND: Data on the typical time point of occurrence of anastomotic leak (AL) after esophagectomy for esophageal cancer are currently scarce. Therefore, the usefulness of routine radiocontrast agent studies (RRCS) for testing proper healing of the anastomosis after esophagectomy remains unclear. Furthermore, preferred available tools to diagnose postoperative AL and therapeutic options are still under debate. METHODS: We present a retrospective analysis of 328 consecutive patients who underwent esophagectomy for esophageal cancer between 2005 and 2015...
November 7, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29089038/the-impact-of-n-acetylcysteine-and-ascorbic-acid-in-contrast-induced-nephropathy-in-critical-care-patients-an-open-label-randomized-controlled-study
#19
Eleni Palli, Demosthenes Makris, John Papanikolaou, Grigorios Garoufalis, Irini Tsilioni, Paris Zygoulis, Epaminondas Zakynthinos
BACKGROUND: The aim was to investigate whether the use of N-acetylcysteine and ascorbic acid reduce contrast-induced nephropathy incidence in critical care patients. METHODS: This was a one-center, two-arm, prospective, randomized, open-label, controlled trial in the Intensive Care Unit of the University Hospital of Larissa, Greece. Patients with stable renal function, who underwent non urgent contrast-enhanced computed tomography for diagnostic purposes, were included in the study...
October 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29044520/quercetin-protects-against-radiocontrast-medium-toxicity-in-human-renal-proximal-tubular-cells
#20
Michele Andreucci, Teresa Faga, Antonio Pisani, Raffaele Serra, Domenico Russo, Giovambattista De Sarro, Ashour Michael
Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods...
May 2018: Journal of Cellular Physiology
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