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https://www.readbyqxmd.com/read/28281738/efficacy-of-nicorandil-treatment-for-prevention-of-contrast-induced-nephropathy-in-high-risk-patients-undergoing-cardiac-catheterization-a-prospective-randomized-controlled-trial
#1
Leili Iranirad, Seyed Fakhreddin Hejazi, Mohammad Saleh Sadeghi, Shahram Arsang Jang
BACKGROUND: Contrast-induced nephropathy (CIN) remains to be a potentially serious complication of radiographic procedures and is the third leading cause of the acute kidney injury (AKI) among hospitalized patients. This clinical trial was performed to assess the preventive effect of oral nicorandil on CIN in high-risk patients undergoing cardiac catheterization. METHODS: In this prospective, randomized, controlled trial, 128 patients with at least two risk factors for CIN undergoing elective percutaneous coronary intervention (PCI) were randomly assigned to either the nicorandil group or the control group...
March 10, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28258478/in-vitro-diagnosis-of-immediate-drug-hypersensitivity-anno-2017-potentials-and-limitations
#2
REVIEW
I I Decuyper, E A Mangodt, A L Van Gasse, K Claesen, A Uyttebroek, M Faber, V Sabato, C H Bridts, C Mertens, M M Hagendorens, L S De Clerck, Didier G Ebo
BACKGROUND: For most physicians, quantification of drug-specific immunoglobulin E (drug-sIgE) antibodies constitutes the primary in vitro measure to document immediate drug hypersensitivity reactions (IDHR). Unfortunately, this is often insufficient to correctly identify patients with IgE-mediated IDHR and impossible for non-IgE-mediated IDHR that result from alternative routes of basophil and mast cell activation. In these difficult cases, diagnosis might benefit from cellular tests such as basophil activation tests (BAT)...
March 4, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28248433/application-of-bold-mri-and-dti-for-the-evaluation-of-renal-effect-related-to-viscosity-of-iodinated-contrast-agent-in-a-rat-model
#3
Yi Wang, Ke Ren, Yi Liu, Wen-Ge Sun, Jia-Huan Wang, Xin Zhang, Cheng-Hua Wu
PURPOSE: To evaluate the effects of viscosity of contrast agent (CA) on intrarenal oxygenation and diffusion as measured by blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in a rat model. MATERIALS AND METHODS: Radiocontrast iodixanol formulated in three viscosities were designated 270, 320, and 350 (mg iodine/mL). Sixty-three male Wistar rats were divided into four groups. Saline and iodixanol (4 g iodine/kg) were administered...
March 1, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28128875/an-ultrasound-guided-tendon-sparing-lateral-approach-to-injection-of-the-navicular-bursa
#4
K Nottrott, C De Guio, A Khairoun, M Schramme
BACKGROUND: Navicular disease in the horse often requires injection of the navicular bursa. We have developed an ultrasound-guided, lateral needle approach to navicular bursocentesis, which avoids penetration of the deep digital flexor tendon (DDFT) and the need for radiographic control. OBJECTIVES: To describe and evaluate the feasibility and efficacy of an ultrasound-guided, lateral bursocentesis technique. STUDY DESIGN: Cadaveric and in vivo experiments...
January 27, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28100100/a-new-update-for-radiocontrast-induced-nephropathy-aggravated-with-glycerol-in-rats-the-protective-potential-of-epigallocatechin-3-gallate
#5
Saziye Sezin Palabiyik, Busra Dincer, Elif Cadirci, Irfan Cinar, Cemal Gundogdu, Beyzagul Polat, Muhammed Yayla, Zekai Halici
Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n = 6 in each), as follows: Healthy, GLY, CM, GLY + CM, CM + EGCG 50 mg/kg (po), GLY + CM + EGCG 50 mg/kg (po), CM + EGCG 100 mg/kg (po), and GLY + CM + EGCG 100 mg/kg (po)...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/28090570/targeted-inhibition-of-pancreatic-acinar-cell-calcineurin-is-a-novel-strategy-to-prevent-post-ercp-pancreatitis
#6
Abrahim I Orabi, Li Wen, Tanveer A Javed, Tianming Le, Ping Guo, Subramaniam Sanker, David Ricks, Kristy Boggs, John F Eisses, Carlos Castro, Xiangwei Xiao, Krishna Prasadan, Farzad Esni, George K Gittes, Sohail Z Husain
BACKGROUND AND AIMS: There is a pressing need to develop effective preventative therapies for post-ERCP pancreatitis (PEP). We demonstrated that early PEP events are induced through the calcium-activated phosphatase calcineurin and that global calcineurin deletion abolishes PEP in mice. A crucial question is whether acinar cell calcineurin controls the initiation of PEP in vivo. METHODS: We used a mouse model of PEP and examined the effects of in vivo acinar cell-specific calcineurin deletion by either generating a conditional knockout line or infusing a novel AAV-Ela-iCre into the pancreatic duct of a calcineurin floxed line...
January 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27975052/histopathological-evaluation-of-contrast-induced-acute-kidney-injury-rodent-models
#7
REVIEW
Norbert Kiss, Péter Hamar
Contrast-induced acute kidney injury (CI-AKI) can occur in 3-25% of patients receiving radiocontrast material (RCM) despite appropriate preventive measures. Often patients with an atherosclerotic vasculature have to receive large doses of RCM. Thus, animal studies to uncover the exact pathomechanism of CI-AKI are needed. Sensitive and specific histologic end-points are lacking; thus in the present review we summarize the histologic appearance of different rodent models of CI-AKI. Single injection of RCM causes overt renal damage only in rabbits...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27903484/loss-of-kidney-function-after-endovascular-treatment-of-peripheral-arterial-disease
#8
Tim A Sigterman, Lars J J Bolt, Attila G Krasznai, Maarten G Snoeijs, Roel Heijboer, Geert Willem H Schurink, Lee H Bouwman
BACKGROUND: Administration of radiocontrast during endovascular procedures for peripheral arterial disease (PAD) may cause acute kidney injury, which generally recovers with supportive treatment. Long-term effects of endovascular procedures on renal function remain to be investigated. METHOD: This retrospective observational cohort study includes all patients who newly presented to the vascular surgery outpatient clinic with Rutherford class II or III PAD and who were treated with either supervised exercise therapy or endovascular interventions...
November 27, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27852844/bilirubin-levels-are-associated-with-contrast-induced-nephropathy-in-peripheral-artery-disease
#9
Ertan Vuruşkan, Erhan Saraçoğlu
The relationship between contrast-induced nephropathy (CIN) and oxidative mechanisms is well documented. Our aim was to demonstrate the possible relationship between CIN and serum bilirubin as an antioxidant molecule. This retrospective study included 359 patients with peripheral artery disease (PAD) who underwent peripheral diagnostic angiography; 179 developed CIN after the intervention and another 180 were the control group, matched for age, gender, and cardiovascular risk factors. Baseline, 48- to 72-hour, and 30-day laboratory values, major adverse cardiovascular events, and dialysis requirements were recorded...
November 15, 2016: Angiology
https://www.readbyqxmd.com/read/27846008/a-novel-pretreatment-regimen-for-breakthrough-radiocontrast-media-anaphylaxis-in-cardiac-patients
#10
Shari V Montandon, Andrej A Petrov, Merritt L Fajt
BACKGROUND: Radiocontrast media allergy is a severe and potentially life-threatening condition. This creates a clinical dilemma for cardiac patients who require urgent interventions with radiocontrast media. Several pretreatment regimens have been suggested for patients with prior immediate hypersensitivity reactions to radiocontrast media. Despite using pretreatment regimens, breakthrough reactions have been reported in 2.1%-18% of patients with radiocontrast media allergy. Little is known about management of patients with a history of breakthrough radiocontrast media anaphylaxis who require urgent lifesaving procedures...
December 2016: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/27832559/balancing-the-risks-and-benefits-of-using-emergency-diagnostic-radiocontrast-studies-to-diagnose-life-threatening-illness-in-critically-ill-patients-a-decision-analysis
#11
K M Ho
Diagnosis of many life-threatening illnesses, including acute pulmonary embolism, aortic dissection, and ischaemic bowel disease, requires confirmatory radiological imaging with radiocontrast. It is well established that radiocontrast can induce acute kidney injury, especially in patients with pre-existing renal impairment. The decision to proceed with a radiological study with radiocontrast to confirm or exclude a life-threatening, but potentially reversible, illness in patients with renal impairment is difficult...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27781957/valsartan-protects-against-contrast-induced-acute-kidney-injury-in-rats-by-inhibiting-endoplasmic-reticulum-stress-induced-apoptosis
#12
Yan Sun, Ping-An Peng, Yue Ma, Xiaoli Liu, Yi Yu, Shuo Jia, Xiaohan Xu, Sijing Wu, Yujie Zhou
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. While the preventative measures can mitigate the risk of CI-AKI, there remains a need for novel and effective therapeutic approaches. The pathogenesis of CI-AKI is complex and not completely understood. CM-induced renal tubular cell apoptosis caused by the activation of endoplasmic reticulum (ER) stress is involved in CI-AKI...
October 25, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27745988/adverse-reactions-to-contrast-material-a-canadian-update
#13
Alexander Morzycki, Anuj Bhatia, Kieran Murphy
Imaging techniques frequently employ contrast agents to improve image resolution and enhance pathology detection. These gadolinium- and iodine-based media, although generally considered safe, are associated with a number of adverse effects ranging from mild to severe. Reactions are classified as either anaphylactoid ("anaphylaxis-like") or nonanaphylactoid, depending on a number of elements that will be reviewed. Herein, we have summarized predisposing risk factors for adverse events resulting from the use of contrast, their associated pathophysiological mechanisms as well as known prophylaxis for the antitreatment of high-risk patients...
October 13, 2016: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/27704319/clinical-outcomes-of-acute-kidney-injury-developing-outside-the-hospital-in-elderly
#14
K Turgutalp, S Bardak, M Horoz, I Helvacı, S Demir, A A Kiykim
PURPOSE: Although various studies have improved our knowledge about the clinical features and outcomes of acute kidney injury developing in the hospital (AKI-DI) in elderly subjects, data about acute kidney injury developing outside the hospital (AKI-DO) in elderly patients (age ≥ 65 years) are still extremely limited. This study was performed to investigate prevalence, clinical outcomes, hospital cost and related factors of AKI-DO in elderly and very elderly patients. METHODS: We conducted a prospective, observational study in patients (aged ≥ 65 years) who were admitted to our center between May 01, 2012, and May 01, 2013...
January 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/27688297/estimating-the-risk-of-radiocontrast-associated-nephropathy
#15
Emilee Wilhelm-Leen, Maria E Montez-Rath, Glenn Chertow
Estimates of the incidence of radiocontrast-associated nephropathy vary widely and suffer from misclassification of the cause of AKI and confounding. Using the Nationwide Inpatient Sample, we created multiple estimates of the risk of radiocontrast-associated nephropathy among adult patients hospitalized in the United States in 2009. First, we stratified patients according to the presence or absence of 12 relatively common diagnoses associated with AKI and evaluated the rate of AKI between strata. Next, we created a logistic regression model, controlling for comorbidity and acuity of illness, to estimate the risk of AKI associated with radiocontrast administration within each stratum...
February 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27680416/acute-symptomatic-hyponatremia-after-computed-tomography-renal-protocol
#16
Li Yi Lim, Che Ani Mohd Firdaus, Xeng Inn Fam, Eng Hong Goh
Computed tomography (CT) is a widely used imaging modality. Although hyponatremia after CT imaging is rare, its effects can be devastating. Hyperosmolar radiocontrast acts as effective osmoles and causes fluid migration from intracellular into extracellular compartment. Dilutional hyponatremia will ensue if translocation of fluid is in excess of diuresis. This case report detailed an unusual case of acute symptomatic hyponatremia after CT renal protocol and the treatments given after its recognition.
January 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27650237/incidence-of-renal-failure-requiring-hemodialysis-following-transcatheter-aortic-valve-replacement
#17
REVIEW
Vatsal Ladia, Hemang B Panchal, Terrence J O׳Neil, Puja Sitwala, Samit Bhatheja, Rakeshkumar Patel, Vijay Ramu, Debabrata Mukherjee, Ehtisham Mahmud, Timir K Paul
OBJECTIVE: Studies have shown that iodinated radiocontrast use is associated with acute renal failure especially in the presence of chronic kidney disease and multiple factors modulate this risk. The purpose of this meta-analysis is to compare the incidence of renal failure requiring hemodialysis between transfemoral (TF) and transapical (TA) transcatheter aortic valve replacement using the Edwards valve. METHODS: The PubMed database was searched from January 2000 through December 2014...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27648959/adverse-safety-events-in-patients-with-chronic-kidney-disease-ckd
#18
REVIEW
Ada Offurum, Lee-Ann Wagner, Tanisha Gooden
Chronic kidney disease (CKD) confers a higher risk of adverse safety events as a result of many factors including medication dosing errors and use of nephrotoxic drugs, which can cause kidney injury and renal function decline. CKD patients may also have comorbidities such as hypertension and diabetes for which they require more frequent care from different providers, and for which standard, but countervailing treatments, may put them at risk for adverse safety events. Areas covered: In addition to the well-known agents such as iodinated radiocontrast, antimicrobials, diuretics and angiotensin converting enzyme (ACE) inhibitors which can directly affect renal function, safety considerations in the treatment of common CKD complications such as anemia, diabetes, analgesia and thrombosis will also be discussed...
December 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27648932/varied-incidence-of-immediate-adverse-reactions-to-low-osmolar-non-ionic-iodide-radiocontrast-media-used-in-computed-tomography
#19
S R Kim, J H Lee, K H Park, H J Park, J W Park
BACKGROUND: Low-osmolar non-ionic radiocontrast media (RCMs) are commonly used throughout hospitals. However, the incidence of immediate adverse drug reactions (ADRs) to various low-osmolar non-ionic RCMs is not well studied. We compared the incidence of immediate ADRs among different low-osmolar non-ionic RCMs used in computed tomography (CT). METHODS: Severance Hospital has collected data for adverse reactions occurring in-hospital using an internally developed system...
January 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27601148/-iodine-allergy-a%C3%A2-medical-myth-with-risks-for-the-ophthalmological-patient
#20
T U Krohne, J-P Allam, N Novak, F G Holz
BACKGROUND: Preoperative disinfection with povidone-iodine results in a significant reduction of the risk for postoperative endophthalmitis and secondary irreversible vision loss in intraocular surgeries and intravitreal injections. Nevertheless, this important measure is often omitted if so-called "iodine allergy" is suspected. We analyze the physiological and allergological basis for the construct of "iodine allergy". METHODS: This article is based on a selective literature review using the search term "allergy" in combination with "iodine", "povidone", "indocyanine green", or "seafood"...
December 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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