keyword
https://read.qxmd.com/read/38049263/household-dishwashing-detergents-efficiently-inactivate-hsv-1-but-not-the-non-enveloped-viruses-hav-and-mnv-while-all-viruses-were-removed-from-glass-by-manual-scrubbing
#21
JOURNAL ARTICLE
Katja Schilling-Loeffler, Racem Ben Romdhane, Taras Günther, Reimar Johne
This study investigated the stability of herpes simplex virus 1 (HSV-1), hepatitis A virus (HAV) and murine norovirus (MNV) on glass, their inactivation by three household dishwashing detergents and during a glass rinsing process. After drying on glass and storage in darkness, virus titers decreased by 4.7, 5.5 and 4.5 log10 plaque forming units (PFU) in 21, 28 and 14 days for HSV-1, HAV and MNV, respectively. Daylight storage resulted in shorter survival times. While HAV and MNV titers were not significantly affected by 60 s incubation in dishwashing detergents at up to 43 °C, HSV-1 titer decreased significantly by > 4 log10  PFU/mL at the same conditions with each detergent used...
April 2024: Food Microbiology
https://read.qxmd.com/read/38048984/chemogenetic-inhibition-of-locus-coeruleus-to-rostromedial-tegmental-nucleus-noradrenergic-pathway-increases-light-cycle-ethanol-drinking-in-male-and-female-mice-and-blunts-ethanol-induced-cta
#22
JOURNAL ARTICLE
Ana Paula S Dornellas, Todd E Thiele, Montserrat Navarro
We recently showed that chemogenetic activation of the locus coeruleus (LC) to the rostromedial tegmental nucleus (RMTg) noradrenergic (NE) pathway significantly blunted binge-like ethanol drinking and induced aversive-like behaviors in mice. The aim of the present study is to determine if silencing this TH + LC → RMTg noradrenergic pathway promotes increased levels of binge-like ethanol intake and reduced ethanol-induced conditioned taste aversion (CTA). To this end, both male and female TH-ires-cre mice on a C57BL/6 J background were cannulated in the RMTg and injected in the LC with rAVV viruses that encode cre-dependent Gi-expressing designer receptor exclusively activated by designer drugs (DREADDs), or its control, to directly control the activity of NE neurons...
December 2, 2023: Neuropharmacology
https://read.qxmd.com/read/38014065/cholinergic-mu-opioid-receptors-participate-in-nicotine-but-not-ethanol-drinking-behaviors
#23
Cambria R Beane, Kat L Pikus, Delainey G Lewis, Nicolaus Bruns, Mary H Durfee, Roman A Zegarelli, Thomas W Perry, Anna K Radke
Heavy alcohol use and binge drinking are important contributors to alcohol use disorder (AUD). The endogenous opioid system has been implicated in alcohol consumption and preference in both humans and animals. The mu opioid receptor (MOR) is expressed on multiple cells in the striatum, however little is known about the contributions of specific MOR populations to alcohol drinking behaviors. The current study used mice with a genetic deletion of MOR in cholinergic cells (ChAT-Cre/Oprm1 fl/fl ) to examine the role of MORs expressed in cholinergic interneurons (CINs) in home cage self-administration paradigms...
November 16, 2023: bioRxiv
https://read.qxmd.com/read/38006668/adolescent-intermittent-ethanol-exposure-alters-adult-exploratory-and-affective-behaviors-and-cerebellar-grin2b-expression-in-c57bl-6j-mice
#24
JOURNAL ARTICLE
Kati Healey, Renee C Waters, Sherilynn G Knight, Gabriela M Wandling, Nzia I Hall, Brooke N Jones, Mariah J Shobande, Jaela G Melton, Subhash C Pandey, H Scott Swartzwelder, Antoniette M Maldonado-Devincci
Binge drinking is one of the most common patterns (more than 90%) of alcohol consumption by young people. During adolescence, the brain undergoes maturational changes that influence behavioral control and affective behaviors, such as cerebellar brain volume and function in adulthood. We investigated long-term impacts of adolescent binge ethanol exposure on affective and exploratory behaviors and cerebellar gene expression in adult male and female mice. Further, the cerebellum is increasingly recognized as a brain region integrating a multitude of behaviors that span from the traditional primary sensory-motor to affective functions, such as anxiety and stress reactivity...
November 10, 2023: Drug and Alcohol Dependence
https://read.qxmd.com/read/38001264/the-neutral-cb1-antagonist-am6527-reduces-ethanol-seeking-binge-like-consumption-reinforcing-and-withdrawal-effects-in-male-and-female-mice
#25
JOURNAL ARTICLE
Jimit Girish Raghav, Hritik Kumar, Lipin Ji, Kiran Vemuri, Alexandros Makriyannis, Junghyup Suh, Michael Z Leonard, Vivi Dang, Chelsea Ty, Stephen Marandola, Natalie Kane, Annika S Witt, Samar Shaqour, Klaus A Miczek
RATIONALE: Alcohol use disorder (AUD) is a debilitating physiological and psychiatric disorder which affects individuals globally. The current pharmacological interventions to treat AUD are limited, and hence there is an urgent need for a novel pharmacological therapy which can be effective and safe across the population. OBJECTIVE: We aimed to investigate a novel neutral cannabinoid receptor-1 (CB1R) antagonist, AM6527, in several preclinical models of ethanol consumption using male and female C57BL6/J mice...
November 25, 2023: Psychopharmacology
https://read.qxmd.com/read/37999545/carbetocin-inhibits-behavioral-sensitization-to-ethanol-in-male-and-female-mice-independent-of-corticosterone-levels
#26
JOURNAL ARTICLE
Beatriz Yamada Costa, Luana Gasparini Santos, Priscila Marianno, Mariana Rae, Marina Gomes de Almeida, Malcon Carneiro de Brito, Rosângela Eichler, Rosana Camarini
Oxytocin (OXT), a pro-social peptide, is increasingly recognized as a potential protective substance against drug addiction. In the context of ethanol, previous research has shown OXT's properties in reducing self-administration, alleviating motor impairment in rodents, and reducing craving in humans. However, its role in behavioral sensitization, a neuroadaptive response resulting from repeated drug exposure linked to an increased drug incentive, remains unexplored. OXT is recognized for its role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, in which corticosterone is acknowledged as a significant factor in the development of behavioral sensitization...
October 31, 2023: Toxics
https://read.qxmd.com/read/37982929/modeling-brain-gene-expression-in-alcohol-use-disorder-with-genetic-animal-models
#27
JOURNAL ARTICLE
Robert Hitzemann, Angela R Ozburn, Denesa Lockwood, Tamara J Phillips
Animal genetic models have and will continue to provide important new information about the behavioral and physiological adaptations associated with alcohol use disorder (AUD). This chapter focuses on two models, ethanol preference and drinking in the dark (DID), their usefulness in interrogating brain gene expression data and the relevance of the data obtained to interpret AUD-related GWAS and TWAS studies. Both the animal and human data point to the importance for AUD of changes in synaptic transmission (particularly glutamate and GABA transmission), of changes in the extracellular matrix (specifically including collagens, cadherins and protocadherins) and of changes in neuroimmune processes...
November 21, 2023: Current Topics in Behavioral Neurosciences
https://read.qxmd.com/read/37964589/united-we-thrive-friendship-and-subsequent-physical-behavioural-and-psychosocial-health-in-older-adults-an-outcome-wide-longitudinal-approach
#28
JOURNAL ARTICLE
E S Kim, W J Chopik, Y Chen, R Wilkinson, T J VanderWeele
AIMS: Three factors converge to underscore the heightened importance of evaluating the potential health/well-being effects of friendships in older adulthood. First, policymakers, scientists, and the public alike are recognizing the importance of social relationships for health/well-being and creating national policies to promote social connection. Second, many populations are rapidly aging throughout the world. Third, we currently face what some call a 'friendship recession'. Although, growing research documents associations between friendship with better health and well-being, friendship can also have a 'dark side' and can potentially promote negative outcomes...
November 15, 2023: Epidemiology and Psychiatric Sciences
https://read.qxmd.com/read/37961441/short-chain-fatty-acid-valerate-reduces-voluntary-alcohol-intake-in-male-mice
#29
Suresh C Bokoliya, Jordan Russell, Yair Dorsett, Hunter Panier, Vijender Singh, Lauren Daddi, Hanshu Yuan, Liv R Dedon, Zhongmao Liu, Jessica R Barson, Jonathan Covault, Jason A Bubier, Yanjiao Zhou
Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. Development of novel therapeutic and preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied. Results Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking...
October 30, 2023: Research Square
https://read.qxmd.com/read/37957762/sex-differences-in-binge-alcohol-drinking-and-the-behavioral-consequences-of-protracted-abstinence-in-c57bl-6j-mice
#30
JOURNAL ARTICLE
Jean K Rivera-Irizarry, Lia J Zallar, Olivia B Levine, Mary Jane Skelly, Jared E Boyce, Thaddeus Barney, Ruth Kopyto, Kristen E Pleil
BACKGROUND: Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men binge drink more alcohol than women, this demographic gap is quickly shrinking, and preclinical studies demonstrate that females consistently consume more alcohol than males. Further, women are at increased risk for the co-expression of AUD with neuropsychiatric diseases such as anxiety and mood disorders. However, little is understood about chronic voluntary alcohol drinking and its long-term effects on behavior...
November 13, 2023: Biology of Sex Differences
https://read.qxmd.com/read/37926812/taste-receptor-type-1-member-3-enables-western-diet-induced-anxiety-in-mice
#31
JOURNAL ARTICLE
Jae Won Song, Keon-Hee Lee, Hobin Seong, Dong-Mi Shin, Woo-Jeong Shon
BACKGROUND: Accumulating evidence supports that the Western diet (WD), a diet high in saturated fat and sugary drinks, contributes to the pathogenesis of anxiety disorders, which are the most prevalent mental disorders worldwide. However, the underlying mechanisms by which WD causes anxiety remain unclear. Abundant expression of taste receptor type 1 member 3 (TAS1R3) has been identified in the hypothalamus, a key brain area involved in sensing peripheral nutritional signals and regulating anxiety...
November 6, 2023: BMC Biology
https://read.qxmd.com/read/37916300/voluntary-alcohol-consumption-during-distinct-phases-of-adolescence-differentially-alters-adult-fear-acquisition-extinction-and-renewal-in-male-and-female-rats
#32
JOURNAL ARTICLE
J Alex Grizzell, Maryam Vanbaelinghem, Jessica Westerman, Michael P Saddoris
Alcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and mesolimbic systems involved in fear processing. Prior work has investigated the impact of binge-like alcohol consumption on adult fear and stress, but less is known about whether voluntarily consumed alcohol imparts differential effects based on adolescence phases and biological sex. Here, adolescent male and female Long Evans rats were granted daily access to alcohol (15%) during either early (Early-EtOH; P25-45) or late adolescence (Late-EtOH; P45-55) using a modified drinking-in-the-dark design...
November 2, 2023: Stress: the International Journal on the Biology of Stress
https://read.qxmd.com/read/37906392/ameliorative-effects-of-thiamin-on-learning-behavior-and-memory-dysfunction-in-a-rat-model-of-hypothyroidism-implication-of-oxidative-stress-and-acetylcholinesterase
#33
JOURNAL ARTICLE
Rasul Saberi, Naser Mirazi, Sabiheh Amirahmadi, Zahra Kioumarsi Darbandi, Farzaneh Vafaee, Arezoo Rajabian, Mahmoud Hosseini
Hypothyroidism causes learning and memory impairment. Considering the neuroprotective properties of thiamine (Vitamin B1), this study was conducted to investigate the effects of thiamine on acetylcholinesterase (AChE) activity, oxidative damage, and memory deficits in hypothyroid rats.In this study, 50 rats (21 days old) were randomly divided into 5 groups and treated with propylthiouracil (0.05% in drinking water) and thiamine (50, 100, and 200 mg/kg, oral) for 7 weeks. Following that, Morris water maze (MWM) and passive avoidance (PA) tests were performed...
October 31, 2023: Metabolic Brain Disease
https://read.qxmd.com/read/37897999/seasonal-variations-of-biofilm-c-n-and-s-cycling-genes-in-a-pilot-scale-chlorinated-drinking-water-distribution-system
#34
JOURNAL ARTICLE
Yanchu Ke, Wenjun Sun, Shuming Liu, Ying Zhu, Shuang Yan, Xiuli Chen, Shuguang Xie
Biofilms in drinking water distribution systems (DWDS) host diverse microorganisms. However, the functional attributes of DWDS biofilms and their associations with seasonality remain unclear. This study aims to characterize variations in the microbial metabolic traits of DWDS biofilms collected during different seasons, using a pilot-scale DWDS in dark under plug-flow conditions during one-year operation period. Network analysis was used to predict the functional gene hosts. The overall functional attributes determined by shotgun metagenomics exhibited significant differences among seasons...
October 19, 2023: Water Research
https://read.qxmd.com/read/37873067/voluntary-alcohol-consumption-during-distinct-phases-of-adolescence-differentially-alters-adult-fear-acquisition-extinction-and-renewal-in-male-and-female-rats
#35
J Alex Grizzell, Maryam Vanbaelinghem, Jessica Westerman, Michael P Saddoris
Alcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and mesolimbic systems involved in fear processing. Prior work has investigated the impact of binge-like alcohol consumption on adult fear and stress, but less is known about whether voluntarily consumed alcohol imparts differential effects based on adolescence phases and biological sex. Here, adolescent male and female Long Evans rats were granted daily access to alcohol (15%) during either early (Early-EtOH; P25-45) or late adolescence (Late-EtOH; P45-55) using a modified drinking-in-the-dark design...
October 5, 2023: bioRxiv
https://read.qxmd.com/read/37860576/the-clinical-research-on-the-effect-of-hydrogen-rich-water-on-primary-retinitis-pigmentosa
#36
JOURNAL ARTICLE
Xiaohong Chen, Yanjian Chen, Xingchui Lin, Qian Ye, Sheng Zhang, Yunpeng Wang, Meizhu Chen, Weiming Yan
OBJECTIVE: To investigate the feasibility and effectiveness of hydrogen in the treatment of retinitis pigmentosa (RP) patients through the drinking of hydrogen-rich water (HRW). METHODS: RP patients clinically diagnosed in our hospital were selected and given HRW for drinking at 400-500 ml twice a day for four consecutive weeks. Changes in best corrected visual acuity (BCVA), intraocular pressure, the retinal thickness, and choroidal thickness, as well as the amplitude and peak time of visual electrophysiological examinations before and after HRW drinking were observed...
October 2023: Heliyon
https://read.qxmd.com/read/37839822/investigating-the-impact-of-dark-nudges-on-drinking-intentions-a-between-groups-randomized-and-online-experimental-study
#37
JOURNAL ARTICLE
Joel Lewin, Matt Field, Emma Davies
OBJECTIVES: This study explored how 'dark nudges' (tactics used in alcohol industry-funded responsible drinking campaigns) affect drinking intentions, perceived source credibility and whether individual differences in perceptions of prototypical drinkers moderated these effects. DESIGN: Two 2 × 2 between-groups online experimental studies. METHODS: Study 1 (N = 164) presented three alcohol health messages per condition, comprising social norm (healthy/unhealthy ("dark nudge")) by frame (loss/gain)...
October 15, 2023: British Journal of Health Psychology
https://read.qxmd.com/read/37838352/home-cage-voluntary-alcohol-consumption-increases-binge-drinking-without-affecting-abstinence-related-depressive-like-behaviors-or-operant-responding-in-crossed-high-alcohol-preferring-chaps
#38
JOURNAL ARTICLE
Garrett A Winkler, Nicholas J Grahame
Chronic alcohol consumption can lead to tolerance and escalation of drinking in humans and animals, but mechanisms underlying these changes are not fully characterized. Preclinical models can delineate which mechanisms are involved. The chronic intermittent ethanol exposure (CIE) procedure uses forced exposure to vaporized alcohol that elicits withdrawal and increased responding for alcohol in operant tasks in C57BL/6J inbred mice (Lopez et al, 2008; Kliethermes et al., 2006). Chronic two-bottle choice (2BC) drinking in the same strain elicits abstinent-related depression-like behavior (Stevenson et al...
October 12, 2023: Alcohol
https://read.qxmd.com/read/37824093/development-and-evaluation-of-the-dietary-pattern-calculator-dipac-for-personalized-assessment-and-feedback
#39
JOURNAL ARTICLE
Mahsa Jessri, Adelia Jacobs, Alena Praneet Ng, Carol Bennett, Alison Quinlan, Charlotte Nutt, Jennifer Brown, Deirdre Hennessy, Douglas G Manuel
This study aimed to develop and validate a diet assessment screener - the Dietary Pattern Calculator (DiPaC). A scoping review identified currently available short diet quality assessment tools. Twenty-one articles covering 19 unique tools were included. The current tools mainly focused on individual nutrients or food groups or were developed for a specific population, and few ascertained overall dietary patterns. The 24-hour dietary recalls from the nationally representative Canadian Community Health Survey (CCHS)-Nutrition 2015 ( n  = 13,958) were used to derive and validate a personalized dietary pattern informed by the scoping review using weighted partial least squares...
October 12, 2023: Canadian Journal of Dietetic Practice and Research
https://read.qxmd.com/read/37808817/sex-differences-in-binge-alcohol-drinking-and-the-behavioral-consequences-of-protracted-abstinence-in-c57bl-6j-mice
#40
Jean K Rivera-Irizarry, Lia J Zallar, Olivia B Levine, Mary Jane Skelly, Jared E Boyce, Thaddeus Barney, Ruth Kopyto, Kristen E Pleil
BACKGROUND: Binge alcohol drinking is a risk factor linked to numerous disease states including alcohol use disorder (AUD). While men binge drink more alcohol than women, this demographic gap is quickly shrinking, and preclinical studies demonstrate that females consistently consume more alcohol than males. Further, women are at increased risk for the co-expression of AUD with neuropsychiatric diseases such as anxiety and mood disorders. However, little is understood about chronic voluntary alcohol drinking and its long-term effects on behavior...
September 30, 2023: bioRxiv
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