Suresh C Bokoliya, Jordan Russell, Yair Dorsett, Hunter Panier, Vijender Singh, Lauren Daddi, Hanshu Yuan, Liv R Dedon, Zhongmao Liu, Jessica R Barson, Jonathan Covault, Jason A Bubier, Yanjiao Zhou
Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. Development of novel therapeutic and preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied. Results Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking...
October 30, 2023: Research Square