keyword
MENU ▼
Read by QxMD icon Read
search

Drinking in the dark

keyword
https://www.readbyqxmd.com/read/28638713/the-behavioral-and-physiological-effects-of-high-fat-diet-and-alcohol-consumption-sex-differences-in-c57bl6-j-mice
#1
Rachel R Gelineau, Nicole L Arruda, Jasmin A Hicks, Isabella Monteiro De Pina, Aikaterini Hatzidis, Joseph A Seggio
BACKGROUND AND OBJECTIVE: Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different "lifestyle variables" such as diets. Consumption of both high-fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high-fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28630783/highly-sensitive-colorimetric-assay-for-determining-fe-3-based-on-gold-nanoparticles-conjugated-with-glycol-chitosan
#2
Kyungmin Kim, Yun-Sik Nam, Yeonhee Lee, Kang-Bong Lee
A highly sensitive and simple colorimetric assay for the detection of Fe(3+) ions was developed using gold nanoparticles (AuNPs) conjugated with glycol chitosan (GC). The Fe(3+) ion coordinates with the oxygen atoms of GC in a hexadentate manner (O-Fe(3+)-O), decreasing the interparticle distance and inducing aggregation. Time-of-flight secondary ion mass spectrometry showed that the bound Fe(3+) was coordinated to the oxygen atoms of the ethylene glycol in GC, which resulted in a significant color change from light red to dark midnight blue due to aggregation...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28575029/new-evidence-about-the-dark-side-of-social-cohesion-in-promoting-binge-drinking-among-adolescents
#3
Juliana Gabrielle Martins, Haroldo Neves de Paiva, Paula Cristina Pelli Paiva, Raquel Conceição Ferreira, Isabela Almeida Pordeus, Patricia Maria Zarzar, Ichiro Kawachi
Adolescence is characterized by heightened susceptibility to peer influence, which makes adolescents vulnerable to initiating or maintaining risky habits such as heavy drinking. The aim of the study was to investigate the association of social capital with longitudinal changes in the frequency of binge drinking among adolescents at public and private high schools in the city of Diamantina, Brazil. This longitudinal study used two waves of data collected when the adolescents were 12 and 13 years old. At the baseline assessment in 2013 a classroom survey was carried out with a representative sample of 588 students...
2017: PloS One
https://www.readbyqxmd.com/read/28516787/antiproliferative-effect-of-a-food-coloring-on-colon-cancer-cell-line
#4
M Norizadeh Tazehkand
4-MEI (4-Methylimidazole) is used as a chemical intermediate, crude material or component in the manufacture of pharmaceuticals, photographic and photothermographic chemicals, dyes and pigments and agricultural chemicals. 4-MEI is unintentionally found in our food. Caramel colour (which is the most used beverage colouring and food), dark beers and common brands of cola drinks may comprise more than 100 μg of this compound per 12-ounce serving. 4-MEI is widely used by people and colon cancer is common in our countries...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28497360/neuroprotective-effects-of-nigella-sativa-extract-upon-the-hippocampus-in-ptu-induced-hypothyroidism-juvenile-rats-a-stereological-study
#5
Farimah Asiaei, Alireza Fazel, Ali Akbar Rajabzadeh, Mahmoud Hosseini, Farimah Beheshti, Masoumeh Seghatoleslam
This study aimed to examine the neuroprotective effects of Nigella sativa (N. sativa) in the hippocampus of propylthiouracil (PTU)-induced hypothyroid rats during neonatal and juvenile growth. Twenty- five pregnant rats from early gestation (GD 0) were divided into five groups: (1) control (received drinking water), (2) PTU (received 0.005% PTU in drinking water), (3-5) PTU + NS 0.05%, PTU + NS 0.1%, PTU + NS 0.2% (along with PTU, received 0.05%, 0.1% and 0.2% W/V of N. sativa respectively) and treatment continued until postnatal day 60 (PN 60)...
May 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28477089/the-phosphodiesterase-4-inhibitor-roflumilast-decreases-ethanol-consumption-in-c57bl-6j-mice
#6
Xin Liu, Pi-Da Hao, Ming-Feng Yang, Jing-Yi Sun, Lei-Lei Mao, Cun-Dong Fan, Zong-Yong Zhang, Da-Wei Li, Xiao-Yi Yang, Bao-Liang Sun, Han-Ting Zhang
RATIONALE: Alcohol use disorders have become one of the most damaging psychiatric disorders in the world; however, there are no ideal treatments in clinic. Phosphodiesterase-4 (PDE4), an enzyme that specifically hydrolyzes intracellular cyclic AMP (cAMP), has been involved in alcohol use disorders. Roflumilast is the first PDE4 inhibitor approved for treatment of chronic obstructive pulmonary diseases in clinic. It was of particular interest to researchers to determine whether roflumilast altered ethanol consumption...
May 6, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28475596/long-term-rebaudioside-a-treatment-does-not-alter-circadian-activity-rhythms-adiposity-or-insulin-action-in-male-mice
#7
Thomas H Reynolds, Rachelle A Soriano, Obadi A Obadi, Stanley Murkland, Bernard Possidente
Obesity is a major public health problem that is highly associated with insulin resistance and type 2 diabetes, two conditions associated with circadian disruption. To date, dieting is one of the only interventions that result in substantial weight loss, but restricting caloric intake is difficult to maintain long-term. The use of artificial sweeteners, particularly in individuals that consume sugar sweetened beverages (energy drinks, soda), can reduce caloric intake and possibly facilitate weight loss. The purpose of the present study was to examine the effects of the artificial sweetener, rebaudioside A (Reb-A), on circadian rhythms, in vivo insulin action, and the susceptibility to diet-induced obesity...
2017: PloS One
https://www.readbyqxmd.com/read/28473645/dopamine-receptors-differentially-control-binge-alcohol-drinking-mediated-synaptic-plasticity-of-the-core-nucleus-accumbens-direct-and-indirect-pathways
#8
Xincai Ji, Sucharita Saha, Jenya Kolpakova, Melissa Guildford, Andrew R Tapper, Gilles E Martin
Binge alcohol drinking, a behavior characterized by rapid repeated alcohol intake, is most prevalent in young adults and is a risk factor for excessive alcohol consumption and alcohol dependence. Although the alteration of synaptic plasticity is thought to contribute to this behavior, there is currently little evidence that this is the case. We used drinking in the dark (DID) as a model of binge alcohol drinking to assess its effects on spike timing-dependent plasticity (STDP) in medium spiny neurons (MSNs) of the core nucleus accumbens (NAc) by combining patch-clamp recordings with calcium imaging and optogenetics...
May 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28457669/%C3%AE-6%C3%AE-2-nicotinic-acetylcholine-receptors-influence-locomotor-activity-and-ethanol-consumption
#9
Helen M Kamens, Colette Peck, Caitlin Garrity, Alex Gechlik, Brenita C Jenkins, Akshat Rajan
Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system have been implicated in ethanol behaviors. In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption and sedation. A limitation of these studies is that the alteration in the receptor was present throughout development. The recently described α6β2 antagonist, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI), now makes it possible to test for the involvement of these receptors using a pharmacological approach...
June 2017: Alcohol
https://www.readbyqxmd.com/read/28442218/alignment-of-the-transcriptome-with-individual-variation-in-animals-selectively-bred-for-high-drinking-in-the-dark-hdid
#10
Robert Hitzemann, Denesa Oberbeck, Ovidiu Iancu, Priscila Darakjian, Shannon McWeeney, Stephanie Spence, Jason Schlumbohm, Pamela Metten, John Crabbe
Among animals at risk for excessive ethanol consumption such as the HDID selected mouse lines, there is considerable individual variation in the amount of ethanol consumed and the associated blood ethanol concentrations (BECs). For the HDID lines, this variation occurs even though the residual genetic variation associated with the DID phenotype has been largely exhausted and thus is most likely associated with epigenetic factors. Here we focus on the question of whether the genes associated with individual variation in HDID-1 mice are different from those associated with selection (risk) (Iancu et al...
May 2017: Alcohol
https://www.readbyqxmd.com/read/28433417/mechanistic-insights-into-epigenetic-modulation-of-ethanol-consumption
#11
Igor Ponomarev, Claire E Stelly, Hitoshi Morikawa, Yuri A Blednov, R Dayne Mayfield, R Adron Harris
There is growing evidence that small-molecule inhibitors of epigenetic modulators, such as histone deacetylases (HDAC) and DNA methyltransferases (DNMT), can reduce voluntary ethanol consumption in animal models, but molecular and cellular processes underlying this behavioral effect are poorly understood. We used C57BL/6J male mice to investigate the effects of two FDA-approved drugs, decitabine (a DNMT inhibitor) and SAHA (an HDAC inhibitor), on ethanol consumption using two tests: binge-like drinking in the dark (DID) and chronic intermittent every other day (EOD) drinking...
May 2017: Alcohol
https://www.readbyqxmd.com/read/28431906/transgenic-mice-with-increased-astrocyte-expression-of-ccl2-show-altered-behavioral-effects-of-alcohol
#12
Jennifer G Bray, Amanda J Roberts, Donna L Gruol
Emerging research provides strong evidence that activation of CNS glial cells occurs in neurological diseases and brain injury and results in elevated production of neuroimmune factors. These factors can contribute to pathophysiological processes that lead to altered CNS function. Recently, studies have also shown that both acute and chronic alcohol consumption can produce activation of CNS glial cells and the production of neuroimmune factors, particularly the chemokine ligand 2 (CCL2). The consequences of alcohol-induced increases in CCL2 levels in the CNS have yet to be fully elucidated...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28416865/folic-acid-content-and-antioxidant-activity-of-different-types-of-beers-available-in-hungarian-retail
#13
Dániel Koren, Csaba Orbán, Nóra Galló, Szilárd Kun, Beáta Vecseri-Hegyes, Gabriella Kun-Farkas
In this study 40 Hungarian retail beers were evaluated for folic acid content, antioxidant profile and physicochemical parameters. The physicochemical parameters, folic acid content and antioxidant activity of alcohol-free beers were the lowest. Folic acid content of beers aged with sour cherries showed high values, more than 0.4 mg/l and an alcohol-free beer-based mixed drink made with lemon juice contained more than 0.2 mg/l of folic acid. Dark beers and beers aged with sour cherries had the highest antioxidant activity probably owing to their high extract content, components released from the fruits and special malts...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28413623/glutamate-plasticity-woven-through-the-progression-to-alcohol-use-disorder-a-multi-circuit-perspective
#14
REVIEW
Lara Hwa, Joyce Besheer, Thomas Kash
Glutamate signaling in the brain is one of the most studied targets in the alcohol research field. Here, we report the current understanding of how the excitatory neurotransmitter glutamate, its receptors, and its transporters are involved in low, episodic, and heavy alcohol use. Specific animal behavior protocols can be used to assess these different drinking levels, including two-bottle choice, operant self-administration, drinking in the dark, the alcohol deprivation effect, intermittent access to alcohol, and chronic intermittent ethanol vapor inhalation...
2017: F1000Research
https://www.readbyqxmd.com/read/28400722/sex-differences-in-the-physiological-and-behavioral-effects-of-chronic-oral-methylphenidate-treatment-in-rats
#15
Lisa S Robison, Michalis Michaelos, Jason Gandhi, Dennis Fricke, Erick Miao, Chiu-Yim Lam, Anthony Mauceri, Melissa Vitale, Junho Lee, Soyeh Paeng, David E Komatsu, Michael Hadjiargyrou, Panayotis K Thanos
Methylphenidate (MP) is a psychostimulant prescribed for Attention Deficit Hyperactivity Disorder. Previously, we developed a dual bottle 8-h-limited-access-drinking-paradigm for oral MP treatment of rats that mimics the pharmacokinetic profile of treated patients. This study assessed sex differences in response to this treatment. Male and female Sprague Dawley rats were assigned to one of three treatment groups at 4 weeks of age (n = 12/group): Control (water), low dose (LD) MP, and high dose (HD) MP. Rats drank 4 mg/kg MP (LD) or 30 mg/kg MP (HD) during the first hour, and 10 mg/kg (LD) or 60 mg/kg MP (HD) for the remaining 7 h each day...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28398003/midkine-in-the-mouse-ventral-tegmental-area-limits-ethanol-intake-and-ccl2-gene-expression
#16
H Chen, D He, A W Lasek
Midkine (MDK) is a cytokine and neurotrophic factor that is more highly expressed in the brains of alcoholics and in mice predisposed to drink large amounts of ethanol, suggesting that MDK may regulate ethanol consumption. Here we measured ethanol consumption in male and female Mdk knockout (-/-) mice using the two-bottle choice and the drinking in the dark (DID) tests. We found that Mdk -/- mice consumed significantly more ethanol than wild-type controls in both tests. To determine if MDK acts in the ventral tegmental area (VTA) to regulate ethanol consumption, we delivered lentivirus expressing a Mdk shRNA into the VTA of male C57BL/6J mice to locally knockdown Mdk and performed the DID test...
April 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28386220/ethanol-sensitization-during-adolescence-or-adulthood-induces-different-patterns-of-ethanol-consumption-without-affecting-ethanol-metabolism
#17
Priscila F Carrara-Nascimento, Lucas B Hoffmann, Marcos B Contó, Tania Marcourakis, Rosana Camarini
In previous study, we demonstrated that ethanol preexposure may increase ethanol consumption in both adolescent and adult mice, in a two-bottle choice model. We now questioned if ethanol exposure during adolescence results in changes of consumption pattern using a three-bottle choice procedure, considering drinking-in-the-dark and alcohol deprivation effect as strategies for ethanol consumption escalation. We also analyzed aldehyde dehydrogenase (ALDH) activity as a measurement of ethanol metabolism. Adolescent and adult Swiss mice were treated with saline (SAL) or 2...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28381286/no-evidence-of-a-role-of-the-%C3%AE-4-subunit-of-the-nicotinic-acetylcholine-receptor-in-alcohol-related-behaviors
#18
Helen M Kamens, Constanza Silva, Riley McCarthy, Ryan J Cox, Marissa A Ehringer
BACKGROUND: Nicotinic acetylcholine receptors have gained attention in the last several years as mediators of alcohol-related behaviors. The genes that code for the α5, α3, and β4 subunits (Chrna5, Chrna3, and Chrnb4, respectively) map adjacent to each other on human chromosome 15/mouse chromosome 9. Genetic variants in this region have been associated with alcohol phenotypes and mice that overexpress these three subunits have reduced ethanol intake. In the present experiments, we examined the role of the Chrnb4 gene in three ethanol behaviors: consumption, ataxia, and sedation...
April 5, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28322866/decreased-anxiety-voluntary-ethanol-intake-and-ethanol-induced-cpp-acquisition-following-activation-of-the-metabotropic-glutamate-receptor-8-mglur8
#19
Amine Bahi
Metabotropic glutamate receptors (mGluRs) are important modulators of excitatory neurotransmission, and have been implicated in addiction to alcohol and anxiety-related behaviors. However, the behavioral consequence and contribution of individual subtypes are not known yet. This study determined the effects of mGluR8 activation on anxiety-like behavior, voluntary ethanol intake and ethanol-induced conditioned reward. To this aim, anxiety and spontaneous behavior were measured in C57BL/6J mice using the elevated plus maze (EPM), open field (OF) and light-dark box (LDB) tests after systemic injection of the selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine ((S)-3,4-DCPG)...
March 18, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28290543/exploring-the-under-investigated-microbial-dark-matter-of-drinking-water-treatment-plants
#20
Antonia Bruno, Anna Sandionigi, Ermanno Rizzi, Marzia Bernasconi, Saverio Vicario, Andrea Galimberti, Clementina Cocuzza, Massimo Labra, Maurizio Casiraghi
Scientists recently reported the unexpected detection of unknown or poorly studied bacterial diversity in groundwater. The ability to uncover this neglected biodiversity mainly derives from technical improvements, and the term "microbial dark matter" was used to group taxa poorly investigated and not necessarily monophyletic. We focused on such under-investigated microbial dark matter of drinking water treatment plant from groundwater, across carbon filters, to post-chlorination. We tackled this topic using an integrated approach where the efficacy of stringent water filtration (10000 MWCO) in recovering even the smallest environmental microorganisms was coupled with high-throughput DNA sequencing to depict an informative spectrum of the neglected microbial diversity...
March 14, 2017: Scientific Reports
keyword
keyword
90484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"