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https://www.readbyqxmd.com/read/29144544/effects-of-nicotine-on-alcohol-drinking-in-female-mice-selectively-bred-for-high-or-low-alcohol-preference
#1
Marcus M Weera, Molly A Fields, Danielle N Tapp, Nicholas J Grahame, Julia A Chester
BACKGROUND: Studies show that repeated nicotine use associates with high alcohol consumption in humans, and that nicotine exposure sometimes increases alcohol consumption in animal models. However, the relative roles of genetic predisposition to high alcohol consumption, the alcohol drinking patterns, and the timing of nicotine exposure both with respect to alcohol drinking and developmental stage remain unclear. The studies here manipulated all these variables, using mice selectively bred for differences in free-choice alcohol consumption to elucidate the role of genetics and nicotine exposure in alcohol consumption behaviors...
November 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29111360/voluntary-binge-like-ethanol-consumption-site-specifically-increases-c-fos-immunoexpression-in-male-c57bl6-j-mice
#2
Nathan W Burnham, Todd E Thiele
The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-dark" (DID), has not been thoroughly explored. Additionally, studies assessing ethanol-elicited neuronal activation may or may not involve stereotaxic surgery, which could impact c-Fos IR. The experiments detailed herein aimed to assess the effects of voluntary binge-like ethanol consumption on c-Fos IR in brain regions implicated in ethanol intake in animals with and without surgery experience...
October 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/29109060/cannabinoid-1-receptor-neutral-antagonist-reduces-binge-like-alcohol-consumption-and-alcohol-induced-accumbal-dopaminergic-signaling
#3
Andrea Balla, Bin Dong, Borehalli M Shilpa, Kiran Vemuri, Alexandros Makriyannis, Subhash C Pandey, Henry Sershen, Raymond F Suckow, K Yaragudri Vinod
Binge alcohol (ethanol) drinking is associated with profound adverse effects on our health and society. Rimonabant (SR141716A), a CB1 receptor inverse agonist, was previously shown to be effective for nicotine cessation and obesity. However, studies using rimonabant were discontinued as it was associated with an increased risk of depression and anxiety. In the present study, we examined the pharmacokinetics and effects of AM4113, a novel CB1 receptor neutral antagonist on binge-like ethanol drinking in C57BL/6J mice using a two-bottle choice drinking-in-dark (DID) paradigm...
November 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29109058/homer2-within-the-central-nucleus-of-the-amygdala-modulates-withdrawal-induced-anxiety-in-a-mouse-model-of-binge-drinking
#4
K M Lee, M A Coelho, K R Sern, K K Szumlinski
A history of binge-drinking decreases protein expression of the glutamate-related scaffolding protein Homer2 within the central nucleus of the amygdala (CEA), coinciding with behavioral signs of negative affect. To assess the functional relevance of this protein change for withdrawal-induced hyper-anxiety, adult (PND 56) and adolescent (PND 28) male C57BL/6J mice were administered an intra-CEA infusion of an adeno-associated viral vector (AAV) carrying either cDNA to express Homer2 (H2-cDNA) or GFP as control...
November 3, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29090295/neuroprotective-action-of-tea-polyphenols-on-oxidative-stress-induced-apoptosis-through-the-activation-of-the-trkb-creb-bdnf-pathway-and-keap1-nrf2-signaling-pathway-in-sh-sy5y-cells-and-mice-brain
#5
Guoyuan Qi, Yashi Mi, Yiwen Wang, Runnan Li, Shuxian Huang, Xingyu Li, Xuebo Liu
Many studies have shown that oxidative stress is a major cause of cellular injuries in a variety of human diseases including cognitive impairment. Tea polyphenols (TPs), natural plant flavonoids found in tea plant leaves, possess the bioactivity to affect the pathogenesis of several chronic diseases via antioxidant associated mechanisms. However, the possible antioxidant and neuroprotective properties of TPs in the brain of mice housed in constant darkness and in H2O2-stimulated SH-SY5Y cells are yet to be elucidated...
November 1, 2017: Food & Function
https://www.readbyqxmd.com/read/29066961/different-molecular-behavioral-endophenotypes-in-c57bl-6j-mice-predict-the-impact-of-ox1-receptor-blockade-on-binge-like-ethanol-intake
#6
Manuel Alcaraz-Iborra, Francisco Navarrete, Elisa Rodríguez-Ortega, Leticia de la Fuente, Jorge Manzanares, Inmaculada Cubero
Ethanol (EtOH) research has focused on stages of dependence. It is of paramount importance to more deeply understand the neurobehavioral factors promoting increased risk for EtOH binge drinking during the early stages of the addiction cycle. The first objective of this study was to evaluate whether C57BL/6J mice showing high drinking in the dark (DID) exhibit neurobehavioral traits known to contribute to EtOH binge-drinking disorders. Comparing high vs. low drinkers (HD/LD), we evaluated different types of basal anxiety-like responses, EtOH preference and sensitivity to the reinforcing properties of EtOH, and basal mRNA expression of the OX1/OX2 receptors (OX1r/OX2r) within the prefrontal cortex (PFC) and the nucleus accumbens (NAcc)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29033803/moderate-maternal-alcohol-exposure-on-gestational-day-12-impacts-anxiety-like-behavior-in-offspring
#7
Siara K Rouzer, Jesse M Cole, Julia M Johnson, Elena I Varlinskaya, Marvin R Diaz
Among the numerous consequences of prenatal alcohol exposure (PAE) is an increase in anxiety-like behavior that can prove debilitating to daily functioning. A significant body of literature has linked gestational day 12 (G12) heavy ethanol exposure with social anxiety, evident in adolescent males and females. However, the association between non-social anxiety-like behavior and moderate alcohol exposure, a more common pattern of drinking in pregnant women, is yet unidentified. To model moderate PAE (mPAE), we exposed pregnant Sprague-Dawley rats to either room air or vaporized ethanol for 6 h on G12...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28969693/effects-of-melatonin-administration-on-embryo-implantation-and-offspring-growth-in-mice-under-different-schedules-of-photoperiodic-exposure
#8
Lu Zhang, Zhenzhen Zhang, Feng Wang, Xiuzhi Tian, Pengyun Ji, Guoshi Liu
BACKGROUND: Embryo implantation is crucial for animal reproduction. Unsuccessful embryo implantation leads to pregnancy failure, especially in human-assisted conception. Environmental factors have a profound impact on embryo implantation. Because people are being exposed to more light at night, the influence of long-term light exposure on embryo implantation should be explored. METHODS: The effects of long photoperiodic exposure and melatonin on embryo implantation and offspring growth were examined...
October 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28947376/antagonising-tlr4-trif-signalling-before-or-after-a-low-dose-alcohol-binge-during-adolescence-prevents-alcohol-drinking-but-not-seeking-behaviour-in-adulthood
#9
Jonathan Henry Jacobsen, Femke Buisman-Pijlman, Sanam Mustafa, Kenner C Rice, Mark R Hutchinson
Adolescents frequently engage in risky behaviours such as binge drinking. Binge drinking, in turn, perturbs neurodevelopment reinforcing reward seeking behaviour in adulthood. Current animal models are limited in their portrayal of this behaviour and the assessment of neuroimmune involvement (specifically the role of Toll-like receptor 4 (TLR4)). Therefore, the aims of this project were to develop a more relevant animal model of adolescent alcohol exposure and to characterise its effects on TLR4 signalling and alcohol-related behaviours later life...
September 22, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28878635/alcohol-intake-increases-in-adolescent-c57bl-6j-mice-during-intermittent-cycles-of-phase-delayed-long-light-conditions
#10
Joshua J Gamsby, Abby M Pribish, Korey D Stevanovic, Amara Yunus, Danielle Gulick
Adolescents naturally go to bed and awaken late, but are forced to awaken early for school and work. This leads to "social jetlag", a state of circadian desynchrony (CD), in which internal biological rhythms are out of sync with behavioral rhythms. CD is associated with increased alcohol intake in adults, but has been less well-studied in adolescents. The goal of this study was to model adolescent alcohol intake during similar CD conditions in male C57BL/6J mice. Free access alcohol intake, water intake and wheel-running activity were measured during a normal 12HR photoperiod or during alternating photoperiod (Experiment 1: 12 h light for 4 days followed by 18 h light for 3 days, with dark (activity onset) delayed 9 h during the 18HR photoperiod; Experiment 2: 12 h light for 4 days followed by 6 h light for 3 days, with dark onset delayed 3 h during the 6HR photoperiod)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28865114/prenatal-alcohol-exposure-leads-to-enhanced-serine-9-phosphorylation-of-glycogen-synthase-kinase-3%C3%AE-gsk-3%C3%AE-in-the-hippocampal-dentate-gyrus-of-adult-mouse
#11
Lee Anna Cunningham, Jessie Newville, Lu Li, Phillip Tapia, Andrea M Allan, C Fernando Valenzuela
BACKGROUND: The goal of this study was to evaluate the expression and serine 9 phosphorylation of glycogen synthase kinase (GSK-3β) within the adult hippocampal dentate gyrus (DG) in a preclinical mouse model of fetal alcohol spectrum disorders. GSK-3β is a multifunctional kinase that modulates many hippocampal processes affected by gestational alcohol, including synaptic plasticity and adult neurogenesis. GSK-3β is a constitutively active kinase that is negatively regulated by phosphorylation at the serine 9 residue...
November 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28828224/social-and-environmental-enrichment-has-different-effects-on-ethanol-and-sucrose-consumption-in-mice
#12
Joan Y Holgate, Hilary Garcia, Susmita Chatterjee, Selena E Bartlett
BACKGROUND: Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the role that social and environmental experiences play in alcohol and sucrose consumption is critical for developing preventative interventions and treatments for alcohol use disorders and obesity. METHODS: We used the drinking in the dark two-bottle choice (2BC) model of ethanol and sucrose consumption to compare male C57BL/6 mice housed in the IntelliCage (an automated device capable of simultaneously measuring behaviors of up to 16 mice living in an enriched social environment) with mice housed in standard isolated and social environments...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28827047/high-drinking-in-the-dark-hdid-mice-are-sensitive-to-the-effects-of-some-clinically-relevant-drugs-to-reduce-binge-like-drinking
#13
John C Crabbe, Angela R Ozburn, Pamela Metten, Amanda Barkley-Levenson, Jason P Schlumbohm, Stephanie E Spence, Wyatt R Hack, Lawrence C Huang
BACKGROUND: There is a serious public health need for better understanding of alcohol use disorder disease mechanisms and for improved treatments. At this writing, only three drugs are approved by the Food and Drug Administration as medications to treat alcohol use disorders - disulfiram, naltrexone, and acamprosate. Binge drinking is a form of abusive alcohol drinking defined by the NIAAA as a drinking to blood alcohol levels (BALs)>0.08% during a period of approximately 2h. To model genetic risk for binge-like drinking, we have used selective breeding to create a unique animal model, High Drinking in the Dark (HDID) mice...
September 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28820391/deep-brain-stimulation-alters-light-phase-food-intake-microstructure-in-rats
#14
P Prinz, P Kobelt, S Scharner, M Goebel-Stengel, D Harnack, K Faust, Y Winter, M Rose, A Stengel
Treatment of eating disorders like obesity or anorexia is challenging. Options are limited and new approaches desired. An interesting approach is the application of deep brain stimulation (DBS). The nucleus accumbens (NAcc) is part of the food reward system. A pilot study reported that DBS of the NAcc shell modulates food intake and body weight in rats. Underlying mechanisms such as the food intake microstructure are unknown so far. Normal weight female Sprague-Dawley rats were equipped with a custom-made DBS electrode placed unilaterally in the NAcc shell...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28780411/increased-ethanol-drinking-in-humanized-mice-expressing-the-mu-opioid-receptor-a118g-polymorphism-are-mediated-through-sex-specific-mechanisms
#15
Angela N Henderson-Redmond, Tammy E Lowe, Xi B Tian, Daniel J Morgan
The A118G single nucleotide polymorphism (SNP) of the mu-opioid receptor gene (Oprm1) has been implicated in mediating the rewarding effects of alcohol. Clinical and preclinical studies suggest that the G allele may confer a genetic vulnerability to alcohol dependence, though it remains unknown whether these effects are sex-specific. We used male and female mice homozygous for the "humanized" 118AA or 118GG alleles to determine whether the A118G SNP potentiates ethanol consumption in a sex-specific manner in both the two-bottle choice and drinking-in-the-dark (DID) paradigms...
August 2, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28769782/toll-like-receptor-2-is-a-regulator-of-circadian-active-and-inactive-state-consolidation-in-c57bl-6-mice
#16
Nicholas W DeKorver, Tammy R Chaudoin, Stephen J Bonasera
Regulatory systems required to maintain behavioral arousal remain incompletely understood. We describe a previously unappreciated role that toll-like receptor 2 (Tlr2, a membrane bound pattern recognition receptor that recognizes specific bacterial, viral, and fungal peptides), contributes toward regulation of behavioral arousal. In 4-4.5 month old mice with constitutive loss of Tlr2 function (Tlr2(-/-) mice), we note a marked consolidation in the circadian pattern of both active and inactive states. Specifically, Tlr2(-/-) mice demonstrated significantly fewer but longer duration active states during the circadian dark cycle, and significantly fewer but longer duration inactive states during the circadian light cycle...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28765080/activation-of-extrasynaptic-%C3%AE-gabaa-receptors-globally-or-within-the-posterior-vta-has-estrous-dependent-effects-on-consumption-of-alcohol-and-estrous-independent-effects-on-locomotion
#17
Laverne C Melón, Zachary T Nolan, Delphine Colar, Eileen M Moore, Stephen L Boehm
Recent reports support higher than expected rates of binge alcohol consumption among women and girls. Unfortunately, few studies have assessed the mechanisms underlying this pattern of intake in females. Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may selectively target tonic GABAergic inhibition mediated by GABAA receptor subtypes expressing the δ-subunit protein (δ-GABAARs). Indeed, administration of agonists that interact with these δ-GABAARs prior to alcohol access can abolish binge drinking behavior in male mice...
September 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28748375/attenuation-of-ethanol-abstinence-induced-anxiety-and-depressive-like-behavior-by-the-phosphodiesterase-4-inhibitor-rolipram-in-rodents
#18
Mei-Fang Gong, Rui-Ting Wen, Ying Xu, Jian-Chun Pan, Ning Fei, Yan-Meng Zhou, Jiang-Ping Xu, Jian-Hui Liang, Han-Ting Zhang
RATIONALE: Withdrawal symptoms stand as a core feature of alcohol dependence. Our previous results have shown that inhibition of phosphodiesterase-4 (PDE4) decreased ethanol seeking and drinking in alcohol-preferring rodents. However, little is known about whether PDE4 is involved in ethanol abstinence-related behavior. OBJECTIVE: The objective of this study was to characterize the role of PDE4 in the development of anxiety- and depressive-like behavior induced by abstinence from ethanol exposure in different animal models...
October 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28729845/negative-affect-and-excessive-alcohol-intake-incubate-during-protracted-withdrawal-from-binge-drinking-in-adolescent-but-not-adult-mice
#19
Kaziya M Lee, Michal A Coehlo, Noah R Solton, Karen K Szumlinski
Binge-drinking is common in underage alcohol users, yet we know little regarding the biopsychological impact of binge-drinking during early periods of development. Prior work indicated that adolescent male C57BL6/J mice with a 2-week history of binge-drinking (PND28-41) are resilient to the anxiogenic effects of early alcohol withdrawal. Herein, we employed a comparable Drinking-in-the-Dark model to determine how a prior history of binge-drinking during adolescence (EtOH(adolescents)) influences emotionality (assayed with the light-dark box, marble burying test, and the forced swim test) and the propensity to consume alcohol in later life, compared to animals without prior drinking experience...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28679010/factors-influencing-injury-severity-of-bicyclists-involved-in-crashes-with-motor-vehicles-bike-lanes-alcohol-lighting-speed-and-helmet-use
#20
COMPARATIVE STUDY
Kelsey Helak, Dietrich Jehle, Daniel McNabb, Amanda Battisti, Steward Sanford, Mary Claire Lark
OBJECTIVES: In 2014, 726 bicyclists were killed and an additional 50,000 were injured in crashes with motor vehicles. The number of cyclists in the United States is increasing, and as a result there has been a call for more bike lanes. We examined the difference in the severity of injury of bicyclists involved in motor vehicle crashes when riding in the traffic lane compared with riding in a bike lane or on a paved shoulder. We also controlled for other safety factors, including alcohol use, travel speed, posted speed, helmet usage, and lighting conditions to determine their impact on bicyclist safety...
July 2017: Southern Medical Journal
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