keyword
MENU ▼
Read by QxMD icon Read
search

Drinking in the dark

keyword
https://www.readbyqxmd.com/read/29777288/time-shifting-effects-of-methylphenidate-on-daily-rhythms-in-the-diurnal-rodent-arvicanthis-ansorgei
#1
Jorge Mendoza, Hester C van Diepen, Rob Rodrigues Pereira, Johanna H Meijer
People suffering of attention-deficit/hyperactivity disorder (ADHD) and treated with the psychostimulant methylphenidate (MPH) show sleep-wake cycle and daily rhythm alterations despite the beneficial effects of MPH on behavioral symptoms (i.e., hyperactivity, attention). In nocturnal rodents (i.e., mice), chronic exposure to MPH alters the neural activity of the circadian clock in the suprachiasmatic nucleus (SCN), behavioral rhythms, and the sleep-wake cycle. Here, we studied the effects of MPH on daily rhythms of behavior and body temperature of the diurnal rodent Arvicanthis ansorgei...
May 18, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29755411/time-of-day-effects-on-metabolic-and-clock-related-adjustments-to-cold
#2
Frederico Sander Mansur Machado, Zhi Zhang, Yan Su, Paul de Goede, Remi Jansen, Ewout Foppen, Cândido Celso Coimbra, Andries Kalsbeek
Background: Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29753117/pharmacological-inhibition-of-receptor-protein-tyrosine-phosphatase-%C3%AE-%C3%AE-ptprz1-modulates-behavioral-responses-to-ethanol
#3
Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Miryam Pastor, Esther Gramage, Bruno Di Geronimo, José María Zapico, Claire Coderch, Carmen Pérez-García, Amy W Lasek, Beatriz de Pascual-Teresa, Ana Ramos, Gonzalo Herradón
Pleiotrophin (PTN) and Midkine (MK) are neurotrophic factors that are upregulated in the prefrontal cortex after alcohol administration and have been shown to reduce ethanol drinking and reward. PTN and MK are the endogenous inhibitors of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ (a.k.a. PTPRZ1, RPTPβ, PTPζ), suggesting a potential role for this phosphatase in the regulation of alcohol effects. To determine if RPTPβ/ζ regulates ethanol consumption, we treated mice with recently developed small-molecule inhibitors of RPTPβ/ζ (MY10, MY33-3) before testing them for binge-like drinking using the drinking in the dark protocol...
May 9, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29705534/increasing-kynurenine-brain-levels-reduces-ethanol-consumption-in-mice-by-inhibiting-dopamine-release-in-nucleus-accumbens
#4
Pablo Giménez-Gómez, Mercedes Pérez-Hernández, María Dolores Gutiérrez-López, Rebeca Vidal, Cristina Abuin-Martínez, Esther O'Shea, María Isabel Colado
Recent research suggests that ethanol (EtOH) consumption behaviour can be regulated by modifying the kynurenine (KYN) pathway, although the mechanisms involved have not yet been well elucidated. To further explore the implication of the kynurenine pathway in EtOH consumption we inhibited kynurenine 3-monooxygenase (KMO) activity with Ro 61-8048 (100 mg/kg, i.p.), which shifts the KYN metabolic pathway towards kynurenic acid (KYNA) production. KMO inhibition decreases voluntary binge EtOH consumption and EtOH preference in mice subjected to "drinking in the dark" (DID) and "two-bottle choice" paradigms, respectively...
April 18, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29686649/a-free-choice-high-fat-high-sugar-diet-alters-day-night-per2-gene-expression-in-reward-related-brain-areas-in-rats
#5
Aurea Susana Blancas-Velazquez, Unga A Unmehopa, Leslie Eggels, Laura Koekkoek, Andries Kalsbeek, Jorge Mendoza, Susanne E la Fleur
Under normal light-dark conditions, nocturnal rodents consume most of their food during the dark period. Diets high in fat and sugar, however, may affect the day-night feeding rhythm resulting in a higher light phase intake. In vitro and in vivo studies showed that nutrients affect clock-gene expression. We therefore hypothesized that overconsuming fat and sugar alters clock-gene expression in brain structures important for feeding behavior. We determined the effects of a free-choice high-fat high-sugar (fcHFHS) diet on clock-gene expression in rat brain areas related to feeding and reward and compared them with chow-fed rats...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29686629/critical-role-for-g-i-o-protein-activity-in-the-dorsal-striatum-in-the-reduction-of-voluntary-alcohol-intake-in-c57bl-6-mice
#6
Meridith T Robins, Terrance Chiang, Kendall L Mores, Doungkamol Alongkronrusmee, Richard M van Rijn
The transition from non-dependent alcohol use to alcohol dependence involves increased activity of the dorsal striatum. Interestingly, the dorsal striatum expresses a large number of inhibitory G-protein-coupled receptors (GPCRs), which when activated may inhibit alcohol-induced increased activity and can decrease alcohol consumption. Here, we explore the hypothesis that dorsal striatal Gi/o -protein activation is sufficient to reduce voluntary alcohol intake. Using a voluntary, limited-access, two-bottle choice, drink-in-the-dark model of alcohol (10%) consumption, we validated the importance of Gi/o signaling in this region by locally expressing neuron-specific, adeno-associated-virus encoded Gi/o -coupled muscarinic M4 designer receptors exclusively activated by designer drugs (DREADD) in the dorsal striatum and observed a decrease in alcohol intake upon DREADD activation...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29684405/moderate-perinatal-thyroid-hormone-insufficiency-alters-visual-system-function-in-adult-rats
#7
William K Boyes, Laura Degn, Barbara Jane George, Mary E Gilbert
Thyroid hormone (TH) is critical for many aspects of neurodevelopment and can be disrupted by a variety of environmental contaminants. Sensory systems, including audition and vision are vulnerable to TH insufficiencies, but little data are available on visual system development at less than severe levels of TH deprivation. The goal of the current experiments was to explore dose-response relations between graded levels of TH insufficiency during development and the visual function of adult offspring. Pregnant Long Evans rats received 0 or 3 ppm (Experiment 1), or 0, 1, 2, or 3 ppm (Experiment 2) of propylthiouracil (PTU), an inhibitor of thyroid hormone synthesis, in drinking water from gestation day (GD) 6 to postnatal day (PN) 21...
April 20, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29668112/pharmacogenetic-manipulation-of-the-nucleus-accumbens-alters-binge-like-alcohol-drinking-in-mice
#8
Kush Purohit, Puja K Parekh, Joseph Kern, Ryan W Logan, Zheng Liu, Yanhua Huang, Colleen A McClung, John C Crabbe, Angela R Ozburn
BACKGROUND: Chronic alcohol intake leads to long-lasting changes in reward- and stress-related neuronal circuitry. The nucleus accumbens (NAc) is an integral component of this circuitry. Here, we investigate the effects of DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) on neuronal activity in the NAc and binge-like drinking. METHODS: C57BL/6J mice were stereotaxically injected with AAV2 hSyn-HA hM3Dq, -hM4Di, or -eGFP bilaterally into NAc [core + shell, core or shell]...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29666973/betaxanthin-rich-extract-from-cactus-pear-fruits-as-yellow-water-soluble-colorant-with-potential-application-in-foods
#9
José A Fernández-López, María J Roca, José M Angosto, José M Obón
Cactus pear (Opuntia ficus-indica) fruit juice is a source of betaxanthin pigments which can be used as a natural yellow food colorant. The HPLC chromatographic pigment pattern corresponding to the betaxanthin-rich extract revealed the presence of four betaxanthins, of which indicaxanthin (proline-betaxanthin) accounts for around 85%. A betaxanthin-rich water-soluble food colorant from cactus pears fruits was produced by spray-drying microencapsulation using maltodextrin as a wall material. The resulting powder was characterized by scanning electron microscopy, and its apparent color was analyzed by spectrometry...
April 18, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29615880/behavioral-characterization-of-%C3%AE-arrestin-1-knockout-mice-in-anxiety-like-and-alcohol-behaviors
#10
Meridith T Robins, Terrance Chiang, Jennifer N Berry, Mee Jung Ko, Jiwon E Ha, Richard M van Rijn
β-Arrestin 1 and 2 are highly expressed proteins involved in the desensitization of G protein-coupled receptor signaling which also regulate a variety of intracellular signaling pathways. Gene knockout (KO) studies suggest that the two isoforms are not homologous in their effects on baseline and drug-induced behavior; yet, the role of β-arrestin 1 in the central nervous system has been less investigated compared to β-arrestin 2. Here, we investigate how global β-arrestin 1 KO affects anxiety-like and alcohol-related behaviors in male and female C57BL/6 mice...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29550387/assessment-of-depression-like-behavior-and-anhedonia-after-repeated-cycles-of-binge-like-ethanol-drinking-in-male-c57bl-6j-mice
#11
Jeffrey J Olney, S Alex Marshall, Todd E Thiele
Psychological depression is frequently linked to alcohol abuse and even serves as key indicators of an alcohol use disorder (AUD). This relationship is supported by preclinical findings in which depression-like phenotypes develop in animals exposed to chronic intermittent ethanol vapor, a common preclinical model of alcohol dependence. However, the emergence of these maladaptive phenotypes following repeated binge-like ethanol drinking remains relatively unexplored. The purpose of this study was to evaluate depression-like behaviors associated with binge-like consumption in mice...
March 14, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29505808/inhibition-of-glyoxalase-1-reduces-alcohol-self-administration-in-dependent-and-nondependent-rats
#12
Giordano de Guglielmo, Dana E Conlisk, Amanda M Barkley-Levenson, Abraham A Palmer, Olivier George
Previous studies showed that the glyoxalase 1 (Glo1) gene modulates anxiety-like behavior, seizure susceptibility, depression-like behavior, and alcohol drinking in the drinking-in-the-dark paradigm in nondependent mice. Administration of the small-molecule GLO1 inhibitor S-bromobenzylglutathione cyclopentyl diester (pBBG) decreased alcohol drinking in nondependent mice, suggesting a possible therapeutic strategy. However, the preclinical therapeutic efficacy of pBBG in animal models of alcohol dependence remains to be demonstrated...
April 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29476897/sex-dependent-modification-by-chronic-caffeine-of-acute-methamphetamine-effects-on-anxiety-related-behavior-in-rats
#13
Robert N Hughes, Jennifer J Hamilton
For fourteen days, male and female PVG/c hooded rats were provided continuously with either pure drinking water, or water containing caffeine in a quantity approximating a daily dose of 31.1 mg/kg. Then at intervals of 3 days, they were administered 1, 2 mg/kg methamphetamine (MA) or saline before being tested for anxiety-related behavior in a zero maze or a light/dark box, or their short-term spatial memory was assessed in a Y maze following introduction of a novel brightness change in one of the arms...
June 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29448234/gene-expression-changes-in-the-ventral-hippocampus-and-medial-prefrontal-cortex-of-adolescent-alcohol-preferring-p-rats-following-binge-like-alcohol-drinking
#14
Jeanette N McClintick, William J McBride, Richard L Bell, Zheng-Ming Ding, Yunlong Liu, Xiaoling Xuei, Howard J Edenberg
Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal cortex volume and deficits in memory. We used RNA sequencing to assess the effects of adolescent binge drinking on gene expression in these regions. Male adolescent alcohol-preferring (P) rats were exposed to repeated binge drinking (three 1-h sessions/day during the dark/cycle, 5 days/week for 3 weeks starting at 28 days of age; ethanol intakes of 2.5-3 g/kg/session)...
May 2018: Alcohol
https://www.readbyqxmd.com/read/29424141/-adulteration-detection-of-tea-samples-based-on-plant-rbcl-gene-sequencing
#15
Minxuan Wang, Yongjie Zhang
Tea is one of the most popular drinks in the world, but counterfeit or adulterated tea can be found now and then on the tea market. The traditional methods dependent on sensory, physical and chemical tests cannot identify the composition of adulterated plant species accurately. We developed therefore a method for identification of adulterated plants in tea based on qualitative detection of plant rbcL (Ribulose 1,5-bisphosphate carboxylase-oxygenase large subunit) fragments, which involved amplification, sequencing and sequence analyses of rbcL fragments...
February 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29424043/sex-differences-in-binge-like-etoh-drinking-corticotropin-releasing-hormone-and-corticosterone-effects-of-%C3%AE-endorphin
#16
Todd B Nentwig, Diane E Wilson, Erin M Rhinehart, Judith E Grisel
Binge drinking is an increasingly common pattern of risky use associated with numerous health problems, including alcohol use disorders. Because low basal plasma levels of β-endorphin (β-E) and an increased β-E response to alcohol are evident in genetically at-risk human populations, this peptide is thought to contribute to the susceptibility for disordered drinking. Animal models suggest that the effect of β-E on consumption may be sex-dependent. Here, we studied binge-like EtOH consumption in transgenic mice possessing varying levels of β-E: wild-type controls with 100% of the peptide (β-E +/+), heterozygous mice constitutively modified to possess 50% of wild-type levels (β-E +/-) and mice entirely lacking the capacity to synthesize β-E (-/-)...
February 8, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29404855/an-evaluation-of-neurotoxicity-following-fluoride-exposure-from-gestational-through-adult-ages-in-long-evans-hooded-rats
#17
Christopher A McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S Brar, Ralph Wilson, Amy Brix, Catherine Picut, G Jean Harry
At elevated levels, fluoride (F- ) exposure has been associated with adverse human health effects. In rodents, F- exposure has been reported to induce deficits in motor performance and learning and memory. In this study, we examined Long-Evans hooded male rats maintained on a standard diet (20.5 ppm F- ) or a low F- diet (3.24 ppm F- ) with drinking water exposure to 0, 10, or 20 ppm F- from gestational day 6 through adulthood. At postnatal day 25, brain F- levels were 0.048 or 0.081 μg/g and femur 235 or 379...
February 5, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29396154/association-of-individual-and-neighborhood-factors-with-home-food-availability-evidence-from-the-national-health-and-nutrition-examination-survey
#18
Weiwen Chai, Jessie X Fan, Ming Wen
BACKGROUND: Accumulating evidence suggests the important role of the home food environment in an individual's dietary intake. OBJECTIVE: This study examined the associations of individual and neighborhood-level factors with the availability of healthy and unhealthy foods in the home using a nationally representative sample from the 2007 to 2008 and 2009 to 2010 National Health and Nutrition Examination Surveys (NHANES). DESIGN: A cross-sectional study design was used with NHANES merged with the 2000 census data...
January 27, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29391482/5-ht1a-receptor-dependent-modulation-of-emotional-and-neurogenic-deficits-elicited-by-prolonged-consumption-of-alcohol
#19
Arnauld Belmer, Omkar L Patkar, Vanessa Lanoue, Selena E Bartlett
Repeated episodes of binge-like alcohol consumption produce anxiety, depression and various deleterious effects including alterations in neurogenesis. While the involvement of the serotonin receptor 1 A (5-HT1A ) in the regulation of anxiety-like behavior and neurogenesis is well documented, its contribution to alcohol withdrawal-induced anxiety and alcohol-induced deficits in neurogenesis is less documented. Using the Drinking-In-the-Dark (DID) paradigm to model chronic long-term (12 weeks) binge-like voluntary alcohol consumption in mice, we show that the selective partial activation of 5-HT1A receptors by tandospirone (3 mg/kg) prevents alcohol withdrawal-induced anxiety in a battery of behavioral tests (marble burying, elevated-plus-maze, open-field), which is accompanied by a robust decrease in binge-like ethanol intake (1 and 3 mg/kg)...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29355641/the-nicotinic-receptor-drug-sazetidine-a-reduces-alcohol-consumption-in-mice-without-affecting-concurrent-nicotine-consumption
#20
Jillienne C Touchette, Jamie J Maertens, Margaret M Mason, Kyu Y O'Rourke, Anna M Lee
Alcohol and nicotine addiction are frequently co-morbid. The nicotinic acetylcholine receptors (nAChRs) are critical for both alcohol and nicotine addiction mechanisms, since nAChR drugs that reduce nicotine consumption have been shown to also reduce alcohol consumption. Sazetidine-A, a pre-clinical nAChR drug with agonist and desensitizing effects at α4β2 and α7 nAChRs, has been reported to reduce alcohol consumption and nicotine self-administration in rats when administered at high doses. However, this effect has not been replicated in mice...
May 1, 2018: Neuropharmacology
keyword
keyword
90484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"