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'Breast Cancer'

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https://www.readbyqxmd.com/read/29241203/genome-wide-transcriptome-analysis-of-estrogen-receptor-positive-and-human-epithelial-growth-factor-receptor-2-positive-breast-cancers-by-ribonucleic-acid-sequencing
#1
Pengtao Chen, Wei Song, Liangli Liu
AIM: The aim is to identify complex pathogenesis of breast cancer subtypes and disclose the whole landscape of altered transcriptional activities in these cancers. METHODS: We downloaded raw expression data from public database, and performed transcriptome analysis of 8 estrogen receptor-positive (ER+) breast cancer tissue samples, 8 human epithelial growth factor receptor 2-positive (HER2+) breast cancer tissue samples, and 3 normal breast tissues by identification, functional annotation, and prediction of upstream regulators and cell-surface biomarkers of differentially expressed genes (DEGs)...
December 14, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29241196/calycosin-inhibits-the-migration-and-invasion-of-human-breast-cancer-cells-by-down-regulation-of-foxp3-expression
#2
Shuangxi Li, Yafei Wang, Chan Feng, Guoli Wu, Yu Ye, Jing Tian
BACKGROUND/AIMS: Calycosin, a phytoestrogenic compound, has recently emerged as a promising antitumor drug. It has been shown that calycosin suppresses growth and induces apoptosis of breast cancer cells. However, the effect of calycosin on migration and invasion of breast cancer cells and the underlying molecular mechanisms have not been elucidated. METHODS: Human breast cancer cells MCF-7 and T47D were treated with, or without, different doses (0, 6.25, 12.5, 25, 50, 100 or 150 μM) of calycosin, and the viability of different groups was determined by MTT assay...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241083/a-review-of-the-value-of-human-epidermal-growth-factor-receptor-2-her2-targeted-therapies-in-breast-cancer
#3
REVIEW
N A Nixon, M B Hannouf, S Verma
The cost of cancer drugs continues to escalate with the rapid development and approval of novel therapies, especially over the course of the last decade. In human epidermal growth factor receptor 2 (HER2)-positive breast cancer, the survival benefits gained by new treatments have been undeniably substantial. It is important to assess the financial value of these therapies for decision making at both the societal and individual level. This information is key for managing resources in resource-limited health care systems, while at the same time supporting patient decision-making and conversations between patient and physicians on cost versus benefit...
December 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29241077/pectoral-nerve-blocks-to-improve-analgesia-after-breast-cancer-surgery-a-prospective-randomized-and-controlled-trial
#4
Neethu M, Ravinder Kumar Pandey, Ankur Sharma, Vanlalnghaka Darlong, Jyotsna Punj, Renu Sinha, Preet Mohinder Singh, Nandini Hamshi, Rakesh Garg, Chandralekha Chandralekha, Anurag Srivastava
STUDY OBJECTIVE: To evaluate the analgesic efficacy of ultrasound guided combined pectoral nerve blocks I and II in patients scheduled for surgery for breast cancer. DESIGN: Prospective, randomized, control trial. SETTING: Operating rooms in a tertiary care hospital of Northern India. PATIENTS: Sixty American Society of Anesthesiologists status I to II adult women, aged 18-70years were enrolled in this study. INTERVENTIONS: Patients were randomized into two groups (30 patients in each group), PECS (P) group and control (C) group...
December 11, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29240740/characteristics-of-and-differences-between-pasifika-women-and-new-zealand-european-women-diagnosed-with-breast-cancer-in-new-zealand
#5
Charis Brown, Chunhuan Lao, Ross Lawrenson, Sandar Tin Tin, Michelle Schaaf, Jacquie Kidd, Anne Allan-Moetaua, Josephine Herman, Reena Raamsroop, Ian Campbell, Mark Elwood
AIM: Breast cancer in New Zealand-based Pasifika women is a significant issue. Although Pasifika women have a lower incidence of breast cancer compared to New Zealand European women, they have higher breast cancer mortality and lower five-year survival. The aim of this study was to describe the characteristics and tumour biology of Pasifika women and to compare New Zealand European women to identify what factors impact on early (Stage 1 and 2) vs advanced stage (Stage 3 and 4) at diagnosis...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240706/multi-objective-optimization-algorithm-to-discover-condition-specific-modules-in-multiple-networks
#6
Xiaoke Ma, Penggang Sun, Jianbang Zhao
The advances in biological technologies make it possible to generate data for multiple conditions simultaneously. Discovering the condition-specific modules in multiple networks has great merit in understanding the underlying molecular mechanisms of cells. The available algorithms transform the multiple networks into a single objective optimization problem, which is criticized for its low accuracy. To address this issue, a multi-objective genetic algorithm for condition-specific modules in multiple networks (MOGA-CSM) is developed to discover the condition-specific modules...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29240317/inflammations-of-the-mammary-gland
#7
Tuomo Meretoja, Hanna Ihalainen, Marjut Leidenius
Breast inflammation, i.e. mastitis is an entity with a variable etiology and severity, typically affecting women of fertile age. In most cases, anamnesis reveals the etiology of the disease, bacterial puerperal mastitis associated with breastfeeding being the most common. Periductal mastitis is a breast inflammation typically associated with smoking in women of 40 to 50 years of age, localized to the region of the areola. Granulomatous mastitis and other rare breast inflammations usually require specialized care...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29240257/altered-expression-of-telomere-associated-genes-in-leukocytes-among-brca1-and-brca2-carriers
#8
Hiromi Tanaka, Elizabeth A Phipps, Ting Wei, Xi Wu, Chirayu Goswami, Yunlong Liu, George W Sledge, Lida Mina, Brittney-Shea Herbert
Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age-related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play an important role in telomere maintenance. Although telomere shortening has been reported in BRCA1/2 carriers, the direct effects of BRCA1/2 haploinsufficiency on telomere maintenance and predisposition to cancer development are not completely understood...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29240242/the-9p21-locus-a-potential-therapeutic-target-and-prognostic-marker-in-breast-cancer
#9
REVIEW
Mahdi Rivand, Mohammad-Sadegh Khorrami, Hamid Fiuji, Soodabeh Shahidsales, Malihe Hasanzadeh, Mir Hadi Jazayeri, Seyed Mahdi Hassanian, Gordon A Ferns, Nafiseh Saghafi, Amir Avan
Breast cancer is an important cause of cancer related mortality in women. Despite extensive efforts to identify valid biomarkers for risk stratification, there are relatively few with proven clinical utility. It is recognized that genetic factors play a major role in determining susceptibility to breast cancer. Recent genome-wide-association-studies and gene expression analysis have demonstrated that a locus on chromosome 9p21, which contains three genes; CDKN2B (encoding p15ink4b), CDKN2A (encoding p16ink4a and p14ARF) and the 3' end of CDKN2BAS [an antisense noncoding RNA in the INK4 locus (ANRIL)] are associated with an increased risk of this malignancy...
December 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29239858/prediction-of-breast-cancer-risk-using-a-machine-learning-approach-embedded-with-a-locality-preserving-projection-algorithm
#10
Morteza Heidari, Abolfazl Zargari Khuzani, Alan B Hollingsworth, Gopichandh Danala, Seyedehnafiseh Mirniaharikandehei, Yuchen Qiu, Hong Liu, Bin Zheng
In order to automatically identify a set of effective mammographic image features and build an optimal breast cancer risk stratification model, this study aims to investigate advantages of applying a machine learning approach embedded with a locally preserving projection (LPP) based feature combination and regeneration algorithm to predict short-term breast cancer risk. A dataset involving negative mammograms acquired from 500 women was assembled. This dataset was divided into two age-matched classes of 250 high risk cases in which cancer was detected in the next subsequent mammography screening and 250 low risk cases, which remained negative...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29239836/determinants-of-weight-gain-during-adjuvant-endocrine-therapy-and-association-of-such-weight-gain-with-recurrence-in-long-term-breast-cancer-survivors
#11
Akshara Raghavendra, Arup K Sinha, Janeiro Valle, Yu Shen, Debu Tripathy, Carlos H Barcenas
BACKGROUND: Weight gain is a negative prognostic factor in breast cancer (BC) patients. The risk factors for weight gain during adjuvant endocrine therapy (ET) and the extent to which such weight gain is associated with disease recurrence remain unclear. PATIENTS AND METHODS: We retrospectively identified a cohort of women with a diagnosis of stage I-III, hormone receptor-positive, human epidermal growth factor receptor 2-negative BC from January 1997 to August 2008, who had received initial treatment at the MD Anderson Cancer Center, had completed 5 years of ET, and had remained free of locoregional or distant relapse or contralateral BC for ≥ 5 years after diagnosis...
November 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29239835/income-inequality-and-mortality-owing-to-breast-cancer-evidence-from-brazil
#12
Francisco Winter Dos Santos Figueiredo, Fernando Adami
BACKGROUND: The relationship between breast cancer and inequality income is unclear. This study analyzed the correlation between income inequality and mortality standardized by age and proportional mortality owing to breast cancer among Brazilian women. PATIENTS AND METHODS: This is an ecological study using data of the federative units and Federal District of Brazil in 2010. The age-standardized mortality owing to breast cancer was estimated using data from the Department of Informatics of Brazil's Unified Health System...
November 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29239711/interval-breast-cancer-rates-and-histopathologic-tumor-characteristics-after-false-positive-findings-at-mammography-in-a-population-based-screening-program
#13
Solveig Hofvind, Silje Sagstad, Sofie Sebuødegård, Ying Chen, Marta Roman, Christoph I Lee
Purpose To compare rates and tumor characteristics of interval breast cancers (IBCs) detected after a negative versus false-positive screening among women participating in the Norwegian Breast Cancer Screening Program. Materials and Methods The Cancer Registry Regulation approved this retrospective study. Information about 423 445 women aged 49-71 years who underwent 789 481 full-field digital mammographic screening examinations during 2004-2012 was extracted from the Cancer Registry of Norway. Rates and odds ratios of IBC among women with a negative (the reference group) versus a false-positive screening were estimated by using logistic regression models adjusted for age at diagnosis and county of residence...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29239350/suppression-of-eef-2k-mediated-autophagy-enhances-the-cytotoxicity-of-raddeanin-a-against-human-breast-cancer-cells-in-vitro
#14
Yi-di Guan, Shi-Long Jiang, Pian Yu, Mei Wen, Yi Zhang, Song-Shu Xiao, Xiao-Jun Xu, Yan Cheng
Recent evidence shows that raddeanin A (RA), an oleanane-type triterpenoid saponin extracted from Anemone raddeana Regel, exerts remarkable cytotoxicity against cancer cells in vitro and in vivo. In addition, RA has also been found to activate autophagy in human gastric cancer cells. In this study, we investigated the molecular mechanisms underlying RA-induced autophagy as well as the relationship between RA-induced autophagy and its cytotoxicity in human breast cancer cells in vitro. Treatment with RA (2-8 μmol/L) dose-dependently enhanced autophagy, as evidenced by increased LC3 levels in breast cancer cell lines T47D, MCF-7 and MDA-MB-231...
December 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29239243/lifestyle-changes-in-cancer-patients-undergoing-curative-or-palliative-chemotherapy-is-it-feasible
#15
Karianne Vassbakk-Brovold, Sveinung Berntsen, Liv Fegran, Henrik Lian, Odd Mjåland, Svein Mjåland, Karin Nordin, Stephen Seiler, Christian Kersten
INTRODUCTION: This study aimed to explore the feasibility of an individualized comprehensive lifestyle intervention in cancer patients undergoing curative or palliative chemotherapy. MATERIAL AND METHODS: At one cancer center, serving a population of 180,000, 100 consecutive of 161 eligible newly diagnosed cancer patients starting curative or palliative chemotherapy entered a 12-month comprehensive, individualized lifestyle intervention. Participants received a grouped startup course and monthly counseling, based on self-reported and electronically evaluated lifestyle behaviors...
December 14, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29239219/multifunctional-redox-responsive-and-cd44-receptor-targeting-polymer-drug-nanomedicine-based-curcumin-and-alendronate-synthesis-characterization-and-in-vitro-evaluation
#16
Xue Dong, Shaohua Zou, Chunjing Guo, Kaili Wang, Feng Zhao, Huaying Fan, Jungang Yin, Daquan Chen
The traditional therapy of cancer has systemic side effects, and many cancers, such as human breast cancer and lung cancer easily metastasize to bones, leading to the formation of secondary tumours. This study was aimed at enhancing the anti-tumour effect of curcumin (CUR) and preventing tumour spread to the bone. A novel multifunctional redox-responsive and CD44 receptor targeting polymer-drug, poly alendronate-hyaluronan-S-S-curcumin copolymer (ALN-oHA-S-S-CUR) based CUR and alendronate (ALN) were synthesized successfully with the disulphide bond linker...
December 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29239131/finasteride-treatment-and-male-breast-cancer-a-register-based-cohort-study-in-four-nordic-countries
#17
Mathias Meijer, Lau Caspar Thygesen, Anders Green, Martha Emneus, Klaus Brasso, Peter Iversen, Eero Pukkala, Kristian Bolin, Knut Stavem, Annette K Ersbøll
A potential link has been suggested between dispensed finasteride and increased risk of male breast cancer (MBC). Due to the rare occurrence of MBC, it remains to be established if such a relationship exists. The purpose of this study was to combine nationwide registers in four countries to assess the potential association between dispensed finasteride and MBC. A cohort of all males with dispensed finasteride in Denmark, Finland, Norway, and Sweden (1,365,088 person years) was followed up for up to 15 years for breast cancer, and compared to a cohort of males unexposed to finasteride...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29238974/a-randomized-phase-iii-trial-of-neoadjuvant-recombinant-human-endostatin-docetaxel-and-epirubicin-as-first-line-therapy-for-patients-with-breast-cancer-cbcrt01
#18
Jianghao Chen, Qing Yao, Meiling Huang, Bo Wang, Juliang Zhang, Ting Wang, Yu Ming, Xiaodong Zhou, Qianxin Jia, Yi Huan, Jing Wang, Ling Wang
To further assess the efficacy and safety of recombinant human endostatin (rh-endostatin), a phase III, multicenter, prospective, randomized, controlled clinical trial was conducted. Patients to be treated with neoadjuvant docetaxel and epirubicin (DE) or DE plus rh-endostatin (DEE) were eligible for this trial. The primary endpoint was clinical/pathological response. Secondary endpoints included adverse events and quality of life (QOL). Finally, 803 patients were enrolled and randomly assigned to receive DE (n = 402) or DEE (n = 401) regimen...
December 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29238936/perceived-social-support-mediates-the-longitudinal-relations-between-ambivalence-over-emotional-expression-and-quality-of-life-among-chinese-american-breast-cancer-survivors
#19
William Tsai, Qian Lu
PURPOSE: The present study examined perceived social support as a mediator of the longitudinal link between ambivalence over emotional expression (AEE) and quality of life among a sample of Chinese breast cancer survivors. METHODS: Ninety-six Chinese breast cancer survivors recruited from Southern California completed four surveys in total: (1) a baseline survey (T1), 1-month follow-up (T2), 3-month follow-up (T3), and 6-month follow-up (T4). Participants filled out a paper-pen questionnaire containing the Ambivalence over Emotional Expression Questionnaire (AEQ), the Functional Assessment of Cancer Therapy-General (FACT-G), and the Medical Outcomes Study Social Support Scale (MOS-SSS)...
December 13, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29238750/biomarkers-of-aging-associated-with-past-treatments-in-breast-cancer-survivors
#20
Zorica Scuric, Judith E Carroll, Julienne E Bower, Sam Ramos-Perlberg, Laura Petersen, Stephanie Esquivel, Matt Hogan, Aaron M Chapman, Michael R Irwin, Elizabeth C Breen, Patricia A Ganz, Robert Schiestl
Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors. We examined whether past exposure to chemotherapy and/or radiation treatment was associated with DNA damage, telomerase activity, and telomere length 3-6 years after completion of primary treatments in breast cancer survivors (stage 0-IIIA breast cancer at diagnosis)...
2017: NPJ Breast Cancer
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