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https://www.readbyqxmd.com/read/29052838/research-review-early-intervention-for-infants-and-young-children-with-or-at-risk-of-autism-spectrum-disorder-a-systematic-review
#1
REVIEW
Lorna French, Eilis M M Kennedy
BACKGROUND: There has been increased interest in early screening and intervention for young children with, or at risk of, autism spectrum disorder (ASD). This has generated a debate about the potential harms versus benefits of early identification and treatment. This review aims to identify the evidence base for early intervention in ASD. METHODS: A systematic review searching for randomised controlled trials (RCTs) of interventions for children up to 6 years of age with, or at risk of, ASD was undertaken...
October 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29052014/predictive-validity-of-a-service-setting-based-measure-to-identify-infancy-mental-health-problems-a-population-based-cohort-study
#2
Janni Ammitzbøll, Lau Caspar Thygesen, Bjørn E Holstein, Anette Andersen, Anne Mette Skovgaard
Measures to identify infancy mental health problems are essential to guide interventions and reduce the risk of developmental psychopathology in early years. We investigated a new service-setting-based measure the Copenhagen Infant Mental Health Screening (CIMHS) within the general child health surveillance by community health nurses (CHN). The study population of 2973 infants was assessed by CIMHS at age 9-10 months. A subsample of 416 children was examined at age 1½ years, using parent interviews including the Child Behavior Checklist (CBCL 1½-5), Check List of Autism and Toddlers (CHAT), Infant-Toddler Symptom Checklist (ITSCL), and the Bayley Scales of Infant and Toddler Development (BSID) and observations of behavior, communication, and interaction...
October 20, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29040924/early-social-communication-in-infants-with-fragile-x-syndrome-and-infant-siblings-of-children-with-autism-spectrum-disorder
#3
Laura J Hahn, Nancy C Brady, Lindsay McCary, Lisa Rague, Jane E Roberts
BACKGROUND: Little research in fragile X syndrome (FXS) has prospectively examined early social communication. AIMS: To compare early social communication in infants with FXS, infant siblings of children with autism spectrum disorder (ASIBs), and typically developing (TD) infants. METHODS AND PROCEDURES: Participants were 18 infants with FXS, 21 ASIBs, and 22 TD infants between 7.5-14.5 months. Social communication was coded using the Communication Complexity Scale during the administration of Autism Observation Scale for Infants...
October 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29034499/early-interaction-in-autism-spectrum-disorder-mothers-and-children-s-behaviours-during-joint-engagement
#4
A Kaale, L Smith, A Nordahl-Hansen, M W Fargerland, C Kasari
BACKGROUND: More knowledge about the interaction between young children with autism spectrum disorder and their parents is one way to improve intervention. This study aims to investigate the behaviours of mothers and children with autism spectrum disorder during joint engagement, with a focus on pacing or rate (i.e., incidences per minute) of their behaviours when being in this state. METHOD: Video recordings of 10 min of free-play between 58 children (2-4 years) diagnosed with childhood autism and their mothers were used to examine rate of mothers' and children's behaviours (i...
October 15, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29032701/parent-reported-use-of-interventions-by-toddlers-and-preschoolers-with-autism-spectrum-disorder
#5
Nalin Payakachat, J Mick Tilford, Karen A Kuhlthau
OBJECTIVE: This study examined services used by young children with autism spectrum disorder (ASD) and factors associated with use. METHODS: A retrospective observational study was conducted with baseline data for toddlers (under age three) and preschoolers (three to less than six years) with ASD enrolled in the Autism Speaks Autism Treatment Network registry from 2008 to 2013 (N=2,804). Parents' reports at enrollment of services received by children were documented...
October 16, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29018511/neurocognitive-and-observational-markers-prediction-of-autism-spectrum-disorder-from-infancy-to-mid-childhood
#6
Rachael Bedford, Teodora Gliga, Elizabeth Shephard, Mayada Elsabbagh, Andrew Pickles, Tony Charman, Mark H Johnson
BACKGROUND: Prospective studies of infants at high familial risk for autism spectrum disorder (ASD) have identified a number of putative early markers that are associated with ASD outcome at 3 years of age. However, some diagnostic changes occur between toddlerhood and mid-childhood, which raises the question of whether infant markers remain associated with diagnosis into mid-childhood. METHODS: First, we tested whether infant neurocognitive markers (7-month neural response to eye gaze shifts and 14-month visual disengagement latencies) as well as an observational marker of emerging ASD behaviours (the Autism Observation Scale for Infants; AOSI) predicted ASD outcome in high-risk (HR) 7-year-olds with and without an ASD diagnosis (HR-ASD and HR-No ASD) and low risk (LR) controls...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28989330/maternal-and-neonatal-birth-factors-affecting-the-age-of-asd-diagnosis
#7
Ashley Darcy-Mahoney, Bonnie Minter, Melinda Higgins, Ying Guo, Lauren Head Zauche, Jessica Hirst
Early diagnosis of autism spectrum disorders (ASD) enables early intervention that improves long term functioning of children with ASD but is often delayed until age of school entry. Few studies have identified factors that affect timely diagnosis. This study addressed how maternal education, race, age, marital status as well as neonatal birth factors affect the age at which a child is diagnosed with ASD. This study involved a retrospective analysis of 664 records of children treated at one of the largest autism treatment centers in the United States from March 1, 2009 to December 30, 2010...
December 2016: Newborn and Infant Nursing Reviews: NAINR
https://www.readbyqxmd.com/read/28963042/behavioral-phenotypes-and-neurobiological-mechanisms-in-the-shank1-mouse-model-for-autism-spectrum-disorder-a-translational-perspective
#8
REVIEW
A Özge Sungur, Rainer K W Schwarting, Markus Wöhr
Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, characterized by early-onset deficits in social behavior and communication across multiple contexts, together with restricted, repetitive patterns of behavior, interests, or activities. ASD is among the most heritable neuropsychiatric conditions with heritability estimates higher than 80%, and while available evidence points to a complex set of genetic factors, the SHANK (also known as ProSAP) gene family has emerged as one of the most promising candidates...
September 26, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28949003/longitudinal-follow-up-of-academic-achievement-in-children-with-autism-from-age-2-to-18
#9
So Hyun Kim, Vanessa H Bal, Catherine Lord
OBJECTIVE: This study examined early predictors of and changes in school-age academic achievement and class placement in children referred for autism spectrum disorder (ASD) at age 2. METHOD: Of 111 ASD referrals, 74 were diagnosed with ASD at age 18. Regression analyses were performed to identify age 3 predictors of achievement in arithmetic, passage comprehension, word reading, and spelling at ages 9 and 18. Linear Mixed Models were used to examine predictors of academic growth between ages 9 and 18...
September 26, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28946583/cognitive-rehabilitation-with-neurodevelopmental-disorder-a-systematic-review
#10
Sinae Ahn, Sujin Hwang
BACKGROUND: A variety of cognitive rehabilitation has gained popularity in early childhood with neurodevelopmental disorder at clinical rehabilitation settings. OBJECTIVES: The purpose of this review was to analyze the cognitive therapies used and to analyze the methods applied in children with neurodevelopmental disorders. METHODS: This study searched for experimental studies published between 2006 and 2016 using two databases including EBSCOhost and PubMed...
September 16, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28937691/toward-a-conceptual-framework-for-early-brain-and-behavior-development-in-autism
#11
J Piven, J T Elison, M J Zylka
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have demonstrated that the defining features of autism are not present in the first year of life but emerge late in the first and into the second year. A recent longitudinal neuroimaging study of high-risk siblings revealed a specific pattern of brain development in infants later diagnosed with autism, characterized by cortical surface area hyper-expansion in the first year followed by brain volume overgrowth in the second year that is associated with the emergence of autistic social deficits...
October 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28929805/-it-feels-like-something-difficult-is-coming-back-to-haunt-me-an-exploration-of-meltdowns-associated-with-autistic-spectrum-disorder-from-a-parental-perspective
#12
Indiana Montaque, Rudi Dallos, Becky McKenzie
The research explored the experience and understandings expressed by parents of children with autism concerning 'meltdowns', which are commonly described as distressing, escalating episodes of conflicts. Semi-structured interviews were conducted with six parents of children with a diagnosis of autism regarding their experience of 'meltdowns'. Parents were asked to track the process of the meltdowns as well as to describe their experiences. Three over-arching themes emerged which encapsulated their experience: Living in Dread: Anxiety and fear of escalating patterns, Attempting to Correct for Negative Childhood Experiences and Condemnation from the Self and Others...
September 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28923933/longitudinal-identification-of-clinically-distinct-neurophenotypes-in-young-children-with-fragile-x-syndrome
#13
Jennifer L Bruno, David Romano, Paul Mazaika, Amy A Lightbody, Heather Cody Hazlett, Joseph Piven, Allan L Reiss
Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability. The cognitive, behavioral, and neurological phenotypes observed in affected individuals can vary considerably, making it difficult to predict outcomes and determine the need for interventions. We sought to examine early structural brain growth as a potential marker for identification of clinically meaningful subgroups. Participants included 42 very young boys with FXS who completed a T1-weighted anatomical MRI and cognitive/behavioral assessment at two longitudinal time points, with mean ages of 2...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28914083/the-importance-of-context-in-early-autism-intervention-a-qualitative-south-african-study
#14
Jessy Guler, Petrus J de Vries, Noleen Seris, Nokuthula Shabalala, Lauren Franz
The majority of individuals with autism spectrum disorder live in low- and middle-income countries and receive little or no services from health or social care systems. The development and validation of autism spectrum disorder interventions has almost exclusively occurred in high-income countries, leaving many unanswered questions regarding what contextual factors would need to be considered to ensure the effectiveness of interventions in low- and middle-income countries. This study qualitatively explored contextual factors relevant to the adaptation of a caregiver-mediated early autism spectrum disorder intervention in a low-resource South African setting...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28905160/school-age-outcomes-of-children-diagnosed-early-and-later-with-autism-spectrum-disorder
#15
Megan Louise Erin Clark, Zoe Vinen, Josephine Barbaro, Cheryl Dissanayake
Early diagnosis of Autism Spectrum Disorder is considered best practice, increasing access to early intervention. Yet, many children are diagnosed after 3-years. The current study investigated the school age outcomes of children who received an early and later diagnosis of ASD. The cognitive and behavioural outcomes of children diagnosed early (n = 48), were compared to children diagnosed after 3-years (n = 37). Children diagnosed early accessed more intervention, demonstrated better verbal and overall cognition at school age, were more likely to attend mainstream school and required less ongoing support than children diagnosed later...
September 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28892073/progress-and-roadblocks-in-the-search-for-brain-based-biomarkers-of-autism-and-attention-deficit-hyperactivity-disorder
#16
REVIEW
L Q Uddin, D R Dajani, W Voorhies, H Bednarz, R K Kana
Children with neurodevelopmental disorders benefit most from early interventions and treatments. The development and validation of brain-based biomarkers to aid in objective diagnosis can facilitate this important clinical aim. The objective of this review is to provide an overview of current progress in the use of neuroimaging to identify brain-based biomarkers for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), two prevalent neurodevelopmental disorders. We summarize empirical work that has laid the foundation for using neuroimaging to objectively quantify brain structure and function in ways that are beginning to be used in biomarker development, noting limitations of the data currently available...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28890936/object-play-in-infants-with-autism-spectrum-disorder-a-longitudinal-retrospective-video-analysis
#17
Kaitlyn P Wilson, Mary W Carter, Heather L Wiener, Margaret L DeRamus, John C Bulluck, Linda R Watson, Elizabeth R Crais, Grace T Baranek
BACKGROUND AND AIMS: Early play behaviors may provide important information regarding later-diagnosed developmental delays. Play behaviors of young children with autism spectrum disorder (ASD) are restricted in diversity, frequency, and complexity. Most ASD research focuses on play in children over 18 months of age. This study examined three groups of infants (later diagnosed with ASD, later diagnosed with other developmental disorders, and typically developing) with the aims of: (1) describing the play behaviors of the three groups of infants at two time points (9-12 months and 15-18 months); (2) examining group differences in four hierarchical levels of play at both time points; (3) comparing groups with respect to the highest level of play achieved; and (4) determining if the highest level of play achieved by infants with developmental delays, including ASD, correlated with later developmental outcomes...
January 2017: Autism Dev Lang Impair
https://www.readbyqxmd.com/read/28883746/clinical-impact-of-early-diagnosis-of-autism-on-the-prognosis-and-parent-child-relationships
#18
REVIEW
Jennifer Harrison Elder, Consuelo Maun Kreider, Susan N Brasher, Margaret Ansell
Autism spectrum disorder (ASD) refers to a lifelong condition that usually appears in late infancy or early childhood, and is characterized by social and communication deficits that impede optimal functioning. Despite widespread research and greater public awareness, ASD has an unclear etiology and no known cure, making it difficult to acquire accurate and timely diagnoses. In addition, once an ASD diagnosis is made, parents find it challenging to navigate the healthcare system and determine which interventions are most effective and appropriate for their child...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28861936/pivotal-response-treatment-for-preschoolers-with-autism-spectrum-disorder-defining-a-predictor-profile
#19
Kristin-Lee Fossum, Loriann Williams, Nancy Garon, Susan E Bryson, Isabel M Smith
Behavioral characteristics of children with autism spectrum disorder (ASD) who respond positively to Pivotal Response Treatment (PRT) have been described previously, based on single-subject design research. The present study examined several such characteristics, as well as positive affect, as predictors of expressive language (EL) gains in a representative sample of preschoolers with ASD (n = 57) enrolled in a PRT-based community early intervention program. Children's cognitive ability, positive affect, and levels of appropriate toy contact measured at the start of intervention each contributed significantly to the prediction of EL outcomes...
August 31, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28861651/parent-mediated-intervention-for-one-year-olds-screened-as-at-risk-for-autism-spectrum-disorder-a-randomized-controlled-trial
#20
Linda R Watson, Elizabeth R Crais, Grace T Baranek, Lauren Turner-Brown, John Sideris, Linn Wakeford, Jessica Kinard, J Steven Reznick, Katrina L Martin, Sallie W Nowell
Theoretically, interventions initiated with at-risk infants prior to the point in time a definitive autism spectrum disorder (ASD) diagnosis can be made will improve outcomes. Pursuing this idea, we tested the efficacy of a parent-mediated early intervention called Adapted Responsive Teaching (ART) via a randomized controlled trial with 87 one-year-olds identified by community screening with the First Year Inventory as at-risk of later ASD diagnoses. We found minimal evidence for main effects of ART on child outcomes...
August 31, 2017: Journal of Autism and Developmental Disorders
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