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JOURNAL ARTICLE
Anna J Harte, Ehsan Ghasemian, Harry Pickering, Joanna Houghton, Ambahun Chernet, Eshetu Sata, Gizachew Yismaw, Taye Zeru, Zerihun Tadesse, E Kelly Callahan, Scott D Nash, Martin Holland
Trachoma is the leading infectious cause of blindness worldwide and is now largely confined to around 40 low- and middle-income countries. It is caused by Chlamydia trachomatis (Ct), a contagious intracellular bacterium. The World Health Organization recommends mass drug administration (MDA) with azithromycin for treatment and control of ocular Ct infections, alongside improving facial cleanliness and environmental conditions to reduce transmission. To understand the molecular epidemiology of trachoma, especially in the context of MDA and transmission dynamics, the identification of Ct genotypes could be useful...
April 25, 2024: PLoS Neglected Tropical Diseases
#2
JOURNAL ARTICLE
Kat S Rock, Lloyd A C Chapman, Andrew P Dobson, Emily R Adams, T Déirdre Hollingsworth
BACKGROUND: Neglected tropical diseases are responsible for considerable morbidity and mortality in low-income populations. International efforts have reduced their global burden, but transmission is persistent and case-finding-based interventions rarely target asymptomatic individuals. METHODS: We develop a generic mathematical modeling framework for analyzing the dynamics of visceral leishmaniasis in the Indian sub-continent (VL), gambiense sleeping sickness (gHAT), and Chagas disease and use it to assess the possible contribution of asymptomatics who later develop disease (pre-symptomatics) and those who do not (non-symptomatics) to the maintenance of infection...
April 25, 2024: Clinical Infectious Diseases
#3
JOURNAL ARTICLE
Panayiota Touloupou, Claudio Fronterre, Jorge Cano, Joaquin M Prada, Morgan Smith, Periklis Kontoroupis, Paul Brown, Rocio Caja Rivera, Sake J de Vlas, Sharmini Gunawardena, Michael A Irvine, Sammy M Njenga, Lisa Reimer, Fikre Seife, Swarnali Sharma, Edwin Michael, Wilma A Stolk, Rachel Pulan, Simon E F Spencer, T Déirdre Hollingsworth
BACKGROUND: Lymphatic filariasis (LF) is a neglected tropical disease targeted for elimination as a public health problem by 2030. Although mass treatments have led to huge reductions in LF prevalence, some countries or regions may find it difficult to achieve elimination by 2030 owing to various factors, including local differences in transmission. Subnational projections of intervention impact are a useful tool in understanding these dynamics, but correctly characterizing their uncertainty is challenging...
April 25, 2024: Clinical Infectious Diseases
#4
JOURNAL ARTICLE
Joaquin M Prada, Panayiota Touloupou, Biruck Kebede, Emanuelle Giorgi, Heven Sime, Morgan Smith, Periklis Kontoroupis, Paul Brown, Jorge Cano, Hajnal Farkas, Mike Irvine, Lisa Reimer, Rocio Caja Rivera, Sake J de Vlas, Edwin Michael, Wilma A Stolk, Rachel Pulan, Simon E F Spencer, T Déirdre Hollingsworth, Fikre Seife
BACKGROUND: Lymphatic filariasis (LF) is a debilitating, poverty-promoting, neglected tropical disease (NTD) targeted for worldwide elimination as a public health problem (EPHP) by 2030. Evaluating progress towards this target for national programmes is challenging, due to differences in disease transmission and interventions at the subnational level. Mathematical models can help address these challenges by capturing spatial heterogeneities and evaluating progress towards LF elimination and how different interventions could be leveraged to achieve elimination by 2030...
April 25, 2024: Clinical Infectious Diseases
#5
JOURNAL ARTICLE
Ariktha Srivathsan, Amza Abdou, Tawfik Al-Khatib, Sue-Chen Apadinuwe, Mouctar D Badiane, Victor Bucumi, Tina Chisenga, George Kabona, Martin Kabore, Sarjo Kebba Kanyi, Lucienne Bella, Nekoua M'po, Michael Masika, Abdellahi Minnih, Henis Mior Sitoe, Sailesh Mishra, Nicholas Olobio, Fatma Juma Omar, Isaac Phiri, Salimato Sanha, Fikre Seife, Shekhar Sharma, Rabebe Tekeraoi, Lamine Traore, Titus Watitu, Yak Yak Bol, Anna Borlase, Michael S Deiner, Kristen K Renneker, P J Hooper, Paul M Emerson, Andreia Vasconcelos, Benjamin F Arnold, Travis C Porco, T Déirdre Hollingsworth, Thomas M Lietman, Seth Blumberg
Assessing the feasibility of 2030 as a target date for global elimination of trachoma, and identification of districts that may require enhanced treatment to meet World Health Organization (WHO) elimination criteria by this date are key challenges in operational planning for trachoma programmes. Here we address these challenges by prospectively evaluating forecasting models of trachomatous inflammation-follicular (TF) prevalence, leveraging ensemble-based approaches. Seven candidate probabilistic models were developed to forecast district-wise TF prevalence in 11 760 districts, trained using district-level data on the population prevalence of TF in children aged 1-9 years from 2004 to 2022...
April 25, 2024: Clinical Infectious Diseases
#6
JOURNAL ARTICLE
Andreia Vasconcelos, Cláudio Nunes-Alves, T Déirdre Hollingsworth
The World Health Organization roadmap for neglected tropical diseases (NTDs) sets out ambitious targets for disease control and elimination by 2030, including 90% fewer people requiring interventions against NTDs and the elimination of at least 1 NTD in 100 countries. Mathematical models are an important tool for understanding NTD dynamics, optimizing interventions, assessing the efficacy of new tools, and estimating the economic costs associated with control programs. As NTD control shifts to increased country ownership and programs progress toward disease elimination, tailored models that better incorporate local context and can help to address questions that are important for decision-making at the national level are gaining importance...
April 25, 2024: Clinical Infectious Diseases
#7
JOURNAL ARTICLE
Hugo C Turner, Klodeta Kura, Barbara Roth, Annette C Kuesel, Sally Kinrade, Maria-Gloria Basáñez
BACKGROUND: Concerns that annual mass administration of ivermectin, the predominant strategy for onchocerciasis control and elimination, may not lead to elimination of parasite transmission (EoT) in all endemic areas have increased interest in alternative treatment strategies. One such strategy is moxidectin. We performed an updated economic assessment of moxidectin- relative to ivermectin-based strategies. METHODS: We investigated annual and biannual community-directed treatment with ivermectin (aCDTI, bCDTI) and moxidectin (aCDTM, bCDTM) with minimal or enhanced coverage (65% or 80% of total population taking the drug, respectively) in intervention-naive areas with 30%, 50%, or 70% microfilarial baseline prevalence (representative of hypo-, meso-, and hyperendemic areas)...
April 25, 2024: Clinical Infectious Diseases
#8
JOURNAL ARTICLE
Andreia Vasconcelos, Jonathan D King, Cláudio Nunes-Alves, Roy Anderson, Daniel Argaw, Maria-Gloria Basáñez, Shakir Bilal, David J Blok, Seth Blumberg, Anna Borlase, Oliver J Brady, Raiha Browning, Nakul Chitnis, Luc E Coffeng, Emily H Crowley, Zulma M Cucunubá, Derek A T Cummings, Christopher Neil Davis, Emma Louise Davis, Matthew Dixon, Andrew Dobson, Louise Dyson, Michael French, Claudio Fronterre, Emanuele Giorgi, Ching-I Huang, Saurabh Jain, Ananthu James, Sung Hye Kim, Klodeta Kura, Ana Lucianez, Michael Marks, Pamela Sabina Mbabazi, Graham F Medley, Edwin Michael, Antonio Montresor, Nyamai Mutono, Thumbi S Mwangi, Kat S Rock, Martha-Idalí Saboyá-Díaz, Misaki Sasanami, Markus Schwehm, Simon E F Spencer, Ariktha Srivathsan, Robert S Stawski, Wilma A Stolk, Samuel A Sutherland, Louis-Albert Tchuem Tchuenté, Sake J de Vlas, Martin Walker, Simon J Brooker, T Déirdre Hollingsworth, Anthony W Solomon, Ibrahima Socé Fall
Over the past decade, considerable progress has been made in the control, elimination, and eradication of neglected tropical diseases (NTDs). Despite these advances, most NTD programs have recently experienced important setbacks; for example, NTD interventions were some of the most frequently and severely impacted by service disruptions due to the coronavirus disease 2019 (COVID-19) pandemic. Mathematical modeling can help inform selection of interventions to meet the targets set out in the NTD road map 2021-2030, and such studies should prioritize questions that are relevant for decision-makers, especially those designing, implementing, and evaluating national and subnational programs...
April 25, 2024: Clinical Infectious Diseases
#9
JOURNAL ARTICLE
Nicolhole Atero, Marisa Torres, Angélica Domínguez, Benjamín Diethelm-Varela, Francisca Córdova-Bührle, Fernando O Mardones
Chagas disease (CD) is a neglected parasitic zoonotic disease that affects over 6 million people worldwide. We conducted a retrospective study to analyze the spatiotemporal trends and risk factors for hospitalization rates of CD with cardiac and digestive diagnoses in Chile. We used the Mann-Kendall analysis for temporal trends, Global Moran's Index, and Local Indicators of Spatial Association to identify spatial autocorrelation, and regression models to determine the risk factors associated with in-hospital mortality and surgical intervention...
April 2024: PLoS Neglected Tropical Diseases
#10
REVIEW
Kathy Sliwinski, Ann Kutney-Lee, Matthew D McHugh, Karen B Lasater
Language barriers significantly affect communication between patients and health care staff and are associated with receipt of lower-quality care. Registered nurses are well positioned members of the health care team to reduce and eliminate disparities for patients with limited English proficiency (LEP). Current evidence recommends nurses use interpreters or translation devices to overcome language barriers; however, these recommendations fail to recognize that structural system-level factors, such as unsupportive work environments and poor nurse-to-patient staffing ratios, reduce nurses' ability to implement these recommendations...
2024: Journal of Health Care for the Poor and Underserved
#11
JOURNAL ARTICLE
Maia Ingram, Ada M Wilkinson-Lee, Namoonga M Mantina, Maria Velasco, Gloria Coronado, Mark Gallegos, Scott C Carvajal
BACKGROUND: Behavioral models play a key role in identifying pathways to better health and provide a foundation for health promotion interventions. However, behavioral models based in epidemiological research may be limited in relevance and utility in practice. OBJECTIVES: We describe a participatory approach within a community-based participatory research partnership for integrating epidemiological and community perspectives into the application of the sociocultural resilience model (SRM)...
2024: Progress in Community Health Partnerships: Research, Education, and Action
#12
JOURNAL ARTICLE
William D Marelich, Brandin Ali, Debra A Murphy, Marya T Schulte, Lisa Armistead
OBJECTIVE: The current study applied survival analysis to examine factors associated with nondisclosure of human immunodeficiency virus (HIV) serostatus among mothers living with HIV (MLH) who had participated in a cognitive-behavioral intervention to disclose their HIV status to their children. METHOD: Data were utilized from MLH in the intervention arm of the teaching, raising, and communicating with kids (TRACK; Schulte et al., 2021) trial focusing on serostatus disclosure/nondisclosure across four time points (baseline, 3, 9, and 15 months)...
April 25, 2024: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
#13
JOURNAL ARTICLE
Seung Eun Lee, Ja-Kyung Seo, Maura Macphee
AIM: The study's aim was to examine how workplace incivility and workload influence nurses' work attitudes (turnover intention, job satisfaction, and organizational commitment) using the stress-strain-outcome framework. BACKGROUND: There is a lack of comprehensive research on the combined effects of workplace incivility and workload on nurses' work attitudes. INTRODUCTION: Two workplace stressors, incivility and workload, were hypothesized to lead to burnout, which in turn influences nurses' work attitudes...
April 25, 2024: International Nursing Review
#14
JOURNAL ARTICLE
Abigail Reay, Lorelle Dismore, Avinash Aujayeb, Catherine Dotchin, Ellen Tullo, John Steer, Katherine Swainston
AIMS AND OBJECTIVES: We sought to gain an understanding of the patient experience during their hospital stay for COVID-19, and the impact of COVID-19 on quality of life post discharge. BACKGROUND: Symptoms of COVID-19 include a persistent cough, dyspnoea and fatigue. Individuals with comorbidities such as cardiovascular disease have a higher risk of contracting COVID-19 and approximately 20% of those diagnosed with COVID-19 are admitted to hospital. Following discharge from hospital, 40% of patients report a worsened quality of life and up to 87% of those discharged from hospital have experienced 'long COVID'...
April 25, 2024: Journal of Clinical Nursing
#15
JOURNAL ARTICLE
Benjamin J Galatzan, Elizabeth Johnson, Tonya Judson, Liang Shan
AIM: This study examines the intricate language and communication patterns of nurse-to-nurse handoffs across three units with varying patient acuity levels and nurse-patient ratios, seeking to identify linguistic factors that may affect the quality of information transfer and patient outcomes. DESIGN: A mixed-methods cross-sectional design. METHODS: This study used the Nurse-to-Nurse Transition of Care Communication Model to explore the content and meaning of language in nursing handoffs within a large academic medical centre...
April 25, 2024: Journal of Clinical Nursing
#16
JOURNAL ARTICLE
Abiud Cantu, Manuel Cantu Gutierrez, Xiaoyu Dong, Connor Leek, Montserrat Anguera, Krithika Lingappan
Recovery from lung injury during the neonatal period requires the orchestration of many biological pathways. The modulation of such pathways can drive the developing lung towards proper repair or persistent maldevelopment that can lead to a disease phenotype. Sex as a biological variable can regulate these pathways differently in the male and female lung exposed to neonatal hyperoxia. In this study, we assessed the contribution of cellular diversity in the male and female neonatal lung following injury. Our objective was to investigate sex and cell-type specific transcriptional changes that drive repair or persistent injury in the neonatal lung and delineate the alterations in the immune-endothelial cell communication networks using single cell RNA sequencing (sc-RNAseq) in a murine model of hyperoxic injury...
December 2023: Redox Biology
#17
REVIEW
Dominika Kohanová, Andrea Solgajová, Floro Cubelo
AIM(S): Teamwork among healthcare professionals is a key aspect of patient safety that influences the prevalence of missed nursing care. The association between teamwork and missed care in acute care hospitals is now well established in the literature. Therefore, this review aimed to synthesise the existing empirical evidence on the association between teamwork and missed care in the acute care setting. DESIGN: A mixed-method systematic review study. METHODS: The search was carried out in February 2023 in four scientific databases, PubMed, ProQuest, Web of Science and Scopus based on their institutional availability...
April 25, 2024: Journal of Clinical Nursing
#18
JOURNAL ARTICLE
Sarah Van Borek, Carmen H Logie, Bibiche Mbende, Laure Stella Ghoma Linguissi, Frannie MacKenzie, Anaïs Ouedraogo, Anoushka Lad, Anicet Boumba, Lesley Gittings, Hugues Loemba
Sex workers experience elevated risks of sexual and gender-based violence (SGBV) from intimate partners, clients, and community members that harms health and human rights. While SGBV contributes to poorer sexual and reproductive health (SRH) outcomes among sex workers, including elevated human immunodeficiency virus (HIV) vulnerabilities, stigma targeting sex workers reduces SRH service access and uptake. The Congo Republic is an exemplar context to address stigma toward sex workers. Sex workers' HIV prevalence (8...
April 25, 2024: Health Promotion Practice
#19
JOURNAL ARTICLE
Suman Pant, Andrew Corwin, Prabhat Adhikari, Subhash Prasad Acharya, Upasana Acharya, Sashi Silwal, Pratima Dawadi, Anil Poudyal, Vibhu Paudyal, Adisak Bhumiratana
Antimicrobial resistance (AMR) is widely regarded as an increasing threat to global public health. Antibiotic treatment guidelines have been increasingly recognized as an effective tool to guide appropriate prescriptions and help curtail antibiotic resistance. The present study aimed to assess physician's adherence to hospital antibiotic treatment guideline recommendations in Nepal and determine predictive variables with a significant association. This was a retrospective, monocentric observational review to investigate the adherence to endorsed guidelines using the medical records of adults admitted to the hospital with a diagnosis of urinary tract infection (UTI), pneumonia, or skin and soft tissue infection (SSTI) from January 2018 to December 2019...
2024: Canadian Journal of Infectious Diseases & Medical Microbiology
#20
JOURNAL ARTICLE
Emily E Bernstein, Jennifer L Greenberg, Hilary Weingarden, Ivar Snorrason, Berta Summers, Jasmine Williams, Rachel Quist, Joshua Curtiss, Oliver Harrison, Sabine Wilhelm
BACKGROUND: Body dysmorphic disorder (BDD) is severe and undertreated. Digital mental health could be key to expanding access to evidence-based treatments, such as cognitive behavioral therapy for BDD (CBT-BDD). Coach guidance is posited to be essential for effective uptake of digital interventions. However, little is known about how different patients may use coaching, what patterns correspond to meaningful outcomes, and how to match coaching to patient needs. METHODS: Participants were 77 adults who received a 12-week guided smartphone CBT-BDD...
June 2024: Internet Interventions
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