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https://www.readbyqxmd.com/read/28066878/safety-and-effectiveness-of-sodium-stibogluconate-and-paromomycin-combination-for-the-treatment-of-visceral-leishmaniasis-in-eastern-africa-results-from-a-pharmacovigilance-programme
#1
Robert Kimutai, Ahmed M Musa, Simon Njoroge, Raymond Omollo, Fabiana Alves, Asrat Hailu, Eltahir A G Khalil, Ermias Diro, Peninah Soipei, Brima Musa, Khalid Salman, Koert Ritmeijer, Francois Chappuis, Juma Rashid, Rezika Mohammed, Asfaw Jameneh, Eyasu Makonnen, Joseph Olobo, Lawrence Okello, Patrick Sagaki, Nathalie Strub, Sally Ellis, Jorge Alvar, Manica Balasegaram, Emilie Alirol, Monique Wasunna
INTRODUCTION: In 2010, WHO recommended a new first-line treatment for visceral leishmaniasis (VL) in Eastern Africa. The new treatment, a combination of intravenous (IV) or intramuscular (IM) sodium stibogluconate (SSG) and IM paromomycin (PM) was an improvement over SSG monotherapy, the previous first-line VL treatment in the region. To monitor the new treatment's safety and effectiveness in routine clinical practice a pharmacovigilance (PV) programme was developed. METHODS: A prospective PV cohort was developed...
January 9, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28031546/sunlight-exposure-and-vitamin-d-status-in-breastfed-infants
#2
Pinky Meena, Aashima Dabas, Dheeraj Shah, Rajeev Kumar Malhotra, S V Madhu, Piyush Gupta
OBJECTIVE: To correlate the sunlight exposure in first 6 months to vitamin D status at 6 months of age in predominantly breastfed infants; and to quantify the sunlight exposure required to achieve serum 25(OH)D level > 20 ng/mL, by 6 months of age. DESIGN: Prospective cohort. SETTING: Tertiary care hospital predominantly catering to urban poor population in Delhi. PARTICIPANTS: 132 healthy infants, delivered at term, and predominantly breastfed were enrolled at 6-8 weeks of age...
December 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/28010926/increased-methylation-of-repetitive-elements-and-dna-repair-genes-is-associated-with-higher-dna-oxidation-in-children-in-an-urbanized-industrial-environment
#3
Isabel Alvarado-Cruz, Marco Sánchez-Guerra, Leticia Hernández-Cadena, Andrea De Vizcaya-Ruiz, Violeta Mugica, Nadia Azenet Pelallo-Martínez, María de Jesús Solís-Heredia, Hyang-Min Byun, Andrea Baccarelli, Betzabet Quintanilla-Vega
DNA methylation in DNA repair genes participates in the DNA damage regulation. Particulate matter (PM), which has metals and polycyclic aromatic hydrocarbons (PAHs) adsorbed, among others has been linked to adverse health outcomes and may modify DNA methylation. To evaluate PM exposure impact on repetitive elements and gene-specific DNA methylation and DNA damage, we conducted a cross-sectional study in 150 schoolchildren (7-10 years old) from an urbanized, industrial area of the metropolitan area of Mexico City (MAMC), which frequently exhibits PM concentrations above safety standards...
January 2017: Mutation Research
https://www.readbyqxmd.com/read/27998266/impact-of-pneumococcal-conjugate-vaccines-on-pneumococcal-meningitis-cases-in-france-between-2001-and-2014-a-time-series-analysis
#4
Anna Alari, Hélène Chaussade, Matthieu Domenech De Cellès, Lénaig Le Fouler, Emmanuelle Varon, Lulla Opatowski, Didier Guillemot, Laurence Watier
BACKGROUND: Pneumococcal meningitis (PM) is a major invasive pneumococcal disease. Two pneumococcal conjugate vaccines (PCVs) have been introduced in France: PCV7 was recommended in 2003 and replaced in 2010 by PCV13, which has six additional serotypes. The impact of introducing those vaccines on the evolution of PM case numbers and serotype distributions in France from 2001 to 2014 is assessed herein. METHODS: Data on 5166 Streptococcus pneumoniae strains isolated from cerebrospinal fluid between 2001 and 2014 in the 22 regions of France were obtained from the National Reference Center for Pneumococci...
December 21, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27987114/when-children-forget-to-remember-effects-of-reduced-working-memory-availability-on-prospective-memory-performance
#5
Lavinia Cheie, Colin MacLeod, Mircea Miclea, Laura Visu-Petra
The preparatory attentional and memory processes theory (PAM) of prospective memory (PM) proposes that prospective remembering is influenced by the variation in the availability of WM resources. Consequently, PM should be impaired when WM resources are reduced either by direct WM manipulation or by individual differences associated with restricted WM performance. Our study tested this prediction in school-age children by examining the independent and interactive effects of three factors known to deplete availability of WM resources: increased processing demands of a concurrent arithmetic task, additional WM span requirements, and high trait anxiety...
December 16, 2016: Memory & Cognition
https://www.readbyqxmd.com/read/27984759/systematic-review-of-the-association-between-particulate-matter-exposure-and-autism-spectrum-disorders
#6
REVIEW
María Morales-Suárez-Varela, Isabel Peraita-Costa, Agustín Llopis-González
Particulate matter (PM) as an environmental pollutant is suspected to be associated with autism spectrum disorders. The aim of the present study was to review the epidemiological literature currently available on the relation between PM exposure and diagnosis of ASD. The PubMed database was searched from November 2015 up to January 2016 by one of the authors. We included observational studies (cohort and case-control studies) published in English carried out in children within the last 10 years, measuring PM exposure and health outcomes related to ASD...
December 13, 2016: Environmental Research
https://www.readbyqxmd.com/read/27966668/predictors-of-polycyclic-aromatic-hydrocarbon-exposure-and-internal-dose-in-inner-city-baltimore-children
#7
Kamau O Peters, D' Ann L Williams, Salahadin Abubaker, Jean Curtin-Brosnan, Meredith C McCormack, Roger Peng, Patrick N Breysse, Elizabeth C Matsui, Nadia N Hansel, Gregory B Diette, Paul T Strickland
Polycyclic aromatic hydrocarbons (PAHs), the by-products of incomplete combustion of organic materials, are commonly found on particulate matter (PM) and have been associated with the development of asthma and asthma exacerbation in urban populations. We examined time spent in the home and outdoors as predictors of exposures to airborne PAHs and measured urinary 1-hydroxypyrene-glucuronide (1-OHPG) as internal dose of PAHs in 118 children aged 5-12 years from Baltimore, MD. During weeklong periods (Saturday-Saturday) in each of four seasons: daily activities were assessed using questionnaires, indoor air nicotine and PM concentrations were monitored, and urine specimens were collected on Tuesday (day 3) and Saturday (day 7) for measurement of 1-OHPG...
December 14, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27784480/-role-of-magnetic-resonance-imaging-in-the-diagnosis-of-juvenile-dermato-myositis-and-polymyositis-in-chinese-children
#8
J M Lai, F Q Wu, Z X Zhou, X Y Yuan, G X Su, S N Li, Y C Yan, J Zhu, M Kang
Objective: To evaluate the utility of magnetic resonance imaging (MRI) in diagnosis of juvenile dermatomyositis and polymyositis (JDM-PM) in children. Method: Fifty-four patients with JDM-PM in the active stage were enrolled in the study group. Twelve patients with benign acute childhood myositis and forty patients with juvenile idiopathic arthritis (JIA) complicated with myositis were enrolled as controls. MRI imaging of thighs was performed in all patients, fast spin echo T1WI, T2WI, and STIR were obtained in all patients...
October 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27778095/impacts-of-meteorological-and-environmental-factors-on-allergic-rhinitis-in-children
#9
Shan He, Zhe Mou, Li Peng, Jie Chen
Meteorological and environmental factors influence the pathogenesis of allergic rhinitis (AR). An understanding of the risk factors will facilitate the development of diagnostic and preventative tools for AR children and improve their quality of life. However, research on the impact of these factors on subjective symptoms in AR children remains scarce. This study explored the relationships between subjective symptoms in pollen and dust mite positive AR children, and meteorological and environmental factors...
October 24, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27627654/efficacy-and-safety-of-ambisome-in-combination-with-sodium-stibogluconate-or-miltefosine-and-miltefosine-monotherapy-for-african-visceral-leishmaniasis-phase-ii-randomized-trial
#10
Monique Wasunna, Simon Njenga, Manica Balasegaram, Neal Alexander, Raymond Omollo, Tansy Edwards, Thomas P C Dorlo, Brima Musa, Mohammed Hassan Sharaf Ali, Mohammed Yasein Elamin, George Kirigi, Rashid Juma, Anke E Kip, Gerard J Schoone, Asrat Hailu, Joseph Olobo, Sally Ellis, Robert Kimutai, Susan Wells, Eltahir Awad Gasim Khalil, Nathalie Strub Wourgaft, Fabiana Alves, Ahmed Musa
BACKGROUND: SSG&PM over 17 days is recommended as first line treatment for visceral leishmaniasis in eastern Africa, but is painful and requires hospitalization. Combination regimens including AmBisome and miltefosine are safe and effective in India, but there are no published data from trials of combination therapies including these drugs from Africa. METHODS: A phase II open-label, non-comparative randomized trial was conducted in Sudan and Kenya to evaluate the efficacy and safety of three treatment regimens: 10 mg/kg single dose AmBisome plus 10 days of SSG (20 mg/kg/day), 10 mg/kg single dose AmBisome plus 10 days of miltefosine (2...
September 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27548250/pediatric-gastrojejunostomy-tube-replacement-effects-of-communication-on-the-need-for-after-hours-procedures
#11
Mark E Sharafinski, Elizabeth Sehnert, David Moe, Liyun Zhang, Pippa Simpson, Nghia J Vo
OBJECTIVES: The aim of the study was to determine whether embedding into the radiology report a patient-specific plan in the event of gastrojejunostomy (GJ) tube dysfunction reduces the need for after-hours utilization of pediatric interventional radiology resources for the replacement of GJ tubes. MATERIALS AND METHODS: This is a Health Insurance Portability and Accountability Act compliant, institutional review board-approved retrospective repeated cross-sectional study of patients requiring after-hours (5 PM-7 AM) or weekend (Saturday and Sunday) GJ tube replacement at a dedicated children's hospital, before and after the inclusion of a patient-specific plan in the radiology report as part of the electronic medical record...
September 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27495000/nutritional-quality-of-foods-and-non-alcoholic-beverages-advertised-on-mexican-television-according-to-three-nutrient-profile-models
#12
Sofía Rincón-Gallardo Patiño, Lizbeth Tolentino-Mayo, Eric Alejandro Flores Monterrubio, Jennifer L Harris, Stefanie Vandevijvere, Juan A Rivera, Simón Barquera
BACKGROUND: Evidence supports that television food advertisements influence children's food preferences and their consumption. However, few studies have examined the extent and nature of food marketing to children in low and middle income countries. This study aims to assess the nutritional quality of foods and beverages advertised on Mexican TV, applying the Mexican, World Health Organization (WHO) European and United Kingdom (UKNPM) nutrient profile models, before the Mexican regulation on food marketing came into effect...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27460212/recent-exposure-to-ultrafine-particles-in-school-children-alters-mir-222-expression-in-the-extracellular-fraction-of-saliva
#13
Annette Vriens, Tim S Nawrot, Nelly D Saenen, Eline B Provost, Michal Kicinski, Wouter Lefebvre, Charlotte Vanpoucke, Jan Van Deun, Olivier De Wever, Karen Vrijens, Patrick De Boever, Michelle Plusquin
BACKGROUND: Ultrafine particles (<100 nm) are ubiquitous present in the air and may contribute to adverse cardiovascular effects. Exposure to air pollutants can alter miRNA expression, which can affect downstream signaling pathways. miRNAs are present both in the intracellular and extracellular environment. In adults, miR-222 and miR-146a were identified as associated with particulate matter exposure. However, there is little evidence of molecular effects of ambient air pollution in children...
2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27439752/haze-is-a-risk-factor-contributing-to-the-rapid-spread-of-respiratory-syncytial-virus-in-children
#14
Qing Ye, Jun-Fen Fu, Jian-Hua Mao, Shi-Qiang Shang
This study investigated whether respiratory syncytial virus (RSV) infection in children was associated with ambient temperature and air pollutants in Hangzhou, China. A distributed lag non-linear model (DLNM) was used to estimate the effects of daily meteorological data and air pollutants on the incidence of RSV infection among children. A total of 3650 childhood RSV infection cases were included in the study. The highest air pollutant concentrations were in January to May and October to December during the year...
July 20, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27412536/-clinical-features-of-childhood-purulent-meningitis-caused-by-escherichia-coli-and-streptococcus-pneumoniae-a-comparative-analysis
#15
COMPARATIVE STUDY
Wei Han, Li Jiang, Jian-Nan Ma, Xiao-Jie Song, Rong He
OBJECTIVE: To investigate the differences in clinical features of childhood purulent meningitis (PM) caused by Escherichia coli and Streptococcus pneumoniae, and to provide help for the selection of antibiotics for PM children with unknown etiology. METHODS: A retrospective analysis was performed for the clinical data of children with PM caused by Escherichia coli (12 children) or Streptococcus pneumoniae (15 children). RESULTS: Compared with the Streptococcus pneumoniae infection group, the Escherichia coli infection group had a significantly higher proportion of children with an age of onset of <3 months and a significantly higher incidence rate of convulsion, but significantly lower incidence rates of severe fever (>39°C) and disturbance of consciousness and a significantly lower proportion of children with an increased leukocyte count at diagnosis (>12×10(9)/L)...
July 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/27360007/muscle-fitness-executive-function-and-academic-performance-in-10-year-old-children-the-ask-study-864-board-180-june-1-3-30-pm-5-00-pm
#16
Jostein Steene-Johannessen, Sigmund A Anderssen, Katrine N Aadland, Geir K Resaland
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27359787/keynote-cardiopulmonary-limitations-and-sex-differences-in-exercising-children-and-adolescents-555-june-1-2-10-pm-2-45-pm
#17
Craig A Harms
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27351879/short-term-association-between-particular-matter-air-pollution-and-pediatric-clinical-visits-for-wheezing-in-a-subarea-of-shanghai
#18
Wenjie Shan, Yanming Lu, Yinshi Guo, Yaqin Li, Lingyun Xu, Lanfang Cao
To assess the association between the concentration of ambient particulate matter (PM) and the pediatric clinical visits for wheezing among children under 3 years old, data of daily air pollutants (PM2.5, PM10, NO2, SO2, CO), meteorological reports, along with the number of daily clinical visits of the children with wheezing at the Pediatric Department of Shanghai Renji Hospital (South Campus) were collected from January through December 2014. Correlation between the levels of air pollutants and the number of clinical patients for wheezing were analyzed by a time series analysis with a generalized addictive model (GAM)...
October 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27307598/prognostic-significance-of-major-histocompatibility-complex-class-ii-expression-in-pediatric-adrenocortical-tumors-a-st-jude-and-children-s-oncology-group-study
#19
Emilia Modolo Pinto, Carlos Rodriguez-Galindo, John Kim Choi, Stanley Pounds, Zhifa Liu, Geoffrey Neale, David Finkelstein, John M Hicks, Alberto S Pappo, Bonald C Figueiredo, Raul C Ribeiro, Gerard P Zambetti
PURPOSE: Histologic markers that differentiate benign and malignant pediatric adrenocortical tumors are lacking. Previous studies have implicated an association of MHC class II expression with adrenocortical tumor prognosis. Here, we determined the expression of MHC class II as well as the cell of origin of these immunologic markers in pediatric adrenocortical tumor. The impact of MHC class II gene expression on outcome was determined in a cohort of uniformly treated children with adrenocortical carcinomas...
December 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27262618/a-panel-study-of-airborne-particulate-matter-composition-versus-concentration-potential-for-inflammatory-response-and-impaired-pulmonary-function-in-children
#20
Masanari Watanabe, Hisashi Noma, Jun Kurai, Hiroyuki Sano, Degejirihu Hantan, Masaru Ueki, Hiroya Kitano, Eiji Shimizu
BACKGROUND: The relationship between airborne particulate matter (PM) and pulmonary function in children has not been consistent among studies, potentially owing to differences in the inflammatory response to PM, based on PM types and sources. The objective of this study was to investigate the effect of airborne PM on pulmonary function in schoolchildren and its potential for an inflammatory response. METHODS: Daily morning peak expiratory flow (PEF) was measured in 339 schoolchildren in February 2015...
June 1, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
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