Mengjie Zhao, Yanhui Li, Chenfei Lu, Fangshu Ding, Miao Xu, Xin Ge, Mengdie Li, Zhen Wang, Jianxing Yin, Junxia Zhang, Xiefeng Wang, Zehe Ge, Hong Xiao, Yong Xiao, Hongyi Liu, Wentao Liu, Yuandong Cao, Qianghu Wang, Yongping You, Xiuxing Wang, Kun Yang, Zhumei Shi, Xu Qian
Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type of brain tumor. However, resistance to radiotherapy remains a major concern. Identification of mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies for treating patients. Here, we report that mitochondrial metabolic pathways are suppressed in radioresistant gliomas through integrated analyses of transcriptomic data from glioma specimens and cell lines. Decreased expression of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α), the key regulator of mitochondrial biogenesis and metabolism, correlated with glioma recurrence and predicted poor prognosis and response to radiation therapy of glioma patients...
January 25, 2023: Cancer Research