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PGC-1 alpha AND mitochondria

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https://www.readbyqxmd.com/read/27896503/effect-of-pgc-1%C3%AE-overexpression-or-silencing-on-mitochondrial-apoptosis-of-goat-luteinized-granulosa-cells
#1
Guo-Min Zhang, Ming-Tian Deng, Yan-Li Zhang, Yi-Xuan Fan, Yong-Jie Wan, Hai-Tao Nie, Zi-Yu Wang, Feng Wang, Zhi-Hai Lei
During goat follicular development, abnormal expression of peroxisome proliferator- activated receptor gamma coactivator-1 alpha (PGC-1α) in granulosa cells (GCs) may contribute to follicular atresia with unknown regulatory mechanisms. In this study, we investigate the effect of ectopic expression or interference of PGC-1α on cell apoptosis of goat first passage granulosa cells (FGCs) in vitro. The results indicate that PGC-1α silencing by short hairpin RNA (shRNA) in goat FGCs significantly reduced mitochondrial DNA (mtDNA) copy number (P < 0...
November 28, 2016: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/27638713/gene-therapy-targeting-mitochondrial-pathway-in-parkinson-s-disease
#2
Chi-Jing Choong, Hideki Mochizuki
Parkinson's disease (PD) presents a relative selective localization of pathology to substantia nigra and well-defined motor symptoms caused by dopaminergic degeneration that makes it an ideal target for gene therapy. Parallel progress in viral vector systems enables the delivery of therapeutic genes directly into brain with reasonable safety along with sustained transgene expression. To date, gene therapy for PD that has reached clinical trial evaluation is mainly based on symptomatic approach that involves enzyme replacement strategy and restorative approach that depends on the addition of neurotrophic factors...
September 16, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/26573541/%C3%AE-hydroxy-%C3%AE-methylbutyrate-mitochondrial-biogenesis-and-skeletal-muscle-health
#3
Xi He, Yehui Duan, Kang Yao, Fengna Li, Yongqing Hou, Guoyao Wu, Yulong Yin
The metabolic roles of mitochondria go far beyond serving exclusively as the major producer of ATP in tissues and cells. Evidence has shown that mitochondria may function as a key regulator of skeletal muscle fiber types and overall well-being. Maintaining skeletal muscle mitochondrial content and function is important for sustaining health throughout the lifespan. Of great importance, β-hydroxy-β-methylbutyrate (HMB, a metabolite of L-leucine) has been proposed to enhance the protein deposition and efficiency of mitochondrial biogenesis in skeletal muscle, as well as muscle strength in both exercise and clinical settings...
March 2016: Amino Acids
https://www.readbyqxmd.com/read/26566717/mitophagy-is-required-for-mitochondrial-biogenesis-and-myogenic-differentiation-of-c2c12-myoblasts
#4
Jon Sin, Allen M Andres, David J R Taylor, Thomas Weston, Yoshimi Hiraumi, Aleksandr Stotland, Brandon J Kim, Chengqun Huang, Kelly S Doran, Roberta A Gottlieb
Myogenesis is a crucial process governing skeletal muscle development and homeostasis. Differentiation of primitive myoblasts into mature myotubes requires a metabolic switch to support the increased energetic demand of contractile muscle. Skeletal myoblasts specifically shift from a highly glycolytic state to relying predominantly on oxidative phosphorylation (OXPHOS) upon differentiation. We have found that this phenomenon requires dramatic remodeling of the mitochondrial network involving both mitochondrial clearance and biogenesis...
2016: Autophagy
https://www.readbyqxmd.com/read/26313355/cetp-expression-protects-female-mice-from-obesity-induced-decline-in-exercise-capacity
#5
David A Cappel, Louise Lantier, Brian T Palmisano, David H Wasserman, John M Stafford
Pharmacological approaches to reduce obesity have not resulted in dramatic reductions in the risk of coronary heart disease (CHD). Exercise, in contrast, reduces CHD risk even in the setting of obesity. Cholesteryl Ester Transfer Protein (CETP) is a lipid transfer protein that shuttles lipids between serum lipoproteins and tissues. There are sexual-dimorphisms in the effects of CETP in humans. Mice naturally lack CETP, but we previously reported that transgenic expression of CETP increases muscle glycolysis in fasting and protects against insulin resistance with high-fat diet (HFD) feeding in female but not male mice...
2015: PloS One
https://www.readbyqxmd.com/read/26210873/peroxisome-proliferator-activated-receptor-%C3%AE-agonists-protect-oligodendrocyte-progenitors-against-tumor-necrosis-factor-alpha-induced-damage-effects-on-mitochondrial-functions-and-differentiation
#6
C De Nuccio, A Bernardo, C Cruciani, R De Simone, S Visentin, L Minghetti
The activation of the nuclear receptor peroxisome proliferator-activated receptor-γ (PPAR-γ) is known to exert anti-inflammatory and neuroprotective effects and PPAR-γ agonists are considered potential therapeutic agents in brain diseases including those affecting myelin. In demyelinating diseases such as multiple sclerosis (MS), inflammation is one of the causes of myelin and axonal damage. Oligodendrocyte (OL) differentiation is highly dependent on mitochondria, which are major targets of inflammatory insult...
September 2015: Experimental Neurology
https://www.readbyqxmd.com/read/26169112/role-of-rho-kinase-inhibition-in-the-protective-effect-of-fasudil-and-simvastatin-against-3-nitropropionic-acid-induced-striatal-neurodegeneration-and-mitochondrial-dysfunction-in-rats
#7
Lamiaa A Ahmed, Hebatallah A Darwish, Rania M Abdelsalam, HebatAllah A Amin
3-Nitropropionic acid (3-NP)-induced neurotoxicity is an experimental model which mimics the pathology and motor abnormalities seen in Huntington's disease (HD) in human. The present investigation was directed to estimate the role of rho kinase (ROCK) inhibition in the possible protective effect of fasudil and simvastatin in 3-NP-induced striatal neurodegeneration in rats. Animals were injected s.c. with 3-NP (20 mg/kg/day) for 1 week with or without administration of fasudil (10 mg/kg/day, p.o.) or simvastatin (20 mg/kg/day, p...
August 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26055129/kinsenoside-mediated-lipolysis-through-an-ampk-dependent-pathway-in-c3h10t1-2-adipocytes-roles-of-ampk-and-ppar%C3%AE-in-the-lipolytic-effect-of-kinsenoside
#8
Kur-Ta Cheng, Yu-Shiou Wang, Hsiu-Chu Chou, Chih-Cheng Chang, Ching-Kuo Lee, Shu-Hui Juan
BACKGROUND: Currently, more than one-third of the global population is overweight or obese, which is a risk factor for major causes of death including cardiovascular disease, numerous cancers, and diabetes. Kinsenoside, a major active component of Anoectochilus formosanus exhibits antihyperglycemic, antihyperliposis, and hepatoprotective effects and can be used to prevent and manage obesity. PURPOSE: This study examined the catabolic effects of kinsenoside on lipolysis in adipocytes transformed from C3H10T1/2 cells...
June 1, 2015: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26041108/regular-postexercise-cooling-enhances-mitochondrial-biogenesis-through-ampk-and-p38-mapk-in-human-skeletal-muscle
#9
Mohammed Ihsan, James F Markworth, Greig Watson, Hui Cheng Choo, Andrew Govus, Toan Pham, Anthony Hickey, David Cameron-Smith, Chris R Abbiss
This study investigated the effect of regular postexercise cold water immersion (CWI) on muscle aerobic adaptations to endurance training. Eight males performed 3 sessions/wk of endurance training for 4 wk. Following each session, subjects immersed one leg in a cold water bath (10°C; COLD) for 15 min, while the contralateral leg served as a control (CON). Muscle biopsies were obtained from vastus lateralis of both CON and COLD legs prior to training and 48 h following the last training session. Samples were analyzed for signaling kinases: p38 MAPK and AMPK, peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), enzyme activities indicative of mitochondrial biogenesis, and protein subunits representative of respiratory chain complexes I-V...
August 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/25982508/apolipoprotein-a1-increases-mitochondrial-biogenesis-through-amp-activated-protein-kinase
#10
Parkyong Song, Yonghoon Kwon, Kyungmoo Yea, Hyo-Youl Moon, Jong Hyuk Yoon, Jaewang Ghim, Hyunjung Hyun, Dayea Kim, Ara Koh, Per-Olof Berggren, Pann-Ghill Suh, Sung Ho Ryu
Apolipoprotein a1, which is a major lipoprotein component of high-density lipoprotein (HDL), was reported to decrease plasma glucose in type 2 diabetes. Although recent studies also have shown that apolipoprotein a1 is involved in triglyceride (TG) metabolism, the mechanisms by which apolipoprotein a1 modulates TG levels remain largely unexplored. Here we demonstrated that apolipoprotein a1 increased mitochondrial DNA and mitochondria contents through sustained AMPK activation in myotubes. This resulted in enhanced fatty acid oxidation and attenuation of free fatty acid-induced insulin resistance features in skeletal muscle...
September 2015: Cellular Signalling
https://www.readbyqxmd.com/read/25843018/pyrroloquinoline-quinone-pqq-producing-escherichia-coli-nissle-1917-ecn-alleviates-age-associated-oxidative-stress-and-hyperlipidemia-and-improves-mitochondrial-function-in-ageing-rats
#11
Ashish Kumar Singh, Sumeet Kumar Pandey, Gourav Saha, Naresh Kumar Gattupalli
BACKGROUND: Ageing involves oxidative stress mediated by Reactive Oxygen Species (ROS) and mitochondrial dysfunction. The present work demonstrates the protective effect of PQQ producing EcN against rotenone induced mitochondrial oxidative stress and consequence of mitochondrial and cellular dysfunction in naturally ageing rat model. PQQ is a potent antioxidant molecule also known to stimulate mitochondrial biogenesis and function in mammals. METHODS: Firstly, adult rats (16-18 weeks old) were treated with rotenone (2...
June 2015: Experimental Gerontology
https://www.readbyqxmd.com/read/25834726/pgc-1%C3%AE-modulates-denervation-induced-mitophagy-in-skeletal-muscle
#12
Anna Vainshtein, Eric Ma Desjardins, Andrea Armani, Marco Sandri, David A Hood
BACKGROUND: Alterations in skeletal muscle contractile activity necessitate an efficient remodeling mechanism. In particular, mitochondrial turnover is essential for tissue homeostasis during muscle adaptations to chronic use and disuse. While mitochondrial biogenesis appears to be largely governed by the transcriptional co-activator peroxisome proliferator co-activator 1 alpha (PGC-1α), selective mitochondrial autophagy (mitophagy) is thought to mediate organelle degradation. However, whether PGC-1α plays a direct role in autophagy is currently unclear...
2015: Skeletal Muscle
https://www.readbyqxmd.com/read/25779891/expression-of-mitochondria-associated-genes-ppargc1a-nrf-1-bcl-2-and-bax-in-follicular-development-and-atresia-of-goat-ovaries
#13
G Zhang, Y Wan, Y Zhang, S Lan, R Jia, Z Wang, Y Fan, F Wang
Most follicles undergo atresia during the developmental process. Follicular atresia is predominantly regulated by apoptosis of granulosa cells, but the mechanism underlying apoptosis via the mitochondria-dependent apoptotic pathway is unclear. We aimed to investigate whether the mitochondria-associated genes peroxisome proliferator-activated receptor-gamma, coactivator1-alpha (PPARGC1A), nuclear respiratory factor-1 (NRF-1), B-cell CLL/lymphoma 2 (BCL-2) and BCL2-associated X protein (BAX) played a role in follicular atresia through this pathway...
June 2015: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/25625009/protein-phosphatase-2c-alpha-knockdown-reduces-angiotensin-ii-mediated-skeletal-muscle-wasting-via-restoration-of-mitochondrial-recycling-and-function
#14
Alexander Michael Tabony, Tadashi Yoshida, Sergiy Sukhanov, Patrice Delafontaine
BACKGROUND: Circulating angiotensin II (AngII) is elevated in congestive heart failure (CHF), and leads to skeletal muscle wasting, which is strongly associated with poor patient outcomes. We previously found that AngII upregulates protein phosphatase 2C-alpha (PP2Cα) and dephosphorylates AMP-activated protein kinase (AMPK), a critical regulator of cellular metabolism, in skeletal muscle. METHODS: To determine the role of PP2Cα in AngII-induced wasting, gastrocnemius (Gas) muscles of FVB mice were injected with scrambled or PP2Cα siRNA and mice were infused with saline or AngII for 4 days...
2014: Skeletal Muscle
https://www.readbyqxmd.com/read/25542506/%C3%AE-lipoic-acid-treatment-increases-mitochondrial-biogenesis-and-promotes-beige-adipose-features-in-subcutaneous-adipocytes-from-overweight-obese-subjects
#15
Marta Fernández-Galilea, Patricia Pérez-Matute, Pedro L Prieto-Hontoria, Marianne Houssier, María A Burrell, Dominique Langin, J Alfredo Martínez, María J Moreno-Aliaga
α-Lipoic acid (α-Lip) is a natural occurring antioxidant with beneficial anti-obesity properties. The aim of this study was to investigate the putative effects of α-Lip on mitochondrial biogenesis and the acquirement of brown-like characteristics by subcutaneous adipocytes from overweight/obese subjects. Thus, fully differentiated human subcutaneous adipocytes were treated with α-Lip (100 and 250μM) for 24h for studies on mitochondrial content and morphology, mitochondrial DNA (mtDNA) copy number, fatty acid oxidation enzymes and brown/beige characteristic genes...
March 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25541436/17%C3%AE-estradiol-prevents-cardiac-diastolic-dysfunction-by-stimulating-mitochondrial-function-a-preclinical-study-in-a-mouse-model-of-a-human-hypertrophic-cardiomyopathy-mutation
#16
Youzhou Chen, Zhuoli Zhang, Fenghuan Hu, Weixian Yang, Jiansong Yuan, Jingang Cui, Shujing Hao, Jie Hu, Ying Zhou, Shubin Qiao
OBJECTIVE: We investigated the effect of ovariectomy (OVX) and 17β-estradiol (E2) replacement on both mitochondrial and myocardial function in cTnT-Q92 transgenic mice generated by cardiac-restricted expression of a human hypertrophic cardiomyopathy (HCM) mutation. METHODS: The cTnT-Q92 mice were ovariectomized at twenty weeks of age and were treated with either placebo (OVX group) or E2 (OVX+E2 group) for twelve weeks before being sacrificed. Wild-type and cTnT-Q92 female mice receiving sham operation were used as controls...
March 2015: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/25535334/enhanced-cardiac-akt-protein-kinase-b-signaling-contributes-to-pathological-cardiac-hypertrophy-in-part-by-impairing-mitochondrial-function-via-transcriptional-repression-of-mitochondrion-targeted-nuclear-genes
#17
Adam R Wende, Brian T O'Neill, Heiko Bugger, Christian Riehle, Joseph Tuinei, Jonathan Buchanan, Kensuke Tsushima, Li Wang, Pilar Caro, Aili Guo, Crystal Sloan, Bum Jun Kim, Xiaohui Wang, Renata O Pereira, Mark A McCrory, Brenna G Nye, Gloria A Benavides, Victor M Darley-Usmar, Tetsuo Shioi, Bart C Weimer, E Dale Abel
Sustained Akt activation induces cardiac hypertrophy (LVH), which may lead to heart failure. This study tested the hypothesis that Akt activation contributes to mitochondrial dysfunction in pathological LVH. Akt activation induced LVH and progressive repression of mitochondrial fatty acid oxidation (FAO) pathways. Preventing LVH by inhibiting mTOR failed to prevent the decline in mitochondrial function, but glucose utilization was maintained. Akt activation represses expression of mitochondrial regulatory, FAO, and oxidative phosphorylation genes in vivo that correlate with the duration of Akt activation in part by reducing FOXO-mediated transcriptional activation of mitochondrion-targeted nuclear genes in concert with reduced signaling via peroxisome proliferator-activated receptor α (PPARα)/PGC-1α and other transcriptional regulators...
March 2015: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/25492529/astroglial-pgc-1alpha-increases-mitochondrial-antioxidant-capacity-and-suppresses-inflammation-implications-for-multiple-sclerosis
#18
Philip G Nijland, Maarten E Witte, Bert van het Hof, Susanne van der Pol, Jan Bauer, Hans Lassmann, Paul van der Valk, Helga E de Vries, Jack van Horssen
Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredoxin-2, which are involved in limiting ROS-induced damage. In this study, we explored the distribution and role of the mitochondrial antioxidants peroxiredoxin-3 and thioredoxin-2 as well as their regulator peroxisome proliferator-activated receptor gamma coactivator1-alpha (PGC-1α) in MS pathogenesis...
December 10, 2014: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/25489948/sirt3-a-mitochondrial-nad%C3%A2-%C2%BA-dependent-deacetylase-is-involved-in-the-regulation-of-myoblast-differentiation
#19
Waed Abdel Khalek, Fabienne Cortade, Vincent Ollendorff, Laure Lapasset, Lionel Tintignac, Béatrice Chabi, Chantal Wrutniak-Cabello
Sirtuin 3 (SIRT3), one of the seven mammalian sirtuins, is a mitochondrial NAD+-dependent deacetylase known to control key metabolic pathways. SIRT3 deacetylases and activates a large number of mitochondrial enzymes involved in the respiratory chain, in ATP production, and in both the citric acid and urea cycles. We have previously shown that the regulation of myoblast differentiation is tightly linked to mitochondrial activity. Since SIRT3 modulates mitochondrial activity, we decide to address its role during myoblast differentiation...
2014: PloS One
https://www.readbyqxmd.com/read/25450972/mitochondria-in-peroxisome-deficient-hepatocytes-exhibit-impaired-respiration-depleted-dna-and-pgc-1%C3%AE-independent-proliferation
#20
Annelies Peeters, Abhijit Babaji Shinde, Ruud Dirkx, Joél Smet, Katrien De Bock, Marc Espeel, Ilse Vanhorebeek, Arnaud Vanlander, Rudy Van Coster, Peter Carmeliet, Marc Fransen, Paul P Van Veldhoven, Myriam Baes
The tight interrelationship between peroxisomes and mitochondria is illustrated by their cooperation in lipid metabolism, antiviral innate immunity and shared use of proteins executing organellar fission. In addition, we previously reported that disruption of peroxisome biogenesis in hepatocytes severely impacts on mitochondrial integrity, primarily damaging the inner membrane. Here we investigated the molecular impairments of the dysfunctional mitochondria in hepatocyte selective Pex5 knockout mice. First, by using blue native electrophoresis and in-gel activity stainings we showed that the respiratory complexes were differentially affected with reduction of complexes I and III and incomplete assembly of complex V, whereas complexes II and IV were normally active...
February 2015: Biochimica et Biophysica Acta
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