Xiaoyu Sun, Yifan Ping, Xumin Li, Yixin Mao, Yang Chen, Lixi Shi, Xinhua Hong, Liang Chen, Shuhong Chen, Zelin Cao, Pan Chen, Zhongchen Song, Daniel Wismeijer, Gang Wu, Yinhui Ji, Shengbin Huang
AIM: To investigate whether silibinin impacts diabetic periodontitis (DP) via mitochondrial regulation. MATERIALS AND METHODS: In vivo, rats were divided into the control, diabetes, DP, and DP combined with silibinin groups. Diabetes and periodontitis were induced by streptozocin and silk ligation, respectively. Bone turnover was evaluated by microcomputed tomography, histology, and immunohistochemistry. In vitro, human periodontal ligament cells (hPDLCs) were exposed to hydroxy peroxide (H2 O2 ) with or without silibinin...
March 20, 2023: Journal of Clinical Periodontology