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https://www.readbyqxmd.com/read/29315765/treatment-of-male-stress-urinary-incontinence-with-the-adjustable-transobturator-male-system-outcomes-of-a-multi-center-iberian-study
#1
Javier C Angulo, Francisco Cruz, Cristina Esquinas, Ignacio Arance, Margarida Manso, Andrés Rodríguez, Javier Pereira, Antonio Ojea, Manuel Carballo, Miguel Rabassa, Antoine Teyrouz, Gregorio Escribano, Elena Rodríguez, Fernando Teba, Guillermo Celada, Blanca Madurga, Jose L Álvarez-Ossorio, Jõao P Marcelino, Francisco E Martins
AIM: To evaluate effectiveness and safety of the adjustable transobturator male system (ATOMS) for male stress urinary incontinence (SUI). MATERIAL AND METHODS: A retrospective multicenter study was conducted in nine Iberian institutions using a board-approved database for 215 patients intervened between 2012 and 2017, with no case excluded. Continence status, patient satisfaction, number, and grade of complications (Clavien-Dindo) and factors affecting dry rate at adjustment were evaluated...
January 9, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29313165/effectiveness-of-sacral-nerve-stimulation-in-fecal-incontinence-after-multimodal-oncologic-treatment-for-pelvic-malignancies-a-multicenter-study-with-2-year-follow-up
#2
M Schiano di Visconte, G A Santoro, N Cracco, G Sarzo, G Bellio, M Brunner, Z Cui, K E Matzel
BACKGROUND: To assess whether sacral nerve stimulation (SNS) is an effective treatment for severe fecal incontinence (FI) after radiotherapy (RT)/chemoRT (CRT) in combination with pelvic surgery. METHODS: A multicenter study was conducted on patients with FI that developed after multimodal therapy for pelvic tumors and was refractory to non-operative management, who were treated with SNS between November 2009 and November 2012. Data were prospectively collected and retrospectively analyzed...
January 8, 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29298660/adjuvant-stereotactic-fractionated-radiotherapy-to-the-resection-cavity-in-recurrent-glioblastoma-the-gliocave-study-noa-17-aro-2016-3-dktk-rog-trial
#3
Christoph Straube, Hagen Scherb, Jens Gempt, Jan Kirschke, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E Combs
BACKGROUND: Glioblastoma relapses in the vast majority of cases within 1 year. Maximum safe resection of the recurrent glioblastoma can be offered in some cases. Re-irradiation has been established for the treatment of recurrent glioblastoma, too. In both cases, adjuvant treatment, mostly using temozolomide, can improve PFS and OS after these interventions. However, combining gross tumor resection and adjuvant re-radiotherapy to the resection cavity has not been tested so far. METHODS/DESIGN: In the multicenter two-armed randomized Phase II GlioCave Study, fractionated stereotactic radiotherapy to the resection cavity, after gross tumor resection of recurrent glioblastoma, will be compared to observation...
January 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29288842/an-integrative-survival-analysis-with-identification-of-prognostic-factors-in-the-patients-with-coexisting-glioma-and-intracranial-aneurysm
#4
Xiaodong Niu, Tianwei Wang, Jin Li, Liping Niu, Yuan Yang, Xiang Wang, Yanhui Liu, Qing Mao
OBJECTIVE: This study aimed to perform an integrative clinical and survival analysis for the patients with coexisting glioma and intracranial aneurysm and to assess the influence of prognostic factors on overall survival (OS). METHODS: A systematic literature search on PubMed and Web of Science was performed for literature in English published from 1951 to Aug 2017. Detailed information including clinical characteristics, treatments, critical events, and time to events for survival analysis was extracted from the included articles...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29280453/multicenter-randomized-double-blind-placebo-controlled-trial-gortec-groupe-oncologie-radiotherapie-tete-et-cou-2009-01-evaluating-the-effect-of-the-regenerating-agent-on-radiodermatitis-of-head-and-neck-cancer-patients
#5
Yungan Tao, Anne Auperin, Christian Sire, Michel Martin, Marie-Gabrielle Saliou, Etienne Bardet, Xu Shan Sun, Thierry Chatellier, Clotilde Morand, Alexandre Cornely, Moussa Angokai, Alessia Di Rito, Ketty Kichenin, Pierre Blanchard, Ida D'Onofrio, Jean Bourhis
PURPOSE: Concomitant cetuximab and radiation therapy (RT) can induce severe radiodermatitis in patients with head and neck cancer (HNC). OTD70DERM, a regenerating agent (RGTA), is a structural and functional analogue of glycosaminoglycans. Preclinical studies have shown that topical RGTA can markedly reduce radiation-induced mucosal and cutaneous toxicities without tumor protection. The present study aimed to evaluate the effect of topical RGTA on radiodermatitis in patients with HNC undergoing RT and cetuximab, for whom RT-induced skin reactions are frequent and/or severe...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29245275/s-1-versus-s-1-plus-cisplatin-concurrent-intensity-modulated-radiation-therapy-in-the-treatment-of-esophageal-squamous-cell-carcinoma-study-protocol-for-a-randomized-controlled-phase-ii-trial
#6
Yixue Wen, Zhenhuan Zhao, Jidong Miao, Qilin Yang, Yan Gui, Mingqiang Sun, Honggang Tian, Qiang Jia, Dongbiao Liao, Chen Yang, Xiaobo Du
INTRODUCTION: Chemotherapy regimens are often a 2-drug regimen in concurrent chemotherapy and radiotherapy for esophageal cancer (EC). However, some retrospective studies have suggested that for patients with EC receiving radiotherapy combined with 2-drug chemotherapy have the severe toxicity. And S-1 alone with the combination of radiotherapy treatment effect is good, and achieved good clinical remission rate. The purpose of this trial is compare the efficacy and toxicity of combining S-1 or S-1 plus cisplatin with radiotherapy for esophageal squamous cell carcinoma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29240541/surveillance-or-metastasis-directed-therapy-for-oligometastatic-prostate-cancer-recurrence-a-prospective-randomized-multicenter-phase-ii-trial
#7
Piet Ost, Dries Reynders, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Aurélie De Bruycker, Bieke Lambert, Louke Delrue, Renée Bultijnck, Tom Claeys, Els Goetghebeur, Geert Villeirs, Kathia De Man, Filip Ameye, Ignace Billiet, Steven Joniau, Friedl Vanhaverbeke, Gert De Meerleer
Purpose Retrospective studies suggest that metastasis-directed therapy (MDT) for oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to assess the benefit of MDT in a randomized phase II trial. Patients and Methods In this multicenter, randomized, phase II study, patients with asymptomatic PCa were eligible if they had had a biochemical recurrence after primary PCa treatment with curative intent, three or fewer extracranial metastatic lesions on choline positron emission tomography-computed tomography, and serum testosterone levels > 50 ng/mL...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29207866/interobserver-variation-in-target-volume-for-salvage-radiotherapy-in-recurrent-prostate-cancer-patients-after-radical-prostatectomy-using-ct-versus-combined-ct-and-mri-a-multicenter-study-krog-13-11
#8
Eonju Lee, Won Park, Sung Hwan Ahn, Jae Ho Cho, Jin Hee Kim, Kwan Ho Cho, Young Min Choi, Jae-Sung Kim, Jin Ho Kim, Hong-Seok Jang, Young-Seok Kim, Taek-Keun Nam
Purpose: To investigate interobserver variation in target volume delineations for prostate cancer salvage radiotherapy using planning computed tomography (CT) versus combined planning CT and magnetic resonance imaging (MRI). Materials and Methods: Ten radiation oncologists independently delineated a target volume on the planning CT scans of five cases with different pathological status after radical prostatectomy. Two weeks later, this was repeated with the addition of planning MRI...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29207632/addition-of-5-fluorouracil-to-first-line-induction-chemotherapy-with-docetaxel-and-cisplatin-before-concurrent-chemoradiotherapy-does-not-improve-survival-in-locoregionally-advanced-nasopharyngeal-carcinoma
#9
Wang Fangzheng, Jiang Chuner, Wang Lei, Yan Fengqin, Ye Zhimin, Sun Quanquan, Liu Tongxin, Xu Min, Wu Peng, Long Bin, Rihito Aizawa, Masoto Sakamoto, Fu Zhenfu
Although a multicenter, randomized study indicated that induction chemotherapy (IC) with docetaxel/cisplatin/fluorouracil (TPF) before concurrent chemoradiotherapy (CCRT) improves survival outcomes, it remains unclear whether TPF is the best IC regimen for treating locoregionally advanced nasopharyngeal carcinoma (NPC). Our aim was to compare the efficacy and toxicities of TPF vs. docetaxel/cisplatin (TP) IC followed by CCRT in patients with locoregionally advanced NPC. One hundred thirty-two patients with locoregionally advanced NPC received 21-day cycles of IC with either TPF or TP...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29202720/high-precision-radiotherapy-of-motor-deficits-due-to-metastatic-spinal-cord-compression-pre-mode-a-multicenter-phase-2-study
#10
Dirk Rades, Jon Cacicedo, Antonio J Conde-Moreno, Claudia Doemer, Jürgen Dunst, Darejan Lomidze, Barbara Segedin, Denise Olbrich, Niels Henrik Holländer
BACKGROUND: For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are often significantly impaired, an overall treatment time of 1 week would be preferable if resulting in similar outcomes as longer programs. This may be achieved with 5 × 5 Gy in 1 week, since the biologically effective dose is similar to 10 × 3 Gy...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29192364/liver-metastases-from-prostate-cancer-at-11c-choline-pet-ct-a-multicenter-retrospective-analysis
#11
Pietro Ghedini, I Bossert, L Zanoni, F Ceci, T Graziani, P Castellucci, V Ambrosini, F Massari, E Nobili, B Melotti, A Musto, S Zoboli, L Antunovic, M Kirienko, A Chiti, C Mosconi, A Ardizzoni, R Golfieri, S Fanti, C Nanni
AIM: During our daily clinical practice using 11C-Choline PET/CT for restaging patients affected by relapsing prostate cancer (rPCa) we noticed an unusual but significant occurrence of hypodense hepatic lesions with a different tracer uptake. Thus, we decided to evaluate the possible correlation between rPCa and these lesions as possible hepatic metastases. MATERIALS AND METHODS: We retrospectively enrolled 542 patients diagnosed with rPCa in biochemical relapse after a radical treatment (surgery and/or radiotherapy)...
November 30, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29190707/hypofractionated-stereotactic-boost-in-intermediate-risk-prostate-carcinoma-preliminary-results-of-a-multicenter-phase-ii-trial-ckno-pro
#12
David Pasquier, Philippe Nickers, Didier Peiffert, Philippe Maingon, Pascal Pommier, Thomas Lacornerie, Geoffrey Martinage, Emmanuelle Tresch, Eric Lartigau
PURPOSE: Dose escalation may improve curability in intermediate-risk prostate carcinoma. A multicenter national program was developed to assess toxicity and tumor response with hypofractionated stereotactic boost after conventional radiotherapy in intermediate-risk prostate cancer. METHODS AND MATERIAL: Between August 2010 and April 2013, 76 patients with intermediated-risk prostate carcinoma were included in the study. A first course delivered 46 Gy by IMRT (68...
2017: PloS One
https://www.readbyqxmd.com/read/29189507/acute-myeloid-leukemia-with-central-nervous-system-involvement-in-children-experience-from-the-french-protocol-analysis-elam02
#13
Arthur Felix, Thierry Leblanc, Arnaud Petit, Brigitte Nelkem, Yves Bertrand, Virginie Gandemer, Anne Sirvent, Catherine Paillard, Claudine Schmitt, Pierre Simon Rohrlich, Odile Fenneteau, Christine Ragu, Gerard Michel, Anne Auvrignon, André Baruchel, Guy Leverger
Central nervous system (CNS) involvement at diagnosis of pediatric acute myeloid leukemia (AML) is not considered as an independent prognostic factor. This study describes the prognostic value of pediatric AML with CNS involvement at diagnosis. Pediatric patients were treated for de novo AML in the French multicenter trial ELAM02. Lumbar puncture was carried out in the first week, and the treatment was adapted to the CNS status. No patient received CNS radiotherapy. The patients were classified into 2 groups: CNS+ and CNS-...
November 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29189448/tumor-boost-using-external-beam-radiation-in-cervical-cancer-patients-unable-to-receive-intracavitary-brachytherapy-outcome-from-a-multicenter-retrospective-study-korean-radiation-oncology-group-1419
#14
Haeyoung Kim, Young Seok Kim, Ji Hyeon Joo, Keun-Yong Eom, Won Park, Jin Hee Kim, Jong Hoon Lee, Yeon Sil Kim, Seok Ho Lee, Kijung Ahn, Yong Bae Kim, Me-Yeon Lee, Sei Kyung Chang
PURPOSE: We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. METHODS: A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. RESULTS: A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B...
November 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29173331/dental-disease-before-radiotherapy-in-patients-with-head-and-neck-cancer-clinical-registry-of-dental-outcomes-in-head-and-neck-cancer-patients
#15
Michael T Brennan, Nathaniel S Treister, Thomas P Sollecito, Brian L Schmidt, Lauren L Patton, Kusha Mohammadi, Leslie Long Simpson, Helen Voelker, James S Hodges, Rajesh V Lalla
BACKGROUND: No evidence-based guidelines exist for preventive dental care before radiation therapy (RT) in patients with head and neck cancer (HNC). An ongoing multicenter, prospective cohort study, Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad), is addressing this knowledge gap. The authors evaluated the level of dental disease before RT in the OraRad cohort, factors associated with dental disease, and dental treatment recommendations made before RT. METHODS: As part of OraRad, the authors assessed caries, periodontal disease, dental recommendations, and dental interventions performed before RT...
December 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29154240/polish-consensus-on-treatment-of-gastric-cancer-update-2017
#16
Jan Kulig, Grzegorz Wallner, Michał Drews, Mariusz Frączek, Arkadiusz Jeziorski, Wojciech Kielan, Piotr Kołodziejczyk, Anna Nasierowska-Guttmejer, Teresa Starzyńska, Krzysztof Zinkiewicz, Marek Wojtukiewicz, W Tomasz Skoczylas, Piotr Richter, Marek Krawczyk
The "Polish Research on Gastric Cancer" project has been continued since 1986. The main aim of this project, which is a multicenter and interdisciplinary research, is enhancing the treatment results of gastric cancer patients by developing and promoting the use of optimal methods for diagnosis and treatment, both surgical as well as combined. One of the more important achievements of the project is the development and publication of a document named "Polish Consensus on Treatment of Patients with Gastric Cancer", whose first version was published in 1998...
October 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29130235/-a-meta-analysis-on-risk-factors-of-postoperative-perineal-wound-complications-after-abdominoperineal-resection-for-rectal-cancer
#17
Senqi Lu, Xiaofeng Chang, Xiaodong Yang, Decai Yu, Qigen Huang, Feng Wang
OBJECTIVE: To investigate the risk factors of postoperative perineal wound complications after abdominoperineal resection for rectal cancer. METHODS: The databases of Medline, Embase, Web of Science, Ovid, Cochrane Library, CBM, CNKI, VIP and WANFANG were searched for the studies of abdominoperineal resection up to October 2016. The quality of the included studies was assessed by using "Cochrane collaboration's tool for assessing risk of bias" and "the Newcastle-Ottawa Scale"...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29127531/impact-of-a-robotic-surgical-system-on-treatment-choice-for-men-with-clinically-organ-confined-prostate-cancer
#18
Takashi Kobayashi, Kent Kanao, Motoo Araki, Naoki Terada, Yasuyuki Kobayashi, Atsuro Sawada, Takahiro Inoue, Shin Ebara, Toyohiko Watanabe, Tomomi Kamba, Makoto Sumitomo, Yasutomo Nasu, Osamu Ogawa
BACKGROUND: Introducing a new surgical technology may affect behaviors and attitudes of patients and surgeons about clinical practice. Robot-assisted laparoscopic radical prostatectomy (RALP) was approved in 2012 in Japan. We investigated whether the introduction of this system affected the treatment of organ-confined prostate cancer (PCa) and the use of radical prostatectomy (RP). METHODS: We conducted a retrospective multicenter study on 718 patients with clinically determined organ-confined PCa treated at one of three Japanese academic institutions in 2011 (n = 338) or 2013 (n = 380)...
November 11, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29126389/safety-and-efficacy-of-abiraterone-acetate-in-chemotherapy-naive-patients-with-metastatic-castration-resistant-prostate-cancer-an-italian-multicenter-real-life-study
#19
Luca Cindolo, Clara Natoli, Cosimo De Nunzio, Michele De Tursi, Maurizio Valeriani, Silvana Giacinti, Salvatore Micali, Mino Rizzo, Giampaolo Bianchi, Eugenio Martorana, Marcello Scarcia, Giuseppe Mario Ludovico, Pierluigi Bove, Anastasia Laudisi, Oscar Selvaggio, Giuseppe Carrieri, Maida Bada, Pietro Castellan, Stefano Boccasile, Pasquale Ditonno, Paolo Chiodini, Paolo Verze, Vincenzo Mirone, Luigi Schips
BACKGROUND: To evaluate the safety and efficacy of abiraterone acetate (AA) in the "real life" clinical practice for men with chemotherapy-naïve metastatic castration-resistant prostate. METHODS: A consecutive series of patients with mCRPC in 9 Italian tertiary centres treated with AA was collected. Demographics, clinical parameters, treatment outcomes and toxicity were recorded. The Brief Pain Inventory scale Q3 was tracked and patient treatment satisfaction was evaluated...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29122304/-the-efficacy-of-multimodal-treatment-for-symptomatic-vertebral-hemangiomas-a-report-of-27%C3%A2-cases-and-a-review-of-the-literature
#20
V Delabar, M Bruneau, P A Beuriat, F Zairi, S Fuentes, R Riva, B Gori, C Barrey
INTRODUCTION: Vertebral hemangiomas (VH) represent the most common primary bone tumor of the spine and are rarely symptomatic. Currently, there is no consensus for treatment and many therapeutic options are available, alone or in combination including cementoplasty, sclerotherapy, surgery, embolization and/or radiotherapy. OBJECTIVE: To evaluate the clinical and radiological outcome of a multimodal management for symptomatic VH. METHODS: A consecutive prospective and retrospective multicenter study was conducted to review cases of symptomatic VHs between 2005 and 2015...
November 6, 2017: Neuro-Chirurgie
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