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Multicenter radiotherapy

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https://www.readbyqxmd.com/read/27865372/phase-ii-study-of-panitumumab-and-paclitaxel-as-first-line-treatment-in-recurrent-or-metastatic-head-and-neck-cancer-ttcc-2009-03-vectitax-study
#1
Elvira Del Barco Morillo, Ricard Mesía, Juan Carlos Adansa Klain, Silvia Vázquez Fernández, Joaquina Martínez-Galán, Miguel Pastor Borgoñon, Cyntia González-Rivas, Javier Caballero Daroqui, Alfonso Berrocal, Javier Martínez-Trufero, Ruth Vera, Juan Jesús Cruz-Hernández
OBJECTIVE: To evaluate the activity and safety profile of panitumumab in combination with paclitaxel in patients with recurrent or metastatic SCCHN. MATERIALS AND METHODS: The VECTITAX phase II, open-label, multicenter study included patients with confirmed metastatic and/or recurrent SCCHN deemed to be untreatable by surgery or radiotherapy and ECOG PS=0-1. All patients received paclitaxel (80mg/m(2)/week) and panitumumab (6mg/kg/2weeks) until disease progression or unacceptable toxicity...
November 2016: Oral Oncology
https://www.readbyqxmd.com/read/27862836/3-year-data-of-the-advancexp-male-sling-results-of-a-prospective-multicenter-study
#2
Ricarda M Bauer, Markus T Grabbert, Benedikt Klehr, Peter Gebhartl, Christian Gozzi, Roland Homberg, Florian May, Peter Rehder, Christian G Stief, Alexander Kretschmer
OBJECTIVES: In recent years, several studies showed the effectiveness and safety of the AdVance sling for the treatment of male stress urinary incontinence (SUI). In 2010 the second generation of Advance, the AdVance XP was introduced with several changes of the sling design and with a new needle shape. Aim of the study was to evaluate the efficacy and safety of the AdVance XP sling in male SUI after radical prostatectomy in a prospective multicenter study. METHODS: In total 115 patients were included...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27856201/daily-practice-management-of-pt1a-b-pn0-breast-carcinoma-a-prospective-french-odissee-cohort-study
#3
Florence Dalenc, Frédérique Penault-Llorca, Monique Cohen, Gilles Houvenaeghel, Jean-Marc Piat, Philippe Liegeois, Laurent Puyuelo, Jean-Philippe Suchaud, Mohammed Zouai, Magali Lacroix-Triki, Nina Radosevic-Robin, Chahinez Benkanoun, Hanane Attar-Rabia, Marie-Pierre Chauvet, Joseph Gligorov, Yazid Belkacemi
BACKGROUND: Most breast cancer (BC) tumors ≤10 mm have an excellent prognosis. The subgroups with a higher risk for distant recurrence requiring adjuvant systemic therapy are not precisely defined in current international guidelines. PATIENTS AND METHODS: The OBSERVATOIRE DES PETITS CANCERS DU SEIN HER2 +/- (ODISSEE) study was a prospective, multicenter, cohort study that aimed to describe the daily adjuvant management and outcome of 616 patients with unifocal, invasive pT1a-b pN0 nonmetastatic BC who underwent surgery...
August 31, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27845907/matched-analysis-of-induction-chemotherapy-plus-chemoradiotherapy-versus-induction-chemotherapy-plus-radiotherapy-alone-in-locoregionally-advanced-nasopharyngeal-carcinoma-a-multicenter-study
#4
Bin Zhang, Ying Hu, Rui-Hua Xiong, Yu-Fei Pan, Qian-Lan Xu, Xiang-Yun Kong, Rui Cai, Qiu-Qiu Chen, Hua-Ying Tang, Wei Jiang
BACKGROUND: The relative efficacy of induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) versus IC followed by radiotherapy (RT) alone in locoregionally advanced NPC remains unclear. METHODS: A total of 877 patients with locally advanced NPC who underwent IC/CCRT or IC/RT at four institutions in China between January 2004 and December 2010 were retrospectively assessed. IC was cisplatin-based combination chemotherapy; concurrent chemotherapy, single agent cisplatin...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834629/malignant-peripheral-nerve-sheath-tumors-of-the-spine-results-of-surgical-management-from-a-multicenter-study
#5
Dean Chou, Mark H Bilsky, Alessandro Luzzati, Charles G Fisher, Ziya L Gokaslan, Laurence D Rhines, Mark B Dekutoski, Michael G Fehlings, Ravi Ghag, Peter Varga, Stefano Boriani, Niccole M Germscheid, Jeremy J Reynolds
OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft-tissue sarcomas. Resection is the mainstay of treatment and the most important prognostic factor. However, complete resection of spinal MPNSTs with tumor-free margins is challenging due to the likelihood of residual tumor cells. The objective of this study was to describe whether the type of Enneking resection in the management of spinal MPNSTs had an effect on local recurrence and survival. METHODS The AOSpine Knowledge Forum Tumor developed a multicenter database that includes demographic, diagnostic, therapeutic, local recurrence, and survival data on patients with primary spinal column tumors...
November 11, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27810161/impact-of-hodgkin-or-non-hodgkin-lymphoma-and-their-treatments-on-sperm-aneuploidy-a-prospective-study-by-the-french-cecos-network
#6
Guillaume Martinez, Marie Walschaerts, Marine Le Mitouard, Remi Borye, Claire Thomas, Jacques Auger, Isabelle Berthaut, Florence Brugnon, Myriam Daudin, Nathalie Moinard, Célia Ravel, Jacqueline Saias, Ethel Szerman, Nathalie Rives, Sylviane Hennebicq, Louis Bujan
OBJECTIVE: To assess sperm production and aneuploidy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) before and after treatments. DESIGN: Multicenter, prospective, longitudinal study of lymphoma patients analyzed before treatment and after 3, 6, 12, and 24 months. SETTING: University hospitals. PATIENT(S): Forty-five HL and 13 NHL patients were investigated before and after treatment. Treatment regimens were classified in two groups: ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) with or without (±) radiotherapy, and CHOP (doxorubicin, cyclophosphamide, vincristine, prednisone)/MOPP-ABV (mechlorethamine, oncovin, procarbazine, prednisone-doxorubicin, bleomycin, vinblastine)...
October 31, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27809459/survey-of-the-patterns-of-using-stereotactic-ablative-radiotherapy-for-early-stage-non-small-cell-lung-cancer-in-korea
#7
Sanghyuk Song, Ji Hyun Chang, Hak Jae Kim, Yeon Sil Kim, Jin Hee Kim, Yong Chan Ahn, Jae-Sung Kim, Si Yeol Song, Sung Ho Moon, Moon June Cho, Seon Min Youn
Purpose: Stereotactic ablative radiotherapy (SABR) is an effective emerging technique for early-stage non-small cell lung cancer (NSCLC). We investigated the current practice of SABR for early-stage NSCLC in Korea. Materials and Methods: We conducted a nationwide survey of SABR for NSCLC by sending e-mails to all board-certified members of the Korean Society for Radiation Oncology. The survey included 23 questions focusing on the technical aspects of SABR and 18 questions seeking the participants' opinions on specific clinical scenarios in the use of SABR for early-stage NSCLC...
October 31, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27796823/comprehensive-treatment-with-chinese-medicine-in-patients-with-advanced-non-small-cell-lung-cancer-a-multicenter-prospective-cohort-study
#8
Jie Liu, Hong-Sheng Lin, Wei Hou, Bao-Jin Hua, Pei-Tong Zhang, Jie Li, Shen-Yu Wang, Ying Xie, Yue Zhang, Guang-Ru Xie, Mei-Ying Zhang, Wen-Guang Shi, Nian-Bo Guan, Tian-Yu Guan, Cong-Huang Li, Li-Yuan Lu, Ying Zhang, Dao-Rui Li, Hao Liu
OBJECTIVE: To determine whether additional Chinese medicine (CM) could prolong survival and improve the quality of life (QOL) in patients with advanced non-small cell lung cancer (NSCLC) compared with Western medicine (WM) alone. METHODS: This was a multicenter, prospective cohort study. A total of 474 hospitalized patients with stage III-IV NSCLC were recruited and divided into 2 groups. Patients in the WM group received radiotherapy, chemotherapy, and optimal supportive therapy according to the National Comprehensive Cancer Network (NCCN) guidelines...
October 28, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27793036/optimal-radiation-dose-for-patients-with-one-to-three-lymph-node-positive-breast-cancer-following-breast-conserving-surgery-and-anthracycline-plus-taxane-based-chemotherapy-a-retrospective-multicenter-analysis-krog-1418
#9
Haeyoung Kim, Won Park, Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Yeon-Joo Kim, Eun Sook Lee, Keun Seok Lee, Han-Sung Kang, In Hae Park, Kyung Hwan Shin, Kyubo Kim, Kyung Ran Park, Yong Bae Kim, Sung Ja Ahn, Jong Hoon Lee, Jin Hee Kim, Mison Chun, Hyung-Sik Lee, Jung Soo Kim, Jong-Young Lee
BACKGROUND AND PURPOSE: This study was performed to determine optimal radiation dose in pN1 breast cancer patients who received breast conserving surgery (BCS) and anthracycline plus taxane (AT)-based chemotherapy.  Materials and Methods: Retrospective chart reviews were performed in 1,147 patients who were treated between January 2006 and December 2010. The impact of radiation dose on treatment outcomes was evaluated. RESULTS: Median follow-up time was 66 months...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27770397/intermittent-versus-continuous-androgen-deprivation-therapy-to-biochemical-recurrence-after-external-beam-radiotherapy-a-phase-3-gicor-study
#10
F Casas, I Henríquez, A Bejar, X Maldonado, A Alvarez, C González-Sansegundo, A Boladeras, F Ferrer, A Hervás, I Herruzo, M Caro, I Rodriguez, C Ferrer
PURPOSE: We compared biochemical control and quality of life with intermittent (6 months) versus continuous (36 months) androgen deprivation therapy (ADT) in a non-inferiority randomized phase 3 trial in patients with biochemical failure (BF) after external beam radical radiotherapy (EBRT). MATERIALS AND METHODS: Patients were stratified according to the Gleason score (GS) and were classified as low risk with a GS < 6 and 7 (3 + 4) and high risk with a GS of 7 (4 + 3) and >7...
October 21, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27768621/biological-mesh-closure-of-the-pelvic-floor-after-extralevator-abdominoperineal-resection-for-rectal-cancer-a-multicenter-randomized-controlled-trial-the-biopex-study
#11
Gijsbert D Musters, Charlotte E L Klaver, Robbert J I Bosker, Jacobus W A Burger, Peter van Duijvendijk, Boudewijn van Etten, Anna A W van Geloven, Eelco J R de Graaf, Christiaan Hoff, Jeroen W A Leijtens, Harm J T Rutten, Baljit Singh, Ronald J C L M Vuylsteke, Johannes H W de Wilt, Marcel G W Dijkgraaf, Willem A Bemelman, Pieter J Tanis
OBJECTIVE: To determine the effect of biological mesh closure on perineal wound healing after extralevator abdominoperineal resection (eAPR). BACKGROUND: Perineal wound complications frequently occur after eAPR with preoperative radiotherapy for rectal cancer. Cohort studies have suggested that biological mesh closure of the pelvic floor improves perineal wound healing. METHODS: Patients were randomly assigned to primary closure (standard arm) or biological mesh closure (intervention arm)...
September 20, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27765457/a-machine-learning-tool-for-re-planning-and-adaptive-rt-a-multicenter-cohort-investigation
#12
G Guidi, N Maffei, B Meduri, E D'Angelo, G M Mistretta, P Ceroni, A Ciarmatori, A Bernabei, S Maggi, M Cardinali, V E Morabito, F Rosica, S Malara, A Savini, G Orlandi, C D'Ugo, F Bunkheila, M Bono, S Lappi, C Blasi, F Lohr, T Costi
PURPOSE: To predict patients who would benefit from adaptive radiotherapy (ART) and re-planning intervention based on machine learning from anatomical and dosimetric variations in a retrospective dataset. MATERIALS AND METHODS: 90 patients (pts) treated for head-neck cancer (H&N) formed a multicenter data-set. 41 H&N pts (45.6%) were considered for learning; 49 pts (54.4%) were used to test the tool. A homemade machine-learning classifier was developed to analyze volume and dose variations of parotid glands (PG)...
October 17, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27764904/incorporating-risk-factors-to-identify-the-indication-of-post-mastectomy-radiotherapy-in-n1-breast-cancer-treated-with-optimal-systemic-therapy-a-multicenter-analysis-in-korea-krog-14-23
#13
Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Seung Do Ahn, Ja Young Kim, Won Park, Yong Bae Kim, Yeon-Joo Kim, Jin Hee Kim, Kyubo Kim, Kyung Ran Park, Hyun Soo Shin, Bae Kwon Jeong, Sun Young Lee, Suzy Kim
Purpose: In a recent meta-analysis, post-mastectomy radiotherapy (PMRT) reduced any first recurrence (AFR) and improved survival in N1 and N2 patients. We investigated risk factors for AFR in N1 after optimal systemic therapy without PMRT, to define a subgroup of patients who may benefit from PMRT. Materials and Methods: 1,382 pT1-2N1M0 breast cancer patients treated with mastectomy without PMRT between 2005 and 2010 were retrospectively analyzed. Only 0.6% had no systemic therapy...
October 19, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27764781/a-phase-ii-open-label-multicenter-study-of-gefitinib-in-combination-with-irradiation-followed-by-chemotherapy-in-patients-with-inoperable-stage-iii-non-small-cell-lung-cancer
#14
Antonin Levy, Etienne Bardet, Benjamin Lacas, Jean-Pierre Pignon, Julien Adam, Ludovic Lacroix, Xavier Artignan, Pierre Verrelle, Cécile Le Péchoux
BACKGROUND: Gefitinib is an oral EGFR tyrosine kinase inhibitors which may act as a radiosensitizer. PATIENTS AND METHODS: This phase II study evaluated the efficacy of gefitinib 250 mg once daily in combination with thoracic radiotherapy (66 Gy in 6.5 weeks, 2 Gy/day, 5 fractions/week) followed by consolidation chemotherapy (IV cisplatin and vinorelbine) as first line treatment in a population of unselected stage IIIB NSCLC patients according to EGFR mutation status...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27758723/-new-developments-in-the-treatment-of-pancreatic-cancer
#15
H A Marsman, M G Besselink
- The incidence of pancreatic cancer is increasing due to the ageing population among other things, while 5-year survival has improved in the past two decades from 3 to 7%.- In case of biliary obstruction due to pancreatic cancer, biliary drainage before surgery or ablative therapy using a covered metal stent instead of plastic reduces the rate of complications.- In patients with metastasized pancreatic cancer a combination of folinic acid, fluorouracil, irinotecan and oxaliplatin (FOLFIRINOX) results in improved survival...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27746888/primary-hepatic-lymphoma-a-retrospective-multicenter-rare-cancer-network-study
#16
Gamze Ugurluer, Robert C Miller, Yexiong Li, Juliette Thariat, Pirus Ghadjar, Ulrike Schick, Mahmut Ozsahin
Primary hepatic lymphoma (PHL) is a rare malignancy. We aimed to assess the clinical profile, outcome and prognostic factors in PHL through the Rare Cancer Network (RCN). A retrospective analysis of 41 patients was performed. Median age was 62 years (range, 23-86 years) with a male-to-female ratio of 1.9:1.0. Abdominal pain or discomfort was the most common presenting symptom. Regarding B-symptoms, 19.5% of patients had fever, 17.1% weight loss, and 9.8% night sweats. The most common radiological presentation was multiple lesions...
September 5, 2016: Rare Tumors
https://www.readbyqxmd.com/read/27725911/comparison-between-nedaplatin-and-cisplatin-plus-docetaxel-combined-with-intensity-modulated-radiotherapy-for-locoregionally-advanced-nasopharyngeal-carcinoma-a-multicenter-randomized-phase-ii-clinical-trial
#17
Chunyuan Tang, Fang Wu, Rensheng Wang, Heming Lu, Guisheng Li, Meilian Liu, Haisheng Zhu, Jinxian Zhu, Yong Zhang, Kai Hu
Nasopharyngeal carcinoma (NPC) is highly incident in southern China. Metastasis is the major cause of death in NPC patients. Concurrent chemoradiotherapy (CCRT) has been accepted as standard in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma (NPC). However, induction chemotherapy (IC) also has benefits in this disease, especially in the patients with certain high-risk factors such as bulky and/or extensive nodal disease. It has been presented that adding IC to CCRT might be a reasonable approach and need more work to confirm...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27687815/capecitabine-and-oxaliplatin-prior-and-concurrent-to-preoperative-pelvic-radiotherapy-in-patients-with-locally-advanced-rectal-cancer-long-term-outcome
#18
Viviane Hess, Ralph Winterhalder, Roger von Moos, Lucas Widmer, Priska Stocker, Monika Jermann, Richard Herrmann, Dieter Koeberle
BACKGROUND: The risk/benefit ratio of any treatment can only be fully assessed if long-term results of both efficacy and toxicity are taken into account. Whereas the combined modality treatment of locally advanced rectal cancer (LARC) has considerably improved prognosis, particularly with regard to local control, long-term results-including patient-reported outcomes-are underreported. PATIENTS AND METHODS: Patients with LARC treated within a multicenter single-arm phase II study were prospectively assessed for at least 5 years after surgery...
July 30, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27680061/-evaluation-of-the-selection-between-thoracoscopic-and-open-esophagectomy
#19
Lijie Tan, Han Tang
Esophageal cancer is one of the most common digestive tract cancers in our country. Although multimodality therapy has been used in the treatment of esophageal cancer, such as radiotherapy, chemotherapy and targeted therapy, surgery plays its irreplaceable role. With the development of techniques and innovation of instruments, minimally invasive esophagectomy is introduced into practice worldwide. Due to its less trauma and fewer complications, minimally invasive esophagectomy draws great attention, however, controversy exists in the question whether minimally invasive esophagectomy has similar efficacy to open esophagectomy...
September 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27663950/multiple-training-interventions-significantly-improve-reproducibility-of-pet-ct-based-lung-cancer-radiotherapy-target-volume-delineation-using-an-iaea-study-protocol
#20
Tom Konert, Wouter V Vogel, Sarah Everitt, Michael P MacManus, Daniela Thorwarth, Elena Fidarova, Diana Paez, Jan-Jakob Sonke, Gerard G Hanna
BACKGROUND AND PURPOSE: To assess the impact of a standardized delineation protocol and training interventions on PET/CT-based target volume delineation (TVD) in NSCLC in a multicenter setting. MATERIAL AND METHODS: Over a one-year period, 11 pairs, comprised each of a radiation oncologist and nuclear medicine physician with limited experience in PET/CT-based TVD for NSCLC from nine different countries took part in a training program through an International Atomic Energy Agency (IAEA) study (NCT02247713)...
September 20, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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