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https://www.readbyqxmd.com/read/29771474/neurocog-fx-study-a-multicenter-cohort-study-on-cognitive-dysfunction-in-patients-with-early-breast-cancer
#1
Oliver Rick, Monika Reuß-Borst, Timm Dauelsberg, Holger Hass, Volker König, Reiner Caspari, Gabriele Götz-Keil, Jürgen Pfitzner, Christa Kerschgens, Klaus Fliessbach, Christian Hoppe
OBJECTIVE: Complaints about cognitive dysfunction (CD) reportedly persist in approximately one third of breast cancer patients but the nature of CD and possible risk factors are unknown. METHODS: A cross-sectional, multicenter study was set-up at 9 German oncological rehabilitation centers. Objective cognitive performance was assessed by the NeuroCog FX test, a short computerized screening (duration <30 min) which assesses working memory, alertness, verbal/figural memory and language/executive...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29769060/biopro-rcmi-1505-trial-multicenter-study-evaluating-the-use-of-a-biodegradable-balloon-for-the-treatment-of-intermediate-risk-prostate-cancer-by-intensity-modulated-radiotherapy-study-protocol
#2
David Pasquier, Emilie Bogart, François Bonodeau, Thomas Lacornerie, Eric Lartigau, Igor Latorzeff
BACKGROUND: Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases risks of urinary and bowel toxicity. Recently the contribution of "spacers" positioned in the septum between the rectum and the prostate could improve the functional results of intensity modulated radiation therapy (IMRT). To date most of the evaluated devices were polyethylen glycol (PEG) and hyaluronic acid (HA)...
May 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29763623/molecular-pathological-radiological-and-immune-profiling-of-non-brainstem-pediatric-high-grade-glioma-from-the-herby-phase-ii-randomized-trial
#3
Alan Mackay, Anna Burford, Valeria Molinari, David T W Jones, Elisa Izquierdo, Jurriaan Brouwer-Visser, Felice Giangaspero, Christine Haberler, Torsten Pietsch, Thomas S Jacques, Dominique Figarella-Branger, Daniel Rodriguez, Paul S Morgan, Pichai Raman, Angela J Waanders, Adam C Resnick, Maura Massimino, Maria Luisa Garrè, Helen Smith, David Capper, Stefan M Pfister, Thomas Würdinger, Rachel Tam, Josep Garcia, Meghna Das Thakur, Gilles Vassal, Jacques Grill, Tim Jaspan, Pascale Varlet, Chris Jones
The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors (mismatch repair deficiency and somatic POLE/POLD1 mutations) and those biologically resembling pleomorphic xanthoastrocytoma ([PXA]-like, driven by BRAF_V600E or NF1 mutation) had significantly more CD8+ tumor-infiltrating lymphocytes, and longer survival with the addition of BEV...
May 14, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29761908/rituximab-maintenance-therapy-of-follicular-lymphoma-in-clinical-practice
#4
Ulrich Dührsen, Stefanie Broszeit-Luft, Annette Dieing, Andreas Lück, Piotr Porowski, Marcel Reiser, Ulrike Schwinger, Sandra Klawitter, Katja Krumm, Kathleen Jentsch-Ullrich
Standard of care for patients with symptomatic, advanced-stage follicular lymphoma (FL) is rituximab-containing chemoimmunotherapy followed by rituximab maintenance. This prospective, multicenter, noninterventional study analyzed how efficacy and safety data from randomized controlled trials translate into clinical practice in Germany. Both treatment-naïve and relapsed/refractory patients with FL, who responded to rituximab-containing induction and were scheduled for rituximab maintenance, were observed for 24 months...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29760798/a-multicenter-retrospective-comparison-of-sequential-versus-sandwich-chemoradiotherapy-for-stage-ie-iie-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#5
Jin Li, Yajun Li, Meizuo Zhong, Wei Liu, Xianling Liu, Jiwei Li, Kunlun Li, Pingyong Yi
Background: Chemotherapy and radiotherapy are critical for treating early-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL); however, the optimal therapy sequence remains unclear. Therefore, we performed this study to compare the efficacy of L-asparaginase/pegaspargase-based sequential versus sandwich chemoradiotherapy for patients newly diagnosed with stage IE-IIE ENKTL. Methods: Patients were categorized into sequential ( N = 111) and sandwich ( N = 104) groups. Chemotherapy regimens included GELOX, SMILE, and VLP...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29759332/sunset-stereotactic-radiation-for-ultracentral-non-small-cell-lung-cancer-a-safety-and-efficacy-trial
#6
Meredith Giuliani, Ashwathy S Mathew, Houda Bahig, Scott V Bratman, Edith Filion, Daniel Glick, Alexander V Louie, Srinivas Raman, Anand Swaminath, Andrew Warner, Vivian Yau, David Palma
BACKGROUND: Lung stereotactic body radiotherapy (SBRT) is considered a standard curative treatment for medically inoperable early stage non-small-cell lung cancer (NSCLC). Patients with ultracentral tumors (signifying tumors whose planning target volume touches or overlaps the central bronchial tree, esophagus, or pulmonary artery) may be at higher risk of serious toxicities such as bronchial stricture and collapse, esophageal strictures, tracheal-esophageal fistula, and hemorrhage. The primary objective of the study is to determine the maximum tolerated dose of radiotherapy for ultracentral NSCLC...
April 18, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29757457/the-role-of-adjuvant-treatment-in-early-stage-oral-cavity-squamous-cell-carcinoma-an-international-collaborative-study
#7
Eran Fridman, Shorook Na'ara, Jaiprakash Agarwal, Moran Amit, Gideon Bachar, Andrea Bolzoni Villaret, Jose Brandao, Claudio R Cernea, Pankaj Chaturvedi, Jonathan Clark, Ardalan Ebrahimi, Dan M Fliss, Sashikanth Jonnalagadda, Hugo F Kohler, Luiz P Kowalski, Matthias Kreppel, Chun-Ta Liao, Snehal G Patel, Raj P Patel, K Thomas Robbins, Jatin P Shah, Thomas Shpitzer, Tzu-Chen Yen, Joachim E Zöller, Ziv Gil
BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis...
May 14, 2018: Cancer
https://www.readbyqxmd.com/read/29739712/radiotherapy-is-essential-after-complete-response-to-asparaginase-containing-chemotherapy-in-early-stage-extranodal-nasal-type-nk-t-cell-lymphoma-a-multicenter-study-from-the-china-lymphoma-collaborative-group-clcg
#8
Xiu-Wen Deng, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Mei Dong, Shu-Nan Qi, Yong Yang, Ye-Xiong Li
PURPOSE: This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). PATIENTS AND METHODS: Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CT + RT), and 38 patients did not (CT alone). RESULTS: Compared to CT alone, CT + RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC)...
May 5, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29739356/korean-society-of-coloproctology-kscp-trial-of-consolidation-chemotherapy-for-locally-advanced-mid-or-low-rectal-cancer-after-neoadjuvant-concurrent-chemoradiotherapy-a-multicenter-randomized-controlled-trial-konclude
#9
Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee, Suk-Hwan Lee
BACKGROUND: Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) has been a standard treatment option for locally advanced rectal cancer with improved local control. However, systemic recurrence despite neoadjuvant CRT remained unchanged. The only significant prognostic factor proven to be important was pathologic complete response (pCR) after neoadjuvant CRT. Several efforts have been tried to improve survival of patients who treated with neoadjuvant CRT and to achieve more pCR including adding cytotoxic chemotherapeutic agents, chronologic modification of chemotherapy schedule or adding chemotherapy during the perioperative period...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29731160/contouring-of-prostate-tumors-on-multiparametric-mri-evaluation-of-clinical-delineations-in-a-multicenter-radiotherapy-trial
#10
Marcel A van Schie, Cuong V Dinh, Petra J van Houdt, Floris J Pos, Stijn W T J P Heijmink, Linda G W Kerkmeijer, Alexis N T J Kotte, Raymond Oyen, Karin Haustermans, Uulke A van der Heide
PURPOSE: To date no guidelines are available for contouring prostate cancer inside the gland, as visible on multiparametric (mp-) MRI. We assessed inter-institutional differences in interpretation of mp-MRI in the multicenter phase III FLAME trial. METHODS: We analyzed clinical delineations on mp-MRI and clinical characteristics from 260 patients across three institutes. We performed a logistic regression analysis to examine each institute's weighting of T2w, ADC and Ktrans intensity maps in the delineation of the cancer...
May 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29730776/vaginal-brachytherapy-for-endometrial-cancer
#11
Peter Hass, Selvi Seinsch, Holm Eggemann, Tanja Ignatov, Stephan Seitz, Atanas Ignatov
BACKGROUND: There is limited information about survival effect of vaginal brachytherapy (VBT) and its comparison to external beam pelvic radiotherapy (EBRT) and no radiotherapy (no-RT) of endometrial cancer patients. PATIENTS AND METHODS: We performed a multicenter retrospective registry study of 1550 patients with endometrial cancer treated by no-RT (n = 702), VBT (n = 430) and EBRT ± VBT (n = 418). The outcome measure was overall survival. RESULTS: RT did not improve the overall survival of patients with a low risk of recurrence...
May 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29718892/clinical-application-of-oral-meglumine-diatrizoate-esophagogram-in-screening-esophageal-fistula-during-radiotherapy-for-esophageal-cancer
#12
Lidan Geng, Rong Wu, He Hu, Yu Zhao, Lingli Fan, Zhenhua Zhao, Dongbiao Liao, Musheng Li, Miao Xiang, Ying Ma, Xiaobo Du
INTRODUCTION: Esophageal fistula is a serious and common complication of radiotherapy for esophageal cancer. Therefore, early diagnosis and treatment is necessary. Because of side effect of barium esophagography, it cannot be used to screening esophageal fistula during radiotherapy. Meglumine diatrizoate is an ionic contrast agent, its adverse reactions were rarely seen when it was used in the body cavity. The purpose of this trial is identified the sensitivity and specificity of oral meglumine diatrizoate in an esophagogram for screening esophageal fistula during radiotherapy...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29712887/short-course-versus-long-course-chemoradiotherapy-for-stage-ie-iie-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-multicenter-retrospective-study
#13
Jin Li, Yajun Li, Meizuo Zhong, Xianling Liu, Yinghui Song, Jiwei Li, Kunlun Li, Pingyong Yi
BACKGROUND This study compared clinical outcomes and adverse events between L-asparaginase/pegaspargase-based short-course and long-course chemoradiotherapy in newly diagnosed stage IE-IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL). MATERIAL AND METHODS Patients were categorized into a short-course (2-4 chemotherapy cycles, median: 4, n=153) and long-course group (5-6 cycles, median: 6, n=83). The chemotherapy regimens included GELOX, SMILE, and VLP. The radiotherapy dose was 40-63 Gy (median: 55 Gy)...
May 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29706189/risk-factors-for-salivary-gland-cancers-in-france-results-from-a-case-control-study-the-icare-study
#14
Loredana Radoï, Christine Barul, Gwenn Menvielle, Matthieu Carton, Mireille Matrat, Marie Sanchez, Corinne Pilorget, Michel Velten, Isabelle Stücker, Danièle Luce
OBJECTIVES: Epidemiological studies on the risk factors for salivary gland cancers (SGC) are rare, concern a small sample size, and show inconsistent results. The aim of the present work was to analyze several risk factors for SGC, using the data from the ICARE study, a multicenter, population-based case-control study. MATERIALS AND METHODS: Data from 73 SGC cases and 3555 controls were collected using a standardized questionnaire on lifestyle habits, personal and family medical history, and lifetime occupational history...
May 2018: Oral Oncology
https://www.readbyqxmd.com/read/29698060/dosimetric-comparison-of-five-different-techniques-for-craniospinal-irradiation-across-15-european-centers-analysis-on-behalf-of-the-siop-e-btg-radiotherapy-working-group
#15
Enrica Seravalli, Mirjam Bosman, Yasmin Lassen-Ramshad, Anne Vestergaard, Foppe Oldenburger, Jorrit Visser, Efi Koutsouveli, Chryssa Paraskevopoulou, Gail Horan, Thankamma Ajithkumar, Beate Timmermann, Carolina-Sofia Fuentes, Gillian Whitfield, Thomas Marchant, Laetitia Padovani, Eloise Garnier, Lorenza Gandola, Silvia Meroni, Bianca A W Hoeben, Martijn Kusters, Claire Alapetite, Sandra Losa, Farid Goudjil, Henriette Magelssen, Morten Egeberg Evensen, Frank Saran, Gregory Smyth, Barbara Rombi, Roberto Righetto, Rolf-Dieter Kortmann, Geert O Janssens
PURPOSE: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy® , proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. MATERIAL AND METHODS: A multicenter (n = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy® , PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29696815/multicenter-analysis-of-stereotactic-radiotherapy-of-the-resection-cavity-in-patients-with-brain-metastases
#16
Stephanie E Combs, Angelika Bilger, Christian Diehl, Eva Bretzinger, Hannah Lorenz, Oliver Oehlke, Hanno M Specht, Anna Kirstein, Anca-Ligia Grosu
Brain metastases show a recurrence rate of about 50% after surgical resection. Adjuvant radiotherapy can prevent progression; however, whole-brain radiotherapy (WBRT) can be associated with significant side effects. Local hypofractionated stereotactic radiotherapy (HFSRT) is a good alternative to provide local control with minimal toxicity. In this multicenter analysis, we evaluated the treatment outcome of local HFSRT after resection brain metastases in 181 patients. Patient's characteristics, treatment data as well as follow-up data were collected and analyzed with special focus on local control, locoregional control and survival...
April 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29683790/multicenter-phase-ib-trial-of-carboxyamidotriazole-orotate-and-temozolomide-for-recurrent-and-newly-diagnosed-glioblastoma-and-other-anaplastic-gliomas
#17
Antonio Omuro, Kathryn Beal, Katharine McNeill, Robert J Young, Alissa Thomas, Xuling Lin, Robert Terziev, Thomas J Kaley, Lisa M DeAngelis, Mariza Daras, Igor T Gavrilovic, Ingo Mellinghoff, Eli L Diamond, Andrew McKeown, Malbora Manne, Andrew Caterfino, Krishna Patel, Linda Bavisotto, Greg Gorman, Michael Lamson, Philip Gutin, Viviane Tabar, Debyani Chakravarty, Timothy A Chan, Cameron W Brennan, Elizabeth Garrett-Mayer, Rashida A Karmali, Elena Pentsova
Purpose Carboxyamidotriazole orotate (CTO) is a novel oral inhibitor of non-voltage-dependent calcium channels with modulatory effects in multiple cell-signaling pathways and synergistic effects with temozolomide (TMZ) in glioblastoma (GBM) models. We conducted a phase IB study combining CTO with two standard TMZ schedules in GBM. Methods In cohort 1, patients with recurrent anaplastic gliomas or GBM received escalating doses of CTO (219 to 812.5 mg/m2 once daily or 600 mg fixed once-daily dose) combined with TMZ (150 mg/m2 5 days during each 28-day cycle)...
April 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29673111/comparison-of-epidemiological-features-clinicopathological-features-and-treatments-between-premenopausal-and-postmenopausal-female-breast-cancer-patients-in-western-china-a-retrospective-multicenter-study-of-15-389-female-patients
#18
REVIEW
Fan Feng, Yuxian Wei, Ke Zheng, Yujing Li, Lu Zhang, Tielin Wang, Yanli Zhang, Hongyuan Li, Guosheng Ren, Fan Li
Premenopausal and postmenopausal breast cancers are considered different types. Thus, this study aimed to explore differences in risk factors, epidemiological features, clinicopathological features, and treatment modes of premenopausal breast cancer compared to postmenopausal patients in western China. This was a hospital-based, retrospective, multicenter epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group database, we obtained the records of 15,389 female breast cancers between January 2010 and April 2017...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29661497/postoperative-chemotherapy-for-node-positive-cervical-cancer-results-of-a-multicenter-phase-ii-trial-jgog1067
#19
Maki Matoda, Nobuhiro Takeshima, Hirofumi Michimae, Takashi Iwata, Harushige Yokota, Yutaka Torii, Yorito Yamamoto, Kazuhiro Takehara, Shin Nishio, Hirokuni Takano, Mika Mizuno, Yoshiyuki Takahashi, Yuji Takei, Tetsuya Hasegawa, Mikio Mikami, Takayuki Enomoto, Daisuke Aoki, Toru Sugiyama
OBJECTIVE: This multicenter phase II Japanese Gynecologic Oncology Group study (JGOG1067) was designed to evaluate the efficacy and safety of postoperative chemotherapy in patients with node-positive cervical cancer. METHODS: Patients with stage IB-IIA squamous cervical cancer who underwent radical hysterectomy and were confirmed to have pelvic lymph node metastasis were eligible for this study. The patients postoperatively received irinotecan (CPT-11; 60mg/m2 intravenously on days 1 and 8) and nedaplatin (NDP; 80mg/m2 intravenously on day 1)...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29661218/endometrial-cancer-survivors-follow-up-care-ensure-less-is-more-evaluating-patient-satisfaction-and-cost-effectiveness-of-a-reduced-follow-up-schedule-study-protocol-of-a-randomized-controlled-trial
#20
Nicole P M Ezendam, Belle H de Rooij, Roy F P M Kruitwagen, Carien L Creutzberg, Ingrid van Loon, Dorry Boll, M Caroline Vos, Lonneke V van de Poll-Franse
BACKGROUND: It has often been hypothesized that the frequency of follow-up visits for patients with early-stage endometrial cancer could be decreased. However, studies evaluating effects of a reduced follow-up schedule among this patient group are lacking. The aim of this study is to assess patient satisfaction and cost-effectiveness of a less frequent follow-up schedule compared to the schedule according to the Dutch guideline. METHODS: In this multicenter randomized controlled trial, patients diagnosed in the Netherlands with stage 1A and 1B low-risk endometrial cancer, for whom adjuvant radiotherapy is not indicated (n = 282), are randomized...
April 16, 2018: Trials
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