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Delineation radiotherapy

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https://www.readbyqxmd.com/read/28511960/inadequate-target-volume-delineation-and-local-regional-recurrence-after-intensity-modulated-radiotherapy-for-human-papillomavirus-positive-oropharynx-cancer
#1
Allen M Chen, Robert Chin, Philip Beron, Taeko Yoshizaki, Argin G Mikaeilian, Minsong Cao
PURPOSE: To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS AND MATERIALS: The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset...
May 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28510808/development-of-a-contouring-guide-in-three-different-head-set-ups-for-hippocampal-sparing-radiotherapy-a-practical-approach
#2
Saide Di Biase, Marianna Trignani, Luciana Caravatta, Paul Ioan Voicu, Clelia Di Carlo, Annamaria Vinciguerra, Antonietta Augurio, Francesca Perrotti, Valentina Panara, Domenico Genovesi
BACKGROUNDS: Irradiation of the hippocampus plays a role in neurocognitive toxicity. Its delineation is complex and in practice different head position can vary hippocampus morphology on axial images; so atlas in a single standard position can result ineffective to describe different hippocampal morphologies in different head set-up. The purpose of our study was to develop a guide based on magnetic resonance imaging for hippocampus delineation in three different head set-ups. MATERIALS AND METHODS: Three patients were selected to elaborate our guide...
May 16, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28499659/-spinal-stereotactic-body-radiotherapy-french-assessment-in-2016
#3
I Pougnet, E Jaegle, R Garcia, F Tessier, J C Faivre, G Louvel, E Gross, L Gonzague, M Benchalal, A Ducteil, S Supiot, D Autret, J B Clavier, X Mirabel, A Bellière, D Wdowczyk, S Heymann, I Barillot, B de La Lande, V Passerat, M P Sunyach, F Lipinski, D Thibouw, F Guichard, B Chauvet, J Thariat, A Arnaud
PURPOSE: Stereotactic body radiotherapy to vertebral column remains uncommon practice and only relevant in selected group of patients. The main objective of the study was to describe the current state of medical practices of stereotactic body radiotherapy to vertebral column in France in 2016 and to assess the diversity of practices to identify areas for improvement and establish a common database set for this technique. MATERIALS AND METHODS: A questionnaire was written with contribution of a medical physicist, a radiation oncologist, an information technologist and a radiotherapy resident...
May 9, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28499658/-radiotherapy-volume-delineation-based-on-18-f-fluorodeoxyglucose-positron-emission-tomography-for-locally-advanced-or-inoperable-oesophageal-cancer
#4
J Encaoua, R Abgral, C Leleu, O El Kabbaj, P Caradec, D Bourhis, O Pradier, U Schick
PURPOSE: To study the impact on radiotherapy planning of an automatically segmented target volume delineation based on ((18)F)-fluorodeoxy-D-glucose (FDG)-hybrid positron emission tomography-computed tomography (PET-CT) compared to a manually delineation based on computed tomography (CT) in oesophageal carcinoma patients. METHODS AND MATERIALS: Fifty-eight patients diagnosed with oesophageal cancer between September 2009 and November 2014 were included. The majority had squamous cell carcinoma (84...
May 9, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28478912/quality-assurance-of-radiotherapy-in-the-ongoing-eortc-1219-dahanca-29-trial-for-hpv-p16-negative-squamous-cell-carcinoma-of-the-head-and-neck-results-of-the-benchmark-case-procedure
#5
Melissa Christiaens, Sandra Collette, Jens Overgaard, Vincent Gregoire, Joanna Kazmierska, Pierre Castadot, Jordi Giralt, Warren Grant, Milan Tomsej, Raquel Bar-Deroma, Angelo F Monti, Coen Wilhelm Hurkmans, Damien Charles Weber
BACKGROUND AND PURPOSE: The phase III EORTC 1219-DAHANCA 29 intergroup trial evaluates the influence of nimorazole in patients with locally advanced head and neck cancer when treated with accelerated radiotherapy (RT) in combination with chemotherapy. This article describes the results of the RT Benchmark Case (BC) performed before patient inclusion. MATERIALS AND METHODS: The participating centers were asked to perform a 2-step BC, consisting of (1) a delineation and (2) a planning exercise according to the protocol guidelines...
May 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28471306/salvage-lenvatinib-therapy-in-metastatic-anaplastic-thyroid-cancer
#6
Nicole M Iniguez Ariza, Mabel Ryder, Crystal R Hilger, Keith C Bible
BACKGROUND: Historical anaplastic thyroid cancer (ATC) outcomes have been terrible, with a median survival of only 5 months and <20% 1-year survival. Improved outcomes are now achieved with aggressive initial therapy in stages IVA and IVB disease, but patients with distant metastatic disease (stage IVC) still do poorly; improved therapies are sorely needed. Kinase inhibitors have emerged as promising agents in the therapy of advanced medullary and differentiated thyroid cancer, but there are limited data regarding use of lenvatinib in ATC...
May 4, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28469512/does-motion-assessment-with-4-dimensional-computed-tomographic-imaging-for-non-small-cell-lung-cancer-radiotherapy-improve-target-volume-coverage
#7
Naseer Ahmed, Sankar Venkataraman, Kate Johnson, Keith Sutherland, Shaun K Loewen
INTRODUCTION: Modern radiotherapy with 4-dimensional computed tomographic (4D-CT) image acquisition for non-small cell lung cancer (NSCLC) captures respiratory-mediated tumor motion to provide more accurate target delineation. This study compares conventional 3-dimensional (3D) conformal radiotherapy (3DCRT) plans generated with standard helical free-breathing CT (FBCT) with plans generated on 4D-CT contoured volumes to determine whether target volume coverage is affected. MATERIALS AND METHODS: Fifteen patients with stage I to IV NSCLC were enrolled in the study...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/28464749/contouring-and-dose-calculation-in-head-and-neck-cancer-radiotherapy-after-reduction-of-metal-artifacts-in-ct-images
#8
Christian Rønn Hansen, Rasmus Lübeck Christiansen, Ebbe Laugaard Lorenzen, Anders Smedegaard Bertelsen, Jon Thor Asmussen, Niels Gyldenkerne, Jesper Grau Eriksen, Jørgen Johansen, Carsten Brink
BACKGROUND: Delineation accuracy of the gross tumor volume (GTV) in radiotherapy planning for head and neck (H&N) cancer is affected by computed tomography (CT) artifacts from metal implants which obscure identification of tumor as well as organs at risk (OAR). This study investigates the impact of metal artifact reduction (MAR) in H&N patients in terms of delineation consistency and dose calculation precision in radiation treatment planning. MATERIAL AND METHODS: Tumor and OAR delineations were evaluated in planning CT scans of eleven oropharynx patients with streaking artifacts in the tumor region preceding curative radiotherapy (RT)...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28464746/autodelineation-of-cervical-cancers-using-multiparametric-magnetic-resonance-imaging-and-machine-learning
#9
Turid Torheim, Eirik Malinen, Knut Håkon Hole, Kjersti Vassmo Lund, Ulf G Indahl, Heidi Lyng, Knut Kvaal, Cecilia M Futsaether
BACKGROUND: Tumour delineation is a challenging, time-consuming and complex part of radiotherapy planning. In this study, an automatic method for delineating locally advanced cervical cancers was developed using a machine learning approach. MATERIALS AND METHODS: A method for tumour segmentation based on image voxel classification using Fisher?s Linear Discriminant Analysis (LDA) was developed. This was applied to magnetic resonance (MR) images of 78 patients with locally advanced cervical cancer...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28464740/defining-the-hypoxic-target-volume-based-on-positron-emission-tomography-for-image-guided-radiotherapy-the-influence-of-the-choice-of-the-reference-region-and-conversion-function
#10
Emely Lindblom, Alexandru Dasu, Johan Uhrdin, Aniek Even, Wouter van Elmpt, Philippe Lambin, Peter Wersäll, Iuliana Toma-Dasu
BACKGROUND: Hypoxia imaged by positron emission tomography (PET) is a potential target for optimization in radiotherapy. However, the implementation of this approach with respect to the conversion of intensities in the images into oxygenation and radiosensitivity maps is not straightforward. This study investigated the feasibility of applying two conversion approaches previously derived for (18)F-labeled fluoromisonidazole ((18)F-FMISO)-PET images for the hypoxia tracer (18)F-flortanidazole ((18)F-HX4)...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28464739/magnetic-resonance-only-workflow-and-validation-of-dose-calculations-for-radiotherapy-of-prostate-cancer
#11
Rasmus L Christiansen, Henrik R Jensen, Carsten Brink
BACKGROUND: Current state of the art radiotherapy planning of prostate cancer utilises magnetic resonance (MR) for soft tissue delineation and computed tomography (CT) to provide an electron density map for dose calculation. This dual scan workflow is prone to setup and registration error. This study evaluates the feasibility of an MR-only workflow and the validity of dose calculation from an MR derived pseudo CT. MATERIAL AND METHODS: Thirty prostate cancer patients were CT and MR scanned...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28462852/stereotactic-robotic-body-radiotherapy-for-patients-with-unresectable-hepatic-oligorecurrence
#12
Patrick Berkovic, Akos Gulyban, Paul Viet Nguyen, David Dechambre, Philippe Martinive, Nicolas Jansen, Ferenc Lakosi, Levente Janvary, Philippe A Coucke
BACKGROUND: The purpose of this study was to analyze local control (LC), liver progression-free survival (PFS), and distant PFS (DFS), overall survival (OS), and toxicity in a cohort of patients treated with stereotactic body radiotherapy (SBRT) with fiducial tracking for oligorecurrent liver lesions; and to evaluate the potential influence of lesion size, systemic treatment, physical and biologically effective dose (BED), treatment calculation algorithms and other parameters on the obtained results...
March 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28461787/dosimetric-impact-in-the-dose-volume-histograms-of-rectal-and-vesical-wall-contouring-in-prostate-cancer-imrt-treatments
#13
Laura Gómez, Carlos Andrés, Antonio Ruiz
AIM: The main purpose of this study was to evaluate the differences in dose-volume histograms of IMRT treatments for prostate cancer based on the delineation of the main organs at risk (rectum and bladder) as solid organs or by contouring their wall. BACKGROUND: Rectum and bladder have typically been delineated as solid organs, including the waste material, which, in practice, can lead to an erroneous assessment of the risk of adverse effects. MATERIALS AND METHODS: A retrospective study was made on 25 patients treated with IMRT radiotherapy for prostate adenocarcinoma...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28461783/ct-and-mri-based-gross-target-volume-comparison-in-vestibular-schwannomas
#14
Bhudevi Soubhagya N Kulkarni, Harjot Bajwa, Mukka Chandrashekhar, Sunil Dutt Sharma, Rohith Singareddy, Dileep Gudipudi, Shabbir Ahmad, Alok Kumar, N V N Madusudan Sresty, Alluri Krishnam Raju
AIM: This study represents an enumeration and comparison of gross target volumes (GTV) as delineated independently on contrast-enhanced computed tomography (CT) and T1 and T2 weighted magnetic resonance imaging (MRI) in vestibular schwannomas (VS). BACKGROUND: Multiple imaging in radiotherapy improves target localization. METHODS AND MATERIALS: 42 patients of VS were considered for this prospective study with one patient showing bilateral tumor...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28459800/t2-weighted-4d-magnetic-resonance-imaging-for-application-in-magnetic-resonance-guided-radiotherapy-treatment-planning
#15
Joshua N Freedman, David J Collins, Hannah Bainbridge, Christopher M Rank, Simeon Nill, Marc Kachelrieß, Uwe Oelfke, Martin O Leach, Andreas Wetscherek
OBJECTIVES: The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D (4D-T1w) MRI, to support treatment planning in MR-guided radiotherapy. MATERIALS AND METHODS: Ten patients with primary non-small cell lung cancer were scanned at 1.5 T axially with a volumetric T2-weighted turbo spin echo sequence gated to exhalation and a volumetric T1-weighted stack-of-stars spoiled gradient echo sequence with golden angle spacing acquired in free breathing...
April 28, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28453911/validation-of-biomechanical-deformable-image-registration-in-the-abdomen-thorax-and-pelvis-in-a-commercial-radiotherapy-treatment-planning-system
#16
Michael Velec, Joanne L Moseley, Stina Svensson, Björn Hårdemark, David A Jaffray, Kristy K Brock
PURPOSE: The accuracy of deformable image registration tools can vary widely between imaging modalities and specific implementations of the same algorithms. A biomechanical model-based algorithm initially developed in-house at an academic institution was translated into a commercial radiotherapy treatment planning system and validated for multiple imaging modalities and anatomic sites. METHODS: Biomechanical deformable registration (Morfeus) is a geometry driven algorithm based on the finite element method...
April 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28434797/patterns-of-care-survey-radiotherapy-for-women-with-locally-advanced-cervical-cancer
#17
Peter de Boer, Ina M Jürgenliemk-Schulz, Henrike Westerveld, Astrid A C de Leeuw, Raquel Dávila-Fajardo, Coen R N Rasch, Bradley R Pieters, Lukas J A Stalpers
BACKGROUND AND PURPOSE: Regarding latest developments, the need of a radiotherapy 'Patterns of Care' survey was expressed by the Dutch National Platform Radiotherapy for Gynaecological Cancer (LPRGT). Therefore, this study investigated current practice for cervical cancer in all 16 radiation oncology centres in the Netherlands specialised in gynaecological oncology. MATERIAL AND METHODS: A structured 'patterns of care' questionnaire was completed and followed by an in-depth interview with radiation oncologists from all radiotherapy centres specialised in gynaecological oncology...
April 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28428149/local-control-and-toxicity-of-adaptive-radiotherapy-using-weekly-ct-imaging-results-from-the-lartia-trial-in-stage-iii-nsclc
#18
Sara Ramella, Michele Fiore, Sonia Silipigni, Maria Cristina Zappa, Massimo Jaus, Antonio Maria Alberti, Paolo Matteucci, Elisabetta Molfese, Patrizia Cornacchione, Carlo Greco, Lucio Trodella, Edy Ippolito, Rolando Maria D'Angelillo
INTRODUCTION: Anatomical change of tumor during radiotherapy contributes to target missing. However, in the case of tumor shrinkage, adaptation of volume could result in an increased incidence of recurrence in the area of target reduction. This study aims to investigate the incidence of failure of the adaptive approach and, in particular, the risk for local recurrence in the area excluded after replanning. METHODS: In this prospective study, patients with locally advanced NSCLC treated with concomitant chemoradiation underwent weekly chest computed tomography simulation during treatment...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28427510/central-nervous-system-gliomas
#19
REVIEW
Michele Reni, Elena Mazza, Silvia Zanon, Gemma Gatta, Charles J Vecht
Evidence-based practical guidelines on diagnosis, prognosis, and treatment on the most frequent adult brain tumours are delineated. In Europe, 27,000 new cases of malignant glial tumours and 1000 new cases of malignant ependymal tumours are diagnosed every year. The most common glial tumours are glioblastoma multiforme and anaplastic glioma, comprising more than 50% and 10%, respectively, of the total gliomas. Prognosis of gliomas is generally poor. Environmental and genetic factors have been correlated with an increased risk of developing brain tumours...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28414799/comprehensive-evaluation-of-ten-deformable-image-registration-algorithms-for-contour-propagation-between-ct-and-cone-beam-ct-images-in-adaptive-head-neck-radiotherapy
#20
Xin Li, Yuyu Zhang, Yinghua Shi, Shuyu Wu, Yang Xiao, Xuejun Gu, Xin Zhen, Linghong Zhou
Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N) cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT)...
2017: PloS One
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