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Delineation radiotherapy

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https://www.readbyqxmd.com/read/28643737/changes-in-pharyngeal-constrictor-volumes-during-head-and-neck-radiation-therapy-implications-for-dose-delivery
#1
Akila Kumarasiri, Chang Liu, Mona Kamal, Correen Fraser, Stephen Brown, Indrin J Chetty, Jinkoo Kim, Farzan Siddiqui
OBJECTIVE: The objective of this study was to evaluate the anatomical changes and associated dosimetric consequences to pharyngeal constrictor muscles (PCMs) that occur during head and neck (H and N) radiotherapy (RT). MATERIALS AND METHODS: A cohort of 13 oropharyngeal cancer patients with daily cone beam computed tomography (CBCT) was retrospectively studied. On every 5th CBCT image, PCM was manually delineated by a radiation oncologist. The anterior-posterior PCM thickness was measured at the midline level of C3 vertebral body...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28640699/brain-tumor-imaging
#2
Kevin M Brindle, José L Izquierdo-García, David Y Lewis, Richard J Mair, Alan J Wright
Modern imaging techniques, particularly functional imaging techniques that interrogate some specific aspect of underlying tumor biology, have enormous potential in neuro-oncology for disease detection, grading, and tumor delineation to guide biopsy and resection; monitoring treatment response; and targeting radiotherapy. This brief review considers the role of magnetic resonance imaging and spectroscopy, and positron emission tomography in these areas and discusses the factors that limit translation of new techniques to the clinic, in particular, the cost and difficulties associated with validation in multicenter clinical trials...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28639030/utilization-of-hypofractionated-whole-breast-radiation-therapy-in-patients-receiving-chemotherapy-a-national-cancer-database-analysis
#3
Tejan P Diwanji, Jason K Molitoris, Arpit M Chhabra, James W Snider, Soren M Bentzen, Katherine H Tkaczuk, Paula Y Rosenblatt, Susan B Kesmodel, Emily C Bellavance, Randi J Cohen, Sally B Cheston, Elizabeth M Nichols, Steven J Feigenberg
PURPOSE: Results from four major hypofractionated whole-breast radiotherapy (HF-WBRT) trials have demonstrated equivalence in select patients with early-stage breast cancer when compared with conventionally fractionated WBRT (CF-WBRT). Because relatively little data were available on patients receiving neoadjuvant or adjuvant chemotherapy, consensus guidelines published in 2011 did not endorse the use of HF-WBRT in this population. Our goal is to evaluate trends in utilization of HF-WBRT in patients receiving chemotherapy...
June 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28633674/primary-tumor-volume-delineation-in-head-and-neck-cancer-missing-the-tip-of-the-iceberg
#4
Olgun Elicin, Dario Terribilini, Mohamed Shelan, Werner Volken, Etienne Mathier, Alan Dal Pra, Daniel M Aebersold, Michael K Fix, Peter Manser
BACKGROUND: The aim was to evaluate the geometric and corresponding dosimetric differences between two delineation strategies for head and neck tumors neighboring air cavities. METHODS: Primary gross and clinical tumor volumes (GTV and CTV) of 14 patients with oropharynx or larynx tumors were contoured using a soft tissue window (S). In a second strategy, the same volumes were contoured with an extension to include the parts which became visible on lung window (L)...
June 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28620579/delineation-of-the-prostate-bed-the-invisible-target-is-still-an-issue
#5
Igor Latorzeff, Paul Sargos, Geneviève Loos, Stéphane Supiot, Stéphane Guerif, Christian Carrie
For pathological high-risk prostate cancer, adjuvant irradiation has shown a survival benefit. Phase III studies have highlighted that half men would face biochemical relapse and would be candidate for radiotherapy at adjuvant or salvage times. Despite at least four published international contouring guidelines from different collaborative groups, discrepancies remain for volumes, delineation, and margins to be considered in order to optimize radiotherapy planning. This article from "Groupe d'Etude des Tumeurs UroGénitales (GETUG)" members will focus on controversies to help clinicians to create best volume delineation for adjuvant or salvage post prostatectomy radiotherapy...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28611300/consistency-mapping-of-16-lymph-node-stations-in-gastric-cancer-by-ct-based-vessel-guided-delineation-of-255-patients
#6
Shuhang Xu, Lingling Feng, Yongming Chen, Ying Sun, Yao Lu, Shaomin Huang, Yang Fu, Rongqin Zheng, Yujing Zhang, Rong Zhang
In order to refine the location and metastasis-risk density of 16 lymph node stations of gastric cancer for neoadjuvant radiotherapy, we retrospectively reviewed the initial images and pathological reports of 255 gastric cancer patients with lymphatic metastasis. Metastatic lymph nodes identified in the initial computed tomography images were investigated by two radiologists with gastrointestinal specialty. A circle with a diameter of 5 mm was used to identify the central position of each metastatic lymph node, defined as the LNc (the central position of the lymph node)...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608305/quality-assurance-of-the-preopanc-trial-2012-003181-40-for-preoperative-radiochemotherapy-in-pancreatic-cancer-the-dummy-run
#7
Eva Versteijne, Eelco Lens, Astrid van der Horst, Arjan Bel, Jorrit Visser, Cornelis J A Punt, Mustafa Suker, Casper H J van Eijck, Geertjan van Tienhoven
BACKGROUND: The Dutch Pancreatic Cancer Group initiated the national, multicentre, controlled PREOPANC trial, randomising between preoperative radiochemotherapy and direct explorative laparotomy for patients with (borderline) resectable pancreatic cancer. The aim of this dummy run is to evaluate compliance with the radiotherapy protocol of this trial, and the quality of delineation and radiation plans. METHODS: Eleven radiation oncology departments open for accrual of patients in the PREOPANC trial were provided with all necessary information of a selected 'dummy' patient...
June 12, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28605532/pet-imaging-in-patients-with-meningioma-report-of-the-rano-pet-group
#8
Norbert Galldiks, Nathalie L Albert, Michael Sommerauer, Anca L Grosu, Ute Ganswindt, Ian Law, Matthias Preusser, Emilie Le Rhun, Michael A Vogelbaum, Gelareh Zadeh, Frédéric Dhermain, Michael Weller, Karl-Josef Langen, Jörg C Tonn
Meningiomas are the most frequent non-glial primary brain tumors and represent about 30% of brain tumors. Usually, diagnosis and treatment planning are based on neuroimaging using mainly magnetic resonance imaging (MRI) or rarely computed tomography (CT). Most common treatment options are neurosurgical resection and radiotherapy, e.g., radiosurgery or external fractionated radiotherapy. For follow-up after treatment, structural imaging techniques such as MRI or CT are used. However, these structural imaging modalities have limitations, particularly in terms of tumor delineation as well as diagnosis of posttherapeutic reactive changes...
June 12, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28600083/evaluation-of-clinical-target-volume-expansion-required-for-involved-site-neck-radiotherapy-for-lymphoma-to-account-for-the-absence-of-a-pre-chemotherapy-pet-ct-in-the-radiotherapy-treatment-position
#9
David Bird, Chirag Patel, Andrew F Scarsbrook, Viv Cosgrove, Emma Thomas, Di Gilson, Robin J D Prestwich
BACKGROUND AND PURPOSE: Involved site radiotherapy clinical target volume (CTV) for lymphoma requires an expansion to account for the absence of radiotherapy treatment-position pre-chemotherapy imaging, which is not widely implemented. This prospective imaging study aims to quantify CTV expansion required for neck radiotherapy. MATERIALS AND METHODS: 10 patients from a prospective single centre imaging study underwent a pre-chemotherapy FDG-PET-CT in both the diagnostic and radiotherapy treatment position, and subsequently received neck radiotherapy post-chemotherapy...
June 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28597183/discrepancies-between-nccn-and-esmo-guidelines-in-the-management-of-anal-cancer-a-qualitative-review
#10
REVIEW
Natalie Johnson, Gianluca Pellino, Constantinos Simillis, Shengyang Qiu, Stella Nikolaou, Daniel L Baird, Shahnawaz Rasheed, Paris P Tekkis, Christos Kontovounisios
There is an ever-growing need, with the ongoing developments in research and the progress towards patient centered care, to delineate standardized protocols of management of anal cancer. However, guidelines from different societies show some degree of disagreement. This is a systematic review of the literature to identify similarities and discrepancies between the guidelines for the management of anal cancer drafted by the European Society for Medical Oncology (ESMO) and by the National Comprehensive Cancer Network (NCCN)...
June 8, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28557799/repeatability-of-dose-painting-by-numbers-treatment-planning-in-prostate-cancer-radiotherapy-based-on-multiparametric-magnetic-resonance-imaging
#11
Marcel A van Schie, Peter Steenbergen, Cuong Viet Dinh, Ghazaleh Ghobadi, Petra van Houdt, Floris Pos, Stijn Heijmink, Henk van der Poel, Steffen Renisch, Torbjoern Vik, Uulke van der Heide
Dose painting by numbers (DPBN) refers to a voxel-wise prescription of radiation dose modelled from functional image characteristics, in contrast to dose painting by contours which requires delineations to define the target for dose escalation. The direct relation between functional imaging characteristics and DPBN implies that random variations in images may propagate into the dose distribution. The stability of MR-only prostate cancer treatment planning based on DPBN with respect to these variations is as yet unknown...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28557792/the-approximate-entropy-concept-extended-to-three-dimensions-for-calibrated-single-parameter-structural-complexity-interrogation-of-volumetric-images
#12
Christopher J Moore, Tom Marchant
Reconstructive volumetric imaging permeates medical practice because of its apparently clear depiction of anatomy. However, the tell tale signs of abnormality and its delineation for treatment demand experts work at the threshold of visibility for hints of structure. Hitherto, a suitable assistive metric that chimes with clinical experience has been absent. This paper develops the complexity measure approximate entropy (ApEn) from its one-dimensional physiological origin into a three-dimensional (3D) algorithm to fill this gap...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28556781/supine-mri-for-regional-breast-radiotherapy-imaging-axillary-lymph-nodes-before-and-after-sentinel-node-biopsy
#13
Tristan C F van Heijst, Debora Eschbach-Zandbergen, Nienke Hoekstra, Bram van Asselen, Jan Lagendijk, Helena Verkooijen, Ruud Pijnappel, Stephanie de Waard, Arjen Witkamp, Thijs van Dalen, H J G van den Bongard, Marielle Philippens
Regional radiotherapy (RT) is increasingly used in breast-cancer treatment. Conventionally, computed tomography (CT) is performed for RT planning. Lymph node (LN) target levels are delineated according to anatomical boundaries. MRI could enable individual LN delineation. The purpose was to evaluate applicability of MRI for LN detection in supine treatment position, before and after sentinel-node biopsy (SNB). 23 female breast-cancer patients (cTis-3N0M0) underwent 1.5T MRI, before and after SNB, additional to CT...
May 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28547592/impact-of-interim-progression-during-the-surgery-to-radiotherapy-interval-and-its-predictors-in-glioblastoma-treated-with-temozolomide-based-radiochemotherapy
#14
Chan Woo Wee, Eunji Kim, Tae Min Kim, Chul-Kee Park, Jin Wook Kim, Seung Hong Choi, Roh-Eul Yoo, Soon-Tae Lee, Il Han Kim
This study was designed to investigate the impact of interim progression of disease (PD) during the surgery-to-radiotherapy interval (SRI) and its predictors in glioblastoma based on MRIs. A total of 222 patients were planned for radiotherapy (RT) and 166 of them were evaluable for the presence of interim PD by 2 separate MRIs. The size criteria from the updated Response Assessment in Neuro-Oncology criteria was adopted to determine interim PD. 32 (19.3%) patients experienced interim PD, and their median survival (MS) was shorter than patients without PD in univariate (11...
May 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28545588/patterns-of-local-regional-recurrence-after-conformal-and-intensity-modulated-radiotherapy-for-head-and-neck-cancer
#15
Safora Johansen, Mathilde H Norman, Einar Dale, Cecilie D Amdal, Torbjørn Furre, Eirik Malinen, Jan F Evensen
AIM: To evaluate the patterns of loco-regional recurrences in head and neck cancer patients METHODS: Twenty-six out of 112 patients treated with primary or postoperative 3D CRT or IMRT for their primary and recurrent disease between 2007 and 2013 were included. The CT images of recurrent disease were rigidly registered with the primary CT images for each patient. To assess overlaps and overlap localization, the recurrence volume overlapping with the primary target volume was identified...
May 25, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28543364/diffusion-weighted-mri-with-minimal-distortion-in-head-and-neck-radiotherapy-using-a-turbo-spin-echo-acquisition-method
#16
Tim Schakel, Johannes M Hoogduin, Chris H J Terhaard, Marielle E P Philippens
PURPOSE: Diffusion weighted (DW) MRI, showing high contrast between tumor and background tissue, is a promising technique in radiotherapy for tumor delineation. However, its use for head-and-neck patients is hampered by poor geometric accuracy in conventional echo planar imaging (EPI) DW-MRI. An alternative turbo spin echo sequence, DW-SPLICE, is implemented and demonstrated in patients. METHODS: The DW-SPLICE sequence was implemented on a 3.0T system and evaluated in 10 patients...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28537761/correlation-analysis-of-18-f-fluorodeoxyglucose-and-18-f-fluoroazomycin-arabinoside-uptake-distributions-in-lung-tumours-during-radiation-therapy
#17
Dario Di Perri, John A Lee, Anne Bol, François-Xavier Hanin, Guillaume Janssens, Daniel Labar, Annie Robert, Edmond Sterpin, Xavier Geets
BACKGROUND: PET-guided dose painting (DP) aims to target radioresistant tumour regions in order to improve radiotherapy (RT) outcome. Besides the well-known [(18)F]fluorodeoxyglucose (FDG), the hypoxia positron emission tomography (PET) tracer [(18)F]fluoroazomycin arabinoside (FAZA) could provide further useful information to guide the radiation dose prescription. In this study, we compare the spatial distributions of FDG and FAZA PET uptakes in lung tumours. MATERIAL AND METHODS: Fourteen patients with unresectable lung cancer underwent FDG and FAZA 4D-PET/CT on consecutive days at three time-points: prior to RT (pre), and during the second (w2), and the third (w3) weeks of RT...
May 24, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28537101/clinical-findings-in-25-patients-with-sinonasal-or-nasopharyngeal-extramedullary-plasmacytoma-in-a-four-decade-single-centre-series
#18
Seija Inkeri Vento, Pauli Vähämurto, Kaija Silventoinen, Marja-Liisa Karjalainen-Lindsberg, Susanna Mannisto, Sirpa Leppä, Antti Aarni Mäkitie
OBJECTIVES: Extramedullary plasmacytoma in the sinonasal tract or nasopharynx is rare. The aim of the study was to review data on symptoms, clinical findings, treatment and follow-up of plasmacytomas in the sinonasal and nasopharyngeal regions in order to delineate the main clinical characteristics and the optimal management. METHOD: Twenty-five patients with sinonasal or nasopharyngeal plasmacytoma, diagnosed and treated at the Helsinki University Hospital during a 39-year period from 1975 to 2013 were retrospectively reviewed...
May 24, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28534430/variability-in-axillary-lymph-node-delineation-for-breast-cancer-radiotherapy-in-presence-of-guidelines-on-a-multi-institutional-platform
#19
Delia Ciardo, Angela Argenone, Genoveva Ionela Boboc, Francesca Cucciarelli, Fiorenza De Rose, Maria Carmen De Santis, Alessandra Huscher, Edy Ippolito, Maria Rosa La Porta, Lorenza Marino, Ilaria Meaglia, Isabella Palumbo, Francesca Rossi, Paolo Alpi, Mario Bignardi, Alessio Bonanni, Domenico Cante, Tino Ceschia, Letizia Fabbietti, Marco Lupattelli, Elisa Donatella Mantero, Alessia Monaco, Patrizia Porcu, Vincenzo Ravo, Sonia Silipigni, Angelo Tozzi, Vincenza Umina, Dario Zerini, Luigi Bordonaro, Giorgia Capezzali, Elena Clerici, Sarah Pia Colangione, Michela Dispinzieri, Jessica Dognini, Laura Donadoni, Sara Falivene, Alessandra Fozza, Barbara Grilli, Roberta Guarnaccia, Eva Iannacone, Valentina Lancellotta, Agnese Prisco, Rosalinda Ricotti, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Maria Cristina Leonardi
AIM: To quantify the variability between radiation oncologists (ROs) when outlining axillary nodes in breast cancer. MATERIAL AND METHODS: For each participating center, three ROs with different levels of expertise, i.e., junior (J), senior (S) and expert (E), contoured axillary nodal levels (L1, L2, L3 and L4) on the CT images of three different patients (P) of an increasing degree of anatomical complexity (from P1 to P2 to P3), according to contouring guidelines...
August 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#20
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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