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Delineation radiotherapy

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https://www.readbyqxmd.com/read/29774168/evaluating-the-potential-for-maximized-t-cell-redistribution-entropy-to-improve-abscopal-responses-to-radiotherapy
#1
Rachel Walker, Jonathan D Schoenfeld, Shari Pilon-Thomas, Jan Poleszczuk, Heiko Enderling
The potential for local radiation therapy to elicit systemic (abscopal) anti-tumor immune responses has been receiving a significant amount of attention over the last decade. We recently developed a mathematical framework designed to simulate the systemic dissemination of activated T cells among multiple metastatic sites. This framework allowed the identification of non-intuitive patterns of T cell redistribution after localized therapy, and offered suggestions as to the optimal site to irradiate in order to increase the magnitude of an immune-mediated abscopal response...
September 2017: Convergent Science Physical Oncology
https://www.readbyqxmd.com/read/29757474/automated-patient-specific-transperineal-ultrasound-probe-setups-for-prostate-cancer-patients-undergoing-radiotherapy
#2
Saskia Maria Camps, Frank Verhaegen, Ben G L Vanneste, Peter H N de With, Davide Fontanarosa
PURPOSE: The use of ultrasound imaging is not widespread in prostate cancer radiotherapy workflows, despite several advantages (e.g. allowing real-time volumetric organ tracking). This can be partially attributed to the need for a trained operator during acquisition and interpretation of the images. We introduce and evaluate an algorithm that can propose a patient-specific transperineal ultrasound probe setup, based on a CT scan and anatomical structure delineations. The use of this setup during the simulation and treatment stage could improve usability of ultrasound imaging for relatively untrained operators (radiotherapists with less than one year experience with ultrasound)...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29751842/psma-pet-based-radiotherapy-a-review-of-initial-experiences-survey-on-current-practice-and-future-perspectives
#3
REVIEW
Sebastian Zschaeck, Fabian Lohaus, Marcus Beck, Gregor Habl, Stephanie Kroeze, Constantinos Zamboglou, Stefan Alexander Koerber, Jürgen Debus, Tobias Hölscher, Peter Wust, Ute Ganswindt, Alexander D J Baur, Klaus Zöphel, Nikola Cihoric, Matthias Guckenberger, Stephanie E Combs, Anca Ligia Grosu, Pirus Ghadjar, Claus Belka
68 Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy...
May 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29740097/impact-of-18-f-fet-pet-on-target-volume-definition-and-tumor-progression-of-recurrent-high-grade-glioma-treated-with-carbon-ion-radiotherapy
#4
Charlotte Debus, Maria Waltenberger, Ralf Floca, Ali Afshar-Oromieh, Nina Bougatf, Sebastian Adeberg, Sabine Heiland, Martin Bendszus, Wolfgang Wick, Stefan Rieken, Uwe Haberkorn, Jürgen Debus, Maximilian Knoll, Amir Abdollahi
High-precision radiotherapy (HPR) of recurrent high grade glioma (HGG) requires accurate spatial allocation of these infiltrative tumors. We investigated the impact of 18 F-FET PET on tumor delineation and progression of recurrent HGG after HPR with carbon ions. T1 contrast enhanced MRI and 18 F-FET-PET scans of 26 HGG patients were fused with radiotherapy planning volumes. PET-positive (PET+) tumor volumes using different isocontours (I%) were systematically investigated and compared with MRI-derived gross tumor volumes (GTV)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733238/dose-response-relationships-of-the-sigmoid-for-urgency-syndrome-after-gynecological-radiotherapy
#5
Eleftheria Alevronta, Viktor Skokic, Ulrica Wilderäng, Gail Dunberger, Fei Sjöberg, Cecilia Bull, Karin Bergmark, Rebecka Jörnsten, Gunnar Steineck
PURPOSE: To find out what organs and doses are most relevant for 'radiation-induced urgency syndrome' in order to derive the corresponding dose-response relationships as an aid for avoiding the syndrome in the future. MATERIAL AND METHODS: From a larger group of gynecological cancer survivors followed-up 2-14 years, we identified 98 whom had undergone external beam radiation therapy but not brachytherapy and not having a stoma. Of those survivors, 24 developed urgency syndrome...
May 7, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29731160/contouring-of-prostate-tumors-on-multiparametric-mri-evaluation-of-clinical-delineations-in-a-multicenter-radiotherapy-trial
#6
Marcel A van Schie, Cuong V Dinh, Petra J van Houdt, Floris J Pos, Stijn W T J P Heijmink, Linda G W Kerkmeijer, Alexis N T J Kotte, Raymond Oyen, Karin Haustermans, Uulke A van der Heide
PURPOSE: To date no guidelines are available for contouring prostate cancer inside the gland, as visible on multiparametric (mp-) MRI. We assessed inter-institutional differences in interpretation of mp-MRI in the multicenter phase III FLAME trial. METHODS: We analyzed clinical delineations on mp-MRI and clinical characteristics from 260 patients across three institutes. We performed a logistic regression analysis to examine each institute's weighting of T2w, ADC and Ktrans intensity maps in the delineation of the cancer...
May 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29729847/siope-brain-tumor-group-consensus-guideline-on-craniospinal-target-volume-delineation-for-high-precision-radiotherapy
#7
Thankamma Ajithkumar, Gail Horan, Laetitia Padovani, Nicky Thorp, Beate Timmermann, Claire Alapetite, Lorenza Gandola, Monica Ramos, Karen Van Beek, Melissa Christiaens, Yasmin Lassen-Ramshad, Henriette Magelssen, Kristina Nilsson, Frank Saran, Barbara Rombi, Rolf Kortmann, Geert O Janssens
OBJECTIVE: To develop a consensus guideline for craniospinal target volume (TV) delineation in children and young adults participating in SIOPE studies in the era of high-precision radiotherapy. METHODS AND MATERIALS: During four consensus meetings (Cambridge, Essen, Liverpool, and Marseille), conventional field-based TV has been translated into image-guided high-precision craniospinal TV by a group of expert paediatric radiation oncologists and enhanced by MRI images of liquor distribution...
May 2, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29729845/plan-optimization-for-mediastinal-radiotherapy-estimation-of-coronary-arteries-motion-with-ecg-gated-cardiac-imaging-and-creation-of-compensatory-expansion-margins
#8
Mario Levis, Viola De Luca, Christian Fiandra, Simona Veglia, Antonella Fava, Marco Gatti, Mauro Giorgi, Sara Bartoncini, Federica Cadoni, Domenica Garabello, Riccardo Ragona, Andrea Riccardo Filippi, Umberto Ricardi
BACKGROUND AND PURPOSE: Inadvertent heart and coronary arteries (CA) irradiation may increase the risk of coronary artery disease (CAD) in patients receiving thoracic irradiation. To date, the entity of cardiac-related CA displacement and the possible margins to be used for planning organs at risk volume (PRV) have been poorly described. Aim of this study was to quantify CA displacement and to estimate PRV through the use of ECG-gated computed tomography (CT) scans. MATERIAL AND METHODS: Eight patients received an ECG-gated intravenous contrast enhanced CT for non-cancer related reasons...
May 2, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29721766/radiotherapy-volume-delineation-using-18f-fdg-pet-ct-modifies-gross-node-volume-in-patients-with-oesophageal-cancer
#9
E Jimenez-Jimenez, P Mateos, N Aymar, R Roncero, I Ortiz, M Gimenez, J Pardo, J Salinas, S Sabater
PURPOSE: Evidence supporting the use of 18F-FDG-PET/CT in the segmentation process of oesophageal cancer for radiotherapy planning is limited. Our aim was to compare the volumes and tumour lengths defined by fused PET/CT vs. CT simulation. MATERIALS AND METHODS: Twenty-nine patients were analyzed. All patients underwent a single PET/CT simulation scan. Two separate GTVs were defined: one based on CT data alone and another based on fused PET/CT data. Volume sizes for both data sets were compared and the spatial overlap was assessed by the Dice similarity coefficient (DSC)...
May 2, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29714086/a-dosimetric-evaluation-on-applying-rtog-based-and-ct-mri-based-delineation-methods-to-brachial-plexus-in-radiotherapy-of-nasopharyngeal-carcinoma-treated-with-helical-tomotherapy
#10
Chi-Him Li, Vincent Wc Wu, George Chiu
OBJECTIVE: In radiotherapy of nasopharyngeal carcinoma (NPC) patients, the brachial plexus (BP) situating at both sides of the neck are often irradiated to high dose. This study was to evaluate different BP delineation methods and analyse the dosimetric consequences when applying BP dose constraints in radiotherapy planning of NPC. METHODS: 15 NPC cases treated radically with helical tomotherapy were recruited. Apart from the original treatment plan (Plan A), two new plans (Plan B & C) with additional BP dose constraints were computed using the same planning computed tomography (CT) images, structures and planning parameters...
May 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29708544/radiation-planning-assistant-a-streamlined-fully-automated-radiotherapy-treatment-planning-system
#11
Laurence E Court, Kelly Kisling, Rachel McCarroll, Lifei Zhang, Jinzhong Yang, Hannah Simonds, Monique du Toit, Chris Trauernicht, Hester Burger, Jeannette Parkes, Mike Mejia, Maureen Bojador, Peter Balter, Daniela Branco, Angela Steinmann, Garrett Baltz, Skylar Gay, Brian Anderson, Carlos Cardenas, Anuja Jhingran, Simona Shaitelman, Oliver Bogler, Kathleen Schmeller, David Followill, Rebecca Howell, Christopher Nelson, Christine Peterson, Beth Beadle
The Radiation Planning Assistant (RPA) is a system developed for the fully automated creation of radiotherapy treatment plans, including volume-modulated arc therapy (VMAT) plans for patients with head/neck cancer and 4-field box plans for patients with cervical cancer. It is a combination of specially developed in-house software that uses an application programming interface to communicate with a commercial radiotherapy treatment planning system. It also interfaces with a commercial secondary dose verification software...
April 11, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29707697/joint-segmentation-of-multiple-thoracic-organs-in-ct-images-with-two-collaborative-deep-architectures
#12
Roger Trullo, Caroline Petitjean, Dong Nie, Dinggang Shen, Su Ruan
Computed Tomography (CT) is the standard imaging technique for radiotherapy planning. The delineation of Organs at Risk (OAR) in thoracic CT images is a necessary step before radiotherapy, for preventing irradiation of healthy organs. However, due to low contrast, multi-organ segmentation is a challenge. In this paper, we focus on developing a novel framework for automatic delineation of OARs. Different from previous works in OAR segmentation where each organ is segmented separately, we propose two collaborative deep architectures to jointly segment all organs, including esophagus, heart, aorta and trachea...
September 2017: Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support: Third International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, Held in Conjunction with MICCAI 2017, Québec City, QC, Canada, Septembe
https://www.readbyqxmd.com/read/29703501/heart-volume-reduction-during-radiotherapy-involving-the-thoracic-region-in-children-an-unexplained-phenomenon
#13
Irma W E M van Dijk, Jorrit Visser, Jan Wiersma, Jessica R van Boggelen, Brian V Balgobind, Elizabeth A M Lieke Feijen, Sophie C Huijskens, Wouter E M Kok, Leontien C M Kremer, Coen R N Rasch, Arjan Bel
BACKGROUND AND PURPOSE: Radiotherapy involving the thoracic region is associated with cardiotoxicity in long-term childhood cancer survivors. We quantified heart volume changes during radiotherapy in children (<18 years) and investigated correlations with patient and treatment related characteristics. MATERIAL AND METHODS: Between 2010 and 2016, 34 children received radiotherapy involving the thoracic region. We delineated heart contours and measured heart volumes on 114 CBCTs...
April 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29698389/importance-of-integrating-nanotechnology-with-pharmacology-and-physiology-for-innovative-drug-delivery-and-therapy-an-illustration-with-firsthand-examples
#14
REVIEW
Rui Xue Zhang, Jason Li, Tian Zhang, Mohammad A Amini, Chunsheng He, Brian Lu, Taksim Ahmed, HoYin Lip, Andrew M Rauth, Xiao Yu Wu
Nanotechnology has been applied extensively in drug delivery to improve the therapeutic outcomes of various diseases. Tremendous efforts have been focused on the development of novel nanoparticles and delineation of the physicochemical properties of nanoparticles in relation to their biological fate and functions. However, in the design and evaluation of these nanotechnology-based drug delivery systems, the pharmacology of delivered drugs and the (patho-)physiology of the host have received less attention. In this review, we discuss important pharmacological mechanisms, physiological characteristics, and pathological factors that have been integrated into the design of nanotechnology-enabled drug delivery systems and therapies...
May 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29698060/dosimetric-comparison-of-five-different-techniques-for-craniospinal-irradiation-across-15-european-centers-analysis-on-behalf-of-the-siop-e-btg-radiotherapy-working-group
#15
Enrica Seravalli, Mirjam Bosman, Yasmin Lassen-Ramshad, Anne Vestergaard, Foppe Oldenburger, Jorrit Visser, Efi Koutsouveli, Chryssa Paraskevopoulou, Gail Horan, Thankamma Ajithkumar, Beate Timmermann, Carolina-Sofia Fuentes, Gillian Whitfield, Thomas Marchant, Laetitia Padovani, Eloise Garnier, Lorenza Gandola, Silvia Meroni, Bianca A W Hoeben, Martijn Kusters, Claire Alapetite, Sandra Losa, Farid Goudjil, Henriette Magelssen, Morten Egeberg Evensen, Frank Saran, Gregory Smyth, Barbara Rombi, Roberto Righetto, Rolf-Dieter Kortmann, Geert O Janssens
PURPOSE: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy® , proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year-old patient, we aimed to compare dose distributions of five CSI techniques applied across Europe and generated according to the participating institute protocols, therefore representing daily practice. MATERIAL AND METHODS: A multicenter (n = 15) dosimetric analysis of five different techniques for CSI (3D-CRT, IMRT, VMAT, TomoTherapy® , PBS; 3 centers per technique) was performed using the same patient data, set of delineations and dose prescription (36...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29681500/moving-toward-uniform-and-evidence-based-practice-of-radiotherapy-for-management-of-cervical-cancer-in-ontario-canada
#16
Negin Shahid, Timothy Craig, Mary Westerland, Allison Ashworth, Michelle Ang, David D'Souza, Raxa Sankreacha, Anthony Fyles, Michael Milosevic, Iwa Kong
PURPOSE: To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province. METHODS AND MATERIALS: An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care Ontario Gynecology Community of Practice (CoP) in 2013. The survey included 72 questions in four different categories: general/demographic, pretreatment assessment, external beam radiotherapy (EBRT), and brachytherapy (BT)...
April 19, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29680921/neurosurgical-treatment-of-gangliogliomas-in-children-and-adolescents-long-term-follow-up-of-a-single-institution-series-of-32-patients
#17
Tryggve Lundar, Bernt Johan Due-Tønnessen, Radek Fric, Arild Egge, Bård Krossnes, Paulina Due-Tønnessen, Einar Stensvold, Petter Brandal
OBJECT: The object of this study was to delineate long-term results of the surgical treatment of pediatric tumors classified as ganglioglioma or gangliocytoma. METHODS: A cohort of consecutive patients 19 years or younger who had undergone primary resection of CNS tumors during the years 1980-2016 at a single institution were reviewed in this retrospective study of surgical morbidity, mortality, and academic achievement and/or work participation. Gross motor function and activities of daily living were scored using the Barthel Index (BI)...
April 22, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29670654/toxicities-associated-with-cisplatin-based-chemotherapy-and-radiotherapy-in-long-term-testicular-cancer-survivors
#18
REVIEW
Chunkit Fung, Paul Dinh, Shirin Ardeshir-Rouhani-Fard, Kerry Schaffer, Sophie D Fossa, Lois B Travis
Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro- and ototoxicity, pulmonary complications, nephrotoxicity, hypogonadism, infertility, and avascular necrosis...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29668513/prognostic-value-of-metabolic-tumor-volume-and-total-lesion-glycolysis-in-esophageal-carcinoma-patients-treated-with-definitive-chemoradiotherapy
#19
Berna A Yildirim, Nese Torun, Ozan C Guler, Cem Onal
PURPOSE: The aim of this study was to evaluate the prognostic importance metabolic tumor volume (MTV), total lesion glycolysis (TLG), and standardized uptake value (SUV) in patients with esophageal cancer treated with definitive chemoradiotherapy. PATIENTS AND METHODS: Seventy-two esophageal cancer patients treated with definitive chemoradiotherapy [57 (79%) patients] or definitive radiotherapy [15 (21%) patients] were retrospectively analyzed. The regions equal to or greater than SUV of 2...
April 17, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#20
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
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