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Delineation radiotherapy

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https://www.readbyqxmd.com/read/28927030/implementation-of-diffusion-weighted-magnetic-resonance-imaging-in-target-delineation-of-central-lung-cancer-accompanied-with-atelectasis-in-precision-radiotherapy
#1
Xinli Zhang, Zheng Fu, Guanzhong Gong, Hong Wei, Jinghao Duan, Zhaoqiu Chen, Xiangming Chen, Ruozheng Wang, Yong Yin
Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emission tomography (PET) in the target delineation of cancer. However, the implication of DW-MRI in lung cancer, the leading cause of cancer-associated mortality worldwide, has not been extensively evaluated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28919003/inter-observer-agreement-in-gtv-delineation-of-bone-metastases-on-ct-and-impact-of-mr-imaging-a-multicenter-study
#2
A S Gerlich, J M van der Velden, A N T J Kotte, C L Tseng, G Fanetti, W S C Eppinga, N Kasperts, M P W Intven, F A Pameijer, M E P Philippens, H M Verkooijen, E Seravalli
BACKGROUND AND PURPOSE: The use of Stereotactic Body Radiotherapy (SBRT) for bone metastases is increasing rapidly. Therefore, knowledge of the inter-observer differences in tumor volume delineation is essential to guarantee precise dose delivery. The aim of this study is to compare inter-observer agreement in bone metastases delineated on different imaging modalities. MATERIAL AND METHODS: Twenty consecutive patients with bone metastases treated with SBRT were selected...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28890821/feasibility-and-reproducibility-of-substituting-oral-contrast-with-water-for-duodenal-volume-delineation-in-patients-undergoing-pancreatic-stereotactic-body-radiotherapy
#3
Guangyin Wu, Vivek Verma, Matthias F Haefner, Sicong Li, Chi Lin
BACKGROUND: This is the first known report evaluating the feasibility of substituting oral contrast with water in efforts to delineate the duodenum for pancreatic stereotactic body radiotherapy (SBRT). METHODS: From January 2015 to August 2016, 13 patients were simulated after ingestion of 8 ounces of water approximately 15-20 min prior to their simulation scan. We examined the feasibility of contouring the duodenum thereafter, and measured the duodenal volume as well as its variation...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28886980/-dose-constraints-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-small-bowel-and-duodenum
#4
F Goupy, E Chajon, J Castelli, É Le Prisé, L Duvergé, N Jaksic, G Vogin, É Monpetit, V Klein, L de Bosschère, P Maingon
Radiotherapy of abdominopelvic primary or secondary lesions in conformational or stereotactic techniques is in full development. The small bowel is highly sensitive to irradiation and is the main organ at risk limiting prescription doses. This literature review aims to define the dose constraints to the small bowel and the duodenum in conformational and stereotactic body radiotherapy. The small bowel including the duodenum, jejunum and ileum is delineated on the simulation scanner. The radio-induced intestinal toxicities are acute related to the cellular depopulation of the intestinal mucosa, and late of more complex pathophysiology associating depletion in stem cells, microangiopathy, chronic inflammation and fibrosis...
September 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28885196/propagation-of-registration-uncertainty-during-multi-fraction-cervical-cancer-brachytherapy
#5
Alborz Amir-Khalili, Ghassan Hamarneh, Roja Zakariaee, Ingrid Spadinger, Rafeef Abugharbieh
Multi-fraction cervical cancer brachytherapy is a form of image-guided radiotherapy that heavily relies on 3D imaging during treatment planning, delivery, and quality control. In this context, deformable image registration can increase the accuracy of dosimetric evaluations, provided that one can account for the uncertainties associated with the registration process. To enable such capability, we propose a mathematical framework that first estimates the registration uncertainty and subsequently propagates the effects of the computed uncertainties from the registration stage through to the visualizations, organ segmentations, and dosimetric evaluations...
September 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28885090/difference-in-target-definition-using-three-different-methods-to-include-respiratory-motion-in-radiotherapy-of-lung-cancer
#6
Ditte Sloth Møller, Marianne Marquard Knap, Tine Bisballe Nyeng, Azza Ahmed Khalil, Marianne Ingerslev Holt, Maria Kandi, Lone Hoffmann
INTRODUCTION: Minimizing the planning target volume (PTV) while ensuring sufficient target coverage during the entire respiratory cycle is essential for free-breathing radiotherapy of lung cancer. Different methods are used to incorporate the respiratory motion into the PTV. MATERIAL AND METHODS: Fifteen patients were analyzed. Respiration can be included in the target delineation process creating a respiratory GTV, denoted iGTV. Alternatively, the respiratory amplitude (A) can be measured based on the 4D-CT and A can be incorporated in the margin expansion...
September 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28866897/superior-target-delineation-for-stereotactic-body-radiotherapy-of-bone-metastases-from-renal-cell-carcinoma-on-mri-compared-to-ct
#7
Fieke M Prins, Joanne M van der Velden, Anne S Gerlich, Alexis N T J Kotte, Wietse S C Eppinga, Nicolien Kasperts, Jorrit J Verlaan, Frank A Pameijer, Linda G W Kerkmeijer
BACKGROUND: In metastatic renal cell carcinoma (mRCC) there has been a treatment shift towards targeted therapy, which has resulted in improved overall survival. Therefore, there is a need for better local control of the tumor and its metastases. Image-guided stereotactic body radiotherapy (SBRT) in bone metastases provides improved symptom palliation and local control. With the use of SBRT there is a need for accurate target delineation. The hypothesis is that MRI allows for better visualization of the extend of bone metastases in mRCC and will optimize the accuracy of tumor delineation for stereotactic radiotherapy purposes, compared with CT only...
July 11, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28865521/emphasis-on-repair-not-just-avoidance-of-injury-facilitates-prudent-stereotactic-ablative-radiotherapy
#8
REVIEW
D W Nathan Kim, Paul M Medin, Robert D Timmerman
Stereotactic ablative radiotherapy (SAbR) is a potent, hypofractionated treatment against cancer which puts adjacent normal tissue in potential peril. Accurate delineation of normal tissue injury risks from SAbR has been challenging, and lack of clear understanding of SAbR tolerance continues to limit its potential. In this review, we contend that SAbR effects on normal tissue could be akin to a surgical "wound," and that adequate wound repair of organs at risk is an essential component of effective SAbR therapy...
October 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28864225/rna-interference-for-glioblastoma-therapy-innovation-ladder-from-the-bench-to-clinical-trials
#9
REVIEW
Eunice L Lozada-Delgado, Nilmary Grafals-Ruiz, Pablo E Vivas-Mejía
Glioblastoma multiforme (GBM) is the most common and deadliest type of primary brain tumor with a prognosis of 14months after diagnosis. Current treatment for GBM patients includes "total" tumor resection, temozolomide-based chemotherapy, radiotherapy or a combination of these options. Although, several targeted therapies, gene therapy, and immunotherapy are currently in the clinic and/or in clinical trials, the overall survival of GBM patients has hardly improved over the last two decades. Therefore, novel multitarget modalities are urgently needed...
August 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/28862115/new-language-and-old-problems-in-breast-cancer-radiotherapy
#10
Ion Christian Chiricuţă
New developments in breast cancer radiotherapy make possible new standards in treatment recommandations based on international guidelines. Developments in radiotherapy irradiation techniques from 2D to 3D-Conformal RT and to IMRT (Intensity Modulated Arc Therapy) make possible to reduce the usual side effects on the organs at risk as: skin, lung, miocard, bone, esophagus and brahial plexus. Dispite of all these progresses acute and late side effects are present. Side effects are as old as the radiotherapy was used...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28859933/evaluation-of-high-dose-volumetric-ct-to-reduce-inter-observer-delineation-variability-and-ptv-margins-for-prostate-cancer-radiotherapy
#11
Hamideh Alasti, Young-Bin Cho, Charles Catton, Alejandro Berlin, Peter Chung, Andrew Bayley, Aaron Vandermeer, Vickie Kong, David Jaffray
PURPOSE: The aim was to determine whether the enhanced soft tissue contrast provided by high-dose volumetric CT (HDVCT) can reduce inter-observer variability in delineating prostate compared to helical conventional CT (CCT) scans and 3T MRI scans for patients undergoing radical prostate cancer radiotherapy. Secondly, to quantify the potential PTV reduction with decreased inter-observer variability. MATERIALS AND METHODS: A 320 slice volumetric CT scanner was used...
August 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28834112/the-role-of-ct-myelography-in-sparing-the-spinal-cord-during-definitive-radiotherapy-in-vertebral-hemangioma
#12
S P Sudha, M S Gopalakrishnan, K Saravanan
INTRODUCTION: The spinal cord is poorly visualized on CT images but is well visualized in MRI images. However, implants used for spinal stabilization can produce artifacts on the MRI images which can interfere with identification of the cord. CT myelography in conjunction with CT simulation helps to clearly delineate the cord. MATERIALS AND METHODS: CT simulation was done in a patient with vertebral hemangioma. Pre- and post myelography images were obtained. Two plans were generated on pre and post myelography CT images using Eclipse™ treatment planning system (TPS) version 10...
August 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28830717/mid-radiotherapy-pet-ct-for-prognostication-and-detection-of-early-progression-in-patients-with-stage-iii-non-small-cell-lung-cancer
#13
Michael F Gensheimer, Julian C Hong, Christine Chang-Halpenny, Hui Zhu, Neville C W Eclov, Jacqueline To, James D Murphy, Heather A Wakelee, Joel W Neal, Quynh-Thu Le, Wendy Y Hara, Andrew Quon, Peter G Maxim, Edward E Graves, Michael R Olson, Maximilian Diehn, Billy W Loo
BACKGROUND AND PURPOSE: Pre- and mid-radiotherapy FDG-PET metrics have been proposed as biomarkers of recurrence and survival in patients treated for stage III non-small cell lung cancer. We evaluated these metrics in patients treated with definitive radiation therapy (RT). We also evaluated outcomes after progression on mid-radiotherapy PET/CT. MATERIAL AND METHODS: Seventy-seven patients treated with RT with or without chemotherapy were included in this retrospective study...
August 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28830203/multimodal-image-registration-for-the-identification-of-dominant-intraprostatic-lesion-in-high-precision-radiotherapy-treatments
#14
Delia Ciardo, Barbara Alicja Jereczek-Fossa, Giuseppe Petralia, Giorgia Timon, Dario Zerini, Raffaella Cambria, Elena Rondi, Federica Cattani, Alessia Bazani, Rosalinda Ricotti, Maria Garioni, Davide Maestri, Giulia Marvaso, Paola Romanelli, Marco Riboldi, Guido Baroni, Roberto Orecchia
PURPOSE: The integration of computed tomography (CT) and multiparametric magnetic resonance imaging (mpMRI) is a challenging task in high-precision radiotherapy for prostate cancer. A simple methodology for multimodal deformable image registration (DIR) of prostate cancer patients is presented. METHODS: CT and mpMRI of ten patients were considered. Organs at risk and prostate were contoured on both scans. The dominant intraprostatic lesion was additionally delineated on magnetic resonance imaging...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28830202/radiological-distribution-of-brain-metastases-and-it-s-implication-for-the-hippocampus-avoidance-in-whole-brain-radiotherapy-approach
#15
Yi-Min Han, Gang Cai, Wei-Min Chai, Cheng Xu, Lu Cao, Dan Ou, Jia-Yi Chen, Youlia M Kirova
PURPOSE: Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less impaired cognitive function than conventional WBRT. The study aims to assess the radiological distribution of BMs with relation to the hippocampus and peri-hippocampus(PH) region as defined by the RTOG 0933 for better understanding of margin definition in HA-WBRT treatment planning. METHODS: Consecutive patients with diagnosis of BM from enhanced MRI between 03/2011 and 07/2016 were analyzed...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28811150/best-practice-recommendations-for-the-retention-of-radiotherapy-records
#16
E Lockhart, K Bak, L J Schreiner, D C Hodgson, E Gutierrez, P Warde, M B Sharpe
This paper offers best practice recommendations for the maintenance and retention of radiotherapy health records and technical information for cancer programmes. The recommendations are based on a review of the published and grey literature, feedback from key informants from seven countries and expert consensus. Ideally, complete health records should be retained for 5 years beyond the patient's lifetime, regardless of where they are created and maintained. Technical information constituting the radiotherapy plan should also be retained beyond the patient's lifetime for 5 years, including the primary images, contours of delineated targets and critical organs, dose distributions and other radiotherapy plan objects...
August 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28806994/patterns-of-locoregional-failure-following-post-operative-intensity-modulated-radiotherapy-to-oral-cavity-cancer-quantitative-spatial-and-dosimetric-analysis-using-a-deformable-image-registration-workflow
#17
Abdallah S R Mohamed, Andrew J Wong, Clifton D Fuller, Mona Kamal, Gary B Gunn, Jack Phan, William H Morrison, Beth M Beadle, Heath Skinner, Stephen Y Lai, Sean R Quinlan-Davidson, Abdelaziz M Belal, Ahmed G El-Gowily, Steven J Frank, David I Rosenthal, Adam S Garden
BACKGROUND: We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). METHODS: Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28806990/dvh-and-ntcp-based-dosimetric-comparison-of-different-longitudinal-margins-for-vmat-imrt-of-esophageal-cancer
#18
S Münch, M Oechsner, S E Combs, D Habermehl
PURPOSE: To cover the microscopic tumor spread in squamous cell carcinoma of the esophagus (SCC), longitudinal margins of 3-4 cm are used for radiotherapy (RT) protocols. However, smaller margins of 2-3 cm might be reasonable when advanced diagnostic imaging is integrated into target volume delineation. Purpose of this study was to compare the dose distribution and deposition to the organs at risk (OAR) for different longitudinal margins using a DVH- and NTCP-based approach. METHODS: Ten patients with SCC of the middle or lower third were retrospectively selected...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28803447/registration-free-automatic-identification-of-gold-fiducial-markers-in-mri-target-delineation-images-for-prostate-radiotherapy
#19
Christian Gustafsson, Juha Korhonen, Emilia Persson, Adalsteinn Gunnlaugsson, Tufve Nyholm, Lars E Olsson
PURPOSE: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appear hyperintense on CT. On T2 weighted (T2w) MRI target delineation images the GFM appear as a small signal void similar to calcifications and post biopsy fibrosis. It can therefore be difficult to identify the markers without CT...
August 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28802328/hybrid-pet-mri-co-segmentation-based-on-joint-fuzzy-connectedness-and-graph-cut
#20
Arafet Sbei, Khaoula ElBedoui, Walid Barhoumi, Philippe Maksud, Chokri Maktouf
BACKGROUND AND OBJECTIVE: Tumor segmentation from hybrid PET/MRI scans may be highly beneficial in radiotherapy treatment planning. Indeed, it gives for both modalities the suitable information that could make the delineation of tumors more accurate than using each one apart. We aim in this work to propose a co-segmentation method that deals with several challenges, notably the lack of one-to-one correspondence between tumors of the two modalities and the boundaries' smoothing. METHODS: The proposed method is designed to surpass these limits, we propose a segmentation method based on the GCsum(max) technique...
October 2017: Computer Methods and Programs in Biomedicine
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