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Delineation radiotherapy

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https://www.readbyqxmd.com/read/28811150/best-practice-recommendations-for-the-retention-of-radiotherapy-records
#1
E Lockhart, K Bak, L J Schreiner, D C Hodgson, E Gutierrez, P Warde, M B Sharpe
This paper offers best practice recommendations for the maintenance and retention of radiotherapy health records and technical information for cancer programmes. The recommendations are based on a review of the published and grey literature, feedback from key informants from seven countries and expert consensus. Ideally, complete health records should be retained for 5 years beyond the patient's lifetime, regardless of where they are created and maintained. Technical information constituting the radiotherapy plan should also be retained beyond the patient's lifetime for 5 years, including the primary images, contours of delineated targets and critical organs, dose distributions and other radiotherapy plan objects...
August 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28806994/patterns-of-locoregional-failure-following-post-operative-intensity-modulated-radiotherapy-to-oral-cavity-cancer-quantitative-spatial-and-dosimetric-analysis-using-a-deformable-image-registration-workflow
#2
Abdallah S R Mohamed, Andrew J Wong, Clifton D Fuller, Mona Kamal, Gary B Gunn, Jack Phan, William H Morrison, Beth M Beadle, Heath Skinner, Stephen Y Lai, Sean R Quinlan-Davidson, Abdelaziz M Belal, Ahmed G El-Gowily, Steven J Frank, David I Rosenthal, Adam S Garden
BACKGROUND: We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). METHODS: Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28806990/dvh-and-ntcp-based-dosimetric-comparison-of-different-longitudinal-margins-for-vmat-imrt-of-esophageal-cancer
#3
S Münch, M Oechsner, S E Combs, D Habermehl
PURPOSE: To cover the microscopic tumor spread in squamous cell carcinoma of the esophagus (SCC), longitudinal margins of 3-4 cm are used for radiotherapy (RT) protocols. However, smaller margins of 2-3 cm might be reasonable when advanced diagnostic imaging is integrated into target volume delineation. Purpose of this study was to compare the dose distribution and deposition to the organs at risk (OAR) for different longitudinal margins using a DVH- and NTCP-based approach. METHODS: Ten patients with SCC of the middle or lower third were retrospectively selected...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28803447/registration-free-automatic-identification-of-gold-fiducial-markers-in-mri-target-delineation-images-for-prostate-radiotherapy
#4
Christian Gustafsson, Juha Korhonen, Emilia Persson, Adalsteinn Gunnlaugsson, Tufve Nyholm, Lars E Olsson
PURPOSE: The superior soft tissue contrast of magnetic resonance imaging (MRI) compared to computed tomography (CT) has urged the integration of MRI and elimination of CT in radiotherapy treatment (RT) for prostate. An intraprostatic gold fiducial marker (GFM) appear hyperintense on CT. On T2 weighted (T2w) MRI target delineation images the GFM appear as a small signal void similar to calcifications and post biopsy fibrosis. It can therefore be difficult to identify the markers without CT...
August 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28802328/hybrid-pet-mri-co-segmentation-based-on-joint-fuzzy-connectedness-and-graph-cut
#5
Arafet Sbei, Khaoula ElBedoui, Walid Barhoumi, Philippe Maksud, Chokri Maktouf
BACKGROUND AND OBJECTIVE: Tumor segmentation from hybrid PET/MRI scans may be highly beneficial in radiotherapy treatment planning. Indeed, it gives for both modalities the suitable information that could make the delineation of tumors more accurate than using each one apart. We aim in this work to propose a co-segmentation method that deals with several challenges, notably the lack of one-to-one correspondence between tumors of the two modalities and the boundaries' smoothing. METHODS: The proposed method is designed to surpass these limits, we propose a segmentation method based on the GCsum(max) technique...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28792468/real-time-external-respiratory-motion-measuring-technique-using-an-rgb-d-camera-and-principal-component-analysis
#6
Udaya Wijenayake, Soon-Yong Park
Accurate tracking and modeling of internal and external respiratory motion in the thoracic and abdominal regions of a human body is a highly discussed topic in external beam radiotherapy treatment. Errors in target/normal tissue delineation and dose calculation and the increment of the healthy tissues being exposed to high radiation doses are some of the unsolicited problems caused due to inaccurate tracking of the respiratory motion. Many related works have been introduced for respiratory motion modeling, but a majority of them highly depend on radiography/fluoroscopy imaging, wearable markers or surgical node implanting techniques...
August 9, 2017: Sensors
https://www.readbyqxmd.com/read/28781156/evaluation-of-deformed-image-based-dose-calculations-for-adaptive-radiotherapy-of-nasopharyngeal-carcinoma
#7
Miranda Poon, Catherine Holborn, Ka Fai Cheng, Winky Wing Ki Fung, George Chiu
The ultimate goal of adaptive radiotherapy (ART) is to deliver truly customized radiation treatments. Currently, the quality of cone-beam computed tomography (CBCT) images is still inferior to that of conventional CT images in contour delineations and dose calculations for replanning purposes. This retrospective study aims to evaluate the dosimetric accuracy of using deformed conventional CT images for dose calculations, in the hope of inferring the feasibility of ART using planning CT (PCT) images that deformed to up-to-date CBCT images for patients with nasopharyngeal carcinoma (NPC)...
August 3, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28766726/a-novel-3d-printed-phantom-insert-for-4d-pet-ct-imaging-and-simultaneous-integrated-boost-radiotherapy
#8
Laura Cerviño, Dima Soultan, Mariel Cornell, Adam Yock, Niclas Pettersson, William Y Song, Joseph Aguilera, Sunil Advani, James Murphy, Carl Ho, Claude James, Anthony Paravati, Robin Coope, Bradford Gill, Vitali Moiseenko
PURPOSE: To construct a 3D-printed phantom insert designed to mimic the variable PET tracer uptake seen in lung tumor volumes and a matching dosimetric insert to be used in simultaneous integrated boost (SIB) phantom studies, and to evaluate the design through end-to-end tests. METHODS: A set of phantom inserts was designed and manufactured for a realistic representation of gated radiotherapy steps from 4D PET/CT scanning to dose delivery. A cylindrical phantom (φ80x120 mm) holds inserts for PET/CT scanning...
August 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/28749231/phase-%C3%A2-study-of-concurrent-chemoradiotherapy-with-a-modified-target-volumes-delineation-method-for-inoperable-esophageal-cancer-patients
#9
Wenyi Zhang, Huifang Li, Xingxing Chen, Meng Su, Ruifang Lin, Changlin Zou
OBJECTIVE: A Phase || study was designed to test the safety and efficacy of concurrent chemoradiotherapy with a modified target volumes delineation method for inoperable esophageal cancer patients. METHODS: All eligible patients were treated with concurrent chemoradiotherapy. The method of delineating target volume was as follow: Planning gross target volume (PGTV) was defined as the primary gross tumor volume (GTV-t) plus a 3 cm margin longitudinally and a 0...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28749171/prospective-evaluation-of-a-specific-technique-of-sexual-function-preservation-in-external-beam-radiotherapy-for-prostate-cancer
#10
Hamza Samlali, Corina Udrescu, Ariane Lapierre, Ciprian Enachescu, Alain Ruffion, Patrice Jalade, Olivier Chapet
OBJECTIVES: Sexual preservation is an important issue in the treatment of localized prostate cancer. A technique of irradiation was developed to better preserve this function and has been evaluated. METHODS: Eleven patients, with no erectile dysfunction (ED), were treated with daily IMRTIGRT (total dose: 76-78 Gy). The pudendal arteries, penile bulb and cavernous body were delineated on the planning CT scan. The doses to these structures (with a 5 mm margin) were optimized to be as low as possible...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28740459/dosimetric-predictors-of-treatment-related-lymphopenia-induced-by-palliative-radiotherapy-predictive-ability-of-dose-volume-parameters-based-on-body-surface-contour
#11
Tetsuo Saito, Ryo Toya, Tomohiko Matsuyama, Akiko Semba, Natsuo Oya
BACKGROUND: Radiation-related lymphopenia has been associated with poor patient outcome. Our aim was to identify predictors of lymphopenia after palliative radiotherapy, with a focus on dose-volume parameters. PATIENTS AND METHODS: To retrospectively assess patients with various cancers who had undergone palliative radiotherapy, we delineated three organs at risk: the volume enclosed by the body surface contour (body A), the volume left after excluding air, pleural effusion, ascites, bile, urine, and intestinal content (body B), and the volume of the bone marrow (BM)...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740451/mri-reduces-variation-of-contouring-for-boost-clinical-target-volume-in-breast-cancer-patients-without-surgical-clips-in-the-tumour-bed
#12
Noora Al-Hammadi, Palmira Caparrotti, Saju Divakar, Mohamed Riyas, Suparna Halsnad Chandramouli, Rabih Hammoud, Jillian Hayes, Maeve Mc Garry, Satheesh Prasad Paloor, Primoz Petric
BACKGROUND: Omitting the placement of clips inside tumour bed during breast cancer surgery poses a challenge for delineation of lumpectomy cavity clinical target volume (CTVLC). We aimed to quantify inter-observer variation and accuracy for CT- and MRI-based segmentation of CTVLC in patients without clips. PATIENTS AND METHODS: CT- and MRI-simulator images of 12 breast cancer patients, treated by breast conserving surgery and radiotherapy, were included in this study...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740408/induction-chemotherapy-followed-by-intensity-modulated-radiotherapy-with-reduced-gross-tumor-volume-delineation-for-stage-t3-4-nasopharyngeal-carcinoma
#13
Fen Xue, Chaosu Hu, Xiayun He
PURPOSE: A common problem in stage T3-4 nasopharyngeal carcinoma (NPC) is the narrow gap between the primary tumor and neurological structures, which makes dose optimization difficult. Considering that significant tumor shrinkage may occur during induction chemotherapy (IC), this study explored the efficacy of intensity-modulated radiotherapy (IMRT) using reduced gross tumor volume (GTV) in the treatment of T3-4 NPC. PATIENTS AND METHODS: Between January 2009 and April 2014, 103 patients with non-metastatic stage T3-4 NPC were prospectively recruited...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28736648/the-utility-of-positron-emission-tomography-computed-tomography-in-target-delineation-for-stereotactic-body-radiotherapy-for-liver-metastasis-from-primary-gastric-cancer-an-illustrative-case-report-and-literature-review
#14
Gary D Lewis, Stephen B Chiang, E Brian Butler, Bin S Teh
The liver is a common site for metastatic disease for many cancers. Radiation therapy is one means of treatment for liver metastases, especially for patients unable to undergo surgery or ineligible for systemic chemotherapy. In particular, stereotactic body radiotherapy (SBRT) has become an important option in the treatment of metastatic disease in the liver. SBRT delivers ablative doses of radiation in relatively few fractions. As such, precise and clear imaging plays an important role in maximizing disease control while minimizing normal tissue toxicity...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28723274/identifying-voxels-at-risk-for-progression-in-glioblastoma-based-on-dosimetry-physiologic-and-metabolic-mri
#15
Mekhail Anwar, Annette M Molinaro, Olivier Morin, Susan M Chang, Daphne A Haas-Kogan, Sarah J Nelson, Janine M Lupo
Despite the longstanding role of radiation in cancer treatment and the presence of advanced, high-resolution imaging techniques, delineation of voxels at-risk for progression remains purely a geometric expansion of anatomic images, missing subclinical disease at risk for recurrence while treating potentially uninvolved tissue and increasing toxicity. This remains despite the modern ability to precisely shape radiation fields. A striking example of this is the treatment of glioblastoma, a highly infiltrative tumor that may benefit from accurate identification of subclinical disease...
July 19, 2017: Radiation Research
https://www.readbyqxmd.com/read/28716090/clinical-workflow-for-mr-only-simulation-and-planning-in-prostate
#16
Neelam Tyagi, Sandra Fontenla, Michael Zelefsky, Marcia Chong-Ton, Kyle Ostergren, Niral Shah, Lizette Warner, Mo Kadbi, Jim Mechalakos, Margie Hunt
PURPOSE: To describe the details and experience of implementing a MR-only workflow in the clinic for simulation and planning of prostate cancer patients. METHODS: Forty-eight prostate cancer patients from June 2016 - Dec 2016 receiving external beam radiotherapy were scheduled to undergo MR-only simulation. MR images were acquired for contouring (T2w axial, coronal, sagittal), synthetic-CT generation (3D FFE-based) and fiducial identification (3D bFFE-based). The total acquisition time was 25 min...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28712277/moderate-hypofractionated-image-guided-thoracic-radiotherapy-for-locally-advanced-node-positive-non-small-cell-lung-cancer-patients-with-very-limited-lung-function-a-case-report
#17
Farkhad Manapov, Olarn Roengvoraphoj, Minglun Li, Chukwuka Eze
Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second [FEV1] ≤ 1 L) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28707199/radiation-induced-inflammatory-cascade-and-its-reverberating-crosstalks-as-potential-cause-of-post-radiotherapy-second-malignancies
#18
REVIEW
Sonia Gandhi, Sudhir Chandna
The disease-free survival following radiotherapy is often limited by the development of second/secondary cancers. This significant impediment to effective cancer treatment implicated even in the modern-day radiotherapy needs to be countered effectively. Critical analysis reveals that besides achieving effective tumor control, radiotherapy elicits certain cellular and systemic inflammatory events in tumor infiltrate, which remain relatively stable and tend to facilitate "in-field" or "out of field" oncogenesis in due course of time...
July 13, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28695316/interobserver-variability-in-target-volume-delineation-of-hepatocellular-carcinoma-an-analysis-of-the-working-group-stereotactic-radiotherapy-of-the-german-society-for-radiation-oncology-degro
#19
E Gkika, S Tanadini-Lang, S Kirste, P A Holzner, H P Neeff, H C Rischke, T Reese, F Lohaus, M N Duma, K Dieckmann, R Semrau, M Stockinger, D Imhoff, N Kremers, M F Häfner, N Andratschke, U Nestle, A L Grosu, M Guckenberger, T B Brunner
BACKGROUND: Definition of gross tumor volume (GTV) in hepatocellular carcinoma (HCC) requires dedicated imaging in multiple contrast medium phases. The aim of this study was to evaluate the interobserver agreement (IOA) in gross tumor delineation of HCC in a multicenter panel. METHODS: The analysis was performed within the "Stereotactic Radiotherapy" working group of the German Society for Radiation Oncology (DEGRO). The GTVs of three anonymized HCC cases were delineated by 16 physicians from nine centers using multiphasic CT scans...
July 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28660318/reduced-volume-radiotherapy-for-patients-with-localized-intracranial-nongerminoma-germ-cell-tumors
#20
Brian De, Oren Cahlon, Ira J Dunkel, Kevin C De Braganca, Yasmin Khakoo, Stephen W Gilheeney, Mark M Souweidane, Suzanne L Wolden
Craniospinal irradiation is standard radiotherapy (RT) for localized intracranial nongerminoma germ cell tumors (NGGCT). Given its toxicity, there is interest in using smaller fields. We examined outcomes of NGGCT patients receiving reduced-volume RT at a single institution. Records of 16 patients who received reduced-volume RT as part of definitive treatment between 1996 and 2016 were reviewed. Median age at presentation was 10.8 years (range 4.6-41.0 years). Ten patients had pineal tumors and 6 had suprasellar tumors...
June 28, 2017: Journal of Neuro-oncology
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