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Delineation radiotherapy

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https://www.readbyqxmd.com/read/28203163/is-the-deep-inspiration-breath-hold-technique-superior-to-the-free-breathing-technique-in-cardiac-and-lung-sparing-while-treating-both-left-sided-post-mastectomy-chest-wall-and-supraclavicular-regions
#1
Anupama Darapu, Rajesh Balakrishnan, Patricia Sebastian, Mohamathu Rafic Kather Hussain, Paul Ravindran, Subhashini John
AIMS: To evaluate the efficacy of the deep inspirational breath-hold (DIBH) technique and its dosimetric advantages over the free breathing (FB) technique in cardiac (heart and left anterior descending artery [LAD]) and ipsilateral lung sparing in left-sided post-mastectomy field-in-field conformal radiotherapy. DIBH is highly reproducible, and this study aims to find out its dosimetric benefits over FB. MATERIALS AND METHODS: Nineteen left-sided mastectomy patients were immobilized using breast boards with both arms positioned above the head...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28181819/dose-escalation-study-with-respiratory-gated-carbon-ion-scanning-radiotherapy-using-a-simultaneous-integrated-boost-for-pancreatic-cancer-simulation-with-four-dimensional-computed-tomography
#2
Shohei Kawashiro, Shinichiro Mori, Shigeru Yamada, Kentaro Miki, Kenji Nemoto, Hiroshi Tsuji, Tadashi Kamada
OBJECTIVES: Pancreatic cancer is a difficult-to-treat disease with a persistently high mortality rate. We evaluated dose distribution simulation with respiratory-gated carbon-ion pencil beam scanning (C-PBS) with a simultaneous integrated boost (SIB) to increase tumor dose, sparing organs at risk (OARs). METHODS: Using four-dimensional computed tomography (4DCT) data of 12 patients, we delineated gross tumor volume (GTV) and two clinical target volumes (CTVs). To consider beam range intrafractional uncertainty, we calculated field-specific target volumes (FTVs), from which two planning target volumes (PTVs) were generated...
February 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28179345/correlation-of-tumor-and-peritumoral-edema-volumes-with-survival-in-patients-with-cerebral-metastases
#3
Johannes Kerschbaumer, Marlies Bauer, Marina Popovscaia, Astrid E Grams, Claudius Thomé, Christian F Freyschlag
BACKGROUND: Surgical resection in combination with radiotherapy in selected cases remains the best option for patients with cerebral metastases. Postoperative relapse of brain metastases occurs frequently and can be reduced by postoperative whole-brain radiotherapy (WBRT). Continuous spread of tumor cells from the primary lesions is debated as a cause of recurrence. It is well known that in gliomas, infiltration takes place within the surrounding edema. Obviously, most brain metastases are usually associated with peritumoral edema, which may act as an indicator of infiltration and more aggressive tumor biology...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28168933/incidental-dose-to-pelvic-nodes-in-bladder-only-radiotherapy
#4
Shirley Lewis, Vedang Murthy, Umesh Mahantshetty, Shyam Kishore Shrivastava
BACKGROUND AND PURPOSE: Although there is a strong biological rationale to electively treat the pelvic nodes during bladder preservation, its clinical benefit is uncertain. This may be explained by the incidental dose received by the nodal regions when treating the bladder alone. This study was conducted to investigate the doses received by the different pelvic nodal regions when the bladder alone is treated by standard conformal radiotherapy. METHODS AND MATERIALS: The computed tomography data sets of 20 patients with node-negative muscle-invasive bladder cancer treated in a bladder preservation protocol were studied...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28168798/-18-f-fdg-pet-ct-for-planning-external-beam-radiotherapy-alters-therapy-in-11-of-581-patients
#5
Charlotte Birk Christensen, Annika Loft-Jakobsen, Per Munck Af Rosenschöld, Liselotte Højgaard, Henrik Roed, Anne K Berthelsen
BACKGROUND: (18) F-FDG PET/CT (FDG PET/CT) used in radiotherapy planning for extra-cerebral malignancy may reveal metastases to distant sites that may affect the choice of therapy. AIM: To investigate the role of FDG PET/CT on treatment strategy changes induced by the use of PET/CT as part of the radiotherapy planning. 'A major change of treatment strategy' was defined as either including more lesions in the gross tumour volume (GTV) distant from the primary tumour or a change in treatment modalities...
February 6, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28156588/evaluation-of-an-advanced-practice-radiation-therapist-role-in-palliative-radiation-therapy
#6
Tanya Holt
: 136 Background: To evaluate the impact a new Advanced Practice Palliative Radiation Therapist (APRT) role had on patients treated with palliative intent, with respect to reducing time from referral to treatment. To evaluate the technical ability of the APRT to delineate palliative field borders on digitally reconstructed radiographs (DRR) compared to the treating Radiation Oncologist (RO). METHODS: The time in working days from referral to treatment and referral to planning was recorded for all palliative patients having 10 fractions or less...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152619/a-multinational-report-of-technical-factors-on-stereotactic-body-radiotherapy-for-oligometastases
#7
Kristin J Redmond, Simon S Lo, Roi Dagan, Ian Poon, Matthew C Foote, Darby Erler, Young Lee, Frank Lohr, Tithi Biswas, Umberto Ricardi, Arjun Sahgal
AIM: Oligometastatic cancer is being increasingly managed with aggressive local therapy using stereotactic body radiation therapy (SBRT). However, few guidelines exist. We summarize the results of an international survey reviewing technical factors for extracranial SBRT for oligometastatic disease to guide safe management. MATERIALS & METHODS: Seven high-volume centers contributed. Levels of agreement were categorized as strong (6-7 common responses), moderate (4-5), low (2-3) or no agreement...
February 3, 2017: Future Oncology
https://www.readbyqxmd.com/read/28134979/a-multiresolution-prostate-representation-for-automatic-segmentation-in-magnetic-resonance-images
#8
Charlens Alvarez, Fabio Martínez, Eduardo Romero
PURPOSE: Accurate prostate delineation is necessary in radiotherapy processes for concentrating the dose onto the prostate and reducing side effects in neighboring organs. Currently, manual delineation is performed over Magnetic Resonance Imaging (MRI) taking advantage of its high soft tissue contrast property. Nevertheless, since human intervention is a consuming task with high intra and inter-observer variability rates, (semi)-automatic organ delineation tools have emerged to cope with these challenges, reducing the time spent for these tasks...
January 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28126329/head-and-neck-target-delineation-using-a-novel-pet-automatic-segmentation-algorithm
#9
B Berthon, M Evans, C Marshall, N Palaniappan, N Cole, V Jayaprakasam, T Rackley, E Spezi
PURPOSE: To evaluate the feasibility and impact of using a novel advanced PET auto-segmentation method in Head and Neck (H&N) radiotherapy treatment (RT) planning. METHODS: ATLAAS, Automatic decision Tree-based Learning Algorithm for Advanced Segmentation, previously developed and validated on pre-clinical data, was applied to (18)F-FDG-PET/CT scans of 20 H&N patients undergoing Intensity Modulated Radiation Therapy. Primary Gross Tumour Volumes (GTVs) manually delineated on CT/MRI scans (GTVpCT/MRI), together with ATLAAS-generated contours (GTVpATLAAS) were used to derive the RT planning GTV (GTVpfinal)...
January 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28126030/a-review-of-substitute-ct-generation-for-mri-only-radiation-therapy
#10
REVIEW
Jens M Edmund, Tufve Nyholm
Radiotherapy based on magnetic resonance imaging as the sole modality (MRI-only RT) is an area of growing scientific interest due to the increasing use of MRI for both target and normal tissue delineation and the development of MR based delivery systems. One major issue in MRI-only RT is the assignment of electron densities (ED) to MRI scans for dose calculation and a similar need for attenuation correction can be found for hybrid PET/MR systems. The ED assigned MRI scan is here named a substitute CT (sCT)...
January 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28121369/four-dimensional-diffusion-weighted-mr-imaging-4d-dwi-a-feasibility-study
#11
Yilin Liu, Xiaodong Zhong, Brian G Czito, Manisha Palta, Mustafa R Bashir, Brian M Dale, Fang-Fang Yin, Jing Cai
PURPOSE: Diffusion-weighted Magnetic Resonance Imaging (DWI) has been shown to be a powerful tool for cancer detection with high tumor-to-tissue contrast. This study aims to investigate the feasibility of developing a four-dimensional DWI technique (4D-DWI) for imaging respiratory motion for radiation therapy applications. MATERIALS/METHODS: Image acquisition was performed by repeatedly imaging a volume of interest (VOI) using an interleaved multislice single-shot echo-planar imaging (EPI) 2D-DWI sequence in the axial plane...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28120144/predicting-prostate-tumour-location-from-multiparametric-mri-using-gaussian-kernel-support-vector-machines-a-preliminary-study
#12
Yu Sun, Hayley Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Martin A Ebert, Annette Haworth
The performance of a support vector machine (SVM) algorithm was investigated to predict prostate tumour location using multi-parametric MRI (mpMRI) data. The purpose was to obtain information of prostate tumour location for the implementation of bio-focused radiotherapy. In vivo mpMRI data were collected from 16 patients prior to radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted imaging and dynamic contrast enhanced imaging. In vivo mpMRI was registered with 'ground truth' histology, using ex vivo MRI as an intermediate registration step to improve accuracy...
January 24, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28118614/identification-of-risk-factors-and-the%C3%A2-pattern-of-lower-cervical-lymph-node-metastasis-in-esophageal-cancer-implications-for-radiotherapy-target-delineation
#13
Yijun Luo, Xiaoli Wang, Yuhui Liu, Chengang Wang, Yong Huang, Jinming Yu, Minghuan Li
Radiotherapy remains the important therapeutic strategy for patients with esophageal cancer (EC). At present, there is no uniform opinion or standard care on the range of radiotherapy in the treatment of EC patients. This study aimed to investigate the risk factors associated with lower cervical lymph node metastasis (LNM) and to explore the distribution pattern of lower cervical metastatic lymph nodes. It could provide useful information regarding accurate target volume delineation for EC. We identified 239 patients who initial diagnosed with esophageal squamous cell carcinoma...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28105886/interobserver-delineation-uncertainty-in-involved-node-radiation-therapy-inrt-for-early-stage-hodgkin-lymphoma-on-behalf-of-the-radiotherapy-committee-of-the-eortc-lymphoma-group
#14
Marianne C Aznar, Theodore Girinsky, Anne Kiil Berthelsen, Berthe Aleman, Max Beijert, Martin Hutchings, Yolande Lievens, Paul Meijnders, Peter Meidahl Petersen, Deborah Schut, Maja V Maraldo, Richard van der Maazen, Lena Specht
BACKGROUND AND PURPOSE: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. MATERIALS AND METHODS: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck)...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28104034/-patterns-of-recurrence-in-patients-with-stage-%C3%A2-thoracic-esophageal-squamous-cell-carcinoma-after-radical-resection
#15
Y X Wang, Q Yang, M He, R Qiu, J Li, S C Zhu, X Y Qiao, Z Qi
Objective: To evaluate the patterns of recurrence and their value on target delineation for postoperative radiotherapy (RT) in patients with stage Ⅲ thoracic esophageal squamous cell carcinoma (ESCC) after esophagectomy. Methods: 395 patients (302 male and 93 female) of stage Ⅲ thoracic ESCC after radical resection were enrolled in this study. Among them, 375 patients were treated with two-field and other 20 with three-field esopahgectomy. 97 patients were treated with surgery alone, 212 with adjuvant postoperative chemotherapy (CT), 56 with radiotherapy (RT) and 30 with CT plus RT...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28089158/cardiac-dose-and-survival-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#16
Amode R Tembhekar, Cari L Wright, Megan E Daly
INTRODUCTION: Recent analyses have identified cardiac dose as an important predictor of overall survival (OS) after chemoradiation for locally advanced non-small-cell lung cancer (NSCLC). However, the survival influence of the cardiac dose after stereotactic body radiotherapy (SBRT) is unknown. We performed a dose-volume histogram (DVH) analysis of patients treated with SBRT for early stage NSCLC to examine survival and cardiac toxicity. MATERIALS AND METHODS: We reviewed the medical records of patients who had undergone SBRT for early-stage NSCLC from June 2007 to June 2015 and documented the cardiac DVH parameters, including the maximum and mean dose and percentage of volume receiving >5, >10, >20, and >30 Gy (V5, V10, V20, and V30, respectively)...
December 22, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28087071/development-of-delineation-for-the-left-anterior-descending-coronary-artery-region-in-left-breast-cancer-radiotherapy-an-optimized-organ-at-risk
#17
Jie Lee, Kai-Lung Hua, Shih-Ming Hsu, Jhen-Bin Lin, Chou-Hsien Lee, Kuo-Wei Lu, Kun-Yao Dai, Xu-Nian Huang, Jun-Zhao Huang, Meng-Hao Wu, Yu-Jen Chen
BACKGROUND AND PURPOSE: The left anterior descending coronary artery (LAD) and diagonal branches (DBs) are blurred on computed tomography (CT). We aimed to define the LAD region (LADR) with adequate inclusion of the LAD and DBs and contouring consistency. METHODS AND MATERIALS: The LADR was defined using coronary CT angiograms. The inclusion ratio was used to assess the LAD and DBs inclusion by the LADR. Four radiation oncologists delineated the LAD and LADR, using contrast-enhanced CT of 15 patients undergoing left breast radiotherapy...
January 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28079816/a-comparison-study-between-gross-tumor-volumes-defined-by-preoperative-magnetic-resonance-imaging-postoperative-specimens-and-tumor-bed-for-radiotherapy-after-breast-conserving-surgery
#18
COMPARATIVE STUDY
Aiping Zhang, Jianbin Li, Wei Wang, Yongsheng Wang, Dianbin Mu, Zhaoqiu Chen, Qian Shao, Fengxiang Li
BACKGROUND: The identification and contouring of target volume is important for breast-conserving therapy. The aim of the study was to compare preoperative magnetic resonance imaging (MRI), postoperative pathology, excised specimens' (ES) size, and tumor bed (TB) delineation as methods for determining the gross tumor volume (GTV) for radiotherapy after breast-conserving surgery (BCS). METHODS: Thirty-three patients with breast cancer who underwent preoperative MRI and radiotherapy after BCS were enrolled...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078638/-11-c-methionine-positron-emission-tomography-delineates-non-contrast-enhancing-tumor-regions-at-high-risk-for-recurrence-in-pediatric-high-grade-glioma
#19
John T Lucas, Nick Serrano, Hyun Kim, Xingyu Li, Scott E Snyder, Scott Hwang, Yimei Li, Chia-Ho Hua, Alberto Broniscer, Thomas E Merchant, Barry L Shulkin
We assessed the prognostic utility of (11)C-Methionine positron emission tomography (MET-PET) in pediatric high-grade glioma (HGG). Thirty-one children had 62 MET-PET studies. Segmented tumor volumes from co-registered magnetic resonance studies were assessed for concordance with MET-PET uptake using Boolean operations. The tumor volume at diagnosis and treatment failure was assessed relative to MET-PET avid volume. The prognostic impact of MET-PET-delineated non-contrast enhancing tumor (NCET) was assessed...
January 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28055249/volumetry-of-the-dominant-intraprostatic-tumour-lesion-intersequence-and-interobserver-differences-on-multiparametric-mri
#20
Hugh Harvey, Matthew R Orton, Veronica A Morgan, Chris Parker, David Dearnaley, Cyril Fisher, Nandita M deSouza
OBJECTIVES: To establish interobserver reproducibility of tumour volumetry on individual multiparametric(mp) prostate MRI sequences, validate measurements with histology and determine whether functional to morphological volume ratios reflect Gleason score. METHODS: Forty-one men with prostate cancer treated with prostatectomy (cohort 1) or radical radiotherapy (cohort 2) who had pre-treatment mp (T2-W, DW-, DCE-) MRI were studied retrospectively. Dominant intraprostatic lesions (DIPLs) were manually delineated on each sequence and volumes compared between observers (n=40 analysable) and with radical prostatectomy (n=20)...
January 5, 2017: British Journal of Radiology
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