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Contouring radiotherapy

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https://www.readbyqxmd.com/read/28105886/interobserver-delineation-uncertainty-in-involved-node-radiation-therapy-inrt-for-early-stage-hodgkin-lymphoma-on-behalf-of-the-radiotherapy-committee-of-the-eortc-lymphoma-group
#1
Marianne C Aznar, Theodore Girinsky, Anne Kiil Berthelsen, Berthe Aleman, Max Beijert, Martin Hutchings, Yolande Lievens, Paul Meijnders, Peter Meidahl Petersen, Deborah Schut, Maja V Maraldo, Richard van der Maazen, Lena Specht
BACKGROUND AND PURPOSE: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. MATERIALS AND METHODS: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck)...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28091565/-18-f-flt-and-18-f-fdg-pet-ct-in-predicting-response-to-chemoradiotherapy-in-nasopharyngeal-carcinoma-preliminary-results
#2
Shi Qi, Yang Zhongyi, Zhang Yingjian, Hu Chaosu
The purpose of this study was to explore the feasibility of (18)F-Fluorothymidine ((18)F-FLT) and (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in predicting treatment response of nasopharyngeal carcinoma (NPC). Patients with NPC of Stage II-IVB were prospectively enrolled, receiving 2 cycles of neoadjuvant chemotherapy (NACT), followed by concurrent chemoradiotherapy. Each patient underwent pretreatment and post-NACT FLT PET/CT and FDG PET/CT. Standard uptake values (SUV) and tumor volume were measured...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089480/deep-inspiration-breath-hold-produces-a-clinically-meaningful-reduction-in-ipsilateral-lung-dose-during-locoregional-radiation-therapy-for-some-women-with-right-sided-breast-cancer
#3
Jessica L Conway, Leigh Conroy, Lindsay Harper, Marie Scheifele, Haocheng Li, Wendy L Smith, Tannis Graham, Tien Phan, Ivo A Olivotto
PURPOSE: The goal of the work described here was to determine whether deep inspiration breath-hold (DIBH) produces a clinically meaningful reduction in pulmonary dose compared with free breathing (FB) during locoregional radiation for right-sided breast cancer. METHODS AND MATERIALS: Four-field, modified-wide tangent plans with full nodal coverage were developed for 30 consecutive patients on paired DIBH and FB CT scans. Nodes were contoured according to European Society for Radiotherapy and Oncology guidelines...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28087071/development-of-delineation-for-the-left-anterior-descending-coronary-artery-region-in-left-breast-cancer-radiotherapy-an-optimized-organ-at-risk
#4
Jie Lee, Kai-Lung Hua, Shih-Ming Hsu, Jhen-Bin Lin, Chou-Hsien Lee, Kuo-Wei Lu, Kun-Yao Dai, Xu-Nian Huang, Jun-Zhao Huang, Meng-Hao Wu, Yu-Jen Chen
BACKGROUND AND PURPOSE: The left anterior descending coronary artery (LAD) and diagonal branches (DBs) are blurred on computed tomography (CT). We aimed to define the LAD region (LADR) with adequate inclusion of the LAD and DBs and contouring consistency. METHODS AND MATERIALS: The LADR was defined using coronary CT angiograms. The inclusion ratio was used to assess the LAD and DBs inclusion by the LADR. Four radiation oncologists delineated the LAD and LADR, using contrast-enhanced CT of 15 patients undergoing left breast radiotherapy...
January 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28079816/a-comparison-study-between-gross-tumor-volumes-defined-by-preoperative-magnetic-resonance-imaging-postoperative-specimens-and-tumor-bed-for-radiotherapy-after-breast-conserving-surgery
#5
Aiping Zhang, Jianbin Li, Wei Wang, Yongsheng Wang, Dianbin Mu, Zhaoqiu Chen, Qian Shao, Fengxiang Li
BACKGROUND: The identification and contouring of target volume is important for breast-conserving therapy. The aim of the study was to compare preoperative magnetic resonance imaging (MRI), postoperative pathology, excised specimens' (ES) size, and tumor bed (TB) delineation as methods for determining the gross tumor volume (GTV) for radiotherapy after breast-conserving surgery (BCS). METHODS: Thirty-three patients with breast cancer who underwent preoperative MRI and radiotherapy after BCS were enrolled...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28052737/changes-in-tumor-volumes-and-spatial-locations-relative-to-normal-tissues-during-cervical-cancer-radiotherapy-assessed-by-cone-beam-computed-tomography
#6
Wenjuan Chen, Penggang Bai, Jianji Pan, Yuanji Xu, Kaiqiang Chen
PURPOSE: To assess changes in the volumes and spatial locations of tumors and surrounding organs by cone beam computed tomography during treatment for cervical cancer. MATERIALS AND METHODS: Sixteen patients with cervical cancer had intensity-modulated radiotherapy and off-line cone beam computed tomography during chemotherapy and/or radiation therapy. The gross tumor volume (GTV-T) and clinical target volumes (CTVs) were contoured on the planning computed tomography and weekly cone beam computed tomography image, and changes in volumes and spatial locations were evaluated using the volume difference method and Dice similarity coefficients...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28048870/su-f-j-81-evaluation-of-automated-deformable-registration-between-planning-computed-tomography-ct-and-daily-cone-beam-ct-images-over-the-course-of-prostate-cancer-radiotherapy
#7
J Matney, J Hammers, O Kaidar-Person, A Wang, R Chen, S Das, L Marks, P Mavroidis
PURPOSE: To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy. METHODS: A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048849/su-f-j-174-a-series-of-computational-human-phantoms-in-dicom-rt-format-for-normal-tissue-dose-reconstruction-in-epidemiological-studies
#8
A Pyakuryal, B Moroz, C Lee, C Pelletier, J Jung, C Lee
PURPOSE: Epidemiological studies of second cancer risk in radiotherapy patients often require individualized dose estimates of normal tissues. Prior to 3D conformal radiation therapy planning, patient anatomy information was mostly limited to 2D radiological images or not even available. Generic patient CT images are often used in commercial radiotherapy treatment planning system (TPS) to reconstruct normal tissue doses. The objective of the current work was to develop a series of reference size computational human phantoms in DICOM-RT format for direct use in dose reconstruction in TPS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048814/su-f-j-123-ct-based-determination-of-dibh-variability-and-its-dosimetric-impact-on-post-mastectomy-plus-regional-nodal-radiation-therapy
#9
M Malin, H Kang, K Tatebe, Y Hasan, S Chmura, H Al-Hallaq
PURPOSE: Breast cancer radiotherapy delivered using voluntary deep inspiration breath-hold (DIBH) requires reproducible breath holds, particularly when matching supraclavicular fields to tangential fields. We studied the impact of variation in DIBHs on CTV and OAR dose metrics by comparing the dose distribution computed on two DIBH CT scans taken at the time of simulation. METHODS: Ten patients receiving 50Gy in 25 fractions to the left chestwall and regional lymph nodes were studied...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048805/su-f-r-42-association-of-radiomic-and-metabolic-tumor-volumes-in-radiation-treatment-of-glioblastoma-multiforme
#10
C Lopez, N Nagornaya, N Parra, D Kwon, F Ishkanian, A Markoe, A Maudsley, R Stoyanova
PURPOSE: High-throughput extraction of imaging and metabolomic quantitative features from MRI and MR Spectroscopy Imaging (MRSI) of Glioblastoma Multiforme (GBM) results in tens of variables per patient. In radiotherapy (RT) of GBM, the relevant metabolic tumor volumes (MTVs) are related to aberrant levels of N-acetyl Aspartate (NAA) and Choline (Cho). Corresponding Clinical Target Volumes (CTVs) for RT planning are based on Contrast Enhancing T1-weighted MRI (CE-T1w) and T2-weighted/Fluid Attenuated Inversion Recovery (FLAIR) MRI...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048778/su-f-t-101-insight-into-dosimetry-workload-and-planning-timelines-a-6-year-review-at-one-institution
#11
R Cardan, R Popple, H Smith, J Fiveash
PURPOSE: To elucidate realistic clinical treatment planning workload and timelines to improve understanding for patients, payers, and other institutions involved in radiotherapy processes. METHODS: A web based tool was developed using Oracle Express (Oracle Corp, Redwood City, CA) which allowed communication between the physicians and staff about the current state of the patient plan. For 6 years, all patient courses were logged and time-stamped in 22 discreet steps which detailed start and stop times for simulation, contouring, and treatment planning tasks...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048724/su-f-j-84-comparison-of-quantitative-deformable-image-registration-evaluation-tools-application-to-prostate-igart
#12
N Dogan, E Weiss, W Sleeman, G Christensen, J Williamson, J Ford
PURPOSE: Errors in displacement vector fields (DVFs) generated by Deformable Image Registration (DIR) algorithms can give rise to significant uncertainties in contour propagation and dose accumulation in Image-Guided Adaptive Radiotherapy (IGART). The purpose of this work is to assess the accuracy of two DIR algorithms using a variety of quality metrics for prostate IGART. METHODS: Pelvic CT images were selected from an anonymized database of nineteen prostate patients who underwent 8-12 serial scans during radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048697/su-f-t-199-a-new-strategy-for-integrating-photon-with-proton-and-carbon-ion-in-the-treatment-planning
#13
Z Chen, J Wang, W Hu
PURPOSE: The aim of this study was to develop a viable strategy to integrate photon plan and proton/carbon ion plan based on deformable registration. METHODS: Two prostate cancer patients were enrolled in this study. Each patient has 2 CTs, which were input in the Raystation radiotherapy treatment planning system (TPS). CT1 was deformed to the second CT2 using the Hybrid deformation method. The dice similarity coefficient (DSC) parameter was used to evaluate the difference between the actual structures (bladder, rectum and CTV) and the corresponding deformed structures on CT2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048694/su-f-j-62-assessment-of-dose-changes-due-to-anterior-posterior-patient-separation-during-daily-mvct-scans
#14
M Leney, A Nalichowski, S Patel
PURPOSE: To determine the effects of patient separation on absolute dose and dose distribution in patients undergoing pelvic radiotherapy on TomoTherapy. METHODS: An Alderson RANDO phantom with 4cm of bolus was imaged on a CT simulator and the resulting scans were contoured as a whole pelvic case. Using TomoTherapy Planning Station, the plan was designed to give 45 Gy to 95% of the treatment volume in 25 fractions. TomoTherapy MVCT scans were performed on the RANDO phantom with 2cm and 4cm of bolus removed to simulate visible changes in a patient's anatomy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048690/su-f-j-22-lung-volumevariability-assessed-by-bh-cbct-in-3d-surface-image-guided-deep-inspirationbreath-hold-dibh-radiotherapy-for-left-sided-breast-cancer
#15
A Gutierrez, D Stanley, N Papanikolaou, R Crownover
PURPOSE: With the increasing use of DIBH techniques for left-sided breast cancer, 3D surface-image guided DIBH techniques have improved patient setup and facilitated DIBH radiation delivery. However, quantification of the daily separation between the heart and left breast still presents a challenge. One method of assuring separation is to ensure consistent left lung filling. With this in mind, the aim of this study is to retrospectively quantify left lung volume from weekly breath hold-CBCTs (bh-CBCT) of left-sided breast patients treated using a 3D surface imaging system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048684/su-f-t-115-uncertainty-in-the-esophagus-dose-in-retrospective-epidemiological-study-of-breast-cancer-radiotherapy-patients
#16
E Mosher, S Kim, C Lee, C Pelletier, J Jung, E Jones, C Lee
PURPOSE: Epidemiological studies of second cancer risks in breast cancer radiotherapy patients often use generic patient anatomy to reconstruct normal tissue doses when CT images of patients are not available. To evaluate the uncertainty involved in the dosimetry approach, we evaluated the esophagus dose in five sample patients by simulating breast cancer treatments. METHODS: We obtained the diagnostic CT images of five anonymized adult female patients in different Body Mass Index (BMI) categories (16- 36kg/m2) from National Institutes of Health Clinical Center...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048680/tu-ab-202-12-a-novel-method-to-map-endoscopic-video-to-ct-for-treatment-planning-and-toxicity-analysis-in-radiation-therapy
#17
W Ingram, J Yang, B Beadle, R Wendt, A Rao, L Court
PURPOSE: Endoscopic examinations are routine procedures for head-and-neck cancer patients. Our goal is to develop a method to map the recorded video to CT, providing valuable information for radiotherapy treatment planning and toxicity analysis. METHODS: We map video frames to CT via virtual endoscopic images rendered at the real endoscope's CT-space coordinates. We developed two complementary methods to find these coordinates by maximizing real-to-virtual image similarity:(1)Endoscope Tracking: moves the virtual endoscope frame-by-frame until the desired frame is reached...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048665/su-f-t-243-major-risks-in-radiotherapy-a-review-based-on-risk-analysis-literature
#18
J López-Tarjuelo, A Bouché-Babiloni, V Morillo-Macías, M Guasp-Tortajada, N Iglesias-Montenegro, P Monasor-Denia, C Ferrer-Albiach
PURPOSE: We present a literature review of risk analyses in radiotherapy to highlight the most reported risks and facilitate the spread of this valuable information so that professionals can be aware of these major threats before performing their own studies. METHODS: We considered studies with at least an estimation of the probability of occurrence of an adverse event (O) and its associated severity (S). They cover external beam radiotherapy, brachytherapy, intraoperative radiotherapy, and stereotactic techniques...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048630/su-f-t-250-what-does-it-take-to-correctly-assess-the-high-failure-modes-of-an-advanced-radiotherapy-procedure-such-as-stereotactic-body-radiation-therapy
#19
D Han, D Vile, M Rosu, J Palta
PURPOSE: Assess the correct implementation of risk-based methodology of TG 100 to optimize quality management and patient safety procedures for Stereotactic Body Radiation Therapy. METHODS: A detailed process map of SBRT treatment procedure was generated by a team of three physicists with varying clinical experience at our institution to assess the potential high-risk failure modes. The probabilities of occurrence (O), severity (S) and detectability (D) for potential failure mode in each step of the process map were assigned by these individuals independently on the scale from1 to 10...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048487/su-c-bra-03-an-automated-and-quick-contour-errordetection-for-auto-segmentation-in-online-adaptive-radiotherapy
#20
J Zhang, O Ates, X Li
PURPOSE: To develop a tool that can quickly and automatically assess contour quality generated from auto segmentation during online adaptive replanning. METHODS: Due to the strict time requirement of online replanning and lack of 'ground truth' contours in daily images, our method starts with assessing image registration accuracy focusing on the surface of the organ in question. Several metrics tightly related to registration accuracy including Jacobian maps, contours shell deformation, and voxel-based root mean square (RMS) analysis were computed...
June 2016: Medical Physics
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