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Contouring radiotherapy

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https://www.readbyqxmd.com/read/29331573/deformable-image-registration-based-contour-propagation-yields-clinically-acceptable-plans-for-mri-based-cervical-cancer-brachytherapy-planning
#1
Christina Hunter Chapman, Daniel Polan, Karen Vineberg, Shruti Jolly, Katherine E Maturen, Kristy K Brock, Joann I Prisciandaro
PURPOSE: To study the dosimetric impact of deformable image registration-based contour propagation on MRI-based cervical cancer brachytherapy planning. METHODS AND MATERIALS: High-risk clinical target volume (HRCTV) and organ-at-risk (OAR) contours were delineated on MR images of 10 patients who underwent ring and tandem brachytherapy. A second set of contours were propagated using a commercially available deformable registration algorithm. "Manual-contour" and "propagated-contour" plans were optimized to achieve a maximum dose to the most minimally exposed 90% of the volume (D90) (%) of 6 Gy/fraction, respecting minimum dose to the most exposed 2cc of the volume (D2cc) OAR constraints of 5...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29312726/is-a-clinical-target-volume-ctv-necessary-for-locally-advanced-non-small-cell-lung-cancer-treated-with-intensity-modulated-radiotherapy-a-dosimetric-evaluation-of-three-different-treatment-plans
#2
Fan Xia, Lijun Zhou, Xi Yang, Li Chu, Xiaofei Zhang, Jinjin Chu, Weigang Hu, Zhengfei Zhu
Background: The aim of this study was to determine the feasibility of omitting the clinical target volume (CTV) in patients with locally advanced non-small cell lung cancer (NSCLC) treated with intensity-modulated radiotherapy (IMRT) by comparing dosimetric characteristics of three different IMRT plans with or without CTV implementation. Methods: Thirteen patients with stage III NSCLC were reviewed. Target volumes were contoured such that the planning target volume (PTV) derived from the gross tumor volume (GTV) directly was named PTV_g and that from GTV plus CTV margin was named PTV_c...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29300184/correlations-between-contouring-similarity-metrics-and-simulated-treatment-outcome-for-prostate-radiotherapy
#3
Dale Roach, Michael G Jameson, Jason A Dowling, Martin Andrew Ebert, Peter B Greer, Angel M Kennedy, Sandie Watt, Lois C Holloway
Many similarity metrics exist for inter-observer contouring variation studies, however no correlation between metric choice and prostate cancer radiotherapy dosimetry has been explored. These correlations were investigated in this study. Two separate trials were undertaken, the first a thirty-five patient cohort with three observers, the second a five patient dataset with ten observers. Clinical and planning target volumes (CTV and PTV), rectum, and bladder were independently contoured by all observers in each trial...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29290281/optimising-volumetric-arc-radiotherapy-for-dental-rehabilitation-in-oropharynx-cancer-a-retrospective-dosimetry-review-and-feasibility-planning-study
#4
Sean M O'Cathail, Naveen Karir, Ketan Shah
PURPOSE: To assess the dosimetry to dentally relevant substructures within the mandible/maxilla, establish the predictors of increased mean anterior mandible dose and assess the feasibility of rationale optimisation of dose to the anterior mandible (AM) volume to aid reconstructive dental surgery planning, where the AM is a critical structure. MATERIALS AND METHODS: In a cohort of radically treated oropharynx cancer patients we conducted a retrospective dosimetry analysis of mandible/maxilla volumes, created using a published atlas...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29277799/long-term-outcomes-of-a-dose-reduction-trial-to-decrease-late-gastrointestinal-toxicity-in-patients-with-prostate-cancer-receiving-soft-tissue-matched-image-guided-intensity-modulated-radiotherapy
#5
Naomi Sasaki, Hideya Yamazaki, Daisuke Shimizu, Gen Suzuki, Koji Masui, Satoaki Nakamura, Haruumi Okabe, Tatsuyuki Nishikawa, Ken Yoshida
BACKGROUND/AIM: We experienced an unexpected high incidence of gastrointestinal (GI) toxicity in patients undergoing image-guided intensity-modulated radiotherapy (IG-IMRT) using helical tomotherapy in our initial 2.2 Gy/fraction schedule for prostate cancer; hence, a dose-reduction trial from 2.2 Gy to 2 Gy/fraction was conducted using modified planning target volume (PTV) contouring. PATIENTS AND METHODS: We compared 130 patients treated using 2.2 Gy/fraction (Group A) and 144 treated using the 2 Gy/fraction (Group B) with modified PTV (excluding rectal volume) with a median follow-up period of 62 months...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29209915/classification-of-early-stage-non-small-cell-lung-cancers-on-computed-tomographic-images-into-histological-types-using-radiomic-features-interobserver-delineation-variability-analysis
#6
Akihiro Haga, Wataru Takahashi, Shuri Aoki, Kanabu Nawa, Hideomi Yamashita, Osamu Abe, Keiichi Nakagawa
Radiomics, which involves the extraction of large numbers of quantitative features from medical images, has attracted attention in cancer research. In radiomics analysis, tumor segmentation is a crucial step. In this study, we evaluated the potential application of radiomics for predicting the histology of early stage non-small cell lung cancer (NSCLC) by analyzing interobserver variability in tumor delineation. Forty patient datasets were included in this study, 21 involving adenocarcinomas and 19 involving squamous cell carcinomas...
December 5, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29208513/clinical-evaluation-of-atlas-and-deep-learning-based-automatic-contouring-for-lung-cancer
#7
Tim Lustberg, Johan van Soest, Mark Gooding, Devis Peressutti, Paul Aljabar, Judith van der Stoep, Wouter van Elmpt, Andre Dekker
BACKGROUND AND PURPOSE: Contouring of organs at risk (OARs) is an important but time consuming part of radiotherapy treatment planning. The aim of this study was to investigate whether using institutional created software-generated contouring will save time if used as a starting point for manual OAR contouring for lung cancer patients. MATERIAL AND METHODS: Twenty CT scans of stage I-III NSCLC patients were used to compare user adjusted contours after an atlas-based and deep learning contour, against manual delineation...
December 2, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29207964/concordance-of-fdg-pet-ct-metabolic-tumour-volume-versus-dw-mri-functional-tumour-volume-with-t2-weighted-anatomical-tumour-volume-in-cervical-cancer
#8
Alta Y T Lai, Jose A U Perucho, Xiaopei Xu, Edward S Hui, Elaine Y P Lee
BACKGROUND: 18F-fluoro-deoxyglucose positron emission tomography with computed tomography (FDG PET/CT) has been employed to define radiotherapy targets using a threshold based on the standardised uptake value (SUV), and has been described for use in cervical cancer. The aim of this study was to evaluate the concordance between the metabolic tumour volume (MTV) measured on FDG PET/CT and the anatomical tumour volume (ATV) measured on T2-weighted magnetic resonance imaging (T2W-MRI); and compared with the functional tumour volume (FTV) measured on diffusion-weighted MRI (DW-MRI) in cervical cancer, taking the T2W-ATV as gold standard...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29204170/locally-advanced-squamous-cell-cervical-cancer-in-a-patient-with-septate-uterus
#9
Guler Yavas, Cagdas Yavas, Gokcen Inan
A 33-year-old premenopausal multiparous woman with the history of septate uterus was referred to the hospital with menorrhagia and inter-menstrual bleeding occurring for the last 6 months. Work-up revealed a stage IIB cervical cancer. The patient underwent curative chemo/radiotherapy. The patient's septate uterus presented several difficulties during application. Brachytherapy was applied using standard computed tomography-compatible tandem and ovoids. The high-risk clinical target volume (HR-CTV), intermediate risk CTV, and organs at risk were contoured according to the Groupe Européen de Curiethérapie - European Society for Radiology and Oncology (GEC-ESTRO) guidelines...
October 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29203290/patterns-of-locoregional-failure-in-locally-advanced-non-small-cell-lung-cancer-treated-with-definitive-conformal-radiotherapy-results-from-the-gating-2006-trial
#10
Emmanuel Jouglar, Vanina Isnardi, Dorothée Goulon, Céline Ségura-Ferlay, Myriam Ayadi, Claire Dupuy, Jean-Yves Douillard, Marc-André Mahé, Line Claude
PURPOSE: To determine the patterns of locoregional failure (LRF) in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy (RT). PATIENTS AND METHODS: One hundred and fifty-four patients from the Gating 2006 prospective randomized trial were treated with conformal RT with or without respiratory motion management. For patients with a LRF as first event, treatment planning with simulation CT, pre-treatment 18FDG PET-CT and post-treatment images demonstrating recurrence were registered and analyzed...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29198390/comparison-between-dvh-based-doses-and-icru-point-based-doses-to-the-rectum-and-the-bladder-using-ct-based-high-dose-rate-brachytherapy-to-the-cervix
#11
Ramya Rangarajan, Saravanan Subramanian, Kalyani Gopalakrishnan
Traditionally, doses to the bladder and the rectum were quantified using the bladder and rectal reference points defined by the International Commission on Radiation Units and Measurements (ICRU) in Report No. 38. In this study, we compared the 0.1-, 1.0-, 2.0-cc doses to the bladder and the rectum with the corresponding ICRU point doses using computed tomography (CT)-based planning in the intracavitary brachytherapy of carcinoma of the cervix. CT datasets of 136 consecutive intracavitary brachytherapy insertions between January and May 2015 were analyzed...
November 29, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29187475/reliable-radiation-technique-to-minimize-ovarian-dose-during-radiation-prophylaxis-of-heterotopic-ossification
#12
Waleed F Mourad, Satyaseelan Packianathan, Weisi Yan, Mahboubeh Pishgou, John K Ma, Sherif G Shaaban, Edward M Marchan, Rui He, Paul N Mobit, Chunli Claus Yang, Srinivasan Vijayakumar
BACKGROUND/AIM: Scattered radiation during radiotherapy (RT) directed at the hip joint poses concerns about ovarian function in patients of reproductive age. Here, we report the impact of using a split-beam technique (SBT) and different photon energies on the total ovary dose during radiation prophylaxis of heterotopic ossification (HO). PATIENTS AND METHODS: This was a single-institution, retrospective study of 32-patients with traumatic acetabular fractures (TAF)...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29184684/impact-of-sarcopenia-on-outcomes-of-locally-advanced-esophageal-cancer-patients-treated-with-neoadjuvant-chemoradiation-followed-by-surgery
#13
Gilbert Z Murimwa, Puja S Venkat, William Jin, Susan Leuthold, Kujtim Latifi, Khaldoun Almhanna, Jose M Pimiento, Jacques-Pierre Fontaine, Sarah E Hoffe, Jessica M Frakes
Background: Sarcopenia is an independent predictor of clinical outcomes in multiple gastrointestinal cancers. Total psoas area (TPA), as measured on a single cross-sectional CT image at the L4 vertebral body level, has been correlated with sarcopenia. We sought to evaluate whether TPA was predictive of acute grade ≥3 toxicity, pathologic response, and overall survival in patients with locally advanced esophageal cancer receiving tri-modality therapy. Methods: An institutional database of esophageal cancer patients treated with neoadjuvant chemoradiation followed by surgery was queried...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29178498/technical-note-solving-the-chinese-postman-problem-for-effective-contour-deformation
#14
Jingqian Wang, Yongbin Zhang, Lifei Zhang, Lei Dong, Peter A Balter, Laurence E Court, Jinzhong Yang
PURPOSE: To develop a practical approach for accurate contour deformation when deformable image registration (DIR) is used for atlas-based segmentation or contour propagation in image-guided radiotherapy. METHODS: We developed a contour deformation approach based on 3D mesh operations. The 2D contours represented by a series of points in each slice were first converted to a 3D triangular mesh, which was deformed by the deformation vectors resulting from DIR. A set of parallel 2D planes then cut through the deformed 3D mesh, generating unordered points and line segments, to be reorganized into a set of 2D contour points...
November 27, 2017: Medical Physics
https://www.readbyqxmd.com/read/29176059/multi-gpu-configuration-of-4d-intensity-modulated-radiation-therapy-inverse-planning-using-global-optimization
#15
Aaron Michael Hagan, Amit Sawant, Michael Folkerts, Arezoo Modiri
We report on the design, implementation and characterization of a multi-graphic processing unit (GPU) computational platform for higher-order optimization in radiotherapy treatment planning. In collaboration with a commercial vendor (Varian Medical Systems, Palo Alto, CA), a research prototype GPU-enabled Eclipse (V13.6) workstation was configured. The hardware consisted of dual 8-core xeon processors, 256 GB RAM and four NVIDIA Tesla K80 general purpose GPUs. We demonstrate the utility of this platform for large radiotherapy optimization problems through the development and characterization of a parallelized particle swarm optimization (PSO) four dimensional (4D) intensity modulated radiation therapy (IMRT) technique...
November 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29169657/short-interactive-workshops-reduce-variability-in-contouring-treatment-volumes-for-spine-stereotactic-body-radiation-therapy-experience-with-the-estro-falcon-programme-and-educase%C3%A2-training-tool
#16
Berardino De Bari, Max Dahele, Miika Palmu, Scott Kaylor, Luis Schiappacasse, Matthias Guckenberger
We report the results of 4, 2-h contouring workshops on target volume definition for spinal stereotactic radiotherapy. They combined traditional teaching methods with a web-based contouring/contour-analysis platform and led to a significant reduction in delineation variability. Short, interactive workshops can reduce interobserver variability in spine SBRT target volume delineation.
November 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29166129/initial-observations-of-intra-and-inter-fractional-motion-variation-in-mr-guided-lung-sbrt
#17
David H Thomas, Anand Santhanam, Amar U Kishan, Minsong Cao, James Lamb, Yugang Min, Dylan O'Connell, Yingli Yang, Nzhde Agazaryan, Percy Lee, Daniel Low
OBJECTIVE: To evaluate variations in intra- and inter-fractional tumor motion, and the effect on ITV contour accuracy, using deformable image registration of real-time 2D-sagital cine-mode MRI acquired during lung SBRT treatments. METHODS: Five lung tumor patients underwent free breathing SBRT treatments on the ViewRay system, with dose prescribed to a planning target volume (PTV; defined as a 3-6 mm expansion of the 4DCT-ITV). Sagittal slice cine-MR images (3.5x3...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29123458/comparison-of-mri-sequences-in-ideal-fiducial-maker-based-radiotherapy-for-prostate-cancer
#18
Osamu Tanaka, Hisao Komeda, Mitsuyoshi Hattori, Shigeki Hirose, Eiichi Yama, Masayuki Matsuo
Aim: Prostate contouring using CT alone is difficult. To overcome the uncertainty, CT/MRI registration using a fiducial marker is generally performed. However, visualization of the marker itself can be difficult with MRI. This study aimed to determine the optimal MRI pulse sequence for defining the marker as well as the prostate outline among five sequences. Materials and methods: A total of 21 consecutive patients with prostate cancer were enrolled. Two gold fiducial markers were placed before CT/MRI examination...
November 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29123013/68ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#19
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (68Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with 68Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover 68Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of 68Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29119677/minimal-mask-immobilization-with-optical-surface-guidance-for-head-and-neck-radiotherapy
#20
Bo Zhao, Genevieve Maquilan, Steve Jiang, David L Schwartz
PURPOSE: Full face and neck thermoplastic masks provide standard-of-care immobilization for patients receiving H&N IMRT. However, these masks are uncomfortable and increase skin dose. The purpose of this pilot trial was to investigate the feasibility and setup accuracy of minimal face and neck mask immobilization with optical surface guidance. METHODS: Twenty patients enrolled onto this IRB-approved protocol. Patients were immobilized with masks securing only forehead and chin...
November 9, 2017: Journal of Applied Clinical Medical Physics
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