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https://www.readbyqxmd.com/read/28944624/immediate-autologous-breast-reconstruction-after-neoadjuvant-chemoradiotherapy-for-breast-cancer-initial-results-of-the-first-29-patients
#1
Damien Grinsell, Meron Pitcher, Shirley Wong, Mario Guerrieri, Hans H M Nielsen
BACKGROUND: Breast reconstruction after mastectomy in the treatment of locally advanced breast cancer is often done in stages and before radiotherapy. We have previously published an algorithm for immediate free autologous reconstruction after neoadjuvant chemotherapy and preoperative radiotherapy. This protocol was designed to provide a shorter and simpler reconstructive path whilst improving cosmesis and maintaining oncological efficiency. METHODS: A total of 29 patients were included and underwent surgery for 30 cancers by the first author between 2010 and September 2015...
September 24, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28943051/a-case-of-adult-congenital-laryngeal-cleft-asymptomatic-until-hypopharynx-cancer-treatment
#2
Kotaro Shimizu, Atsuhiko Uno, Kazuya Takemura, Naoki Ashida, Ryohei Oya, Takahiro Kitamura, Yukinori Takenaka, Yoshifumi Yamamoto
Laryngeal cleft is an anomaly of failed posterior closure of the larynx. Most cases are diagnosed and need treatment early in life due to respiratory and swallowing problems. We report an unusual case of a 66-year-old man with an asymptomatic laryngeal cleft until treatment for hypopharyngeal cancer. During concurrent chemoradiotherapy (CCRT), despite reduced tumor volume, he presented severe dysphagia and dyspnea, followed by severe pneumonia twice. Because CCRT had to be discontinued, a pharyngolaryngectomy was performed for the cancer treatment...
September 21, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28943022/patient-reported-quality-of-life-outcomes-following-treatment-for-oral-cancer
#3
J Breeze, A Rennie, D Dawson, J Tipper, K-U Rehman, N Grew, N Pigadas
Patient-reported quality of life (QoL) outcomes have the potential to assist clinicians in providing individually tailored treatment decisions. QoL assessments were collected prospectively for 168 consecutive patients treated for oral cancer between 1 January 2010 and 31 December 2014 using the University of Washington Quality of Life Questionnaire. Patients were followed up for 18 months post-treatment. Sub-group analyses were performed using paired t-tests and analysis of variance (ANOVA) to compare the effects of adjunctive chemoradiotherapy, type of bone resection, and methods of soft and hard tissue flap reconstruction...
September 21, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28940411/the-impact-of-perioperative-ca19-9-change-on-the-survival-and-recurrence-patterns-after-adjuvant-chemoradiotherapy-in-resectable-extrahepatic-cholangiocarcinoma
#4
Byoung Hyuck Kim, Eunji Kim, Kyubo Kim, Jin-Young Jang, Sun Whe Kim, Do-Youn Oh, Eui Kyu Chie
BACKGROUNDS: Perioperative CA19-9 value in pancreato-biliary cancers has been recognized as a prognostic factor. Herein, we investigated survival differences and recurrence patterns after adjuvant chemoradiotherapy by perioperative CA19-9 change in surgically resected extrahepatic cholangiocarcinoma. METHODS: Patients were divided into those with preoperative normal CA19-9 (Group 1, n = 52), those with high preoperative and normalized postoperative CA19-9 (Group 2, n = 80), and those with both high pre- and postoperative CA19-9 (Group 3, n = 21)...
September 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28940101/the-role-of-interim-fdg-pet-ct-after-induction-chemotherapy-as-a-predictor-of-concurrent-chemoradiotherapy-efficacy-and-prognosis-for-head-and-neck-cancer
#5
Ka-Rham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Sang-Hee Cho, Ik-Joo Chung, Ki Seong Park, Sae-Ryung Kang, Seong Young Kwon, Woong-Ki Chung, Woo Kyun Bae
PURPOSE: Induction chemotherapy (ICT) with docetaxel, cisplatin, and 5-fluorouracil (TPF) followed by concurrent chemoradiotherapy (CCRT) has the advantages of organ preservation and systemic control in head and neck cancer (HNC). Early prediction of CCRT efficacy may help identify patients who will benefit more from surgery than from CCRT. We investigated the role of interim 18-fluoro-2-deoxy-glucose positron emission tomography computed tomography (FDG PET-CT) after ICT to predict the efficacy of CCRT and clinical outcomes...
September 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28939744/radiomics-analysis-for-evaluation-of-pathological-complete-response-to-neoadjuvant-chemoradiotherapy-in-locally-advanced-rectal-cancer
#6
Zhenyu Liu, Xiao-Yan Zhang, Yan-Jie Shi, Lin Wang, Hai-Tao Zhu, Zhen-Chao Tang, Shuo Wang, Xiao-Ting Li, Jie Tian, Ying-Shi Sun
PURPOSE: To develop and validate a radiomics model for evaluating pathological complete response (pCR) to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer (LARC). EXPERIMENTAL DESIGN: We enrolled 222 patients (152 in the primary cohort and 70 in the validation cohort) with clinicopathologically confirmed LARC who received chemoradiotherapy before surgery. All patients underwent T2-weighted and diffusion-weighted imaging before and after chemoradiotherapy; 2252 radiomic features were extracted from each patient pre- and post-treatment imaging...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28939541/ganglioglioma-progression-to-combined-anaplastic-ganglioglioma-and-anaplastic-pleomorphic-xanthoastrocytoma-case-report-and-literature-review
#7
A Rosselló, G Plans, N Vidal-Sarró, A Fernández-Coello, A Gabarrós
BACKGROUND: Composite ganglioma and pleomorphic xanthoastrocytoma with anaplastic features in both components is an extremely rare glioneuronal tumor. 5 cases of anaplastic progression in the glioma component have been reported. These tumors generally affect young patients who suffer brain tumor-related epilepsy, are usually located in the temporal lobe or in the cerebellum, and may associate leptomeningeal spreading. Its current optimal treatment consists of maximal safe surgical resection and adjuvant chemoradiotherapy...
September 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28939179/heart-dose-associated-with-overall-survival-in-locally-advanced-nsclc-patients-treated-with-hypofractionated-chemoradiotherapy
#8
Barbara Stam, Erik van der Bijl, Judi van Diessen, Maddalena M G Rossi, Angela Tijhuis, José S A Belderbos, Eugène Damen, Jan-Jakob Sonke
Association of heart dose and overall survival was investigated in a cohort including 469 locally-advanced NSCLC patients receiving daily low-dose hypofractionated chemo-radiotherapy. Significant associations were found over a range of dose parameters. Multivariate analysis showed significant associations of heart_V2Gy:HR=1.007%(-1) (95% CI:1.002-1.013; p=0.006), age:HR=1.026year(-1) (1.011-1.042; p=0.001) and GTV volume:HR=1.001cc(-1) (1.000-1.002; p=0.006) with overall survival.
September 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28939061/chemoradiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-oropharynx-does-completion-of-systemic-therapy-affect-outcomes
#9
Michael Baine, Tim Dorius, Nathan Bennion, Morshed Alam, Lynette Smith, Weining Zhen, Apar Ganti
INTRODUCTION: Current standard of care for locally advanced squamous cell carcinoma of the oropharynx (LA-OPC) consists of concurrent chemoradiotherapy. Due to toxicities associated with this treatment, a significant portion of patients are unable to complete the systemic therapy portion of their treatment course. The impact of incomplete systemic therapy on patient outcomes remains unclear. METHODS: Demographic, treatment, and outcome data were retrospectively collected for patients with LA-OPC treated definitively with concurrent chemoradiotherapy between 2007 and 2014...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28938679/association-of-immunologic-markers-from-complete-blood-counts-with-the-response-to-preoperative-chemoradiotherapy-and-prognosis-in-locally-advanced-rectal-cancer
#10
Sung Woo Jung, In Ja Park, Se Heon Oh, Seung-Seop Yeom, Jong Lyul Lee, Yong Sik Yoon, Chan Wook Kim, Seok-Byung Lim, Jung Bok Lee, Chang Sik Yu, Jin Cheon Kim
We investigated retrospectively whether immunologic markers from a complete blood count (CBC) are associated with the responsiveness to preoperative chemoradiotherapy (PCRT) and oncologic outcomes in 984 patients with locally advanced rectal cancer (LARC) who also underwent radical surgery from 2005 to 2013. CBC parameters including the neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) were recorded. Pathologic responses to PCRT were evaluated in the resected specimens using the tumor regression grade system...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938617/development-and-validation-of-nomogram-based-on-lncrna-zfas1-for-predicting-survival-in-lymph-node-negative-esophageal-squamous-cell-carcinoma-patients
#11
Hongtai Shi, Zhenhua Liu, Dong Pei, Youqin Jiang, Haiwen Zhu, Bin Chen
BACKGROUND: There is increasing evidence of a relationship between long non-coding RNA (lncRNA) and cancer. This study aimed to examine the prognostic value of the lncRNA ZFAS1 in esophageal squamous cell carcinoma (ESCC). RESULTS: The results showed that ZFAS1 expression was significantly higher in ESCC tissues compared with the corresponding adjacent normal tissues (P < 0.001). ESCC patients with high ZFAS1 expression had a poor overall survival (OS). Histological grade, T stage and ZFAS1 expression were integrated to develop the nomogram...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938543/predictive-clinical-model-of-tumor-response-after-chemoradiation-in-rectal-cancer
#12
Marisa D Santos, Cristina Silva, Anabela Rocha, Carlos Nogueira, Fernando Castro-Poças, António Araujo, Eduarda Matos, Carina Pereira, Rui Medeiros, Carlos Lopes
Survival improvement in rectal cancer treated with neoadjuvant chemoradiotherapy (nCRT) is achieved only if pathological response occurs. Mandard tumor regression grade (TRG) proved to be a valid system to measure nCRT response. The ability to predict tumor response before treatment may significantly have impact the selection of patients for nCRT in rectal cancer. The aim is to identify potential predictive pretreatment factors for Mandard response and build a clinical predictive model design. 167 patients with locally advanced rectal cancer were treated with nCRT and curative surgery...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937321/enhancement-of-radiotherapy-efficacy-by-pleiotropic-liposomes-encapsulated-paclitaxel-and-perfluorotributylamine
#13
Xing Jiang, Baoli Zhang, Zaigang Zhou, Lingtong Meng, Zhiling Sun, Yun Xu, Qiuping Xu, Ahu Yuan, Lixia Yu, Hanqing Qian, Jinhui Wu, Yiqiao Hu, Baorui Liu
Paclitaxel (PTX) is widely used as a radiosensitizer in the clinical treatment of cancer. However, the efficacy of chemoradiotherapy is limited by the hostility of the tumor microenvironment such as hypoxia. To overcome this constraint, we designed pleiotropic radiotherapy sensitized liposomes containing perfluorotributylamine (PFTBA) and PTX. The results showed that liposomes significantly accumulated in the tumor site. PFTBA in liposomes dramatically reversed tumor hypoxia and improved the sensitivity of tumor radiotherapy...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28937269/dose-escalation-using-contact-x-ray-brachytherapy-papillon-for-rectal-cancer-does-it-improve-the-chance-of-organ-preservation
#14
Arthur Sun Myint, Fraser McLean Smith, Simon William Gollins, Helen Wong, Christopher Rao, Karen Whitmarsh, Raj Sripadam, Paul Rooney, Michael Jeremy Hershman, Zsolt Fekete, Kate Perkins, D Mark Pritchard
OBJECTIVE: A watch and wait policy for patients with a complete clinical response (cCR) after external beam chemoradiotherapy (EBCRT) for rectal cancer is an attractive option. However, approximately a third of tumours will regrow, which requires surgical salvage for cure. We assessed whether contact x-ray brachytherapy (CXB) can improve organ preservation by avoiding surgery for local regrowth. METHODS: From our institutional database, we identified 200 of 573 patients treated by CXB from 2003 to 2012...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937265/salvage-radiotherapy-for-locoregionally-recurrent-extrahepatic-bile-ducth-cancer-after-radical-surgery
#15
Eunji Kim, Yi-Jun Kim, Kyubo Kim, Changoon Song, Jae-Sung Kim, Do-Youn Oh, Eun Mi Nam, Eui Kyu Chie
OBJECTIVE: This study evaluated the outcome of salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer. METHODS: We performed a retrospective review of 23 extrahepatic bile duct cancer patients who underwent radiotherapy with or without concomitant chemotherapy for isolated locoregional recurrence after radical surgery between August 2001 and September 2013. The median disease-free interval was 11.8 months. Salvage radiotherapy was delivered to the recurrent tumor with or without initial operation bed up to a median dose of 54 Gy (range, 45-60)...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28935271/magnetic-resonance-imaging-during-definitive-chemoradiotherapy-can-predict-tumor-recurrence-and-patient-survival-in-locally-advanced-cervical-cancer-a-multi-institutional-retrospective-analysis-of-krog-16-01
#16
Sea-Won Lee, Seok Ho Lee, Juree Kim, Yeon-Sil Kim, Mee Sun Yoon, Songmi Jeong, Jin Hee Kim, Jayoung Lee, Keun-Yong Eom, Bae Kwon Jeong, Soo Yoon Sung, Sung Jong Lee, Jong Hoon Lee
OBJECTIVE: Definitive chemoradiotherapy (CRT) followed by brachytherapy is a standard treatment for locally advanced cervical cancer. During CRT, marked reduction of cervical tumor is often observed in magnetic resonance imaging (MRI). The primary aim of this study was to assess the association between tumor response in MRI using FIGO classification and clinical outcomes. METHODS: Multi-institutional data were retrospectively reviewed to identify the significance of MR tumor response on tumor recurrence and patient survival...
September 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28933018/-18-f-fluoromisonidazole-pet-in-rectal-cancer
#17
Tanuj Puri, Tessa A Greenhalgh, James M Wilson, Jamie Franklin, Lia Mun Wang, Victoria Strauss, Chris Cunningham, Mike Partridge, Tim Maughan
BACKGROUND: There is an increasing interest in developing predictive biomarkers of tissue hypoxia using functional imaging for personalised radiotherapy in patients with rectal cancer that are considered for neoadjuvant chemoradiotherapy (CRT). The study explores [(18)F]fluoromisonidazole ([(18)F]FMISO) positron emission tomography (PET) scans for predicting clinical response in rectal cancer patients receiving neoadjuvant CRT. METHODS: Patients with biopsy-proven rectal adenocarcinoma were imaged at 0-45 min, 2 and 4 h, at baseline and after 8-10 fractions of CRT (week 2)...
September 20, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28932724/colorectal-perforation-after-anorectal-manometry-for-low-anterior-resection-syndrome
#18
Kyung Ha Lee, Ji Yeon Kim, Young Hoon Sul
We experienced 3 cases of manometry-induced colon perforation. A 75-year-old man (case 1) underwent anorectal manometry (ARM) 3 years after radiotherapy for prostate cancer and a laparoscopic intersphincteric resection for rectal cancer. A 70-year-old man (case 2) underwent ARM 3 months after conventional neoadjuvant chemoradiotherapy and a laparoscopic low anterior resection for rectal cancer. A 78-year-old man (case 3) underwent ARM 2 months after a laparoscopic intersphincteric resection for rectal cancer...
August 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28931046/clinical-relevance-of-histologic-subtypes-in-locally-advanced-esophageal-carcinoma-treated-with-pre-operative-chemoradiotherapy-experience-of-a-monographic-oncologic-centre
#19
Maria Saigí, Marc Oliva, Luisa Aliste, Mariona Calvo, Gloria Hormigo, Òlbia Serra, Anna Boladeras, Leandre Farran, Javier Robles, Gloria Creus, Ma José Paúles, Joan B Gornals, Eugenia de Lama, Josep Ma Borràs, Núria Sala, Maica Galán
BACKGROUND: Locally advanced esophageal carcinoma (LAEC) represents less than 30% of all diagnosed esophageal carcinoma worldwide. The standard of care for resectable tumours consists of preoperative chemoradiotherapy (CRT) followed by surgery. Despite the curative intent, the prognosis is still poor mainly due to relapse. A multidisciplinary approach is required in order to optimize the therapeutic strategy and follow-up. Differences in outcomes between the two main histological subtypes, adenocarcinoma (ADC) and squamous cell carcinoma (SCC), have been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28929316/mucinous-adenocarcinoma-on-perianal-fistula-a-rising-entity
#20
C J Alvarez-Laso, S Moral, D Rodríguez, A Carrocera, E Azcano, A Cabrera, R Rodríguez
INTRODUCTION: Mucinous adenocarcinoma on perianal fistula is a rare entity; it could be underdiagnosed because it behaves often as a regular perianal fistula. MATERIALS AND METHODS: We have recently treated four cases in our unit. We present them and review the literature, emphasizing on clinical characteristic and therapeutic options. The four patients were male with a mean age of 64. Three of them were classified as locally advances cases and therefore treated with neoadjuvant therapy...
September 19, 2017: Clinical & Translational Oncology
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