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Colorectal tumour marker

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https://www.readbyqxmd.com/read/29220096/hepatic-progenitor-cells-in-metastatic-liver-carcinomas
#1
Ioanna Delladetsima, Stratigoula Sakellariou, Olivier Govaere, Elpida Poulaki, Evangelos Felekouras, Dina Tiniakos
AIMS: Hepatic progenitor cells (HPCs) are activated in various liver diseases but their role in carcinomatous environment remains unknown. We aimed to identify the possible presence and topography of HPCs in liver metastases. METHODS: We examined 14 liver resection specimens for colorectal adenocarcinoma (CRC) (n=13) and anal squamous cell carcinoma (SCC) (n=1) metastases. Immunohistochemical markers of colonic (keratin 20-K20, CDX2) and squamous cell origin (p63), HPC (K19, CD56) and stem cell (CD44) markers, and the biliary marker K7 which may also highlight HPCs were applied on routinely processed tissue sections...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29203974/deterministic-role-of-cea-and-msi-status-in-predicting-outcome-of-crc-patients-a-perspective-study-amongst-hospital-attending-eastern-indian-populations
#2
Banerjee Koyel, Das Priyabrata, Bhattacharya Rittwika, Dasgupta Swati, Mukhopadhyay Soma, Basak Jayasri, Mukhopadhyay Ashis
Carcinoembryonic antigen (CEA) is an important deterministic factor in predicting colorectal carcinoma (CRC) progression. It is also evident that microsatellite instability (MSI) which results in a hypermutable phenotype of genomic DNA is common in CRC. Owing to the scarcity of reports from India, our aim of this study was to understand the clinicopathological correlations of CEA status with surgery and chemotherapy, correlate the same with socio-demographic status of the patients, determine the MSI status amongst them and understand the prognostic implications of CEA and MSI as CRC progression marker amongst patients...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29188366/pre-operative-neutrophil-count-and-neutrophil-lymphocyte-count-ratio-nlcr-in-predicting-the-histological-grade-of-paediatric-brain-tumours-a-preliminary-study
#3
J R F Wilson, F Saeed, A K Tyagi, J R Goodden, G Sivakumar, D Crimmins, M Elliott, S Picton, P D Chumas
INTRODUCTION: The neutrophil-lymphocyte count ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas and has been suggested to be predictive of histological grade and outcome in adult intracranial tumours. The purpose of this study was to determine whether a correlation of the pre-operative neutrophil count (NC) and NLCR with the final histological grade exists in paediatric intracranial tumours. METHODS: A retrospective analysis was undertaken at a single centre...
November 29, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29183892/treatment-of-advanced-colorectal-cancer-in-a-patient-with-cardiotoxic-reactions-to-5-fluorouracil-and-capecitabine-using-suboptimal-doses
#4
Joseph H Cioffi, Derek J Estes, Vaia Florou, Bach Ardalan
A 32-year-old female with stage IV colorectal cancer and metastasis to the liver experienced cardiotoxic reactions after treatment with 5-fluorouracil and its oral prodrug capecitabine even at two-thirds the recommended dose. After careful considerations, the decision was made to attempt capecitabine retrial at a further suboptimal dose with combination chemotherapy where she no longer experienced cardiac events. As a result, the liver tumour shrank and rectal mass stabilised, tumour markers dropped and she underwent surgical resection of both masses...
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29178362/the-relationship-between-18f-fdg-petct-derived-markers-of-tumour-metabolism-and-systemic-inflammation-in-patients-with-recurrent-disease-following-surgery-for-colorectal-cancer
#5
Stephen T McSorley, Bo Y Khor, Kwong Tsang, David Colville, Sai Han, Paul G Horgan, Donald C McMillan
AIM: 18 F FDG-PETCT derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognised to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. METHODS: Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015, who also underwent 18 F FDG-PETCT, at a single centre were included (n =103)...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29166282/adenocarcinoma-of-the-posterior-segment-of-the-gastrointestinal-tract-in-dogs-clinical-endoscopic-histopathological-and-immunohistochemical-findings
#6
J Spużak, R Ciaputa, K Kubiak, M Jankowski, K Glińska-Suchocka, D Poradowski, M Nowak
Of all the tumours in dogs, three percent are located in the intestines, and 36-60% of those tumours affect the large intestine. Adenocarcinomas of the intestines account for 20-35% of the gastrointestinal tumours and for almost 60% of the large intestine tumours. The aim of the study was to analyze clinical disorders and endoscopic, histopathological and immunohistochemical changes in colorectal adenocarcinomas in dogs with the use of the E-cadherin, β-catenin, cytokeratin 20 (CK20), Ki-67 and minichromosome maintenance 3 (MCM-3)...
September 26, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29156712/radiolabelled-polymeric-iga-from-biodistribution-to-a-new-molecular-imaging-tool-in-colorectal-cancer-lung-metastases
#7
Helene Carpenet, Armelle Cuvillier, Aurélie Perraud, Ophélie Martin, Gaël Champier, Marie-Odile Jauberteau, Jacques Monteil, Isabelle Quelven
By radiolabelling monomeric (m) and polymeric (p) IgA with technetium 99m ((99m)Tc), this study assessed IgA biodistribution and tumour-targeting potency. IgA directed against carcinoembryonic antigen (CEA), a colorectal cancer marker, was selected to involve IgA mucosal tropism. Ig was radiolabelled with (99m)Tc-tricarbonyl after derivatisation by 2-iminothiolane. (99m)Tc-IgA was evaluated by in vitro analysis. The biodistributions of radiolabelled anti-CEA mIgA, pIgA and IgG were compared in normal mice. Anti-CEA pIgA tumour uptake was studied in mice bearing the WiDr caecal orthotopic graft...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128614/gene-expression-profiling-in-colon-of-mice-exposed-to-food-additive-titanium-dioxide-e171
#8
Héloïse Proquin, Marlon J Jetten, Marloes C M Jonkhout, Luis G Garduño-Balderas, Jacob J Briedé, Theo M de Kok, Yolanda I Chirino, Henk van Loveren
Dietary factors that may influence the risks of colorectal cancer, including specific supplements, are under investigation. Previous studies showed the capacity of food additive titanium dioxide (E171) to induce DNA damage in vitro and facilitate growth of colorectal tumours in vivo. This study aimed to investigate the molecular mechanisms behind these effects after E171 exposure. BALB/c mice were exposed by gavage to 5 mg/kgbw/day of E171 for 2, 7, 14, and 21 days. Transcriptome changes were studied by whole genome mRNA microarray analysis on the mice's distal colons...
November 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29104111/clinical-and-biological-significance-of-mir-193a-3p-targeted-kras-in-colorectal-cancer-pathogenesis
#9
Afraa Mamoori, Riajul Wahab, Farhadul Islam, Katherine Lee, Jelena Vider, Cu-Tai Lu, Vinod Gopalan, Alfred King-Yin Lam
This study was to investigate the expression pattern, mechanisms and clinicopathological implications of miR-193a-3p in colorectal cancer. Fresh frozen tissues from 70 matched colorectal adenocarciomas and the adjacent non-neoplastic mucosae were prospectively collected. Two colorectal cancer cell lines (SW480 and SW48) and a non-neoplastic colon cell line (FHC) were also used. The expression levels of miR193a-3p in the cells and tissues were measured by quantitative real-time polymerase chain reaction. The expression of KRAS protein as a predicted downstream target for miR-193a was studied by immunohistochemistry...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29101300/pharmacoproteomic-characterisation-of-human-colon-and-rectal-cancer
#10
Martin Frejno, Riccardo Zenezini Chiozzi, Mathias Wilhelm, Heiner Koch, Runsheng Zheng, Susan Klaeger, Benjamin Ruprecht, Chen Meng, Karl Kramer, Anna Jarzab, Stephanie Heinzlmeir, Elaine Johnstone, Enric Domingo, David Kerr, Moritz Jesinghaus, Julia Slotta-Huspenina, Wilko Weichert, Stefan Knapp, Stephan M Feller, Bernhard Kuster
Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome-guided pre-clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the proteomes of 65 colorectal cancer (CRC) cell lines to a depth of > 10,000 proteins using mass spectrometry. Integration with proteomes of 90 CRC patients and matched transcriptomics data defined integrated CRC subtypes, highlighting cell lines representative of each tumour subtype...
November 3, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/29065427/tenascin-c-in-colorectal-cancer-stroma-is-a-predictive-marker-for-liver-metastasis-and-is-a-potent-target-of-mir-198-as-identified-by-microrna-analysis
#11
Tomohiro Murakami, Hirotoshi Kikuchi, Hisato Ishimatsu, Ichirota Iino, Amane Hirotsu, Tomohiro Matsumoto, Yusuke Ozaki, Toshiki Kawabata, Yoshihiro Hiramatsu, Manabu Ohta, Kinji Kamiya, Mayu Fukushima, Satoshi Baba, Kyoko Kitagawa, Masatoshi Kitagawa, Hiroyuki Konno
BACKGROUND: Tumour stroma has important roles in the development of colorectal cancer (CRC) metastasis. We aimed to clarify the roles of microRNAs (miRNAs) and their target genes in CRC stroma in the development of liver metastasis. METHODS: Tumour stroma was isolated from formalin-fixed, paraffin-embedded tissues of primary CRCs with or without liver metastasis by laser capture microdissection, and miRNA expression was analysed using TaqMan miRNA arrays. RESULTS: Hierarchical clustering classified 16 CRCs into two groups according to the existence of synchronous liver metastasis...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28982739/discovery-of-methylated-circulating-dna-biomarkers-for-comprehensive-non-invasive-monitoring-of-treatment-response-in-metastatic-colorectal-cancer
#12
Ludovic Barault, Alessio Amatu, Giulia Siravegna, Agostino Ponzetti, Sebastian Moran, Andrea Cassingena, Benedetta Mussolin, Chiara Falcomatà, Alexandra M Binder, Carmen Cristiano, Daniele Oddo, Simonetta Guarrera, Carlotta Cancelliere, Sara Bustreo, Katia Bencardino, Sean Maden, Alice Vanzati, Patrizia Zavattari, Giuseppe Matullo, Mauro Truini, William M Grady, Patrizia Racca, Karin B Michels, Salvatore Siena, Manel Esteller, Alberto Bardelli, Andrea Sartore-Bianchi, Federica Di Nicolantonio
OBJECTIVE: Mutations in cell-free circulating DNA (cfDNA) have been studied for tracking disease relapse in colorectal cancer (CRC). This approach requires personalised assay design due to the lack of universally mutated genes. In contrast, early methylation alterations are restricted to defined genomic loci allowing comprehensive assay design for population studies. Our objective was to identify cancer-specific methylated biomarkers which could be measured longitudinally in cfDNA (liquid biopsy) to monitor therapeutic outcome in patients with metastatic CRC (mCRC)...
October 5, 2017: Gut
https://www.readbyqxmd.com/read/28903410/rassf6-downregulation-promotes-the-epithelial-mesenchymal-transition-and-predicts-poor-prognosis-in-colorectal-cancer
#13
Rui Zhou, Lin Qiu, Xiaolong Liu, Lijuan Ling, Ninglei Li, Kun Zhou, Jingbo Sun, Jian Yan, Canliang Tan, Xiaoping Huang, Luzhe Han, Liangchun Yin, Gang Xiao, Lixin Liu
Distant metastasis is the primary barrier for the successful treatment of patients with colorectal cancer, and thus, searching for new therapeutic targets by further exploring the molecular mechanisms of colorectal cancer metastasis is important. In this study, we investigated the biological and clinical significance of RASSF6 in colorectal cancer as well as the underlying molecular mechanisms. We found that low RASSF6 expression corresponds to a poor prognosis in colorectal cancer patients, and low RASSF6 expression is distinctly associated with tumour progression...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28894584/serum-human-epididymis-protein-4-levels-in-colorectal-cancer-patients
#14
Yasemi N Kemal, Guzi N Demirag, Abdulkeri M Bedir, Leman Tomak, Murat Derebey, Di Lek Erdem, Ufuk Gör, Idris Yücel
Tumour markers are widely used for the diagnosis, staging and monitoring of colorectal cancer (CRC) patients in clinical practice. Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are the most frequently used biomarkers in CRC patients. A number of studies have recently investigated the presence of human epididymis protein 4 (HE4) overexpression in certain cancer types. Its significance in ovarian and endometrial cancer has been well-demonstrated. The aim of the present study was to evaluate the significance of serum HE4 levels in CRC patients...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28881356/aldehyde-dehydrogenase-1b1-a-novel-immunohistological-marker-for-colorectal-cancer
#15
Akiko Matsumoto, John Arcaroli, Ying Chen, Maura Gasparetto, Veronique Neumeister, David C Thompson, Surendra Singh, Clayton Smith, Wells Messersmith, Vasilis Vasiliou
BACKGROUND: Aldehyde dehydrogenase (ALDH) 1A1 is an immunohistological biomarker of various solid tumours, but has not been successfully proved as a colorectal cancer (CRC) marker. We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1. METHODS: Human CRC explants and cell lines were analysed to identify candidate CRC markers from eight ALDH isozymes including ALDH1A1 and ALDH1B1. A tissue microarray, including paired specimens of normal and tumour tissues, was subsequently analysed to determine if candidate ALDHs could distinguish CRC from normal tissue...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28874631/the-prognostic-role-of-microsatellite-instability-in-colorectal-cancer-patients
#16
Bogdan V Micu, Octavian Andercou, Stefan C Vesa, Carmen M Micu, Tudor R Pop, Nicolae Constantea
BACKGROUND: Data from the literature regarding the prognostic role of DNA mismatch repair system (MMR) in colorectal cancer are still controversial. AIM: The aim of the study was to identify the prognostic role of different phenotypic, clinical and pathological characteristics in microsatellite unstable vs. microsatellite stable colorectal cancer in terms of survival and disease free interval. METHODS: We conducted a retrospective study that included a total of 103 patients who underwent curative surgery for colorectal cancer...
July 28, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28856900/the-development-of-an-artificial-stool-usable-for-the-surveillance-of-faecal-haemoglobin-testing
#17
Akira Miike, Zensuke Ogawa, Ikunosuke Sakurabayashi
Background Faecal occult blood testing is an important diagnostic tool for the detection of colorectal cancer. However, it has not been standardized due to the absence of suitable specimens for surveillance. Methods We developed a ready-to-use artificial stool made from rice flour. This new artificial stool homogeneously contains not only human haemoglobin A0 (HbA0) but also glycerol as an internal standard material. After the collection of the artificial stool into a buffer, the haemoglobin concentration in dispersed solution was measured using a method based on the peroxidase like activity of haemoglobin...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28833449/microrna-145-downregulates-sip1-expression-but-differentially-regulates-proliferation-migration-invasion-and-wnt-signalling-in-sw480-and-sw620-cells
#18
Anusha Sathyanarayanan, Karthik Subramanian Chandrasekaran, Devarajan Karunagaran
microRNA-145 (miR-145) has been shown to act as a tumour suppressor in colorectal cancer but its role in the regulation of epithelial-mesenchymal transition (EMT) is unclear. Ectopic expression of miR-145 suppressed the proliferation, migration and invasion in SW480 but surprisingly enhanced these traits in its metastatic counterpart, SW620 cells while antimiR-145 reversed the effects of miR-145 in both of these human colorectal cancer cells. In SW480 and SW620 cells, Smad-interacting protein 1 (SIP1), was identified as a target of miR-145, and its expression was suppressed both at mRNA and protein levels and siRNA-SIP1 mimicked the effects of miR-145...
August 22, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28833104/low-folate-metabolic-stress-reprograms-dna-methylation-activated-sonic-hedgehog-signaling-to-mediate-cancer-stem-cell-like-signatures-and-invasive-tumour-stage-specific-malignancy-of-human-colorectal-cancers
#19
Hsin-Chun Feng, Jhuan-Yu Lin, Shu-Han Hsu, Wen-Yu Lan, Chang-Sheng Kuo, Yu-Feng Tian, Ding-Ping Sun, Rwei-Fen Syu Huang
The mechanistic role of colonic low folate metabolic stress (LFMS) in colorectal cancer (CRC) malignancy development remains unknown. Folate analysis on the 99 paired human CRC tissues localized LFMS to the deep invasive T3/T4 staged tumours with hypo-methylated sonic hedgehog (Shh) promoter region and amplified expressions of Shh ligand and Gli1 effector, which coincided with deregulated expressions of the epithelial-mesenchymal transition (EMT) mediators. Colonic folate levels of CRC were inversely correlated with pluripotent expressions of the SOX2, NANOG and OCT4 markers (p < 0...
December 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28811822/overall-survival-of-elderly-patients-having-surgery-for-colorectal-cancer-is-comparable-to-younger-patients-results-from-a-south-asian-population
#20
Pramodh Chitral Chandrasinghe, Dileepa Senajith Ediriweera, Thaaqib Nazar, Sumudu Kumarage, Janaki Hewavisenthi, Kemal Ismail Deen
INTRODUCTION: There has been a continuous debate on whether elderly patients with colorectal cancer (CRC) fair worse. The aim of this study is to assess the thirty-day mortality (TDM) and overall survival (OS) of elderly patients undergoing surgery for CRC. METHOD: OS between two groups (≥70 versus <70 years) having surgery for CRC was analyzed. Demographics, tumour characteristics, and serological markers were considered as independent factors. Multivariable analysis was done using the Cox proportional hazard model...
2017: Gastroenterology Research and Practice
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