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https://www.readbyqxmd.com/read/29052437/5-6-dehydrokawain-from-the-rhizome-of-alpinia-mutica-roxb-induced-proangiogenic-tumour-derived-vegf-of-ht-29-colorectal-cancer
#1
Ibrahim Malami, Aliyu Muhammad, Ibrahim B Abubakar, Imaobong C Etti, Peter M Waziri, Ramadan M Abubakar, Halilu E Mshelia
Vascular endothelial growth factor (VEGF) is a glycoprotein vital to the regulation of vascular endothelial cells proliferation, migration and angiogenesis. The expression of VEGF is required for the formation of new blood vessels critical in supplying oxygen and nutrition in the course of tumorigenesis. The present study investigated the effect of 5,6-dehydrokawain isolated from the rhizomes of Alpinia mutica on VEGF expression in vitro using HT-29 cell line. The results revealed that 5,6-dehydrokawain induced the expression of proangiogenic tumour-derived VEGF of HT-29 cells, which may explain the inability of 5,6-dehydrokawain in suppressing cancer cells proliferation...
October 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29048669/microrna%C3%A2-337-inhibits-colorectal-cancer-progression-by-directly-targeting-kras-and-suppressing-the-akt-and-erk-pathways
#2
Xuerong Liu, Yan Wang, Jinglong Zhao
Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Tumour progression and development in CRC is a multi-step process involving a large number of genetic and epigenetic alterations. Previous studies indicated that abnormally expressed microRNAs play critical roles in CRC through regulation of oncogenic and tumour-suppressor genes. Hence, determination of the function of microRNAs may provide novel therapeutic targets for CRC diagnosis and treatments...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29047142/relevance-of-liver-limited-disease-in-metastatic-colorectal-cancer-subgroup-findings-of-the-fire-3-aio-krk0306-trial
#3
Julian Walter Holch, Ingrid Ricard, Sebastian Stintzing, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Ursula Vehling-Kaiser, Salah-Eddin Al-Batran, Tobias Heintges, Christian Lerchenmüller, Christoph Kahl, Frank Kullmann, Werner Scheithauer, Michael Scholz, Sebastian Müller, Hartmut Link, Andreas Rost, Heinz-Gert Höffkes, Markus Moehler, Reinhard Udo Lindig, Lisa Miller-Phillips, Thomas Kirchner, Andreas Jung, Jobst Christian von Einem, Dominik Paul Modest, Volker Heinemann
In metastatic colorectal cancer (mCRC), liver-limited disease (LLD) is associated with a higher chance of metastectomy leading to long-term survival. However, limited data describes the prognostic and predictive relevance of initially unresectable LLD with regard to targeted first-line therapy. The present analysis investigated the relevance of initially unresectable LLD in mCRC patients treated with targeted therapy against either the epidermal growth factor receptor (EGFR) or vascular epithelial growth factor (VEGF)...
October 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29045518/negative-hyper-selection-of-metastatic-colorectal-cancer-patients-for-anti-egfr-monoclonal-antibodies-the-pressing-case-control-study
#4
C Cremolini, F Morano, R Moretto, R Berenato, E Tamborini, F Perrone, D Rossini, A Gloghini, A Busico, G Zucchelli, C Baratelli, E Tamburini, M Tampellini, E Sensi, G Fucà, C Volpi, M Milione, M Di Maio, G Fontanini, F De Braud, A Falcone, F Pietrantonio
Background: Refining the selection of metastatic colorectal cancer (mCRC) patients candidates for anti-EGFR monoclonal antibodies beyond RAS and BRAF testing is a challenge of precision oncology. Several uncommon genomic mechanisms of primary resistance, leading to activation of tyrosine kinase receptors other than EGFR or downstream signaling pathways, have been suggested by preclinical and retrospective studies. Patients and methods: We conducted this multicenter, prospective, case-control study to demonstrate the negative predictive impact of a panel of rare genomic alterations (PRESSING panel), including HER2/MET amplifications, ALK/ROS1/NTRK1-3/RET fusions, and HER2/PI3K/PTEN/AKT1 mutations...
September 25, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045509/the-antibody-drug-conjugate-target-landscape-across-a-broad-range-of-tumour-types
#5
K L Moek, D J A de Groot, E G E de Vries, R S N Fehrmann
Background: Antibody-drug conjugates (ADCs), consisting of an antibody designed against a specific target at the cell membrane linked with a cytotoxic agent, are an emerging class of therapeutics. Since ADC tumour cell targets do not have to be drivers of tumour growth, ADCs are potentially relevant for a wide range of tumours currently lacking clear oncogenic drivers. Therefore, we aimed to define the landscape of ADC targets in a broad range of tumours. Materials and methods: PubMed and ClinicalTrials...
September 25, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044573/higher-igfb3-is-associated-with-increased-incidence-of-colorectal-cancer-in-older-men-independently-of-igf1
#6
Yi X Chan, Helman Alfonso, S A Paul Chubb, Ken K Y Ho, P Gerry Fegan, Graeme J Hankey, Jonathan Golledge, Leon Flicker, Bu B Yeap
OBJECTIVE: Insulin-like growth factor 1 (IGF1) has anabolic and growth-promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk. DESIGN: A prospective cohort study of 4042 men aged ≥70 years. METHODS: Plasma total IGF1, IGFBP1 and IGFBP3 were measured between 2001-2004...
October 16, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29044515/the-human-pkp2-plakophilin-2-gene-is-induced-by-wnt-%C3%AE-catenin-in-normal-and-colon-cancer-associated-fibroblasts
#7
Núria Niell, María Jesús Larriba, Gemma Ferrer-Mayorga, Isabel Sánchez-Pérez, Ramón Cantero, Francisco X Real, Luis Del Peso, Alberto Muñoz, José Manuel González-Sancho
Colorectal cancer results from the malignant transformation of colonic epithelial cells. Stromal fibroblasts are the main component of the tumour microenvironment, and play an important role in the progression of this and other neoplasias. Wnt/β-catenin signalling is essential for colon homeostasis, but aberrant, constitutive activation of this pathway is a hallmark of colorectal cancer. Here we present the first transcriptomic study on the effect of a Wnt factor on human colonic myofibroblasts. Wnt3A regulates the expression of 1136 genes, of which 662 are upregulated and 474 are downregulated in CCD-18Co cells...
October 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29043454/a-fluorescent-oxaliplatin-derivative-for-investigation-of-oxaliplatin-resistance-using-imaging-techniques
#8
Ganna V Kalayda, Maximilian Kullmann, Markus Galanski, Sabrina Gollos
Oxaliplatin is the backbone of chemotherapy for advanced colorectal cancer and undergoes clinical trials for treatment of other tumour entities. However, acquired resistance is a major hurdle. Confocal microscopy is a useful tool to get an insight into the mechanisms of resistance but it requires fluorescent compounds. This work describes the synthesis of the novel oxaliplatin derivative (CFDA-oxPt) featuring 5(6)-carboxyfluorescein diacetate and evaluation of its applicability for the investigation of oxaliplatin resistance using imaging techniques...
October 17, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29042709/derivation-and-basic-characterization-of-colorectal-carcinoma-primary-cell-lines
#9
Lukas Krbal, Jiri Soukup, Stanislav John, Veronika Hanusova
BACKGROUND: Colorectal carcinoma is one of the most common malignancies in western countries. Among different approaches to its research, primary cancer cell lines can play an important role. AIM: The main purposes of this study were: 1) to establish an effective and reproducible method of colorectal cancer cell isolation and cultivation from primary tumours and lymph node metastases and 2) to elucidate the biological features of the tumours favouring successful cell cultivation...
October 17, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29040706/inhibition-of-survivin-expression-after-using-oxaliplatin-and-vinflunine-to-induce-cytogenetic-damage-in-vitro-in-lymphocytes-from-colon-cancer-patients-and-healthy-individuals
#10
Amal A A Alotaibi, Mojgan Najafzadeh, Justin D Davies, Adolf Baumgartner, Diana Anderson
Chemotherapy drugs usually inflict a lethal dose to tumour cells with the consequence that these cells are being killed by cell death. However, each round of chemotherapy also causes damage to normal somatic cells. The DNA cross-linking agent oxaliplatin (OXP), which causes DNA double-strand breaks, and vinflunine (VFN), which disrupts the mitotic spindle, are two of these chemotherapy drugs which were evaluated in vitro using peripheral lymphocytes from colorectal cancer patients and healthy individuals to determine any differential response...
October 4, 2017: Mutagenesis
https://www.readbyqxmd.com/read/29040282/colorectal-carcinoma-tumour-budding-and-podia-formation-in-the-xenograft-microenvironment
#11
Friedrich Prall, Claudia Maletzki, Maja Hühns, Mathias Krohn, Michael Linnebacher
Tumour budding and podia formation are well-appreciated in surgical pathology as an aggressive invasion phenotype of colorectal carcinoma cells that is attained in the microenvironment of the invasive margin. In this study, we addressed how tumour budding and podia formation feature in xenografts. Primary colorectal carcinomas (N = 44) of various molecular types (sporadic standard type, high-degree microsatellite-unstable, CpG island methylator phenotype) were transplanted subcutaneously into T and B cell-deficient NSG mice, making possible immunohistochemistry with routine surgical pathology antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/29039474/evaluation-of-a-radiocobalt-labelled-affibody-molecule-for-imaging-of-human-epidermal-growth-factor-receptor-3-expression
#12
Maria Rosestedt, Ken G Andersson, Bogdan Mitran, Sara S Rinne, Vladimir Tolmachev, John Löfblom, Anna Orlova, Stefan Ståhl
The human epidermal growth factor receptor 3 (HER3) is involved in the development of cancer resistance towards tyrosine kinase-targeted therapies. Several HER3‑targeting therapeutics are currently under clinical evaluation. Non-invasive imaging of HER3 expression could improve patient management. Affibody molecules are small engineered scaffold proteins demonstrating superior properties as targeting probes for molecular imaging compared with monoclonal antibodies. Feasibility of in vivo HER3 imaging using affibody molecules has been previously demonstrated...
October 11, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29035389/-mcc-protein-interacts-with-e-cadherin-and-%C3%AE-catenin-strengthening-cell-cell-adhesion-of-hct116-colon-cancer-cells
#13
F A Benthani, D Herrmann, P N Tran, L Pangon, M C Lucas, A H Allam, N Currey, S Al-Sohaily, M Giry-Laterriere, J Warusavitarne, P Timpson, M R J Kohonen-Corish
E-cadherin and β-catenin are key proteins that are essential in the formation of the epithelial cell layer in the colon but their regulatory pathways that are disrupted in cancer metastasis are not completely understood. Mutated in colorectal cancer (MCC) is a tumour suppressor gene that is silenced by promoter methylation in colorectal cancer and particularly in patients with increased lymph node metastasis. Here, we show that MCC methylation is found in 45% of colon and 24% of rectal cancers and is associated with proximal colon, poorly differentiated, circumferential and mucinous tumours as well as increasing T stage and larger tumour size...
October 16, 2017: Oncogene
https://www.readbyqxmd.com/read/29034252/age-and-outcome-in-gastrointestinal-cancers-a-population-based-evaluation-of-oesophageal-gastric-and-colorectal-cancer
#14
Anne Schlesinger-Raab, Jens Werner, Helmut Friess, Dieter Hölzel, Jutta Engel
BACKGROUND: With demographic changes and partial representativeness of randomized studies the question arises which results are achieved in the treatment of the elderly. The objective was to analyse population-based data on gastrointestinal cancers in terms of age. METHODS: Analyses included data of the Munich Cancer Registry, i.e. 4,014, 10,127 and 42,809 invasive oesophageal, gastric and colorectal cancer patients, respectively, which were diagnosed between 1998 and 2014...
August 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29032802/radioembolisation-of-hepatocellular-carcinoma-a-primer
#15
REVIEW
N Venkatanarasimha, A Gogna, K T A Tong, K Damodharan, P K H Chow, R H G Lo, S Chandramohan
Transarterial radioembolisation (TARE) has gained increasing acceptance as an additional/alternative locoregional treatment option for hepatocellular carcinoma, and colorectal hepatic metastases that present beyond potentially curative options. This is a catheter-based transarterial selective internal brachytherapy that involves injection of radioactive microspheres (usually Y-90) that are delivered selectively to the liver tumours. Owing to the combined radioactive and microembolic effect, the findings at follow-up imaging are significantly different from that seen with other transarterial treatment options...
October 9, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29032208/chitosan-based-nano-formulation-enhanced-the-anticancer-efficacy-of-hesperetin
#16
Lizha Mary, Balaji Sadhasivam, Kanagaraj Palaniyandi, Thangavel Muthuswamy, Ilangovan Ramachandran, Anandhan Balakrishnan, Surajit Pathak, Shoba Narayan, Satish Ramalingam
Cancer is one of the major causes of increased morbidity and mortality in modern society. Colorectal cancer is the third leading cause for cancer related death worldwide. Current chemotherapeutics are not very effective and have severe side effects. Hesperetin is a bioflavonoid from citrus fruits and its clinical use is restricted because of the poor water solubility. Folate receptor is over expressed in various cancer cells. In this regard, we have synthesized the Chitosan Folate Hesperetin nanoparticle (CFH) by covalently conjugating folic acid with chitosan molecules...
October 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29029407/molecular-profiling-of-colorectal-pulmonary-metastases-and-primary-tumours-implications-for-targeted-treatment
#17
Sing Y Moorcraft, Thomas Jones, Brian A Walker, George Ladas, Eleftheria Kalaitzaki, Lina Yuan, Ruwaida Begum, Zakaria Eltahir, Andrew Wotherspoon, Angeles Montero-Fernandez, Larissa S Teixeira Mendes, David Gonzalez de Castro, Sanna Hulkki Wilson, Paula Proszek, Ye M To, Eliza Hawkes, Amitesh Roy, David Cunningham, Sheela Rao, David Watkins, Naureen Starling, Anne M Bowcock, Ian Chau
This study aimed to molecularly characterise colorectal pulmonary metastases (PM) and investigate whether their molecular profiles were concordant with those of the primary tumour. Clinical data and archival formalin fixed paraffin embedded tissue samples were retrospectively collected from patients who underwent ≥ 1 pulmonary metastasectomies for colorectal cancer between 1997-2012. Primary tumour and metastatic samples were analysed using a targeted capture sequencing panel of 46 cancer-associated genes...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027279/long-non-coding-rna-pvt1-emerging-biomarker-in-digestive-system-cancer
#18
REVIEW
Dan-Dan Zhou, Xiu-Fen Liu, Cheng-Wei Lu, Om Prakash Pant, Xiao-Dong Liu
The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest...
October 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29025352/risk-of-colorectal-polyps-and-of-malignancies-in-asymptomatic-carriers-of-mutations-in-the-main-dna-mismatch-repair-genes
#19
Maurizio Ponz de Leon, Monica Pedroni, Annalisa Pezzi, Blerta Sulce, Luca Roncucci, Federica Domati, Giuseppina Rossi, Luca Reggiani Bonetti
OBJECTIVE: Mutation carriers (Mut+) in DNA mismatch repair genes are predisposed to cancer of various organs and to adenomatous polyps; however, they may remain asymptomatic and cancer or polyp-free for several years. We purposed to analyse the clinical follow-up of individuals carrying constitutional mutations in the MLH1, MSH2 or MSH6 genes who were unaffected by benign polyps or malignant tumours at diagnosis. MATERIAL AND METHODS: Mut + subjects (n.81) were members of Lynch syndromes in whom mutations were detected between 1993 and 2015; all were asymptomatic at diagnosis...
October 12, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29023799/mir-214-activates-tp53-but-suppresses-the-expression-of-rela-ctnnb1-and-stat3-in-human-cervical-and-colorectal-cancer-cells
#20
Karthik Subramanian Chandrasekaran, Anusha Sathyanarayanan, Devarajan Karunagaran
High Mobility Group AT-hook 1 (HMGA1) was identified as a target of miR-214 in human cervical and colorectal cancers (CaCx and CRC) in a previous study. While the expression of miR-214 remains suppressed, HMGA1 behaves as a potent oncogene and plays crucial roles in several aberrant signalling pathways by interacting with intermediates like RELA, CTNNB1, STAT3, and TP53 in CaCx and CRC. Hypothetically, miR-214 should be able to regulate the stabilization of some of these intermediates through the regulation of HMGA1...
October 10, 2017: Cell Biochemistry and Function
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