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https://www.readbyqxmd.com/read/29472279/comprehensive-analysis-of-the-mlh1-promoter-region-in-480-patients-with-colorectal-cancer-and-1150-controls-reveals-new-variants-including-one-with-a-heritable-constitutional-mlh1-epimutation
#1
Monika Morak, Ayseguel Ibisler, Gisela Keller, Ellen Jessen, Andreas Laner, Daniela Gonzales-Fassrainer, Melanie Locher, Trisari Massdorf, Anke M Nissen, Anna Benet-Pagès, Elke Holinski-Feder
BACKGROUND: Germline defects in MLH1 , MSH2 , MSH6 and PMS2 predisposing for Lynch syndrome (LS) are mainly based on sequence changes, whereas a constitutional epimutation of MLH1 (CEM) is exceptionally rare. This abnormal MLH1 promoter methylation is not hereditary when arising de novo, whereas a stably heritable and variant-induced CEM was described for one single allele. We searched for MLH1 promoter variants causing a germline or somatic methylation induction or transcriptional repression...
February 22, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29471890/microrna-744-inhibits-cellular-proliferation-and-invasion-of-colorectal-cancer-by-directly-targeting-oncogene-notch1
#2
Jian Shen, Minzhe Li
Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study of miRNAs and their association with CRC may be a promising therapeutic method for patients with this malignancy. MiRNA-744 (miR-744) is abnormally expressed in several types of human cancer. Thus far, little is known about the expression, biological roles and exact mechanisms of miR-744 in CRC. Thus, the present study measured the expression level of miR-744 and investigated its roles and associated molecular mechanisms in CRC...
February 22, 2018: Oncology Research
https://www.readbyqxmd.com/read/29471618/visual-probing-of-rectal-neoplasia-near-infrared-interrogation-of-primary-tumours-and-secondary-lymph-nodes
#3
Haseeb A Khokhar, Eamon Loughman, Moataz Khogali, Niall Mulligan, Donal F O'Shea, Ronan A Cahill
Laparoscopic and endoscopic colorectal intervention and operations have their basis in real-time, image-based decision-making and step-by-step sequenced technical progress. The capacity to visualise accurately malignant disease wherever it may be including within the primary lesion and its draining lymph node basin as well as at potential sites of metastatic harbour (i.e. peritoneum, liver and lung) would allow more accurate surgery at the time of operation and enable personalised, stratified surgical intervention...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29467373/deep-learning-based-tissue-analysis-predicts-outcome-in-colorectal-cancer
#4
Dmitrii Bychkov, Nina Linder, Riku Turkki, Stig Nordling, Panu E Kovanen, Clare Verrill, Margarita Walliander, Mikael Lundin, Caj Haglund, Johan Lundin
Image-based machine learning and deep learning in particular has recently shown expert-level accuracy in medical image classification. In this study, we combine convolutional and recurrent architectures to train a deep network to predict colorectal cancer outcome based on images of tumour tissue samples. The novelty of our approach is that we directly predict patient outcome, without any intermediate tissue classification. We evaluate a set of digitized haematoxylin-eosin-stained tumour tissue microarray (TMA) samples from 420 colorectal cancer patients with clinicopathological and outcome data available...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466973/occurrence-of-colorectal-aberrant-crypt-foci-depending-on-age-and-dietary-patterns-of-patients
#5
Marek Kowalczyk, Marcin Orłowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk, Agnieszka Pedrycz
BACKGROUND: Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can affect the development of several dozen percentages of malignant tumours, including CRC. In the present study, an attempt was made to assess the incidence and growth dynamics of ACF and to determine whether the type of diet affected the development and number of AFC. METHODS: Colonoscopy combined with rectal mucosa staining with 0...
February 21, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29464112/phase-i-study-of-tomuzotuximab-a-glycoengineered-therapeutic-antibody-against-the-epidermal-growth-factor-receptor-in-patients-with-advanced-carcinomas
#6
Walter Fiedler, Sara Cresta, Henning Schulze-Bergkamen, Sara De Dosso, Jens Weidmann, Anna Tessari, Hans Baumeister, Antje Danielczyk, Bruno Dietrich, Steffen Goletz, Alfredo Zurlo, Marc Salzberg, Cristiana Sessa, Luca Gianni
Background: Changes in glycosylation of the constant domain (Fc) of monoclonal antibodies (mAbs) enhance antibody-dependent cell-mediated cytotoxicity independently of downstream effects following receptor blockade by the antibody, thus extending their indication. We investigated the safety, pharmacokinetics, pharmacodynamics and antitumour activity of tomuzotuximab, an IgG1 glycoengineered mAb against the epidermal growth factor receptor with enhanced tumour cytotoxicity in a phase I dose-escalation study (NTC01222637)...
2018: ESMO Open
https://www.readbyqxmd.com/read/29458792/circulating-tumour-dna-a-promising-biomarker-for-the-management-of-colorectal-cancer
#7
REVIEW
Shelize Khakoo, Alexandros Georgiou, Marco Gerlinger, David Cunningham, Naureen Starling
Circulating cell free tumour DNA (ctDNA) maintains the same genomic alterations that are present in the corresponding tumour, thereby allowing for quantitative and qualitative real-time evaluation in body fluids as an alternative to onerous repeat biopsies. Improvements in the sensitivity of techniques used to identify ctDNA has led to a surge of research investigating its role in the detection of: early disease, relapse, response to therapy and emerging drug resistance mechanisms. Following curative surgery, ctDNA detection is a promising marker of minimal residual disease and could better select patients for adjuvant chemotherapy...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29455175/when-a-polyp-is-not-a-polyp-incidental-finding-of-a-sigmoid-schwannoma-at-first-colonoscopic-screening
#8
Alexandra Leonard, Lezah P McCarthy, Danielle M Pastor
Schwannomas, peripheral nerve sheath tumours arising from Schwann cells, are often associated with inherited disorders such as neurofibromatosis. Gastrointestinal schwannomas, while rare, have been reported in those without personal or family history of neurofibromatosis. Diagnoses of these lesions, however, typically follow evaluations prompted by symptomatic presentations associated with abdominal pain, rectal bleeding, change in bowel habits or positive results on faecal occult blood tests performed for colorectal cancer screening...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29450632/author-correction-exploratory-analyses-assessing-the-impact-of-early-tumour-shrinkage-and-depth-of-response-on-survival-outcomes-in-patients-with-ras-wild-type-metastatic-colorectal-cancer-receiving-treatment-in-three-randomised-panitumumab-trials
#9
Julien Taieb, Fernando Rivera, Salvatore Siena, Meinolf Karthaus, Manuel Valladares-Ayerbes, Javier Gallego, Michael Geissler, Reija Koukakis, Gaston Demonty, Marc Peeters
The authors would like to include the following changes in the published article.
February 15, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29449642/nit1-suppresses-tumour-proliferation-by-activating-the-tgf%C3%AE-1-smad2-3-signalling-pathway-in-colorectal-cancer
#10
Chun Lin, Jianming Zhang, Yanxia Lu, Xiaomin Li, Wenjuan Zhang, Wei Zhang, Weihao Lin, Lin Zheng, Xuenong Li
NIT1 protein has been reported to be a potential tumour suppressor in tumour progression. However, little is known about the specific role of NIT1 in tumour development and progression. In this study, we confirmed the specific effects of NIT1 in the regulation of colorectal carcinoma cell proliferation. Here, we showed that NIT1 was significantly downregulated in colorectal cancer tissues compared with that in adjacent normal tissues. The decreased expression of NIT1 was significantly correlated with poor differentiation and more serosal invasion...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29442241/does-the-number-of-operating-specialists-influence-the-conversion-rate-and-outcomes-after-laparoscopic-colorectal-cancer-surgery
#11
Nader K Francis, Nathan J Curtis, Louise Crilly, Emma Noble, Tamsin Dyke, Rob Hipkiss, Richard Dalton, Andrew Allison, Emad Salib, Jonathan Ockrim
BACKGROUND: Laparoscopic techniques in colorectal surgery have been widely utilised due to short-term patient benefits but conversion to open surgery is associated with adverse short- and long-term patient outcomes. The aim of this study was to investigate the influence of dual specialist operating on the conversion rate and patient outcomes following laparoscopic colorectal surgery. METHODS: A prospectively populated colorectal cancer surgery database was reviewed...
February 13, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29440231/-ex-vivo-activity-of-cytotoxic-drugs-and-targeted-agents-in-small-intestinal-nets
#12
Kosmas Daskalakis, Olov Norlen, Andreas Karakatsanis, Per Hellman, Rolf Larsson, Peter Nygren, Peter Stalberg
Small intestinal endocrine tumours (SI-NETs) are generally considered resistant to systemic treatment. To date, predictive markers for drug activity are lacking. Tumour samples from 27 patients with SI-NETs were analyzed ex vivo for sensitivity to a panel of cytotoxic drugs and targeted agents using a short-term total cell kill assay. Samples of renal cancer, colorectal cancer (CRC), ovarian cancer, and chronic lymphocytic leukemia (CLL) were included for comparison. For the SI-NET subset, drug sensitivity was analyzed in relation to clinico-pathological variables and pre-treatment biomarkers...
February 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29439711/liver-resection-surgery-versus-thermal-ablation-for-colorectal-liver-metastases-lava-study-protocol-for-a-randomised-controlled-trial
#13
Kurinchi Gurusamy, Neil Corrigan, Julie Croft, Maureen Twiddy, Stephen Morris, Nick Woodward, Steve Bandula, Daniel Hochhauser, Vicky Napp, Alison Pullan, Nicholas Jakowiw, Raj Prasad, Steven Olde Damink, C J H M van Laarhoven, Johannes H W de Wilt, Julia Brown, Brian R Davidson
BACKGROUND: Although surgical resection has been considered the only curative option for colorectal liver metastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to define the efficacy of resection vs ablation for the treatment of colorectal liver metastases. METHODS: Design and setting: This is a multicentre, open, randomised controlled non-inferiority trial design with internal pilot and will be performed in tertiary liver centres in UK and The Netherlands...
February 13, 2018: Trials
https://www.readbyqxmd.com/read/29439668/hipect4-multicentre-randomized-clinical-trial-to-evaluate-safety-and-efficacy-of-hyperthermic-intra-peritoneal-chemotherapy-hipec-with-mitomycin-c-used-during-surgery-for-treatment-of-locally-advanced-colorectal-carcinoma
#14
A Arjona-Sánchez, P Barrios, E Boldo-Roda, B Camps, J Carrasco-Campos, V Concepción Martín, A García-Fadrique, A Gutiérrez-Calvo, R Morales, G Ortega-Pérez, E Pérez-Viejo, A Prada-Villaverde, J Torres-Melero, E Vicente, P Villarejo-Campos, J M Sánchez-Hidalgo, A Casado-Adam, Ruben García-Martin, Manuel Medina, T Caro, C Villar, Enrique Aranda, M T Cano-Osuna, C Díaz-López, E Torres-Tordera, F J Briceño-Delgado, S Rufián-Peña
BACKGROUND: Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6%. There are promising results using prophylactic HIPEC in this group of patients, and it is estimated that up to 26% of all T4 colon cancer could benefit from this treatment with a minimal morbidity. Adjuvant HIPEC is effective to avoid the possibility of peritoneal seeding after surgical resection...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29438375/telomere-length-and-genetics-are-independent-colorectal-tumour-risk-factors-in-an-evaluation-of-biomarkers-in-normal-bowel
#15
Ceres Fernandez-Rozadilla, Christiana Kartsonaki, Connor Woolley, Michael McClellan, Deb Whittington, Gareth Horgan, Simon Leedham, Skirmantas Kriaucionis, James East, Ian Tomlinson
BACKGROUND: Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors. METHODS: We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29438366/ikk%C3%AE-is-required-in-the-intestinal-epithelial-cells-for-tumour-stemness
#16
Carlota Colomer, Pol Margalef, Jessica Gonzalez, Anna Vert, Anna Bigas, Lluis Espinosa
BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-κB signalling is a key element in cancer, mainly related to the activity of IKKβ. IKKα kinase also participates in this process by mechanisms that are primarily unknown. METHODS: We generated a compound mouse model with mutation in Apc and lacking intestinal epithelial IKKα, produced intestinal organoids and tumour spheroids with different genetic backgrounds, and performed immunohistochemistry and RNA-seq analysis...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29437871/gut-microbiota-modulate-t-cell-trafficking-into-human-colorectal-cancer
#17
Eleonora Cremonesi, Valeria Governa, Jesus Francisco Glaus Garzon, Valentina Mele, Francesca Amicarella, Manuele Giuseppe Muraro, Emanuele Trella, Virginie Galati-Fournier, Daniel Oertli, Silvio Raffael Däster, Raoul A Droeser, Benjamin Weixler, Martin Bolli, Raffaele Rosso, Ulrich Nitsche, Nina Khanna, Adrian Egli, Simone Keck, Julia Slotta-Huspenina, Luigi M Terracciano, Paul Zajac, Giulio Cesare Spagnoli, Serenella Eppenberger-Castori, Klaus-Peter Janssen, Lubor Borsig, Giandomenica Iezzi
OBJECTIVE: Tumour-infiltrating lymphocytes (TILs) favour survival in human colorectal cancer (CRC). Chemotactic factors underlying their recruitment remain undefined. We investigated chemokines attracting T cells into human CRCs, their cellular sources and microenvironmental triggers. DESIGN: Expression of genes encoding immune cell markers, chemokines and bacterial 16S ribosomal RNA (16SrRNA) was assessed by quantitative reverse transcription-PCR in fresh CRC samples and corresponding tumour-free tissues...
February 6, 2018: Gut
https://www.readbyqxmd.com/read/29437041/preoperative-exercise-halves-the-postoperative-complication-rate-in-patients-with-lung-cancer-a-systematic-review-of-the-effect-of-exercise-on-complications-length-of-stay-and-quality-of-life-in-patients-with-cancer
#18
REVIEW
Daniel Steffens, Paula R Beckenkamp, Mark Hancock, Michael Solomon, Jane Young
OBJECTIVE: To investigate the effectiveness of preoperative exercises interventions in patients undergoing oncological surgery, on postoperative complications, length of hospital stay and quality of life. DESIGN: Intervention systematic review with meta-analysis. DATA SOURCES: MEDLINE, Embase and PEDro. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Trials investigating the effectiveness of preoperative exercise for any oncological patient undergoing surgery were included...
February 1, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29429443/colorectal-cancer-in-south-africa-an-assessment-of-disease-presentation-treatment-pathways-and-5-year-survival
#19
M Brand, P Gaylard, J Ramos
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in South Africa (SA), and the sixth most lethal. Approximately 25% of patients will have synchronous metastatic disease at the time of their primary CRC diagnosis. Although chemotherapy is used in most stages of the disease, surgical resection of the primary tumour and metastases remains the most successful treatment modality to achieve cure or prolong survival. To date, no data on CRC presentation and management have been published in SA...
February 1, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29428571/integrative-expression-quantitative-trait-locus-based-analysis-of-colorectal-cancer-identified-a-functional-polymorphism-regulating-slc22a5-expression
#20
Danyi Zou, Jiao Lou, Juntao Ke, Shufang Mei, Jiaoyuan Li, Yajie Gong, Yang Yang, Ying Zhu, Jianbo Tian, Jiang Chang, Rong Zhong, Jing Gong, Xiaoping Miao
Multiple single nucleotide polymorphisms (SNPs) have been found to be highly correlated with colorectal cancer (CRC) risk. However, the variants identified thus far only explain a small part of the cases, suggesting the existence of many uncharacterised genetic determinants. In this study, using the multilevel 'omics' data provided in The Cancer Genome Atlas, we systematically performed expression quantitative trait locus (eQTL) analysis for CRC and identified nine SNPs with significant effects on mRNA expression (correlation |r| > 0...
February 8, 2018: European Journal of Cancer
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