Pengyan Wang, Can Yue, Kefang Liu, Dan Lu, Sai Liu, Sijia Yao, Xin Li, Xiaoling Su, Keyi Ren, Yan Chai, Jianxun Qi, Yingze Zhao, Yongliang Lou, Zeyu Sun, George F Gao, William J Liu
Marsupials are one of three major mammalian lineages that include the placental eutherians and the egg-laying monotremes. The marsupial brushtail possum is an important protected species in the Australian forest ecosystem. Molecules encoded by the MHC genes are essential mediators of adaptive immune responses in virus-host interactions. Yet, nothing is known about the peptide presentation features of any marsupial MHC class I (MHC I). This study identified a series of possum MHC I Trvu-UB*01:01 binding peptides derived from wobbly possum disease virus (WPDV), a lethal virus of both captive and feral possum populations, and unveiled the structure of marsupial peptide/MHC I complex...
October 15, 2021: Journal of Immunology