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https://www.readbyqxmd.com/read/29121673/influence-of-vitamin-d-on-key-bacterial-taxa-in-infant-microbiota-in-the-koala-birth-cohort-study
#1
Chris E Talsness, John Penders, Eugène H J M Jansen, Jan Damoiseaux, Carel Thijs, Monique Mommers
Vitamin D has immunomodulatory properties giving it the potential to affect microbial colonization of the intestinal tract. We investigated whether maternal vitamin D supplemention, maternal plasma 25-hydroxyvitamin D concentration, or direct supplementation of the infant influences key bacterial taxa within microbiota of one month old infants. Infant and maternal vitamin D supplement use was ascertained via questionnaires. Maternal plasma 25-hydroxyvitamin D was determined at approximately the 36th week of pregnancy...
2017: PloS One
https://www.readbyqxmd.com/read/28993660/molecular-evidence-of-chlamydia-pecorum-and-arthropod-associated-chlamydiae-in-an-expanded-range-of-marsupials
#2
Delaney Burnard, Wilhelmina M Huston, Jonathan K Webb, Martina Jelocnik, Andrea Reiss, Amber Gillett, Sean Fitzgibbon, Scott Carver, Janine Carrucan, Cheyne Flanagan, Peter Timms, Adam Polkinghorne
The order Chlamydiales are biphasic intracellular bacterial pathogens infecting humans and domesticated animals. Wildlife infections have also been reported, with the most studied example being Chlamydia pecorum infections in the koala, an iconic Australian marsupial. In koalas, molecular evidence suggests that spill-over from C. pecorum infected livestock imported into Australia may have had a historical or contemporary role. Despite preliminary evidence that other native Australian marsupials also carry C...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28944032/development-and-field-validation-of-a-regional-management-scale-habitat-model-a-koala-phascolarctos-cinereus-case-study
#3
Bradley Law, Gabriele Caccamo, Paul Roe, Anthony Truskinger, Traecey Brassil, Leroy Gonsalves, Anna McConville, Matthew Stanton
Species distribution models have great potential to efficiently guide management for threatened species, especially for those that are rare or cryptic. We used MaxEnt to develop a regional-scale model for the koala Phascolarctos cinereus at a resolution (250 m) that could be used to guide management. To ensure the model was fit for purpose, we placed emphasis on validating the model using independently-collected field data. We reduced substantial spatial clustering of records in coastal urban areas using a 2-km spatial filter and by modeling separately two subregions separated by the 500-m elevational contour...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28942303/lymphoma-koala-retrovirus-infection-and-reproductive-chlamydiosis-in-a-koala-phascolarctos-cinereus
#4
J Fabijan, L Woolford, S Lathe, G Simmons, F Hemmatzadeh, D J Trott, N Speight
Koala retrovirus (KoRV) infection, thought to be associated with lymphoid neoplasia, and Chlamydia pecorum-related ocular and urogenital disease are both highly prevalent in eastern Australian koala (Phascolarctos cinereus) populations. However, in South Australian koalas, little is known about KoRV infection and C. pecorum-associated disease. We report the first South Australian case of lymphoma in a KoRV-A-positive female koala also affected by severe reproductive chlamydiosis. The koala was from the Mount Lofty Ranges population and was presented with hindlimb lameness...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28929022/development-and-evaluation-of-rapid-novel-isothermal-amplification-assays-for-important-veterinary-pathogens-chlamydia-psittaci-and-chlamydia-pecorum
#5
Martina Jelocnik, Md Mominul Islam, Danielle Madden, Cheryl Jenkins, James Branley, Scott Carver, Adam Polkinghorne
BACKGROUND: Chlamydia psittaci and Chlamydia pecorum are important veterinary pathogens, with the former also being responsible for zoonoses, and the latter adversely affecting koala populations in Australia and livestock globally. The rapid detection of these organisms is still challenging, particularly at the point-of-care (POC). In the present study, we developed and evaluated rapid, sensitive and robust C. psittaci-specific and C. pecorum-specific Loop Mediated Isothermal Amplification (LAMP) assays for detection of these pathogens...
2017: PeerJ
https://www.readbyqxmd.com/read/28845567/assessment-of-florfenicol-as-a-possible-treatment-for-chlamydiosis-in-koalas-phascolarctos-cinereus
#6
C Budd, C Flanagan, A Gillett, J Hanger, J J Loader, M Govendir
OBJECTIVE: Because of limited availability of chloramphenicol to veterinary suppliers, a preliminary study was performed to predict whether an analogue, florfenicol, is an efficacious treatment for chlamydiosis in koalas. METHODS: Florfenicol was administered to koalas with naturally occurring chlamydiosis at 20 mg/kg SC (n = 3) and at 5 mg/kg (n = 3) and 10 mg/kg (n = 3) IV. The estimated areas under the plasma concentration versus time curves (AUC) were compared with the minimum inhibitory concentration to inhibit Chlamydia pecorum...
September 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28845563/in-this-issue-september-2017-identifying-bloodlines-of-animals-with-mutations%C3%A2-%C3%A2-%C3%A2-sexed-semen-in-dairy-cows%C3%A2-%C3%A2-%C3%A2-conventional-vs-automatic-milking-systems%C3%A2-%C3%A2-%C3%A2-overground-endoscopy-in-thoroughbred-horses%C3%A2-%C3%A2-%C3%A2-honeys-for-wound-healing%C3%A2-%C3%A2-%C3%A2-cabergoline-in-anoestrous
#7
EDITORIAL
https://www.readbyqxmd.com/read/28712016/a-survey-of-pesticide-accumulation-in-a-specialist-feeder-the-koala-phascolarctos-cinereus
#8
Caroline Marschner, Damien P Higgins, Mark B Krockenberger
To maintain profitability in Australia's agricultural and urban landscapes pesticides are used throughout the range of koala habitats. The koala is a specialist feeder, reliant on metabolic enzyme capacities to utilise a toxic diet of eucalypt leaves and is potentially prone to adverse effects when xenobiotic interactions between dietary and anthropogenic xenobiotics occur. The aim of this study was to investigate accumulation of frequently used pesticides in wild koalas in 4 areas of New South Wales and Queensland...
September 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28704730/consistent-patterns-of-vehicle-collision-risk-for-six-mammal-species
#9
Casey Visintin, Rodney van der Ree, Michael A McCarthy
The occurrence and rate of wildlife-vehicle collisions are related to both anthropocentric and environmental variables, however, few studies compare collision risks for multiple species within a model framework that is adaptable and transferable. Our research compares collision risk for multiple species across a large geographic area using a conceptually simple risk framework. We used six species of native terrestrial mammal often involved with wildlife-vehicle collisions in south-east Australia. We related collisions reported to a wildlife organisation to the co-occurrence of each species and a threatening process (presence and movement of road vehicles)...
July 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28704541/increased-genetic-diversity-and-prevalence-of-co-infection-with-trypanosoma-spp-in-koalas-phascolarctos-cinereus-and-their-ticks-identified-using-next-generation-sequencing-ngs
#10
Amanda D Barbosa, Alexander W Gofton, Andrea Paparini, Annachiara Codello, Telleasha Greay, Amber Gillett, Kristin Warren, Peter Irwin, Una Ryan
Infections with Trypanosoma spp. have been associated with poor health and decreased survival of koalas (Phascolarctos cinereus), particularly in the presence of concurrent pathogens such as Chlamydia and koala retrovirus. The present study describes the application of a next-generation sequencing (NGS)-based assay to characterise the prevalence and genetic diversity of trypanosome communities in koalas and two native species of ticks (Ixodes holocyclus and I. tasmani) removed from koala hosts. Among 168 koalas tested, 32...
2017: PloS One
https://www.readbyqxmd.com/read/28701755/microbiota-composition-of-the-koala-phascolarctos-cinereus-ocular-and-urogenital-sites-and-their-association-with-chlamydia-infection-and-disease
#11
Miranda E Vidgen, Jonathan Hanger, Peter Timms
Disease caused by Chlamydia pecorum is characterised by ocular and urogenital infections that can lead to blindness and infertility in koalas. However, koalas that are infected with C. pecorum do not always progress to disease. In other host systems, the influence of the microbiota has been implicated in either accelerating or preventing infections progressing to disease. This study investigates the contribution of koala urogenital and ocular microbiota to Chlamydia infection and disease in a free ranging koala population...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683749/bidirectional-associations-between-activity-related-parenting-practices-and-child-physical-activity-sedentary-screen-based-behavior-and-body-mass-index-a-longitudinal-analysis
#12
Ester F C Sleddens, Jessica S Gubbels, Stef P J Kremers, Eline van der Plas, Carel Thijs
BACKGROUND: It has been generally assumed that activity-related parenting practices influence children's activity behavior and weight status. However, vice versa parents may also change their parenting behaviors in response to their perceptions of their child's activity behavior and weight status. This study examined the bidirectional relationships between activity-related parenting practices, and physical activity, sedentary screen-based behavior, and body mass index (BMI) between children's age of 5 and 7 years...
July 6, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28669101/characterisation-of-mhc-class-i-genes-in-the-koala
#13
Yuanyuan Cheng, Adam Polkinghorne, Amber Gillett, Elizabeth A Jones, Denis O'Meally, Peter Timms, Katherine Belov
Koala (Phascolarctos cinereus) populations are on the decline across the majority of Australia's mainland. Two major diseases threatening the long-term survival of affected koala populations are caused by obligate intracellular pathogens: Chlamydia and koala retrovirus (KoRV). To improve our understanding of the koala immune system, we characterised their major histocompatibility complex (MHC) class I genes, which are centrally involved in presenting foreign peptides derived from intracellular pathogens to cytotoxic T cells...
July 1, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28653387/outbreaks-of-sarcoptic-mange-in-free-ranging-koala-populations-in-victoria-and-south-australia-a-case-series
#14
K N Speight, P L Whiteley, L Woolford, P J Duignan, B Bacci, S Lathe, W Boardman, T F Scheelings, O Funnell, G Underwood, M A Stevenson
OBJECTIVE: To describe outbreaks of sarcoptic mange caused by Sarcoptes scabiei in free-ranging koalas in Victoria (December 2008 to November 2015) and South Australia (October 2011 to September 2014). METHODS: Koalas affected by mange-like lesions were reported by wildlife carers, veterinary practitioners or State Government personnel to the Faculty of Veterinary and Agricultural Sciences at The University of Melbourne and the School of Animal and Veterinary Sciences at The University of Adelaide...
July 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28653384/in-this-issue-july-2017-rhdv-vaccine-protects-against-both-strains-of-virus-%C3%A2-%C3%A2-%C3%A2-olfactory-neuroblastoma-in-a-malamute-%C3%A2-%C3%A2-%C3%A2-coincidental-conditions-affecting-dysphagia-in-a-miniature-poodle-%C3%A2-%C3%A2-%C3%A2-support-for-storing-high-quality-bovine-colostrum-%C3%A2-%C3%A2-%C3%A2-sarcoptic
#15
EDITORIAL
https://www.readbyqxmd.com/read/28625206/organic-food-consumption-during-pregnancy-and-its-association-with-health-related-characteristics-the-koala-birth-cohort-study
#16
Ana Paula Simões-Wüst, Carolina Moltó-Puigmartí, Eugene Hjm Jansen, Martien Cjm van Dongen, Pieter C Dagnelie, Carel Thijs
OBJECTIVE: To investigate the associations of organic food consumption with maternal pre-pregnancy BMI, hypertension and diabetes in pregnancy, and several blood biomarkers of pregnant women. DESIGN: Prospective cohort study. SETTING: Pregnant women were recruited at midwives' practices and through channels related to consumption of food from organic origin. SUBJECTS: Pregnant women who filled in FFQ and donated a blood sample (n 1339)...
August 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28599794/a-novel-combination-adjuvant-platform-for-human-and-animal-vaccines
#17
Ravendra Garg, Lorne Babiuk, Sylvia van Drunen Littel-van den Hurk, Volker Gerdts
Adjuvants are crucial components of many vaccines. They are used to improve the immunogenicity of vaccines with the aim of conferring long-term protection, to enhance the efficacy of vaccines in newborns, elderly or immunocompromised persons, and to reduce the amount of antigen or the number of doses required to elicit effective immunity. Novel combination adjuvants have been tested in both candidate animals and humans vaccines and have generated encouraging results. Recently, we developed a combination adjuvant platform (TriAdj) comprising of three components, namely a TLR agonist, either polyI:C or CpG oligodeoxynucleotides (ODN), host defense peptide and polyphosphazene...
June 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28575080/immunization-of-a-wild-koala-population-with-a-recombinant-chlamydia-pecorum-major-outer-membrane-protein-momp-or-polymorphic-membrane-protein-pmp-based-vaccine-new-insights-into-immune-response-protection-and-clearance
#18
Marion Desclozeaux, Amy Robbins, Martina Jelocnik, Shahneaz Ali Khan, Jon Hanger, Volker Gerdts, Andrew Potter, Adam Polkinghorne, Peter Timms
We assessed the effects of two different single-dose anti-Chlamydia pecorum (C. pecorum) vaccines (containing either Major Outer Membrane Protein (3MOMP) or Polymorphic Membrane Protein (Pmp) as antigens) on the immune response of a group of wild koalas. Both vaccines elicited a systemic humoral response as seen by the production of anti-chlamydial IgG antibodies in more than 90% of vaccinated koalas. A mucosal immune response was also observed, with an increase in Chlamydia-specific mucosal IgG and/or IgA antibodies in some koalas post-vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/28560934/organic-food-consumption-during-pregnancy-is-associated-with-different-consumer-profiles-food-patterns-and-intake-the-koala-birth-cohort-study
#19
Ana Paula Simões-Wüst, Carolina Moltó-Puigmartí, Martien Cjm van Dongen, Pieter C Dagnelie, Carel Thijs
OBJECTIVE: To find out how the consumption of organic food during pregnancy is associated with consumer characteristics, dietary patterns and macro- and micronutrient intakes. DESIGN: Cross-sectional description of consumer characteristics, dietary patterns and macro- and micronutrient intakes associated with consumption of organic food during pregnancy. SETTING: Healthy, pregnant women recruited to a prospective cohort study at midwives' practices in the southern part of the Netherlands; to enrich the study with participants adhering to alternative lifestyles, pregnant women were recruited through various specific channels...
August 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28455999/pharmacokinetics-of-posaconazole-in-koalas-phascolarctos-cinereus-after-intravenous-and-oral-administration
#20
S Gharibi, B Kimble, L Vogelnest, J Barnes, C K Stadler, M Govendir
The pharmacokinetic profile of posaconazole in clinically normal koalas (n = 8) was investigated. Single doses of posaconazole were administered intravenously (i.v.; 3 mg/kg; n = 2) or orally (p.o.; 6 mg/kg; n = 6) with serial plasma samples collected over 24 and 36 hr, respectively. Plasma concentrations of posaconazole were quantified by validated high-performance liquid chromatography. A noncompartmental pharmacokinetic analysis of data was performed. Following i.v. administration, estimates of the median (range) of plasma clearance (CL) and steady-state volume of distribution (Vss ) were 0...
April 29, 2017: Journal of Veterinary Pharmacology and Therapeutics
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