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small bowel bacterial overgrowth

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https://www.readbyqxmd.com/read/27652124/is-it-bowel-associated-dermatosis-arthritis-syndrome-induced-by-small-intestinal-bacteria-overgrowth
#1
Hongjun Zhao, Lijuan Zhao, Wei Shi, Hui Luo, Liping Duan, Yunhui You, Yisha Li, Xiaoxia Zuo
INTRODUCTION: Bowel-associated dermatosis-arthritis syndrome is rare systemic diseases characterized by a prodrome of fever, chills, and influenza-like symptoms with subsequent skin eruptions, myalgias, and polyarthralgias. It is reported to be occurred in Intestinal bypass surgery and inflammatory bowel disease. CASE DESCRIPTION: Herein, we described a 29-years-old man with Bowel-associated dermatosis-arthritis syndrome. He had no history of gastrointestinal surgery and inflammatory bowel disease...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27650225/lubiprostone-accelerates-intestinal-transit-and-alleviates-small-intestinal-bacterial-overgrowth-in-patients-with-chronic-constipation
#2
Irene Sarosiek, Mohammad Bashashati, Alicia Alvarez, Mark Hall, Nagasri Shankar, Yvette Gomez, Richard W McCallum, Jerzy Sarosiek
BACKGROUND: Lubiprostone is an effective treatment for chronic constipation (CC). The mechanism of action of lubiprostone is through increasing fluid secretion and lubrication of the intestinal lumen. The effects of lubiprostone on gastrointestinal transit and small intestinal bacterial overgrowth (SIBO) have not been adequately explored. The current study was designed to investigate whether lubiprostone (1) alters gastrointestinal transit and (2) affects SIBO in patients with constipation...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27648298/utility-of-wireless-motility-capsule-and-lactulose-breath-testing-in-the-evaluation-of-patients-with-chronic-functional-bloating
#3
George Triadafilopoulos
BACKGROUND: The precise aetiology of chronic bloating remains poorly understood and underlying gastroparesis, small bowel bacterial overgrowth and colonic inertia may, individually or collectively, play a role. AIMS: In this retrospective cohort analysis of symptomatic patients with chronic persistent bloating, we determined the clinical utility of wireless motility capsule and lactulose breath test in further defining the underlying aetiology for functional bloating...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27639806/proton-pump-inhibitors-increase-risk-for-hepatic-encephalopathy-in-patients-with-cirrhosis-in-population-study
#4
Chia-Fen Tsai, Mu-Hong Chen, Yen-Po Wang, Chi-Jen Chu, Yi-Hsiang Huang, Han-Chieh Lin, Ming-Chih Hou, Fa-Yauh Lee, Tung-Ping Su, Ching-Liang Lu
BACKGROUND & AIMS: Hepatic encephalopathy (HE) is a serious complication of cirrhosis and is associated with gut dysbiosis. Proton pump inhibitors (PPIs), frequently prescribed to patients with cirrhosis, can contribute to small-bowel bacterial overgrowth. We investigated whether PPI predisposes patients with cirrhosis to HE using a large database of patients. METHODS: We performed a case-control study nested within a sample of Taiwan National Health Insurance beneficiaries (n = 1,000,000), followed up longitudinally from 1998 through 2011...
September 14, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27547007/use-of-rifaximin-in-gastrointestinal-and-liver-diseases
#5
REVIEW
Rani H Shayto, Rachel Abou Mrad, Ala I Sharara
Rifaximin is a broad spectrum oral antibiotic with antimicrobial activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is poorly absorbed and thus has a highly favorable safety profile. Rifaximin has been shown to be effective in the treatment of traveler's diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. In addition, there is emerging evidence for a possible beneficial effect of rifaximin in the treatment of uncomplicated diverticular disease and in the prevention of recurrent diverticulitis...
August 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27501017/rosacea-and-gastrointestinal-disorders-a-population-based-cohort-study
#6
A Egeberg, L B Weinstock, E P Thyssen, G H Gislason, J P Thyssen
BACKGROUND: Rosacea is a common inflammatory facial skin condition. Recent genetic and epidemiologic studies have suggested pathogenic links between rosacea and gastrointestinal disorders, but data are limited. OBJECTIVES: The objective was to investigate the association between rosacea and celiac disease (CeD), Crohn's disease (CD), ulcerative colitis (UC), Helicobactor pylori (HP) infection, small intestinal bacterial overgrowth (SIBO), and irritable bowel syndrome (IBS), respectively...
August 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27402085/small-intestinal-bacterial-overgrowth-is-associated-with-irritable-bowel-syndrome-and-is-independent-of-proton-pump-inhibitor-usage
#7
Evangelos J Giamarellos-Bourboulis, Emmanouel Pyleris, Charalambos Barbatzas, Aikaterini Pistiki, Mark Pimentel
BACKGROUND: Current knowledge suggests that small intestinal overgrowth participates in the pathogenesis of irritable bowel syndrome. It is questionable if this association is modulated by intake of proton pump inhibitors (PPIs). METHODS: In a prospective study, quantitative cultures of duodenal aspirates were performed for aerobic species in 897 consecutive patients undergoing upper GI tract endoscopy. SIBO was defined as equal to or more than 10(3) cfu/ml. The effect of PPI intake on the relationship between SIBO and IBS was the primary endpoint...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27379166/small-intestinal-bacterial-overgrowth-in-patients-with-irritable-bowel-syndrome-clinical-characteristics-psychological-factors-and-peripheral-cytokines
#8
Hua Chu, Mark Fox, Xia Zheng, Yanyong Deng, Yanqin Long, Zhihui Huang, Lijun Du, Fei Xu, Ning Dai
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS). Psychosocial factors and low-grade colonic mucosal immune activation have been suggested to play important roles in the pathophysiology of IBS. In total, 94 patients with IBS and 13 healthy volunteers underwent a 10 g lactulose hydrogen breath test (HBT) with concurrent (99m)Tc scintigraphy. All participants also completed a face-to-face questionnaire survey, including the Hospital Anxiety and Depression Scale, Life Event Stress (LES), and general information...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27373356/-clinical-features-of-irritable-bowel-syndrome-with-small-intestinal-bacterial-overgrowth-and-a-preliminary-study-of-effectiveness-of-rifaximin
#9
Z J Liu, H Wei, L P Duan, S W Zhu, L Zhang, K Wang
OBJECTIVE: To investigate the prevalence and clinical features of small intestinal bacterial overgrowth (SIBO) in diarrhea-predominant irritable bowel syndrome (IBS-D) patients detected by hydrogen and methane in lactulose breath test (LBT), and to study the effects of rifaximin in IBS-D patients. METHODS: Consecutive patients with IBS-D who met Rome Ⅲ criteria, and gender- and age-matched healthy volunteers were enrolled from March 2015 to January 2016 in Peking University Third Hospital...
June 28, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27333193/gut-and-liver-in-vasculitic-disorders
#10
Ulf Müller-Ladner
BACKGROUND: Although the gastrointestinal (GI) tract including its related organs is not generally regarded as one of the primary organ systems of primary and secondary vasculitic disorders, there are numerous mechanisms of these diseases operative in or around the different structures and compartments of the GI tract. KEY MESSAGES: A majority of the respective clinical symptoms and problems are linked to an alteration of (peri)vascular homeostasis. Alteration of perivascular matrix metabolism can also affect the functional integrity and motility of the GI tract...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27331205/clinical-value-of-radionuclide-small-intestine-transit-time-measurement-combined-with-lactulose-hydrogen-breath-test-for-the-diagnosis-of-bacterial-overgrowth-in-irritable-bowel-syndrome
#11
Yanli Ning, Cen Lou, Zhongke Huang, Dongfang Chen, Huacheng Huang, Liang Chen, Bucheng Zhang, Ning Dai, Jianmin Zhao, Xia Zhen
OBJECTIVE: Small intestine bacterial overgrowth (SIBO) may be a pathogenetic factor for irritable bowel syndrome (IBS). This syndrome cannot be explained by structural abnormalities and has no specific diagnostic laboratory tests or biomarkers. We studied quantitatively and semi-quantitatively, using lactulose hydrogen breath test (LHBT), small intestinal transit time (SITT) (99m)technetium-diethylene triamine pentaacetic acid ((99m)Tc-DTPA) in order to examine the mobility of small intestine as an indication of bacterial overgrowth in patients...
May 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27228404/effects-of-rifaximin-on-transit-permeability-fecal-microbiome-and-organic-acid-excretion-in-irritable-bowel-syndrome
#12
Andrés Acosta, Michael Camilleri, Andrea Shin, Sara Linker Nord, Jessica O'Neill, Amber V Gray, Alan J Lueke, Leslie J Donato, Duane D Burton, Lawrence A Szarka, Alan R Zinsmeister, Pamela L Golden, Anthony Fodor
OBJECTIVES: Rifaximin relieves irritable bowel syndrome (IBS) symptoms, bloating, abdominal pain, and loose or watery stools. Our objective was to investigate digestive functions in rifaximin-treated IBS patients. METHODS: In a randomized, double-blind, placebo-controlled, parallel-group study, we compared the effects of rifaximin, 550 mg t.i.d., and placebo for 14 days in nonconstipated IBS and no evidence of small intestinal bacterial overgrowth (SIBO). All subjects completed baseline and on-treatment evaluation of colonic transit by scintigraphy, mucosal permeability by lactulose-mannitol excretion, and fecal microbiome, bile acids, and short chain fatty acids measured on random stool sample...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27163246/hydrogen-sulphide-in-exhaled-breath-a-potential-biomarker-for-small-intestinal-bacterial-overgrowth-in-ibs
#13
Gourab Dutta Banik, Anulekha De, Suman Som, Subhra Jana, Sunil B Daschakraborty, Sujit Chaudhuri, Manik Pradhan
There is a pressing need to develop a novel early-detection strategy for the precise evolution of small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome (IBS) patients. The current method based on a hydrogen breath test (HBT) for the detection of SIBO is highly controversial. HBT has many limitations and drawbacks. It often fails to indentify SIBO when IBS individuals have 'non-hydrogen-producing' colonic bacteria. Here, we show that hydrogen sulphide (H2S) in exhaled breath is distinctly altered for diarrhea-predominant IBS individuals with positive and negative SIBO by the activity of intestinal sulphate-reducing bacteria...
June 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27135726/does-carbohydrate-challenge-testing-predict-clinical-response-in-small-intestinal-bacterial-overgrowth
#14
Sara K Long, Jack A Di Palma
OBJECTIVES: Small intestinal bacterial overgrowth (SIBO) is considered a frequent cause of abdominal symptoms in patients with surgically altered intestinal anatomy or dysmotility conditions and is recognized as a contributing factor in the exacerbation of irritable bowel syndrome symptoms. Diagnostic testing can be used to detect the condition. METHODS: The study group comprised patients who had breath hydrogen and methane lactulose challenge testing. All of the patients were treated with antibiotic regimens that have shown benefit for SIBO...
May 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27111029/management-of-gastroparesis-associated-malnutrition
#15
Shishira Bharadwaj, Krishna Meka, Parul Tandon, Abdullah Rathur, John M Rivas, Hiren Vallabh, Andrea Jevenn, John Guirguis, Imran Sunesara, Amy Nischnick, Andrew Ukleja
Gastroparesis (GP) is a chronic debilitating dysmotility characterized by unrelenting nausea, vomiting, bloating, early satiety, postprandial fullness and abdominal pain. Patients with GP experience other associated conditions, including gastroesophageal reflux disease, gastric bezoars and small bowel bacterial overgrowth. Furthermore, GP is associated with poor quality of life, increased emergency room visits, hospitalizations and subsequent increased healthcare costs. Currently, the managements of GP consist of glycemic control, antiemetics, prokinetics and the use of gastric electrical stimulation...
May 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27109977/reversed-intestinal-segment-revisited
#16
J S Thompson
BACKGROUND: Reversed segments (RS) designed to slow intestinal transit and improve absorption in patients with short bowel syndrome (SBS) are performed infrequently, and patient selection remains controversial. Our aim was to evaluate patient selection and outcome for RS in SBS patients. METHODS: Sixteen adult patients underwent RS among 520 SBS patients. All patients had remnant length >80 cm and rapid intestinal transit. Ten patients had a colon remnant and 12 had an ostomy...
March 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27092333/morpho-functional-evaluation-of-small-bowel-using-wireless-motility-capsule-and-video-capsule-endoscopy-in-patients-with-known-or-suspected-crohn-s-disease-pilot-study
#17
Diana Yung, Sarah Douglas, Anthony R Hobson, Andry Giannakou, John N Plevris, Anastasios Koulaouzidis
BACKGROUND AND STUDY AIMS: SmartPill(®) (Given Imaging Corp.,Yoqneam,Israel) is an ingestible, non-imaging capsule that records physiological data including contractions and pH throughout the gastrointestinal tract. There are scarce data looking at SmartPill(®) assessment of patients with known/suspected small-bowel Crohn's Disease (CD). This pilot study aims to investigate feasibility and safety of SmartPill(®) to assess gut motility in this group.  PATIENTS AND METHODS: Over 1 year, patients with known/suspected CD, referred for small-bowel capsule endoscopy (SBCE), were invited to participate and 12 were recruited (7 female, 5 male, mean age 44...
April 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27055450/beyond-pancreatic-insufficiency-and-liver-disease-in-cystic-fibrosis
#18
REVIEW
Stephanie Demeyer, Kris De Boeck, Peter Witters, Katrien Cosaert
UNLABELLED: Cystic fibrosis is a life shortening hereditary disease, primarily leading to progressive pulmonary infection and exocrine pancreatic dysfunction. Several gastrointestinal complications other than malabsorption can arise during the disease course and with the progressively increasing life span of patients with CF; new and more rare complications are being recognized. We review the literature on gastrointestinal manifestations in CF, excluding the liver and pancreas. CONCLUSION: We describe the clinical presentation and treatment of more common conditions like gastroesophageal reflux, small intestinal bacterial overgrowth, intussusception, meconium ileus, distal intestinal obstruction syndrome, and constipation, and we also discuss what is known on celiac disease, appendicitis, fibrosing colonopathy, inflammation and inflammatory bowel disease and gastrointestinal cancer...
July 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27033447/indomethacin-injury-to-the-rat-small-intestine-is-dependent-upon-biliary-secretion-and-is-associated-with-overgrowth-of-enterococci
#19
Sara A Mayo, Ye K Song, Melissa R Cruz, Tri M Phan, Kavindra V Singh, Danielle A Garsin, Barbara E Murray, Elizabeth J Dial, Lenard M Lichtenberger
NSAIDuse is limited due to the drugs' toxicity to the gastrointestinal mucosa, an action incompletely understood. Lower gut injury induced byNSAIDs is dependent on bile secretion and is reported to increase the growth of a number of bacterial species, including an enterococcal species,Enterococcus faecalis This study examined the relationships between indomethacin (INDO)-induced intestinal injury/bleeding, small bowel overgrowth (SBO) and dissemination of enterococci, and the contribution of bile secretion to these pathological responses...
March 2016: Physiological Reports
https://www.readbyqxmd.com/read/26992249/interpreting-the-lactulose-breath-test-for-the-diagnosis-of-small-intestinal-bacterial-overgrowth
#20
Joseph K Sunny, Cesar J Garcia, Richard W McCallum
INTRODUCTION: Based on literature review, a positive lactulose breath test (LBT) for small intestinal bacterial overgrowth requires an initial peak value of hydrogen within 100 minutes of lactulose ingestion with a second peak before 180minutes. However, using scintigraphic monitoring of lactulose transit time, mean oral-cecal arrival time has been reported as 73minutes. The goal was to propose new criteria for analysing the LBT to overcome false positive interpretations. METHODS: LBTs from our referral center were interpreted as positive after ingestion of 10g of lactulose using the following approach for hydrogen concentrations: (1) The literature guidelines: greater than 20ppm from a baseline less than 10ppm achieved within 100minutes followed by a further rise of greater than 15ppm within 180minutes...
March 2016: American Journal of the Medical Sciences
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