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https://www.readbyqxmd.com/read/28724143/potentially-avoidable-surgical-intensive-care-unit-admissions-and-disposition-delays
#1
Navpreet K Dhillon, Ara Ko, Eric J T Smith, Mayumi Kharabi, Joseph Castongia, Michael Nurok, Bruce L Gewertz, Eric J Ley
Importance: High health care costs encourage initiatives that avoid overuse of resources and identify opportunities to promote appropriate care. Objective: To investigate the causes of potentially avoidable surgical intensive care unit (SICU) admissions and disposition delays to determine whether targeted interventions could decrease these stays. Design, Setting, and Participants: This prospective, observational study focused on potentially avoidable SICU days, as determined by observers with input from the rounding intensivists at a 24-bed open SICU at an urban, academic hospital...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724093/persistence-of-ascaris-spp-ova-in-tropical-soil-cultivated-with-eucalyptus-and-fertilized-with-municipal-biosolids
#2
Marianne F de Faria, Iraê A Guerrini, Fernando C Oliveira, Maria Inês Z Sato, Elayse M Hachich, José Raimundo S Passos, Lívia M L Goulart, Thiago T de S Silva, José L Gava, Joel C Furches, Jason James, Robert B Harrison
In many countries, the main reason for severely restricting or outright banning the land application of class B biosolids is the lack of risk assessment for adverse human health impacts. Among pathogens that are not often studied are helminth ova, including that of the spp. Almost all of the knowledge about the persistence of spp. ova in soils fertilized with biosolids is based on studies developed in North America, Europe, and Asia. These studies have almost always been conducted under temperate climate conditions, which may cause erroneous interpretations when the conclusions are extrapolated to tropical regions such as those found in Brazil...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28724075/a-comprehensive-image-based-phenomic-analysis-reveals-the-complex-genetic-architecture-of-shoot-growth-dynamics-in-rice-oryza-sativa
#3
Malachy T Campbell, Qian Du, Kan Liu, Chris J Brien, Bettina Berger, Chi Zhang, Harkamal Walia
Early vigor is an important trait for many rice ( L.)-growing environments. However, genetic characterization and improvement for early vigor is hindered by the temporal nature of the trait and strong genotype × environment effects. We explored the genetic architecture of shoot growth dynamics during the early and active tillering stages by applying a functional modeling and genomewide association (GWAS) mapping approach on a diversity panel of ∼360 rice accessions. Multiple loci with small effects on shoot growth trajectory were identified, indicating a complex polygenic architecture...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724019/profile-of-mortality-from-external-causes-among-seventh-day-adventists-and-the-general-populations
#4
Ana Paula Costa Velten, Nágela Valadão Cade, Gulnar Azevedo E Silva, Elizabete Regina Araújo de Oliveira
This paper aimed to compare the profile of mortality from external causes among Seventh-day Adventists and the general population of Espírito Santo from 2003 to 2009. A search of Adventists was performed in the nominal database of the Mortality Information System containing data on Adventists provided by the administrative offices of the institution. Deaths from external causes occurred during the study period were then divided into two groups: Adventists and the general population. Adventists had lower proportional mortality from external causes (10%) than the general population (19%), and males were the main reason for this difference...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28723931/why-aren-t-people-with-young-onset-dementia-and-their-supporters-using-formal-services-results-from-the-inspired-study
#5
Monica Cations, Adrienne Withall, Ruth Horsfall, Nicole Denham, Fiona White, Julian Trollor, Clement Loy, Henry Brodaty, Perminder Sachdev, Peter Gonski, Apo Demirkol, Robert G Cumming, Brian Draper
BACKGROUND/AIMS: Despite reporting high levels of burden, supporters of people with young onset dementia (YOD) underuse formal community services. Previous quantitative studies in YOD are of limited utility in guiding service design because they did not consider important contextual barriers to service use. The aim of this study was to identify all relevant barriers and describe the service features considered most important to improving uptake by people with YOD and their supporters...
2017: PloS One
https://www.readbyqxmd.com/read/28723773/development-and-validation-of-risk-stratification-delirium-prediction-model-for-critically-ill-patients-a-prospective-observational-single-center-study
#6
Yu Chen, Hang Du, Bao-Hua Wei, Xue-Ni Chang, Chen-Ming Dong
The objective is to develop a model based on risk stratification to predict delirium among adult critically ill patients and whether early intervention could be provided for high-risk patients, which could reduce the incidence of delirium.We designed a prospective, observational, single-center study. We examined 11 factors, including age, APACHE-II score, coma, emergency operation, mechanical ventilation (MV), multiple trauma, metabolic acidosis, history of hypertension, delirium and dementia, and application of Dexmedetomidine Hydrochloride...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723603/ginkgo-biloba-in-the-treatment-of-tinnitus-an-updated-literature-review
#7
REVIEW
Mohammad Reza Mahmoudian-Sani, Morteza Hashemzadeh-Chaleshtori, Majid Asadi-Samani, Qian Yang
INTRODUCTION: Tinnitus is one of the common diseases of the ear that is associated with numerous physical and mental disorders. One of the known mechanisms in the tinnitus area with unknown reason is oxidative events. Based on the prevalence and economic costs and physical- psychological side effects caused by tinnitus and the importance of finding a suitable solution for its prevention and treatment, the need for further studies becomes more obvious in this context. This review article aimed to review studies on the effectiveness of Ginkgo biloba as a medicinal plant on patients with tinnitus...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723595/pilot-investigation-of-a-topographical-filter-dermal-patch-in-patients-with-tinnitus
#8
Peter Ahnblad
OBJECTIVES: A new topographical filter in a dermal administration patch that organizes water molecules has been suggested as an alternative treatment for manifested tinnitus. The aim of this study was to evaluate this patch in a pilot study. MATERIALS AND METHODS: 12 patients were included (10 completed) in an open study all receiving treatment with daily changed patches. The objectives were to evaluate safety and performance of the patch during and after treatment...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723594/cochlear-implantation-improves-hearing-and-vertigo-in-patients-after-removal-of-vestibular-schwannoma
#9
Ariane Roemer, Thomas Lenarz, Anke Lesinski-Schiedat
OBJECTIVES: With rising quality of speech perception in cochlear implant users, the indication widens. Nowadays, cochlear implantation is reasonable even in vestibular schwannoma patients. Speech perception with a cochlear implant is in these patients as promising as in patients with sensorineural hearing loss. However, the impact of cochlear implantation on vertigo and tinnitus after removal of vestibular schwannoma has not been investigated yet. METHODS: In a retrospective study, we analysed 12 patients treated with a cochlear implant after removal of vestibular schwannoma...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723582/overexpression-and-purification-of-dicer-and-accessory-proteins-for-biochemical-and-structural-studies
#10
Niladri K Sinha, Brenda L Bass
The Dicer family of ribonucleases plays a key role in small RNA-based regulatory pathways by generating short dsRNA fragments that modulate expression of endogenous genes, or protect the host from invasive nucleic acids. Beginning with its initial discovery, biochemical characterization of Dicer has provided insight about its catalytic properties. However, a comprehensive understanding of how Dicer's domains contribute to substrate-specific recognition and catalysis is lacking. One reason for this void is the lack of high-resolution structural information for a metazoan Dicer in the apo- or substrate-bound state...
July 16, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28723562/integrative-genomics-identifies-the-molecular-basis-of-resistance-to-azacitidine-therapy-in-myelodysplastic-syndromes
#11
Ashwin Unnikrishnan, Elli Papaemmanuil, Dominik Beck, Nandan P Deshpande, Arjun Verma, Ashu Kumari, Petter S Woll, Laura A Richards, Kathy Knezevic, Vashe Chandrakanthan, Julie A I Thoms, Melinda L Tursky, Yizhou Huang, Zara Ali, Jake Olivier, Sally Galbraith, Austin G Kulasekararaj, Magnus Tobiasson, Mohsen Karimi, Andrea Pellagatti, Susan R Wilson, Robert Lindeman, Boris Young, Raj Ramakrishna, Christopher Arthur, Richard Stark, Philip Crispin, Jennifer Curnow, Pauline Warburton, Fernando Roncolato, Jacqueline Boultwood, Kevin Lynch, Sten Eirik W Jacobsen, Ghulam J Mufti, Eva Hellstrom-Lindberg, Marc R Wilkins, Karen L MacKenzie, Jason W H Wong, Peter J Campbell, John E Pimanda
Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis and progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA) is the most effective pharmacological option, but only ∼50% of patients respond. A response only manifests after many months of treatment and is transient. The reasons underlying AZA resistance are unknown, and few alternatives exist for non-responders. Here, we show that AZA responders have more hematopoietic progenitor cells (HPCs) in the cell cycle...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28723482/surveillance-of-small-renal-masses-in-young-patients-a-viable-option-in-the-appropriate-candidate
#12
Alexander Kutikov
In young patients the risks of intervention for a renal mass are generally low, the perceived oncologic stakes are significant, and the burden for life-long close monitoring is often judged to be unreasonable. Nevertheless, in an appropriately selected patient for whom a period of active surveillance presents significant value, an interval of close clinical monitoring is a safe and reasonable approach.
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723370/evaluation-and-management-of-postprostatectomy-incontinence-a-systematic-review-of-current-literature
#13
REVIEW
Alexander Kretschmer, Wilhelm Hübner, Jaspreet S Sandhu, Ricarda M Bauer
CONTEXT: Radical prostatectomy is the most common reason for male stress urinary incontinence. There is still uncertainty about its diagnostic and therapeutic management. OBJECTIVE: To evaluate current evidence regarding the diagnosis and therapy of postprostatectomy incontinence (PPI). EVIDENCE ACQUISITION: A systematic review of the literature was performed in October 2015 using the Medline database. EVIDENCE SYNTHESIS: Diagnosis and conservative treatment of PPI are currently mostly based on expert opinions...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723233/treatment-patterns-and-clinical-outcomes-with-pazopanib-in-patients-with-advanced-soft-tissue-sarcomas-in-a-compassionate-use-setting-results-of-the-spire-study
#14
Hans Gelderblom, Ian R Judson, Charlotte Benson, Ofer Merimsky, Giovanni Grignani, Daniela Katz, Klaus W Freivogel, Dara Stein, Minesh Jobanputra, Arron Mungul, Stephanie C Manson, Roberta Sanfilippo
BACKGROUND: A named patient program (NPP) was designed to provide patients with advanced soft-tissue sarcoma (aSTS) access to pazopanib, a multitargeted tyrosine kinase inhibitor. The SPIRE study was a retrospective chart review of participating patients. PATIENTS AND METHODS: Eligibility criteria for the NPP and SPIRE mirrored those of the pivotal phase-III study, PALETTE, which compared pazopanib with placebo in patients ≥18 years with aSTS and whose disease had progressed during or following prior chemotherapy or were otherwise unsuitable for chemotherapy...
July 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28723171/detection-of-methanol-with-fast-response-by-monodispersed-indium-tungsten-oxide-ellipsoidal-nanospheres
#15
Chong Wang, Xueying Kou, Ning Xie, Lanlan Guo, Yanfeng Sun, Xiaohong Chuai, Jian Ma, Peng Sun, Yue Wang, Geyu Lu
Indium tungsten oxide ellipsoidal nanospheres were prepared with different In/W ratios by using a simple hydrothermal method without any surfactant for the first time. Sensors based on different In/W ratios samples were fabricated, and one of the samples exhibited better response to methanol compared with others. High content of defective oxygen (Ov) and proper output proportion of In to W might be the main reasons for the better gas sensing properties. The length of the nanosphere was about 150-200 nm, and the width was about 100 nm...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722767/plastic-deformation-mechanisms-in-a-new-ni-base-single-crystal-superalloy-at-room-temperature
#16
P Zhang, Y Yuan, Z Gao, B Li, G Yang, X Song
The evolution of dislocation configurations in a new Ni-base single crystal superalloy, M4706, during tensile deformation at room temperature is characterised by transmission electron microscopy. Experimental results show that contrary to previous reports, numerous isolated superlattice stacking faults and extended stacking faults are formed in the slightly deformed specimens with and without tertiary γ' precipitates. Meanwhile, it is also found that as the plastic deformation proceeds, the dominant deformation mechanism changes from stacking fault shearing to antiphase boundary shearing...
July 19, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28722747/acute-care-hospitalization-of-aboriginal-children-and-youth
#17
Anne Guèvremont, Gisèle Carrière, Evelyne Bougie, Dafna Kohen
BACKGROUND: Research that has examined Aboriginal children's hospitalization rates at the national level has been limited to analyses of areas with large percentages of Aboriginal residents, rather than of Aboriginal individuals. This study uses linked census and administrative data to describe hospitalization patterns among children and youth aged 0 to 19, by Aboriginal identity, for all provinces and territories except Quebec. DATA AND METHODS: The 2006 Census was linked to the 2006/2007-to-2008/2009 Discharge Abstract Database, which contains hospital records from all acute care facilities (except Quebec)...
July 19, 2017: Health Reports
https://www.readbyqxmd.com/read/28722559/free-versus-subsidised-healthcare-options-for-fee-exemptions-access-to-care-for-vulnerable-groups-and-effects-on-the-health-system-in-burkina-faso
#18
Maurice Yaogo
BACKGROUND: The many forms of healthcare fee exemptions implemented in Burkina Faso since the 2000s have varied between total exemption (free) and cost subsidisation. This article examines both options, their contextual variations and the ways in which they affect access to healthcare for vulnerable people as well as the operation of the health system. This research is part of an interdisciplinary regional program on the elimination of user fees for health services in West Africa (Burkina Faso, Mali and Niger)...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28722493/analysis-of-thirteen-predatory-publishers-a-trap-for-eager-to-publish-researchers
#19
Pravin Bolshete
OBJECTIVE: To demonstrate a strategy employed by predatory publishers to trap eager-to-publish authors or researchers into submitting their work. METHODS: This is a case study of 13 potential, possible, or probable predatory scholarly open-access publishers with similar characteristics. Eleven publishers were included from Beall's list and two additional publishers were identified from a Google web search. Each publisher's site was visited and its content analyzed...
July 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28722487/left-ventricular-hypertrophy-in-acute-stroke-patients-with-known-hypertension
#20
Askiel Bruno, Desiree D Brooks, Taryn A Abrams, Mitra D Poorak, Drew Gunio, Prianka K Kandhal, Aleena Lakhanpal, Arun K Nagabandi, Abiodun E Akinwuntan, Stephen Looney, Pascha E Schafer
BACKGROUND: Despite effective treatments, hypertension remains uncontrolled in nearly half of the people with hypertension in the United States. Uncontrolled hypertension leads to end organ damage, such as left ventricular hypertrophy (LVH). To identify reasons for uncontrolled hypertension, we interviewed acute stroke patients with a history of hypertension and evaluated for LVH. METHODS: Using a standardized questionnaire, we collected demographic, socioeconomic, and health-care data in 300 acute ischemic and hemorrhagic stroke patients in one hospital...
July 19, 2017: Clinical and Experimental Hypertension: CHE
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