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Bone deformity

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https://www.readbyqxmd.com/read/29222607/static-and-fatigue-strength-of-a-novel-anatomically-contoured-implant-compared-to-five-current-open-wedge-high-tibial-osteotomy-plates
#1
Arnaud Diffo Kaze, Stefan Maas, James Belsey, Alexander Hoffmann, Dietrich Pape
BACKGROUND: The purpose of the present study was to compare the mechanical static and fatigue strength of the size 2 osteotomy plate "Activmotion" with the following five other common implants for the treatment of medial knee joint osteoarthritis: the TomoFix small stature, the TomoFix standard, the Contour Lock, the iBalance and the second generation PEEKPower. METHODS: Six fourth-generation tibial bone composites underwent a medial open-wedge high tibial osteotomy (HTO), according to standard techniques, using size 2 Activmotion osteotomy plates...
December 8, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29222266/impact-of-bone-disease-and-pain-in-thalassemia
#2
REVIEW
Antonio Piga
Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any sign of nerve compression, severe osteoporosis, and fragility fractures...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221902/a-comparison-of-patellofemoral-cartilage-morphology-and-deformation-in-anterior-cruciate-ligament-deficient-versus-uninjured-knees
#3
Kwadwo A Owusu-Akyaw, Lauren N Heckelman, Hattie C Cutcliffe, E Grant Sutter, Zoë A Englander, Charles E Spritzer, William E Garrett, Louis E DeFrate
Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics may predispose patients to cartilage degeneration. This study aimed to compare in vivo PFJ morphology and mechanics between ACL deficient and intact knees in subjects with unilateral ACL ruptures. Eight male subjects underwent baseline MRI scans of both knees...
November 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29218382/restrictive-pulmonary-dysfunction-is-associated-with-vertebral-fractures-and-bone-loss-in-elderly-postmenopausal-women
#4
R Watanabe, M Shiraki, M Saito, R Okazaki, D Inoue
Association between lung function and bone metabolism remains controversial. We found that impaired lung function was associated with vertebral fractures and bone loss in Japanese postmenopausal women. While vertebral deformities would impair lung function, respiratory dysfunction might in turn increase fracture risk, suggesting a complex bidirectional interaction. INTRODUCTION: Association between bone metabolism and pulmonary function in the general population is controversial. The aim of this study was to investigate relationship between lung and bone parameters in elderly postmenopausal women...
December 7, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29218364/ultrasound-evaluation-of-stress-injuries-and-physiological-adaptations-in-the-fingers-of-adolescent-competitive-rock-climbers
#5
Kathryn Garcia, Diego Jaramillo, Erika Rubesova
BACKGROUND: The impact of high-intensity, repetitive training on the fingers of adolescent climbers is relatively unknown. OBJECTIVE: To evaluate this effect by ultrasound (US) and to confirm some findings by magnetic resonance imaging (MRI). MATERIALS AND METHODS: The US study was performed in 20 adolescent rock climbers (ages 10-17 years) and 6 non-climbing controls (ages 11-15 years). US was used to examine the third digit of the right hand for differences in thickness of soft tissue, flexor and extensor tendon, volar plate and bony and growth plate adaptations...
December 7, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29217065/orthognathic-considerations-of-vascular-malformations
#6
REVIEW
Luis Delgado, Avanti Verma, Teresa M O, Stuart Super
Vascular malformations affect the craniofacial skeleton in many ways, depending on the type of the lesion and its location. The lesions may exert a mass effect and cause thinning or thickening of the bone or cause expansion from direct bony infiltration. Orthognathic surgery can be used to correct any malocclusion or open bite deformities after the soft tissues are addressed.
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29215438/mucosal-dehiscence-after-alveolar-bone-graft-in-cleft
#7
Giulia Amodeo, Domenico Scopelliti
Cleft lip and palate patient represent a challenging experience for the surgeon. This kind of patients had to be followed by a multidisciplinary team from the beginning to the end to avoid the deformation sequelae. During the several surgical procedures, the bone graft represents a possible procedure that, through the new procedure, could be avoided. Unfortunately, patient treated following the previous procedure must be submitted to alveolar bone graft to coordinate the arch, to restore the maxillary integrity, to allow the correct dentition...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29213174/x-linked-hypophosphatemic-rickets-phex-mutation-a-case-report-and-literature-review
#8
Badi Alenazi, M A Maleque Molla, Abdullah Alshaya, Mahmoud Saleh
Hypophosphatemic rickets is a rare form of rickets that affect children. The diagnosis requires high index of suspicion. We report a case of Hypophosphatemic rickets in 18-month-old Saudi boy presented with delayed walking and lower limb deformity. The diagnosis was confirmed by bone profile, radiological study and genetic testing, which reveled PHEX mutation. The patient was successfully treated by phosphate supplement.
2017: Sudanese Journal of Paediatrics
https://www.readbyqxmd.com/read/29213014/a-case-of-a-giant-mass-in-the-lumbar-region-of-a-newborn-calf
#9
Kazuki Yoshioka, Aika Ishikawa, Makoto Sugiyama, Jun Nagasao, Motohiro Kikuchi
The present report describes a newborn calf with spina bifida that presented with a giant mass of the lumbar region, as well as subsequent gross, histological, and immunohistochemical examinations. A malformed Japanese black calf (estimated weight = 20 kg) was euthanized immediately after birth. A gross evaluation revealed a giant mass (approximately 60 cm × 30 cm × 15 cm) covered by the hair coat in the lumbar region and connected with the hair coat of the trunk. The mass surface was divided by a deep polygonal groove and externally resembled a lobulated kidney...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/29212690/quantifying-the-law-of-diminishing-returns-in-magnetically-controlled-growing-rods
#10
A Ahmad, T Subramanian, P Panteliadis, J Wilson-Macdonald, D A Rothenfluh, C Nnadi
AIMS: Magnetically controlled growing rods (MCGRs) allow non-invasive correction of the spinal deformity in the treatment of early-onset scoliosis. Conventional growing rod systems (CGRS) need repeated surgical distractions: these are associated with the effect of the 'law of diminishing returns'. The primary aim of this study was to quantify this effect in MCGRs over sequential distractions. PATIENTS AND METHODS: A total of 35 patients with a maximum follow-up of 57 months were included in the study...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212689/minimally-invasive-surgery-for-adolescent-idiopathic-scoliosis-correction-of-deformity-and-peri-operative-morbidity-in-70-consecutive-patients
#11
C de Bodman, F Miyanji, B Borner, P-Y Zambelli, G Racloz, R Dayer
AIMS: The aim of this study was to report a retrospective, consecutive series of patients with adolescent idiopathic scoliosis (AIS) who were treated with posterior minimally invasive surgery (MIS) with a mean follow-up of two years (sd 1.4; 0.9 to 0 3.7). Our objectives were to measure the correction of the deformity and record the peri-operative morbidity. Special attention was paid to the operating time (ORT), estimated blood loss (EBL), length of stay (LOS) and further complications...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29206798/a-novel-registration-based-approach-for-3d-assessment-of-posttraumatic-distal-humeral-deformities
#12
Lazaros Vlachopoulos, Fabio Carrillo, Christian Gerber, Gábor Székely, Philipp Fürnstahl
BACKGROUND: With current 3-dimensional (3D) computer-based methods for the assessment of deformities, a surface registration method is applied to superimpose a computer model of the pathological bone onto a mirrored computer model of the contralateral side. However, because of bilateral differences, especially in humeral torsion, such template-based approaches may introduce bias in the assessment of a distal humeral deformity. We hypothesized that a novel registration approach might prove superior to the current approach in reducing such bias, thus yielding improved accuracy of 3D assessment of distal humeral deformities...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29204673/the-role-of-autoantibodies-in-bone-metabolism-and-bone-loss
#13
REVIEW
Barbara Hauser, Ulrike Harre
Many autoimmune diseases are associated with deranged bone metabolism. The resulting localized or systemic bone loss can compromise the quality of life of patients by causing local bone deformities or fragility fractures. There is emerging evidence that antibodies have a direct impact on key players of bone homeostasis, in particular osteoclasts. Clinical and pre-clinical studies provide insight into the function of autoantibodies related to Rheumatoid Arthritis (rheumatoid factor, anti-citrullinated protein antibodies, and anti-carbamylated protein antibodies) and their inflammation-independent interaction with bone cells...
December 4, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29204196/delineate-yet-not-dread-anomalous-vertebral-artery-in-pediatric-congenital-atlantoaxial-dislocation-and-basilar-invagination
#14
Pravin Salunke
Introduction: The deformed joints seen in congenital atlantoaxial dislocation (CAAD) are often associated with vascular anomalies. It is important to identify these vascular anomalies and address them appropriately without compromising the manipulation and fusion of C1-C2 joints. The small bones in pediatric age group pose an additional challenge. Materials and Methods: Data of fifty-six children with CAAD operated in the last 4 years was analyzed. A computed tomography angiogram was obtained preoperatively to assess for the course of the third segment of vertebral artery (VA)...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29203593/loss-of-p53-compensates-osteopenia-in-murine-mysm1-deficiency
#15
Melanie Haffner-Luntzer, Anna Kovtun, Verena Fischer, Katja Prystaz, Adelheid Hainzl, Carsten M Kroeger, Ioanna Krikki, Titus J Brinker, Anita Ignatius, Martina Gatzka
Histone modifications critically contribute to the epigenetic orchestration of bone homeostasis-in part, by modifying the access of transcription factors to specific genes involved in the osteogenic differentiation process of bone marrow mesenchymal stem cells (MSCs) and osteoblasts. Based on our previous finding that histone H2A deubiquitinase 2A-DUB/Mysm1 interacts with the p53 axis in hematopoiesis and tissue development, we analyzed the molecular basis of the skeletal phenotype of Mysm1-deficient mice and dissected the underlying p53-dependent and -independent mechanisms...
December 4, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29203221/distal-femoral-physeal-crush-injury-with-metaphyseal-comminution-a-report-of-two-cases-and-a-new-perspective-to-physeal-injury
#16
Prateek Behera, Nirmal Raj Gopinathan, Avinash Kumar, Balaji Saibaba, Pebam Sudesh, Rakesh John
The physis of a long bone may get 'sandwiched' and crushed between the metaphysis and the epiphysis if it is traumatically loaded along its long axis. Such a physeal injury may lead to complications like angular deformities and growth restrictions and hence, management of such injuries requires adequate planning and attentive execution. Two patients with distal femoral physeal crush injury were treated using a ring fixator such that one ring had the wires passing through the epiphysis and the other through the femoral shaft...
September 28, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29201306/analysis-of-radiographic-parameters-of-the-forearm-in-traumatic-radial-head-dislocation
#17
Hui Taek Kim, Le Viet Can, Tae Young Ahn, In Hee Kim
Background: Various deformities can occur in the forearm bones when the traumatically dislocated radial head is untreated for a long period. Without correction of all deformities, reduction of the dislocated radial head is difficult to maintain, and forearm and elbow motion will deteriorate after reduction. We evaluated radiographic parameters of forearms with traumatically dislocated radial heads (and of the normal sides) to understand the resulting deformities and the effectiveness of surgical treatment...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29201039/multitemporal-volume-registration-for-the-analysis-of-rheumatoid-arthritis-evolution-in-the-wrist
#18
Roberta Ferretti, Silvana G Dellepiane
This paper describes a method based on an automatic segmentation process to coregister carpal bones of the same patient imaged at different time points. A rigid registration was chosen to avoid artificial bone deformations and to allow finding eventual differences in the bone shape due to erosion, disease regression, or other eventual pathological signs. The actual registration step is performed on the basis of principal inertial axes of each carpal bone volume, as estimated from the inertia matrix. In contrast to already published approaches, the proposed method suggests splitting the 3D rotation into successive rotations about one axis at a time (the so-called basic or elemental rotations)...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/29200021/sonographic-findings-of-hands-and-wrists-in-systemic-lupus-erythematosus-patients-with-jaccoud-arthropathy
#19
Carolina Freitas Lins, Daniel Lima de Sá Ribeiro, Willer Gonçalves Dourado Santos, Genevievi Rosa, Viviane Machicado, Ana Luiza Pedreira, Emanuela Pimenta da Fonseca, Anna Paula Mota Duque Souza, Carla Baleeiro Rodrigues Silva, Luana Grazielle Dos Santos Ferreira, Verena Galvão, Isabela Silva de Oliveira, Ajax Merces Atta, Mittermayer Barreto Santiago
INTRODUCTION: Jaccoud arthropathy (JA) is a deforming nonerosive arthropathy, characterized by the presence of "reversible" joint deformity. The study aims at describing the main musculoskeletal ultrasound (US) findings of a series of systemic lupus erythematosus (SLE) patients with JA. METHODS: Consecutive patients diagnosed as having JA and SLE were included in the study. All patients underwent a whole clinical evaluation and US of the hands and wrists. The US scan evaluated the presence of synovial hypertrophy, tenosynovitis, and bone erosions...
December 1, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29197556/mir-195-inhibited-abnormal-activation-of-osteoblast-differentiation-in-mc3t3-e1-cells-via-targeting-raf-1
#20
Chen Chao, Feng Li, Zhiping Tan, Weizhi Zhang, Yifeng Yang, Cheng Luo
BACKGROUND: Recent reports have demonstrated that RAF-1L613V (a mutant of RAF-1) mutant mice show bone deformities similar to Noonan syndrome. It has been suggested that RAF-1L613V might abnormally activate osteoblast differentiation of MC3T3-E1 cells. METHODS: To demonstrate that RAF-1 is associated with bone deformity and that RAF-1L613V dependent bone deformity could be inhibited by microRNA-195 (miR-195), we first investigated the amplifying influence of wild-type RAF-1 (WT) or RAF-1L613V (L613V) on the viability and differentiation of MC3T3-E1 cells induced by bone morphogenetic protein-2 (BMP-2) via 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining, quantitative real-time polymerase chain reaction (qRT-PCR) and western blot analysis...
November 29, 2017: Experimental Cell Research
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