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https://www.readbyqxmd.com/read/29669911/mpc1-is-essential-for-pgc-1%C3%AE-induced-mitochondrial-respiration-and-biogenesis
#1
Eunjin Koh, Young Kyung Kim, Daye Shin, Kyung-Sup Kim
Mitochondrial pyruvate carrier (MPC), which is essential for mitochondrial pyruvate usage, mediates transport of cytosolic pyruvate into mitochondria. Low MPC expression is associated with various cancers, and functionally associated with glycolytic metabolism and stemness. However, the mechanism by which MPC expression is regulated is largely unknown. In this study, we showed that MPC1 is downregulated in human renal cell carcinoma (RCC) due to strong suppression of peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1 alpha (PGC-1α)...
April 18, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29662614/transcriptional-orchestration-of-mitochondrial-homeostasis-in-a-cellular-model-of-pgc-1-related-coactivator-dependent-thyroid-tumor
#2
Solenne Dumont, Soazig Le Pennec, Audrey Donnart, Raluca Teusan, Marja Steenman, Catherine Chevalier, Rémi Houlgatte, Frédérique Savagner
The PGC-1 (Peroxisome proliferator-activated receptor Gamma Coactivator-1) family of coactivators (PGC-1α, PGC-1β, and PRC) plays a central role in the transcriptional control of mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) processes. These coactivators integrate mitochondrial energy production into cell metabolism using complementary pathways. The XTC.UC1 cell line is a mitochondria-rich model of thyroid tumors whose biogenesis is almost exclusively dependent on PRC. Here we aim to propose an integrative view of the cellular pathways regulated by PRC through integration of cDNA and miRNA microarray data and chromatin immunoprecipitation results obtained from XTC...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29604268/mild-aerobic-training-with-blood-flow-restriction-increases-the-hypertrophy-index-and-musk-in-both-slow-and-fast-muscles-of-old-rats-role-of-pgc-1%C3%AE
#3
Mohammad-Ali Bahreini Pour, Siyavash Joukar, Fariborz Hovanloo, Hamid Najafipour, Vida Naderi, Alireza Raji, Saeed Esmaeili-Mahani
AIMS: Existing evidence emphasize the role of mitochondrial dysfunction in sarcopenia which is revealed as loss of skeletal muscle mass and neuromuscular junction remodeling. We assessed the effect of low-intensity aerobic training along with blood flow restriction on muscle hypertrophy index, muscle-specific kinase (MuSK), a pivotal protein of the neuromuscular junction and Peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) in aged male rats. MAIN METHODS: Animals groups were control (CTL), sham (Sh), leg blood flow restriction (BFR), exercise (Ex), sham + exercise (Sh + Ex), and BFR plus exercise (BFR + Ex) groups...
March 28, 2018: Life Sciences
https://www.readbyqxmd.com/read/29559683/plasma-adiponectin-levels-are-correlated-with-body-composition-metabolic-profiles-and-mitochondrial-markers-in-individuals-with-chronic-spinal-cord-injury
#4
Laura C O'Brien, Zachary A Graham, Qun Chen, Edward J Lesnefsky, Christopher Cardozo, Ashraf S Gorgey
STUDY DESIGN: Cross-sectional design. OBJECTIVES: This study examined the relationships between circulating adiponectin levels, body composition, metabolic profile, and measures of skeletal muscle mitochondrial enzyme activity and biogenesis. SETTINGS: Clinical Research in a Medical Center. METHODS: Plasma adiponectin was quantified in 19 individuals with chronic spinal cord injury (SCI). Body composition was evaluated by dual x-ray absorptiometry and magnetic resonance imaging...
March 20, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29557214/current-understanding-and-future-perspectives-of-the-roles-of-sirtuins-in-the-reprogramming-and-differentiation-of-pluripotent-stem-cells
#5
Yi-Chao Hsu, Yu-Ting Wu, Chia-Ling Tsai, Yau-Huei Wei
In mammalian cells, there are seven members of the sirtuin protein family (SIRT1-7). SIRT1, SIRT6, and SIRT7 catalyze posttranslational modification of proteins in the nucleus, SIRT3, SIRT4, and SIRT5 are in the mitochondria and SIRT2 is in the cytosol. SIRT1 can deacetylate the transcription factor SOX2 and regulate induced pluripotent stem cells (iPSCs) reprogramming through the miR-34a-SIRT1-p53 axis. SIRT2 can regulate the function of pluripotent stem cells through GSK3β. SIRT3 can positively regulate PPAR gamma coactivator 1-alpha (PGC-1α) expression during the differentiation of stem cells...
March 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29531537/injected-human-muscle-precursor-cells-overexpressing-pgc-1-%C3%AE-enhance-functional-muscle-regeneration-after-trauma
#6
Deana Haralampieva, Souzan Salemi, Thomas Betzel, Ivana Dinulovic, Stefanie D Krämer, Roger Schibli, Tullio Sulser, Christoph Handschin, Simon M Ametamey, Daniel Eberli
While many groups demonstrated new muscle tissue formation after muscle precursor cell (MPC) injection, the capacity of these cells to heal muscle damage, for example, sphincter in stress urinary incontinence, in long-term is still limited. Therefore, the first goal of our project was to optimize the functional regenerative potential of hMPC by genetic modification to overexpress human peroxisome proliferator-activated receptor gamma coactivator 1-alpha (hPGC-1 α ), key regulator of exercise-mediated adaptation...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29525531/raspberry-ketone-induces-brown-like-adipocyte-formation-through-suppression-of-autophagy-in-adipocytes-and-adipose-tissue
#7
Sy-Ying Leu, Yung-Chieh Tsai, Wen-Chi Chen, Chih-Hsiung Hsu, Yen-Mei Lee, Pao-Yun Cheng
Promoting white adipose tissue (WAT) to acquire brown-like characteristics is a promising approach for obesity treatment. Although raspberry ketone (RK) has been reported to possess antiobesity activity, its effects on the formation of brown-like adipocytes remain unclear. Therefore, we investigated the effects and underlying mechanism of RK on WAT browning in 3T3-L1 adipocytes and rats with ovariectomy (Ovx)-induced obesity. RK (100 μM) significantly induced browning of 3T3-L1 cells by increasing mitochondrial biogenesis and the expression of browning-specific proteins (PR domain containing 16, PRDM16; peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC-1α; uncoupling protein-1, UCP-1) and lipolytic enzymes (hormone-sensitive lipase and adipose triglyceride lipase)...
February 13, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29502862/peroxisome-proliferator-activated-receptor-gamma-coactivator-1-alpha-as-a-novel-target-for-bipolar-disorder-and-other-neuropsychiatric-disorders
#8
REVIEW
Andrew A Nierenberg, Sharmin A Ghaznavi, Isadora Sande Mathias, Kristen K Ellard, Jessica A Janos, Louisa G Sylvia
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a protein that regulates metabolism and inflammation by activating nuclear receptors, especially the family of peroxisome proliferator-activated receptors (PPARs). PGC-1 alpha and PPARs also regulate mitochondrial biogenesis, cellular energy production, thermogenesis, and lipid metabolism. Brain energy metabolism may also be regulated in part by the interaction between PGC-1 alpha and PPARs. Because neurodegenerative diseases (Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis) and bipolar disorder have been associated with dysregulated mitochondrial and brain energy metabolism, PGC-1 alpha may represent a potential drug target for these conditions...
January 10, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29472690/cisplatin-enhances-hepatitis-b-virus-replication-and-pgc-1%C3%AE-expression-through-endoplasmic-reticulum-stress
#9
Xiaosong Li, E Pan, Junke Zhu, Lei Xu, Xuemei Chen, Jingjing Li, Li Liang, Yuan Hu, Jie Xia, Juan Chen, Wannan Chen, Jieli Hu, Kai Wang, Ni Tang, Ailong Huang
Chronic hepatitis B infection remains a serious public health issue worldwide. Hepatitis B virus (HBV) reactivation is commonly reported in patients receiving anticancer therapy, immunosuppressive therapy, or organ and tissue transplantation. However, the precise mechanisms underlying chemotherapeutic agent-related HBV reactivation remain unclear. Here, we report that peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) plays a central role in cisplatin-induced HBV transcription and replication...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29433686/gastrodia-elata-alleviates-mutant-huntingtin-aggregation-through-mitochondrial-function-and-biogenesis-mediation
#10
Chuen-Lin Huang, Kaw-Chen Wang, Ying-Chen Yang, Chun-Tang Chiou, Chia-Hui Tan, Yun-Lian Lin, Nai-Kuei Huang
BACKGROUND: According to the Compendium of Materia Medica, Gastrodia elata (GE) Blume is a top-grade herbal medicine frequently used to treat dizziness, headaches, tetanus, and epilepsy, suggesting that it affects neurological functions. Although studies have supported its effects in preventing diverse neurodegenerations such as Huntington's disease (HD), its mechanisms require further investigation. PURPOSE: To investigate the ability of the molecular mechanism of GE to prevent mutant huntingtin (mHTT) protein aggregation by focusing on mitochondrial function and biogenesis, which have been proposed as the therapeutic targets of HD...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29424256/effect-of-coenzyme-q10-on-mitochondrial-respiratory-proteins-in-trigeminal-neuralgia
#11
Chutikorn Khuankaew, Nattayaporn Apaijai, Passakorn Sawaddiruk, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Surawut Pongsiriwet, Wichittra Tassaneeyakul, Nipon Chattipakorn, Siriporn C Chattipakorn
Trigeminal neuralgia (TN) is the neuropathic pain. Mitochondrial dysfunction, increased oxidative stress, and inflammation demonstrated in chronic pain. Carbamazepine (CBZ) is the first-line drug for TN, however, it is still insufficient. Coenzyme Q10 (CoQ10) has been used as the additional supplement for pain therapy. Nonetheless, mitochondrial respiratory proteins, oxidative stress, and inflammation in TN, and the add-on effects of CoQ10 on those defects have never been investigated. CBZ-treated TN-patients, naïve TN-patients, and control subjects were included...
February 9, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29407753/schisandrin-c-enhances-odontoblastic-differentiation-through-autophagy-and-mitochondrial-biogenesis-in-human-dental-pulp-cells
#12
Jyoti Shrestha Takanche, Jeong-Seok Kim, Ji-Eun Kim, S-H Han, Ho-Keun Yi
OBJECTIVE: To investigate the role of Schisandrin C in odontoblastic differentiation, and its relations between autophagy and mitochondrial biogenesis in human dental pulp cells (HPDCs). DESIGN: Fresh third molars were used, and cultured for HDPCs. Western blotting technique, Alizarin red S staining, alkaline phosphatase (ALP) activity, and confocal microscopy were used to detect autophagy, mitochondrial biogenesis, and odontoblastic differentiation. To understand the mechanism of Schisandrin C, the HDPCs were treated with lipopolysaccharide (LPS), autophagy and heme oxygenase-1 (HO-1) inhibitors: 3-Methyladenine (3-MA) and Zinc protoporphyrin IX (ZnPP), respectively...
January 30, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29400110/scutellarin-ameliorates-nonalcoholic-fatty-liver-disease-through-the-ppar%C3%AE-pgc-1%C3%AE-nrf2-pathway
#13
Xiaoxue Zhang, Renpeng Ji, Huijun Sun, Jinyong Peng, Xiaodong Ma, ChangYuan Wang, Yufeng Fu, Liuchi Bao, Yue Jin
Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutellarin treatment was applied to male C57BL/6 mice maintained on a high-fat diet (HFD) and HepG2 cells challenged with oleic acid. The antioxidation biochemical indicators and lipid levels in the liver and cells were detected by kits...
February 5, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29383690/glia-maturation-factor-dependent-inhibition-of-mitochondrial-pgc-1%C3%AE-triggers-oxidative-stress-mediated-apoptosis-in-n27-rat-dopaminergic-neuronal-cells
#14
Govindhasamy Pushpavathi Selvakumar, Shankar S Iyer, Duraisamy Kempuraj, Murugesan Raju, Ramasamy Thangavel, Daniyal Saeed, Mohammad Ejaz Ahmed, Harris Zahoor, Sudhanshu P Raikwar, Smita Zaheer, Asgar Zaheer
Parkinson's disease (PD) is a progressive neurodegenerative disease affecting over five million individuals worldwide. The exact molecular events underlying PD pathogenesis are still not clearly known. Glia maturation factor (GMF), a neuroinflammatory protein in the brain plays an important role in the pathogenesis of PD. Mitochondrial dysfunctions and oxidative stress trigger apoptosis leading to dopaminergic neuronal degeneration in PD. Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α or PPARGC-α) acts as a transcriptional co-regulator of mitochondrial biogenesis and energy metabolism by controlling oxidative phosphorylation, antioxidant activity, and autophagy...
January 30, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29369849/sirtuin-1-regulates-pulmonary-artery-smooth-muscle-cell-proliferation-role-in-pulmonary-arterial-hypertension
#15
Giada Zurlo, Jérôme Piquereau, Maryline Moulin, Julie Pires Da Silva, Mélanie Gressette, Benoît Ranchoux, Anne Garnier, Renée Ventura-Clapier, Elie Fadel, Marc Humbert, Christophe Lemaire, Frédéric Perros, Vladimir Veksler
OBJECTIVE: Energy metabolism shift from oxidative phosphorylation toward glycolysis in pulmonary artery smooth muscle cells (PASMCs) is suggested to be involved in their hyperproliferation in pulmonary arterial hypertension (PAH). Here, we studied the role of the deacetylase sirtuin1 (SIRT1) in energy metabolism regulation in PASMCs via various pathways including activation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), master regulator of mitochondrial biogenesis...
January 24, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29361788/mir-93-5p-promotes-cell-proliferation-through-down-regulating-ppargc1a-in-hepatocellular-carcinoma-cells-by-bioinformatics-analysis-and-experimental-verification
#16
Xinrui Wang, Zhijun Liao, Zhimin Bai, Yan He, Juan Duan, Leyi Wei
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A, formerly known as PGC-1a) is a transcriptional coactivator and metabolic regulator. Previous studies are mainly focused on the association between PPARGC1A and hepatoma. However, the regulatory mechanism remains unknown. A microRNA associated with cancer (oncomiR), miR-93-5p, has recently been found to play an essential role in tumorigenesis and progression of various carcinomas, including liver cancer. Therefore, this paper aims to explore the regulatory mechanism underlying these two proteins in hepatoma cells...
January 22, 2018: Genes
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#17
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
December 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29275365/2-methoxyestradiol-affects-mitochondrial-biogenesis-pathway-and-succinate-dehydrogenase-complex-flavoprotein-subunit-a-in-osteosarcoma-cancer-cells
#18
Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska, Stephan A Eisler, Ugo Perricone, Giosuè Lo Bosco, Giampaolo Barone, Stephan Nussberger
BACKGROUND/AIM: Dysregulation of mitochondrial pathways is implicated in several diseases, including cancer. Notably, mitochondrial respiration and mitochondrial biogenesis are favored in some invasive cancer cells, such as osteosarcoma. Hence, the aim of the current work was to investigate the effects of 2-methoxyestradiol (2-ME), a potent anticancer agent, on the mitochondrial biogenesis of osteosarcoma cells. MATERIALS AND METHODS: Highly metastatic osteosarcoma 143B cells were treated with 2-ME separately or in combination with L-lactate, or with the solvent (non-treated control cells)...
January 2018: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29273519/adenosine-monophosphate-activated-protein-kinase-modulation-by-berberine-attenuates-mitochondrial-deficits-and-redox-imbalance-in-experimental-diabetic-neuropathy
#19
Veera Ganesh Yerra, Anil Kumar Kalvala, Bhoomika Sherkhane, Aparna Areti, Ashutosh Kumar
Adenosine monophosphate-activated protein kinase (AMPK) has been studied for its myriad metabolic and mitochondrial benefits in several chronic diseases. Recent studies have uncovered its therapeutic potential against mitochondrial dysfunction in cultured dorsal root ganglion (DRG) neurons isolated from streptozotocin (STZ) induced diabetic rats. The present study is aimed at evaluating the pharmacological efficacy of berberine (BRB), a natural AMPK activator against experimental diabetic neuropathy (DN) phenotype developed in STZ (55 mg/kg, i...
March 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29243793/a-new-antioxidant-formulation-reduces-the-apoptotic-and-damaging-effect-of-cigarette-smoke-extract-on-human-bronchial-epithelial-cells
#20
L Vanella, G Li Volti, A Distefano, M Raffaele, V Zingales, R Avola, D Tibullo, I Barbagallo
OBJECTIVE: In this study we evaluated the possible protective effect of an antioxidant formulation containing microfiltered milk derived polypeptides, Curcumin, Vitamin B2, Carnitine and N-Acetyl-cysteine (NAC) in an in vitro model of chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Human bronchial epithelial cells (16HBE) were used in this study. Cells were treated for 24 h in the presence or absence of 10% of cigarette smoke extract (CSE) and in the presence or absence of antioxidant formulation...
December 2017: European Review for Medical and Pharmacological Sciences
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