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https://www.readbyqxmd.com/read/28089770/structural-pierce-into-molecular-mechanism-underlying-clostridium-perfringens-epsilon-toxin-function
#1
Saeed Khalili, Abolfazl Jahangiri, Zahra Sadat Hashemi, Bahman Khalesi, Meysam Mardsoltani, Jafar Amani
Epsilon toxin of the Clostridium perfringens garnered a lot of attention due to its potential for toxicity in humans, extreme potency for cytotoxicity in mice and lack of any approved therapeutics prescribed for human. However, the intricacies of the Epsilon toxin action mechanism are yet to be understood. In this regard, various in silico tools have been exploited to model and refine the 3D structure of the toxin and its two receptors. The receptor proteins were embedded into designed lipid membranes within an aqueous and ionized environment...
January 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28088119/composite-films-of-metal-doped-cos-carbon-allotropes-efficient-electrocatalyst-counter-electrodes-for-high-performance-quantum-dot-sensitized-solar-cells
#2
Seyede Sara Khalili, Hossein Dehghani, Malihe Afrooz
This study reports the enhanced catalytic ability of metal ions-doped CoS and CoS/carbon allotrope counter electrodes (CEs) (synthesized using a successive ionic layer adsorption and reaction (SILAR) method) to improve the power conversion efficiency (η) in quantum dot-sensitized solar cells (QDSSCs). Firstly, doping effects of different metal ions (Mg(2+), Ca(2+), Sr(2+) and Ba(2+)) in the CoS CE on the QDSSCs performance have been investigated. Overall, among the different metal doped CoS CEs, the best energy conversion efficiency of 2...
January 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28079886/hiv-1-nef-is-released-in-extracellular-vesicles-derived-from-astrocytes-evidence-for-nef-mediated-neurotoxicity
#3
A Sami Saribas, Stephanie Cicalese, Taha Mohseni Ahooyi, Kamel Khalili, Shohreh Amini, Ilker Kudret Sariyer
Human immunodeficiency virus-associated neurological disorders (HANDs) affect the majority of AIDS patients and are a significant problem among HIV-1-infected individuals who live longer because of combined anti-retroviral therapies. HIV-1 utilizes a number of viral proteins and subsequent cytokine inductions to unleash its toxicity on neurons. Among HIV-1 viral proteins, Nef is a small protein expressed abundantly in astrocytes of HIV-1-infected brains and has been suggested to have a role in the pathogenesis of HAND...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28079625/older-age-and-health-related-quality-of-life-in-inflammatory-bowel-diseases
#4
Gabriella Velonias, Grace Conway, Elizabeth Andrews, John J Garber, Hamed Khalili, Vijay Yajnik, Ashwin N Ananthakrishnan
BACKGROUND: The burden of inflammatory bowel disease (IBD) in the older population is increasing. Older-onset disease is associated with reduced use of immunosuppressive medications. In addition, older patients may be more vulnerable to the effect of disease-related symptoms and consequently may experience worse health-related quality of life (HRQoL) compared with younger patients. METHODS: This prospective study included a cohort of patients with Crohn's disease and ulcerative colitis recruited from a single center...
January 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28054293/comparison-of-the-effect-of-gastric-bypass-and-sleeve-gastrectomy-on-metabolic-syndrome-and-its-components-in-a-cohort-tehran-obesity-treatment-study-tots
#5
Maryam Barzin, Mohammad Ali Kalantar Motamedi, Sara Serahati, Alireza Khalaj, Peyman Arian, Majid Valizadeh, Davood Khalili, Fereidoun Azizi, Farhad Hosseinpanah
INTRODUCTION: Metabolic syndrome (MetS) is a prevalent counterpart of morbid obesity. With the surgical technique of sleeve gastrectomy (SG) gaining widespread acceptance for weight loss in morbid obese patients, we aimed to undertake a study to compare its effectiveness to gastric bypass (GB) for metabolic control in these patients. METHODS: A total of 425 patients from a prospectively collected database of morbid obese subjects between 18 and 65 years of age undergoing a primary bariatric procedure from March 2013 to September 2015 were included...
January 4, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28050182/working-memory-training-in-the-form-of-structured-games-in-children-with-attention-deficit-hyperactivity-disorder
#6
Fatemeh Khalili Kermani, Mohammad Reza Mohammadi, Fariba Yadegari, Fatemeh Haresabadi, Seyed Mehdi Sadeghi
Objective: In this study, a new training method of working memory (WM) was used in the form of structured games, and the effect of training was evaluated with a controlled design. The training method of WM in the form of structured games includes 20 sets of structured games that can improve WM and performance of executive functions. Method: Sixty children with attention deficit hyperactivity disorder (ADHD) aged 8.5 to 11.2 years (35 boys), using no stimulant medication were selected. We randomly assigned 30 participants to the experimental group and provided them with WM training...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28049030/pregabalin-enhances-myelin-repair-and-attenuates-glial-activation-in-lysolecithin-induced-demyelination-model-of-rat-optic-chiasm
#7
Danyal Daneshdoust, Mohsen Khalili-Fomeshi, Maryam Ghasemi-Kasman, Davoud Ghorbanian, Mona Hashemian, Mohammad Gholami, Aliakbar Moghadamnia, Amir Shojaei
Multiple sclerosis (MS) is an autoimmune disease in which more than 70% of patients experience visual disturbance as the earliest symptoms. Lysolecithin (LPC)-induced focal demyelination model has been developed to evaluate the effects of different therapies on myelin repair improvement. In this study, the effects of pregabalin administration on myelin repair and glial activation were investigated. Local demyelination was induced by administration of LPC (1%, 2μL) into the rat optic chiasm. Rats underwent daily injection of pregabalin (30mg/kg, i...
January 1, 2017: Neuroscience
https://www.readbyqxmd.com/read/28040122/vitrification-of-mouse-mii-oocytes-developmental-competency-using-paclitaxel
#8
Farzaneh Fesahat, Azita Faramarzi, Arezoo Khoradmehr, Marjan Omidi, Fatemeh Anbari, Mohammad Ali Khalili
OBJECTIVE: Oocyte cryopreservation provides an important alternative for fertility preservation for women who will be treated with cytotoxic drugs. However, it can cause spindle disorganization of microtubules, putting the zygote at risk for aneuploidy. Paclitaxel is known to stabilize the microtubules that constitute the spindle. The aim of this study was to investigate the suitable concentration of paclitaxel for adding to the vitrification media to improve the developmental potential of post-thawed mature oocytes to blastocyst formation in mice...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28039621/establishment-and-characterization-of-caspian-horse-fibroblast-cell-bank-in-iran
#9
Abdolreza Daneshvar Amoli, Nazanin Mohebali, Parvaneh Farzaneh, Seyed Abolhassan Shahzadeh Fazeli, Laleh Nikfarjam, Sepideh Ashouri Movasagh, Zahra Moradmand, Meysam Ganjibakhsh, Ahmad Nasimian, Mehrnaz Izadpanah, Faezeh Vakhshiteh, Neda Sadat Gohari, Najmeh Sadat Masoudi, Maryam Farghadan, Shiva Mohamadi Moghanjoghi, Masoud Khalili, Kourosh J Khaledi
Caspian horse, a rare horse breed found in 1965 by Louise Firouz in northern Iran, is a small horse which is reported to be in danger of extinction in its original homeland. There seems to be a great need to prevent extinction of this valuable horse. In this study, 51 fibroblast cell lines from Caspian horse ear marginal tissue were successfully established by sampling 60 horses using primary explant technique. Cells were authenticated and growth curve was plotted. According to results obtained, population doubling time (PDT) was calculated 23 ± 0...
December 30, 2016: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28029080/synthesis-and-study-of-analgesic-and-anti-inflammatory-activities-of-amide-derivatives-of-ibuprofen
#10
Abbas Ahmadi, Mohsen Khalili, Zahra Olama, Shirin Karami, Babak Nahri-Niknafs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastro-intestinal (GI) damage in long-term using of them. In order to obtain the novel NSAIDs with less side effects; carboxylic acid moiety has been modified into various amide groups which is the most active area of research in this family...
December 26, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28028517/preparation-and-characterization-of-poly-hydroxy-butyrate-chitosan-blend-scaffolds-for-tissue-engineering-applications
#11
Saeed Karbasi, Saied Nouri Khorasani, Somayeh Ebrahimi, Shahla Khalili, Farnoosh Fekrat, Davoud Sadeghi
BACKGROUND: Poly (hydroxy butyrate) (PHB) is a biodegradable and biocompatible polymer with good mechanical properties. This polymer could be a promising material for scaffolds if some features improve. MATERIALS AND METHODS: In the present work, new PHB/chitosan blend scaffolds were prepared as a three-dimensional substrate in cartilage tissue engineering. Chitosan in different weight percent was added to PHB and solved in trifluoroacetic acid. Statistical Taguchi method was employed in the design of experiments...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28028513/evaluation-of-endothelial-function-in-exogenous-subclinical-hyperthyroidism-and-the-effect-of-treatment
#12
Sayed Mohammad Hosseini, Elham Khosravi Bakhtyari, Kiyan Heshmat-Ghahdarijani, Noushin Khalili
BACKGROUND: Subclinical hyperthyroidism (SHy) is a widespread condition in which cardiovascular manifestations are frequently occur, but there is still a debate about the vascular responsiveness in it. Measuring flow-mediated dilation (FMD) and intimae-media thickness (IMT) are used to evaluate endothelial function in these patients. MATERIALS AND METHODS: Twenty-five patients with a diagnosis of exogenous SHy and 25 full matched healthy subjects were enrolled. At first FMD of brachial artery and IMT of common carotid artery were obtained from all the participants...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28011798/stepwise-mass-screening-for-atrial-fibrillation-using-n-terminal-pro-b-type-natriuretic-peptide-the-strokestop-ii-study-design
#13
Johan Engdahl, Emma Svennberg, Leif Friberg, Faris Al-Khalili, Viveka Frykman, Katrin Kemp Gudmundsdottir, Tove Fredriksson, Mårten Rosenqvist
AIM: Atrial fibrillation (AF) is the most prevalent clinical arrhythmia and a major risk factor for ischaemic stroke. Treatment with oral anticoagulants (OACs) reduces the risk of stroke by two thirds in AF patients with risk factors. Due to its often paroxysmal and asymptomatic presentation, AF is sometimes challenging to diagnose. So far, AF screening studies have applied opportunistic or systematic screening, most often using a single 12-lead electrocardiogram (ECG) recording or ambulatory ECG...
December 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28003836/dramatic-improvement-in-dissolution-rate-of-albendazole-by-a-simple-one-step-industrially-scalable-technique
#14
Saeed Ghanbarzadeh, Aram Khalili, Abolghasem Jouyban, Shahram Emami, Yousef Javadzadeh, Mohammad Solhi, Hamed Hamishehkar
Low solubility and dissolution rate are the primary challenges in the drug development which substantially impact the oral absorption and bioavailability of drugs. Due to the poor water solubility, Albendazole (ABZ) is poorly absorbed from the gastrointestinal tract and shows low oral bioavailability (5%) which is a major disadvantage for the systemic use of ABZ. To improve the solubility and dissolution rate of ABZ, different classes of hydrophilic excipients such as sugars (lactose, sucrose, and glucose), polyols (mannitol and sorbitol), ionic surfactant (sodium lauryl sulfate) and non-ionic surfactant (Cremophor A25) were co-spray dried with ABZ...
December 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28003811/identification-and-characterization-of-a-novel-association-between-dietary-potassium-and-risk-of-crohn-s-disease-and-ulcerative-colitis
#15
Hamed Khalili, Sakshi Malik, Ashwin N Ananthakrishnan, John J Garber, Leslie M Higuchi, Amit Joshi, Joanna Peloquin, James M Richter, Kathleen O Stewart, Gary C Curhan, Amit Awasthi, Vijay Yajnik, Andrew T Chan
BACKGROUND: Recent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/TH17 pathway, which is critical in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD). METHODS: We conducted a prospective study of U.S. women enrolled in the Nurses' Health Study (NHS) and NHSII who provided detailed and validated information on diet and lifestyle beginning in 1984 in NHS and 1991 in NHSII...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27994802/comparison-of-higher-order-aberrations-after-wavefront-guided-lasik-and-prk-one-year-follow-up-results
#16
Seyed Hamid Reza Jahadi Hosseini, Seyed Mohammad Bagher Abtahi, Mohammad Reza Khalili
PURPOSE: To evaluate the changes and predictability of higher order aberrations (HOAs) after personalized laser in situ keratomileusis (LASIK) and personalized photorefractive keratectomy (PRK) for simple myopia and compound myopic astigmatism. METHODS: In this prospective cross-sectional study, 100 eyes were included. A total of 50 eyes underwent personalized LASIK and 50 eyes underwent personalized PRK. Preoperative and postoperative wavefront data were compared between the two groups...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27987734/bioactivity-and-electrochemical-behavior-of-hydroxyapatite-silicon-multi-walled-carbon-nano-tubes-composite-coatings-synthesized-by-epd-on-niti-alloys-in-simulated-body-fluid
#17
V Khalili, J Khalil-Allafi, J Frenzel, G Eggeler
In order to improve the surface bioactivity of NiTi bone implant and corrosion resistance, hydroxyapatite coating with addition of 20wt% silicon, 1wt% multi walled carbon nano-tubes and both of them were deposited on a NiTi substrate using a cathodic electrophoretic method. The apatite formation ability was estimated using immersion test in the simulated body fluid for 10days. The SEM images of the surface of coatings after immersion in simulated body fluid show that the presence of silicon in the hydroxyapatite coatings accelerates in vitro growth of apatite layer on the coatings...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27981301/a-triple-blinded-randomized-placebo-controlled-clinical-trial-to-evaluate-the-efficacy-and-safety-of-oral-vancomycin-in-primary-sclerosing-cholangitis-a-pilot-study
#18
Shahab Rahimpour, Mohsen Nasiri-Toosi, Hossein Khalili, Nasser Ebrahimi-Daryani, Mohammad Kazem Nouri-Taromlou, Zahra Azizi
BACKGROUND AND AIM: Recent studies have suggested the therapeutic effect of antimicrobial agents on primary sclerosing cholangitis (PSC). Therefore, we aimed to evaluate the efficacy of oral vancomycin in patients with PSC. METHOD: A triple blinded, randomized, placebo-controlled trial was performed on 29 patients (2015-2016) in the Imam Khomeini Hospital, Tehran, Iran (NCT02605213). Patients were divided into two groups by simple randomization method: placebo 11 (37...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27966987/room-temperature-skyrmion-shift-device-for-memory-application
#19
Guoqiang Yu, Pramey Upadhyaya, Qiming Shao, Hao Wu, Gen Yin, Xiang Li, Congli He, Wanjun Jiang, Xiufeng Han, Pedram Khalili Amiri, Kang L Wang
Magnetic skyrmions are intensively explored for potential applications in ultralow-energy data storage and computing. To create practical skyrmionic memory devices, it is necessary to electrically create and manipulate these topologically protected information carriers in thin films, thus realizing both writing and addressing functions. Although room-temperature skyrmions have been previously observed, fully electrically controllable skyrmionic memory devices, integrating both of these functions, have not been developed to date...
December 19, 2016: Nano Letters
https://www.readbyqxmd.com/read/27960524/strong-rashba-edelstein-effect-induced-spin-orbit-torques-in-monolayer-transition-metal-dichalcogenide-ferromagnet-bilayers
#20
Qiming Shao, Guoqiang Yu, Yann-Wen Lan, Yumeng Shi, Ming-Yang Li, Cheng Zheng, Xiaodan Zhu, Lain-Jong Li, Pedram Khalili Amiri, Kang L Wang
The electronic and optoelectronic properties of two-dimensional materials have been extensively explored in graphene and layered transition metal dichalcogenides (TMDs). Spintronics in these two-dimensional materials could provide novel opportunities for future electronics, for example, efficient generation of spin current, which should enable the efficient manipulation of magnetic elements. So far, the quantitative determination of charge current-induced spin current and spin-orbit torques (SOTs) on the magnetic layer adjacent to two-dimensional materials is still lacking...
December 14, 2016: Nano Letters
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