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https://www.readbyqxmd.com/read/29344320/pyoderma-gangrenosum-associated-granulomatosis-with-polyangitis-a-case-report-and-literature-review
#1
Matthew B Zarraga, Nicole Swenson, Brad Glick
Granulomatosis with polyangitis, formerly known as Wegener's granulomatosis, is a multi-system vasculitis that has a variable clinical presentation. Although uncommon, cutaneous symptoms can be the initial presenting symptom of granulomatosis with polyangitis. We present an unusual case of pyoderma gangrenosum followed by a diagnosis of granulomatosis with polyangitis. We also provide a review of current literature on therapeutic options.
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29337388/reactions-of-an-al-p-frustrated-lewis-pair-with-%C3%AE-%C3%AE-unsaturated-carbonyl-compounds-flps-as-efficient-2e-reductants-with-the-formation-of-enolates-a-cis-enediolate-and-an-allene
#2
Werner Uhl, Merten Lange, Jonas C Tendyck, Philipp Wegener, Alexander Hepp, Ernst Ulrich Würthwein
The Al/P based FLP Mes2P-C(AltBu)2=C(H)Ph (1) reacted as an efficient 2e reductant with benzil to afford a cis-enediolate which is coordinated to the FLP via P-O and Al-O bonds and formation of a seven-membered heterocycle (2). The P atom is oxidised from +III to +V. Similar heterocycles (3a to 3f) were formed when 1 was treated with various enones (acroleine, acrylate, acrylamide). The resulting enolates are bound to the FLP via P-C and Al-O bonds. Cyclopropenone gave an adduct (4) with the C=O bond coordinated by P and Al...
January 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29329286/is-the-proportional-recovery-rule-applicable-to-the-lower-limb-after-a-first-ever-ischemic-stroke
#3
Janne M Veerbeek, Caroline Winters, Erwin E H van Wegen, Gert Kwakkel
OBJECTIVE: To investigate (a) the applicability of the proportional recovery rule of spontaneous neurobiological recovery to motor function of the paretic lower extremity (LE); and (b) the presence of fitters and non-fitters of this prognostic rule poststroke. When present, the clinical threshold for fitting nor non-fitting would be determined, as well as within-subject generalizability to the paretic upper extremity (UE). METHODS: Prospective cohort study in which the Fugl-Meyer Assessment (FMA)-LE and FMA-UE were measured <72 hours and 6 months poststroke...
2018: PloS One
https://www.readbyqxmd.com/read/29328034/characteristics-of-articular-syndrome-in-systemic-vasculitis
#4
O Syniachenko, O Khaniukov, Ye Yehudina, H Taktashov, K Gashynova
The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. The study included 525 patients in the ratio of the examined with Henoch-Schonlen purpura, microscopic polyangiitis, cryoglobulinemic vasculitis, polyarteritis nodosa, Takayasu's arteritis, Wegener's granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis Churg-Strauss as a 7:4:3:1:1:1:1...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29320929/metacognitive-reflection-as-a-moderator-of-attitude-strength-versus-attitude-bolstering-implications-for-attitude-similarity-and-attraction
#5
Vanessa Sawicki, Duane T Wegener
"Strong" attitudes often have greater impact than "weak" attitudes. However, emerging research suggests that weak (uncertain) attitudes can substantially influence thinking or behavior. We propose metacognitive reflection as a moderator between traditional strength patterns and these emerging attitude bolstering patterns. Across six studies, research participants encountered a target person who agreed or disagreed with participants' attitudes. When focused on evaluating the target, attitudes predicted target evaluations better when the attitude was held with certainty (Study 1A), or after certainty had been primed (Studies 2A and 3; strength effects)...
January 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29319717/serum-25-hydroxyvitamin-d-levels-in-patients-with-granulomatosis-with-polyangiitis-association-with-respiratory-infection
#6
Mariana O Perez, Ricardo M Oliveira, Mauricio Levy-Neto, Valeria F Caparbo, Rosa M R Pereira
OBJECTIVES: To determine the possible association of serum 25-hydroxyvitamin D (25OHD) levels with disease activity and respiratory infection in granulomatosis with polyangiitis patients during two different periods: winter/spring and summer/autumn. METHODS: Thirty-two granulomatosis with polyangiitis patients were evaluated in the winter/spring, and the same patients (except 5) were evaluated in summer/autumn (n=27). The 25OHD levels were measured by radioimmunoassay...
December 2017: Clinics
https://www.readbyqxmd.com/read/29311036/equipping-future-generations-of-registered-dietitian-nutritionists-and-public-health-nutritionists-a-commentary-on-education-and-training-needs-to-promote-sustainable-food-systems-and-practices-in-the-21st-century
#7
https://www.readbyqxmd.com/read/29307545/pfe-360-induced-lrrk2-inhibition-induces-reversible-non-adverse-renal-changes-in-rats
#8
Michael Aagaard Andersen, Karen Malene Wegener, Steen Larsen, Lassina Badolo, Garrick Paul Smith, Ross Jeggo, Poul Henning Jensen, Florence Sotty, Kenneth Vielsted Christensen, Annemette Thougaard
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no existing therapeutic approach to delay or stop progression. Genetic, biochemical and pre-clinical studies have provided evidence that leucine-rich-repeat-kinase-2 (LRRK2) kinase is involved in the pathogenesis of PD, and small molecule LRRK2 inhibitors represent a novel potential therapeutic approach. However, potentially adverse target-related effects have been discovered in the lung and kidneys of LRRK2 knock-out (ko) mice and rats...
January 4, 2018: Toxicology
https://www.readbyqxmd.com/read/29299913/tracking-hyaluronan-molecularly-imprinted-polymer-coated-carbon-dots-for-cancer-cell-targeting-and-imaging
#9
Bilal Demir, Michael Lemberger, Maria Panagiotopoulou, Paulina Medina-Rangel, Suna Timur, Thomas Hirsch, Bernadette Tse Sum Bui, Joachim Wegener, Karsten Haupt
War against cancer constantly requires new affinity tools to selectively detect, localize and quantify biomarkers for diagnosis or prognosis. Herein, carbon nanodots (CDs), an emerging class of fluorescent nanomaterials, coupled with molecularly imprinted polymers (MIPs), are employed as a biocompatible optical imaging tool for probing cancer biomarkers. First, N-doped CDs were prepared by hydrothermal synthesis using starch as carbon source, and L-tryptophan as nitrogen atom provider to achieve a high quantum yield of (25...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29298257/telephone-based-intervention-to-improve-rehabilitation-engagement-after-spinal-stenosis-surgery-a-prospective-lagged-controlled-trial
#10
Richard L Skolasky, Anica M Maggard, Stephen T Wegener, Lee H Riley
BACKGROUND: Spine surgery outcomes are variable. Patients who participate in and take responsibility for their recovery have improved health outcomes. Interventions to increase patient involvement in their care may improve health outcomes after a surgical procedure. We conducted a prospective interventional trial to compare the effectiveness of health behavior change counseling with usual care to improve health outcomes after lumbar spine surgical procedures. METHODS: In this study, 122 patients with lumbar spinal stenosis undergoing a decompression surgical procedure from December 2009 through August 2012 were enrolled...
January 3, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29276499/usability-of-videogame-based-dexterity-training-in-the-early-rehabilitation-phase-of-stroke-patients-a-pilot-study
#11
Tim Vanbellingen, Suzanne J Filius, Thomas Nyffeler, Erwin E H van Wegen
Background: Approximately 70-80% of stroke survivors have limited activities of daily living, mainly due to dexterous problems. Videogame-based training (VBT) along with virtual reality seems to be beneficial to train upper limb function. Objective: To evaluate the usability of VBT using the Leap Motion Controller (LMC) to train fine manual dexterity in the early rehabilitation phase of stroke patients as an add-on to conventional therapy. Additionally, this study aimed to estimate the feasibility and potential efficacy of the VBT...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29273709/protein-conformational-flexibility-modulates-kinetics-and-thermodynamics-of-drug-binding
#12
M Amaral, D B Kokh, J Bomke, A Wegener, H P Buchstaller, H M Eggenweiler, P Matias, C Sirrenberg, R C Wade, M Frech
Structure-based drug design has often been restricted by the rather static picture of protein-ligand complexes presented by crystal structures, despite the widely accepted importance of protein flexibility in biomolecular recognition. Here we report a detailed experimental and computational study of the drug target, human heat shock protein 90, to explore the contribution of protein dynamics to the binding thermodynamics and kinetics of drug-like compounds. We observe that their binding properties depend on whether the protein has a loop or a helical conformation in the binding site of the ligand-bound state...
December 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29246848/does-reduction-in-sciatica-symptoms-precede-improvement-in-disability-and-physical-health-among-those-treated-surgically-for-intervertebral-disc-herniation-analysis-of-temporal-patterns-in-data-from-the-spine-patient-outcomes-research-trial
#13
Richard L Skolasky, Emily A Scherer, Stephen T Wegener, Tor D Tosteson
BACKGROUND CONTEXT: Pain, pain-related disability, and functional limitations are common consequences of intervertebral disc herniation (IDH). We hypothesized that surgical treatment reduces pain, leading to improvement in pain-related disabilty and, ultimately, better physical health. PURPOSE: To evaluate pathways for improvements in quality of life during the first year after surgery for IDH by studying temporal relationships between sciatica symptoms, pain-related disability, and physical health...
December 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29241587/associations-between-infant-fungal-and-bacterial-dysbiosis-and-childhood-atopic-wheeze-in-a-nonindustrialized-setting
#14
Marie-Claire Arrieta, Andrea Arévalo, Leah Stiemsma, Pedro Dimitriu, Martha E Chico, Sofia Loor, Maritza Vaca, Rozlyn C T Boutin, Evan Morien, Mingliang Jin, Stuart E Turvey, Jens Walter, Laura Wegener Parfrey, Philip J Cooper, Brett Finlay
BACKGROUND: Asthma is the most prevalent chronic disease of childhood. Recently, we identified a critical window early in the life of both mice and Canadian infants during which gut microbial changes (dysbiosis) affect asthma development. Given geographic differences in human gut microbiota worldwide, we studied the effects of gut microbial dysbiosis on atopic wheeze in a population living in a distinct developing world environment. OBJECTIVE: We sought to determine whether microbial alterations in early infancy are associated with the development of atopic wheeze in a nonindustrialized setting...
November 30, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29235943/-trapped-in-an-empty-waiting-room-the-existential-human-core-of-loneliness-in-old-age-a-meta-synthesis
#15
Gabriele Kitzmüller, Anne Clancy, Mojtaba Vaismoradi, Charlotte Wegener, Terese Bondas
Loneliness in old age has a negative influence on quality of life, health, and survival. To understand the phenomenon of loneliness in old age, the voices of lonely older adults should be heard. Therefore, the purpose of this meta-synthesis was to synthesize scientific studies of older adults' experiences of loneliness. Eleven qualitative articles that met the inclusion criteria were analyzed and synthesized according to Noblit and Hare's meta-ethnographic approach. The analysis revealed the overriding meaning of the existential human core of loneliness in old age expressed through the metaphor "trapped in an empty waiting room...
January 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29232823/improving-cerebral-blood-flow-after-arterial-recanalization-a-novel-therapeutic-strategy-in-stroke
#16
REVIEW
Mohamad El Amki, Susanne Wegener
Ischemic stroke is caused by a disruption in blood supply to a region of the brain. It induces dysfunction of brain cells and networks, resulting in sudden neurological deficits. The cause of stroke is vascular, but the consequences are neurological. Decades of research have focused on finding new strategies to reduce the neural damage after cerebral ischemia. However, despite the incredibly huge investment, all strategies targeting neuroprotection have failed to demonstrate clinical efficacy. Today, treatment for stroke consists of dealing with the cause, attempting to remove the occluding blood clot and recanalize the vessel...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29228529/efficacy-of-bronchial-washing-and-brushing-cytology-in-the-diagnosis-of-non-neoplastic-lung-diseases
#17
Rahil Giti, Massood Hosseinzadeh
Flexible fiberoptic bronchoscopy is often the initial technique for diagnosis of lung and bronchial tumors. Many studies have shown the high accuracy rate of bronchial washing and brushing cytology in the evaluation of neoplastic and non-neoplastic bronchopulmonary lesions. The aim of this study is to emphasize the value of the bronchial cytologic findings for diagnosis of non-neoplastic bronchopulmonary lesions. In a cross-sectional study, we retrieved all cases with bronchial washing and brushing cytology from 21 Mach 2014 to 21 December 2015...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228215/mitochondria-are-critical-for-bdnf-mediated-synaptic-and-vascular-plasticity-of-hippocampus-following-repeated-electroconvulsive-seizures
#18
Fenghua Chen, Maryam Ardalan, Betina Elfving, Gregers Wegener, Torsten M Madsen, Jens R Nyengaard
Background: Electroconvulsive therapy (ECT) is a fast acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for the clinical efficacy obtained from a rapid antidepressant response. Here, we investigated the relationship between, synaptic changes and concomitant non-neuronal changes in microvasculature and mitochondria, and it relationship to Brain-derived neurotrophic factor (BDNF) level changes after repeated electroconvulsive seizures (ECS), an animal model of ECT...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29212742/getting-the-first-grant
#19
REVIEW
Susanne Wegener, Mira Katan
No abstract text is available yet for this article.
December 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29211437/a-high-performance-transition-metal-phosphide-alloy-catalyst-for-oxygen-evolution-reaction
#20
Kewei Liu, Changlin Zhang, Yuandong Sun, Guanghui Zhang, Xiaochen Shen, Feng Zou, Haichang Zhang, Zhenwei Wu, Evan C Wegener, Clinton J Taubert, Jeffrey T Miller, Zhenmeng Peng, Yu Zhu
Oxygen evolution reaction (OER) is a pivotal process in many energy conversion and storage techniques, such as water splitting, regenerative fuel cells, and rechargeable metal-air batteries. The synthesis of stable, efficient, non-noble metal-based electrocatalysts for OER has been a long-standing challenge. In this work, a facile and scalable method to synthesize hollow and conductive iron-cobalt phosphide (Fe-Co-P) alloy nanostructures using a Fe-Co metal organic complex as a precursor is described. The Fe-Co-P alloy exhibits excellent OER activity with a specific current density of 10 mA/cm2 being achieved at an overpotential as low as 252 mV...
December 6, 2017: ACS Nano
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