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https://www.readbyqxmd.com/read/28337822/unieuk-time-to-speak-a-common-language-in-protistology
#1
REVIEW
Cédric Berney, Andreea Ciuprina, Sara Bender, Juliet Brodie, Virginia Edgcomb, Eunsoo Kim, Jeena Rajan, Laura Wegener Parfrey, Sina Adl, Stéphane Audic, David Bass, David A Caron, Guy Cochrane, Lucas Czech, Micah Dunthorn, Stefan Geisen, Frank Oliver Glöckner, Frédéric Mahé, Christian Quast, Jonathan Z Kaye, Alastair G B Simpson, Alexandros Stamatakis, Javier Del Campo, Pelin Yilmaz, Colomban de Vargas
THE bewildering organismal and functional complexity of microbial eukaryotes has long fascinated protistologists but exceeded the capacity of this research community to comprehensively study it. Lacking the critical mass for a strong scientific discipline, protistologists remain largely divided into various sub-communities (protozoology versus phycology, aquatic versus terrestrial systems, fossil versus extant organisms, etc.), many of which are adjuncts of other larger fields that may speak different technical languages or use different taxonomic systems...
March 24, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28336006/influence-of-the-integral-quality-monitor-transmission-detector-on-high-energy-photon-beams-a-multi-centre-study
#2
Bozidar Casar, Marlies Pasler, Sonja Wegener, David Hoffman, Cinzia Talamonti, Jianguo Qian, Ignasi Mendez, Denis Brojan, Bruce Perrin, Martijn Kusters, Richard Canters, Stefania Pallotta, Primoz Peterlin
PURPOSE: The influence of the Integral Quality Monitor (IQM) transmission detector on photon beam properties was evaluated in a preclinical phase, using data from nine participating centres: (i) the change of beam quality (beam hardening), (ii) the influence on surface dose, and (iii) the attenuation of the IQM detector. METHODS: For 6 different nominal photon energies (4 standard, 2 FFF) and square field sizes from 1×1cm(2) to 20×20cm(2), the effect of IQM on beam quality was assessed from the PDD20,10 values obtained from the percentage dose depth (PDD) curves, measured with and without IQM in the beam path...
March 20, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28323807/the-trauma-collaborative-care-study-tccs
#3
Stephen T Wegener, Andrew N Pollak, Katherine P Frey, Robert A Hymes, Kristin R Archer, Clifford B Jones, Rachel B Seymour, Robert V OʼToole, Renan C Castillo, Yanjie Huang, Daniel O Scharfstein, Ellen J MacKenzie
Previous research suggests that the care provided to trauma patients could be improved by including early screening and management of emotional distress and psychological comorbidity. The Trauma Collaborative Care (TCC) program, which is based on the principles of well-established models of collaborative care, was designed to address this gap in trauma center care. This article describes the TCC program and the design of a multicenter study to evaluate its effectiveness for improving patient outcomes after major, high-energy orthopaedic trauma at level 1 trauma centers...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28318198/-subglottic-stenosis-as-the-initial-manifestation-of-wegener-s-granulomatosis-in-a-teenager-case-report
#4
Giselle Cuestas, Verónica Rodríguez, Flavia Doormann, Alejandra Pringe, Patricio Bellia Munzón, Gastón Bellia Munzón, Carlos Ortega, Rubén Álvarez
Wegener's granulomatosis is a necrotizing granulomatous vasculitis of autoimmune origin that primarily affects the upper and lower airways and kidneys. It is very rare in children and adolescents. When started at a young age it is often associated with subglottic stenosis. Subglottic stenosis is a potentially fatal manifestation of Wegener's granulomatosis. Its diagnosis requires a high index of suspicion since it might develop in the absence of other signs of activity. Occasionally, subglottic stenosis may present as the initial manifestation of the disease...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317938/on-the-determination-of-%C3%AF-2-in-thin-films-a-comparison-of-one-beam-second-harmonic-generation-measurement-methodologies
#5
Artur Hermans, Clemens Kieninger, Kalle Koskinen, Andreas Wickberg, Eduardo Solano, Jolien Dendooven, Martti Kauranen, Stéphane Clemmen, Martin Wegener, Christian Koos, Roel Baets
The determination of the second-order susceptibility (χ((2))) of thin film samples can be a delicate matter since well-established χ((2)) measurement methodologies such as the Maker fringe technique are best suited for nonlinear materials with large thicknesses typically ranging from tens of microns to several millimeters. Here we compare two different second-harmonic generation setups and the corresponding measurement methodologies that are especially advantageous for thin film χ((2)) characterization. This exercise allows for cross-checking the χ((2)) obtained for identical samples and identifying the main sources of error for the respective techniques...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28306635/ocular-fundus-photography-with-a-smartphone-device-in-acute-hypertension
#6
M Lorenza Muiesan, Massimo Salvetti, Anna Paini, Michela Riviera, Clara Pintossi, Fabio Bertacchini, Efrem Colonetti, Claudia Agabiti-Rosei, Maurizio Poli, Francesco Semeraro, Enrico Agabiti-Rosei, Andrea Russo
BACKGROUND: The ocular fundus examination is infrequently and poorly performed in the emergency department (ED) clinical settings, placing patients at risk for missed diagnosis of hypertensive emergencies. The aim of this study was to investigate the feasibility of the ocular fundus photography with a smartphone small optical device in an ED setting and to compare it with a traditional ocular fundus examination. METHODS: The study included 52 consecutive patients (mean age 69 ± 16 years, 50% women) presenting to a hospital ED with an acute increase in blood pressure (SBP > 180 and/or DBP > 100 mmHg)...
March 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28306365/ulcerative-granuloma-of-the-eyelid-as-the-initial-manifestation-of-granulomatosis-with-polyangiitis-wegener-s-granulomatosis-a-case-report
#7
Helena Brosa Morros, Olaia Subirà, Montse Gomà Gàllego, Maria José Paúles Villar, Ferran Mascaró Zamora, Maravillas Abia Serrano
A 56-year-old-man presented a 2-month history of chalazion in the eyelids without response to treatment and with an inconclusive biopsy. Laboratory results confirmed the presence of Enterobacter cloacae and Streptococcus gordonii infection. Despite appropriate intravenous antibiotic treatment, clinical worsening was observed. Radical surgical excision and total tarsorrhaphy were performed. Following treatment, the patient was asymptomatic for 6 weeks until he developed acute renal failure, generalised arthralgia, acute hypertensive anterior uveitis, and dacryoadenitis...
March 17, 2017: Orbit
https://www.readbyqxmd.com/read/28303064/accessory-left-gastric-artery-aneurysms-in-granulomatosis-with-polyangiitis-a-case-report-and-literature-review
#8
Toshihide Tomosugi, Takuji Takahashi, Yoshihisa Kawase, Koichi Yoshida, Shogo Hayashi, Takefumi Sugiyama, Mitsuya Shimizu, Michita Shoka, Kohichi Sawaki, Eiji Onishi, Naomi Hayashi, Hidenobu Matsushita, Osamu Okochi
Aneurysm formation is a potential complication of granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis. It is a very rare complication, but immediate diagnosis and therapy should be performed because an aneurysm can be life-threatening if it ruptures. An accessory left gastric artery (ALGA) is also a rare variant gastric artery that may obtain its blood supply from the left hepatic artery and left gastric artery. We herein describe a 57-year-old Japanese man who was diagnosed with GPA complicated by aneurysm rupture in an ALGA...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28295009/-refractory-form-of-orbital-granulomatosis-with-polyangiitis-a-clinical-and-morphological-study
#9
E A Kogan, Ya O Grusha, D S Ismailova, P I Novikov, Yu V Abramova, A D Meshkov, E F Rizopulu
Orbital granulomatosis with polyangiitis (Wegener's granulomatosis, GPA), which is characterized by granulomatous inflammation with small-vessel vasculitis, can develop in local and generalized forms of the disease. The introduction of current immunosuppressive therapy regimens has improved the prognosis of the disease; however, there are immunosuppressive treatment-refractory forms of GPA, the morphology of which has been inadequately investigated. The paper describes a clinical case of refractory GPA involving the orbit, as evidenced by histological and immunohistochemical examinations...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28291390/efficacy-and-safety-of-anti-trop-2-antibody-drug-conjugate-sacituzumab-govitecan-immu-132-in-heavily-pretreated-patients-with-metastatic-triple-negative-breast-cancer
#10
Aditya Bardia, Ingrid A Mayer, Jennifer R Diamond, Rebecca L Moroose, Steven J Isakoff, Alexander N Starodub, Nikita C Shah, Joyce O'Shaughnessy, Kevin Kalinsky, Michael Guarino, Vandana Abramson, Dejan Juric, Sara M Tolaney, Jordan Berlin, Wells A Messersmith, Allyson J Ocean, William A Wegener, Pius Maliakal, Robert M Sharkey, Serengulam V Govindan, David M Goldenberg, Linda T Vahdat
Purpose Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan. Patients and Methods We evaluated sacituzumab govitecan in a single-arm, multicenter trial in patients with relapsed/refractory metastatic TNBC who received a 10 mg/kg starting dose on days 1 and 8 of 21-day repeated cycles. The primary end points were safety and objective response rate; secondary end points were progression-free survival and overall survival...
March 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28285216/in-situ-biogas-upgrading-with-pulse-h2-additions-the-relevance-of-methanogen-adaption-and-inorganic-carbon-level
#11
Laura Mia Agneessens, Lars Ditlev Mørck Ottosen, Niels Vinther Voigt, Jeppe Lund Nielsen, Nadieh de Jonge, Christian Holst Fischer, Michael Vedel Wegener Kofoed
Surplus electricity from fluctuating renewable power sources may be converted to CH4 via biomethanisation in anaerobic digesters. The reactor performance and response of methanogen population of mixed-culture reactors was assessed during pulsed H2 injections. Initial H2 uptake rates increased immediately and linearly during consecutive pulse H2 injections for all tested injection rates (0.3 to 1.7LH2/Lsludge/d), while novel high throughput mcrA sequencing revealed an increased abundance of specific hydrogenotrophic methanogens...
February 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28275083/unilateral-cerebellothalamic-tract-ablation-in-essential-tremor-by-mri-guided-focused-ultrasound
#12
Sebastian R Schreglmann, Ronald Bauer, Stefan Hägele-Link, Kailash P Bhatia, Parashkev Natchev, Nikolas Wegener, Anita Lebeda, Beat Werner, Ernst Martin, Georg Kägi
OBJECTIVE: To report results of a prospective trial of unilateral transcranial MRI-guided focused ultrasound (MRIgFUS) ablation of the cerebellothalamic tract in essential tremor (ET). METHODS: This was a prospective, uncontrolled, single-center interventional study. Patients with ET fulfilling criteria for interventional therapy received unilateral ablation of the cerebellothalamic tract (CTT) by MRIgFUS. Motor symptoms, manual dexterity, cognition, and quality of life were assessed before intervention and at 48 hours and 1, 3, and 6 months after intervention...
March 8, 2017: Neurology
https://www.readbyqxmd.com/read/28273603/rare-presentation-of-wegener-s-granulomatosis-in-the-pituitary-gland-case-report-and-literature-review
#13
Samantha M Baird, Upasna Pratap, Catriona McLean, Candice P Law, Nicholas Maartens
INTRODUCTION: Wegener's granulomatosis (WG) is a systemic vasculitis that can affect a variety of organs including ear, nose and throat, lungs and kidneys. However WG is unusual in the pituitary and rare in the central nervous system. PRESENTATION OF CASE: A 56-year-old male with likely WG presented with polyuria and polydipsia despite six months of conservative medical management. MRI scanning revealed an enlarging heterogeneously enhancing pituitary gland. Following endoscopic transsphenoidal pituitary biopsy and debulking, final tissue pathology was diagnostic for WG in the pituitary gland...
February 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28273357/energy-and-field-size-dependence-of-a-silicon-diode-designed-for-small-field-dosimetry
#14
Mehran Yarahmadi, Sonja Wegener, Otto A Sauer
PURPOSE: To investigate the energy dependence/spectral sensitivity of silicon diodes designed for small-field dosimetry and obtain response factors (RFs) for arbitrary photon spectra using Monte Carlo (MC) simulations. METHODS: The EGSnrc user-code DOSRZnrc was used to calculate the dose deposition in water and in the active volume of a stereotactic diode field detector (SFD). Then the RFs of the SFD were calculated for several circular field sizes and energies at 5 cm depth in water...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28268234/-long-term-care-preferences-among-individuals-of-advanced-age-in-germany-results-of-a-population-based-study
#15
André Hajek, Thomas Lehnert, Annemarie Wegener, Steffi G Riedel-Heller, Hans-Helmut König
The need for long-term care is expected to increase markedly in the next decades as a result of demographic ageing. Consequently, it is important to know the long-term care preferences. This study investigated the long-term care preferences among older individuals in Germany. Based on a systematic review and expert interviews, a questionnaire was designed to assess long-term care preferences. Data were gathered from a representative telephone survey of the German population (n=1,006; 65 years and above) in 2015...
March 7, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28268045/mechanisms-governing-precise-protein-biotinylation
#16
REVIEW
Louise M Sternicki, Kate L Wegener, John B Bruning, Grant W Booker, Steven W Polyak
Protein biotinylation is a key post-translational modification found throughout the living world. The covalent attachment of a biotin cofactor onto specific metabolic enzymes is essential for their activity. This modification is distinctive, in that it is carried out by a single enzyme: biotin protein ligase (BPL), an enzyme that is able to biotinylate multiple target substrates without aberrant-off target biotinylation. BPL achieves this target selectivity by recognizing a sequence motif in the context of a highly conserved tertiary structure...
March 3, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28260778/granulomatosis-with-polyangiitis-wegener-granulomatosis-with-unusual-presentation
#17
M A Mannan, K Pasha, S Nahar, K Begum
We came across a 32 years old male admitted in our hospital with prolonged low-grade fever, haemoptysis, leg swelling, weight loss, purpuric rashes and malaena. He received anti-TB treatment at another hospital without any improvement. He was pale with bullous and purpuric lesions over legs and feet. He also had features of consolidation over both lung fields. His CRP was 312mg/L, Urine R/M/E showed 40-50 RBC/HPF, Chest X-ray showed features of bilateral consolidation, c-ANCA-10U/L (positive); Tracheal aspirate for AFB was found to be negative...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28259042/probiotic-treatment-reduces-depressive-like-behaviour-in-rats-independently-of-diet
#18
Anders Abildgaard, Betina Elfving, Marianne Hokland, Gregers Wegener, Sten Lund
The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive disorder (MDD). However, some conceptual and mechanistical aspects need further elucidation. We therefore aimed at investigating whether the habitual diet may interact with the effect of probiotics on depression-related behaviour and further examined some potentially involved mechanisms underlying the microbe-mediated behavioural effects...
February 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28222774/factors-associated-with-preferences-for-long-term-care-settings-in-old-age-evidence-from-a-population-based-survey-in-germany
#19
André Hajek, Thomas Lehnert, Annemarie Wegener, Steffi G Riedel-Heller, Hans-Helmut König
BACKGROUND: Long-term care is one of the most pressing health policy issues in Germany. It is expected that the need for long-term care will increase markedly in the next decades due to demographic shifts. The purpose of this study was to investigate the factors associated with preferences for long-term care settings in old age individuals in Germany. METHODS: Based on expert interviews and a systematic review, a questionnaire was developed to quantify long-term care preferences...
February 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28220286/characteristics-of-hypertrophic-pachymeningitis-in-patients-with-granulomatosis-with-polyangiitis
#20
Hyun Ah Choi, Mi Ji Lee, Chin-Sang Chung
Hypertrophic pachymeningitis (HP) is an important neurologic complication of granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis). The aim of this study is to investigate the clinical features, radiological findings, and diagnostic pitfalls of GPA-related HP. A retrospective chart review was performed to screen patients diagnosed with GPA at Samsung Medical Center between 1997 and 2016. Neurologic manifestation, laboratory findings, neuroimaging data, and clinical course were evaluated in all patients...
February 20, 2017: Journal of Neurology
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