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Maternal influenza

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https://www.readbyqxmd.com/read/28726613/human-metapneumovirus-and-other-respiratory-viral-infections-during-pregnancy-and-birth-nepal
#1
Jennifer L Lenahan, Janet A Englund, Joanne Katz, Jane Kuypers, Anna Wald, Amalia Magaret, James M Tielsch, Subarna K Khatry, Stephen C LeClerq, Laxman Shrestha, Mark C Steinhoff, Helen Y Chu
Human metapneumovirus (HMPV) is a respiratory virus that can cause severe lower respiratory tract disease and even death, primarily in young children. The incidence and characteristics of HMPV have not been well described in pregnant women. As part of a trial of maternal influenza immunization in rural southern Nepal, we conducted prospective, longitudinal, home-based active surveillance for febrile respiratory illness during pregnancy through 6 months postpartum. During 2011-2014, HMPV was detected in 55 of 3,693 women (16...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28720851/microneedle-patch-delivery-of-influenza-vaccine-during-pregnancy-enhances-maternal-immune-responses-promoting-survival-and-long-lasting-passive-immunity-to-offspring
#2
E Stein Esser, Joanna A Pulit-Penaloza, Haripriya Kalluri, Devin McAllister, Elena V Vassilieva, Elizabeth Q Littauer, Nadia Lelutiu, Mark R Prausnitz, Richard W Compans, Ioanna Skountzou
Influenza virus causes life-threatening infections in pregnant women and their newborns. Immunization during pregnancy is the most effective means of preventing maternal and infant mortality/morbidity; however, influenza vaccination rates of pregnant women remain under 50%. Furthermore, the availability of vaccines in low-resource populations is limited. Skin immunization with microneedle patches (MN) is a novel and safe vaccination platform featuring thermostable vaccine formulations. Cold-chain independence and the potential for self-administration can expand influenza vaccination coverage in developing countries...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708952/influenza-vaccination-during-pregnancy-for-prevention-of-influenza-confirmed-illness-in-the-infants-a-systematic-review-and-meta-analysis
#3
Marta C Nunes, Shabir A Madhi
Infants younger than 6 months of age are at particular risk for serious illness from influenza infection. Currently available influenza vaccines are, however, not licensed for use in infants <6 months old. Influenza vaccination during pregnancy elicits robust antibody responses in the women that will protect the infants against influenza infection during the first few months of life. We aimed to determine the impact of influenza vaccination during pregnancy to prevent laboratory-confirmed influenza infection and influenza-associated hospitalisations in infants <6 months old...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28686396/-recommendations-for-the-vaccination-of-pregnant-women-a-booster-injection
#4
Yolanda Mueller, Christiane Sigrid Eberhardt, Alessandro Diana, Begoña Martinez De Tejada
For several decades we have avoided the immunisation of pregnant women, with the only exception being that of the tetanus vaccination in the absence of a previous basic immunisation. Nowadays, it is strongly advised to give several vaccines specifically during pregnancy : maternal immunisations against pertussis and influenza have been shown to prevent complications in both the foetus and the newborn as well as the woman during pregnancy and after delivery. This article aims to review these recommendations, their rationale and to address potential concerns that are often raised by physicians and patients...
October 12, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28656175/epidemiological-and-serological-investigation-into-the-role-of-gestational-maternal-influenza-virus-infection-and-autism-spectrum-disorders
#5
Milada Mahic, Xiaoyu Che, Ezra Susser, Bruce Levin, Ted Reichborn-Kjennerud, Per Magnus, Camilla Stoltenberg, Lokendrasingh Chauhan, Thomas Briese, Michaeline Bresnahan, Pål Surén, Mady Hornig, Siri Mjaaland, W Ian Lipkin
The literature concerning gestational maternal influenza virus infection and risk of autism spectrum disorders (ASD) is inconclusive. To address this uncertainty, we obtained information from questionnaires and samples from the Autism Birth Cohort, a prospective birth cohort comprising mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaires, referrals, and linkages to the Norwegian National Patient Registry, we identified 338 mothers of children with ASD and 348 frequency-matched controls for whom plasma samples that had been collected midpregnancy and after delivery were available for influenza virus serology via luciferase immunoprecipitation and hemagglutinin inhibition assays for influenza virus strains circulating during the study period...
May 2017: MSphere
https://www.readbyqxmd.com/read/28651593/maternal-antibodies-protect-offspring-from-severe-influenza-infection-and-do-not-lead-to-detectable-interference-with-subsequent-offspring-immunization
#6
Joan E M van der Lubbe, Jessica Vreugdenhil, Sarra Damman, Joost Vaneman, Jaco Klap, Jaap Goudsmit, Katarina Radošević, Ramon Roozendaal
BACKGROUND: Various studies have shown that infants under the age of 6 months are especially vulnerable for complications due to influenza. Currently there are no vaccines licensed for use in this age group. Vaccination of pregnant women during the last trimester, recommended by the WHO as protective measure for this vulnerable female population, may provide protection of newborns at this early age. Although it has been observed that maternal vaccination can passively transfer protection, maternal antibodies could possibly also interfere with subsequent active vaccination of the offspring...
June 26, 2017: Virology Journal
https://www.readbyqxmd.com/read/28600447/the-epidemiology-management-and-outcomes-of-bacterial-meningitis-in-infants
#7
Lynda Ouchenir, Christian Renaud, Sarah Khan, Ari Bitnun, Andree-Anne Boisvert, Jane McDonald, Jennifer Bowes, Jason Brophy, Michelle Barton, Joseph Ting, Ashley Roberts, Michael Hawkes, Joan L Robinson
OBJECTIVES: The pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed in this era of increasing antimicrobial resistance, use of conjugated vaccines, and maternal antibiotic prophylaxis for group B Streptococcus (GBS). The objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy. METHODS: This was a cohort study of infants <90 days of age with bacterial meningitis at 7 pediatric tertiary care hospitals across Canada in 2013 and 2014...
June 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28592016/-efficacy-and-safety-of-oseltamivir-in-children-with-suspected-influenza-a-multicenter-randomized-open-label-trial
#8
C H He, C Y Liu, G Y Lin, Q Peng, J Y Liao, J H Lin, T Zhang, X F Zheng, C X Lin, S J Wang, R S Chen, L Deng, Y M Chen
Objective: To evaluate the efficacy and safety of oseltamivir in the treatment of suspected influenza in children. Method: A multicenter, randomized and open-label trial was conducted among 229 individuals with suspected influenza which were collected from the clinic of 5 hospitals in Guangdong province (Guangzhou Women and Children's Medical Center, Shenzhen Baoan District Maternity and Child Care Service Center, the Second Affiliated Hospital of Shantou University Medical College, Dongguan Maternity and Child Care Service Centre, Yuexiu District Children's Hospital of Guangzhou) from April to July 2015...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28584855/febrile-rhinovirus-illness-during-pregnancy-is-associated-with-low-birth-weight-in-nepal
#9
Erin K Philpott, Janet A Englund, Joanne Katz, James Tielsch, Subarna Khatry, Stephen C LeClerq, Laxman Shrestha, Jane Kuypers, Amalia S Magaret, Mark C Steinhoff, Helen Y Chu
BACKGROUND: Adverse birth outcomes, including low birth weight (LBW), defined as <2500 grams, small-for-gestational-age (SGA), and prematurity, contribute to 60%-80% of infant mortality worldwide and may be related to infections during pregnancy. The aim of this study was to assess whether febrile human rhinovirus (HRV) illness is associated with adverse birth outcomes. METHODS: Active household-based weekly surveillance was performed for respiratory illness episodes in pregnant women as part of a community-based, prospective, randomized trial of maternal influenza immunization in rural Nepal...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28575286/efficacy-of-maternal-influenza-vaccination-against-all-cause-lower-respiratory-tract-infection-hospitalizations-in-young-infants-results-from-a-randomized-controlled-trial
#10
Marta C Nunes, Clare L Cutland, Stephanie Jones, Sarah Downs, Adriana Weinberg, Justin R Ortiz, Kathleen M Neuzil, Eric A F Simões, Keith P Klugman, Shabir A Madhi
Background: Influenza immunization of pregnant women protects their young infants against laboratory-confirmed influenza infection. Influenza infection might predispose to subsequent bacterial infections that cause severe pneumonia. In a secondary analysis of a randomized clinical trial (RCT), we evaluated the effect of maternal vaccination on infant hospitalizations for all-cause acute lower respiratory tract infection (ALRI). Methods: Infants born to women who participated in a double-blind placebo-controlled RCT in 2011 and 2012 on the efficacy of trivalent inactivated influenza vaccine (IIV) during pregnancy were followed during the first 6 months of life...
May 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28550954/first-trimester-influenza-vaccination-and-risks-for-major-structural-birth-defects-in-offspring
#11
Elyse Olshen Kharbanda, Gabriela Vazquez-Benitez, Paul A Romitti, Allison L Naleway, T Craig Cheetham, Heather S Lipkind, Nicola P Klein, Grace Lee, Michael L Jackson, Simon J Hambidge, Natalie McCarthy, Frank DeStefano, James D Nordin
OBJECTIVE: To examine risks for major structural birth defects in infants after first trimester inactivated influenza vaccine (IIV) exposures. STUDY DESIGN: In this observational study, we used electronic health data from 7 Vaccine Safety Datalink sites to examine risks for selected major structural defects in infants after maternal IIV exposure. Vaccine exposures for women with continuous insurance enrollment through pregnancy who delivered singleton live births between 2004 and 2013 were identified from standardized files...
May 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28522338/year-round-influenza-immunisation-during-pregnancy-in-nepal-a-phase-4-randomised-placebo-controlled-trial
#12
Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year. METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal...
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28522337/maternal-influenza-immunisation-to-reduce-influenza-infections-and-low-birthweight-in-infants-in-resource-limited-countries
#13
Paul Loubet, Odile Launay
No abstract text is available yet for this article.
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28520789/antigen-specific-immunoglobulin-variable-region-sequencing-measures-humoral-immune-response-to-vaccination-in-the-equine-neonate
#14
Rebecca L Tallmadge, Steven C Miller, Stephen A Parry, Maria Julia B Felippe
The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth. Taken our previous studies on equine B cell ontogeny, we hypothesized that the equine neonate generates a diverse immunoglobulin repertoire in response to vaccination, independently of circulating maternal antibodies. In this study, equine neonates were vaccinated with 3 doses of keyhole limpet hemocyanin (KLH) or equine influenza vaccine, and humoral immune responses were assessed using antigen-specific serum antibodies and B cell Ig variable region sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28510067/immunization-during-pregnancy-impact-on-the-infant
#15
REVIEW
Kirsten P Perrett, Terry M Nolan
Maternal immunization has undergone a paradigm shift in recent years, as women and healthcare providers accept and recognize the benefits of this strategy not only for the pregnant woman but also for the developing fetus and young infant. This article reviews the evidence for active immunization during pregnancy, with an emphasis on perinatal and infant outcomes. Current recommendations for immunization during pregnancy are presented, with particular focus on the routinely recommended vaccines during pregnancy: influenza and Tdap (tetanus, diphtheria, and pertussis)...
August 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28495223/feasibility-of-text-message-influenza-vaccine-safety-monitoring-during-pregnancy
#16
Melissa S Stockwell, Maria Cano, Kathleen Jakob, Karen R Broder, Cynthia Gyamfi-Bannerman, Paula M Castaño, Paige Lewis, Angela Barrett, Oidda I Museru, Ormarys Castellanos, Philip S LaRussa
INTRODUCTION: The feasibility and accuracy of text messaging to monitor events after influenza vaccination throughout pregnancy and the neonatal period has not been studied, but may be important for seasonal and pandemic influenza vaccines and future maternal vaccines. METHODS: This prospective observational study was conducted during 2013-2014 and analyzed in 2015-2016. Enrolled pregnant women receiving inactivated influenza vaccination at a gestational age <20 weeks were sent text messages intermittently through participant-reported pregnancy end to request fever, health events, and neonatal outcomes...
May 2, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#17
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28465095/association-of-influenza-vaccination-during-pregnancy-with-birth-outcomes-in-nicaragua
#18
Carmen S Arriola, Nancy Vasconez, Mark G Thompson, Sonja J Olsen, Ann C Moen, Joseph Bresee, Alba María Ropero
BACKGROUND: Studies have shown that influenza vaccination during pregnancy reduces the risk of influenza disease in pregnant women and their offspring. Some have proposed that maternal vaccination may also have beneficial effects on birth outcomes. In 2014, we conducted an observational study to test this hypothesis using data from two large hospitals in Managua, Nicaragua. METHODS: We conducted a retrospective cohort study to evaluate associations between influenza vaccination and birth outcomes...
May 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28433705/maternal-immunisation-collaborating-with-mother-nature
#19
REVIEW
Arnaud Marchant, Manish Sadarangani, Mathieu Garand, Nicolas Dauby, Valerie Verhasselt, Lenore Pereira, Gordean Bjornson, Christine E Jones, Scott A Halperin, Kathryn M Edwards, Paul Heath, Peter J Openshaw, David W Scheifele, Tobias R Kollmann
Maternal immunisation has the potential to substantially reduce morbidity and mortality from infectious diseases after birth. The success of tetanus, influenza, and pertussis immunisation during pregnancy has led to consideration of additional maternal immunisation strategies to prevent group B streptococcus and respiratory syncytial virus infections, among others. However, many gaps in knowledge regarding the immunobiology of maternal immunisation prevent the optimal design and application of this successful public health intervention...
July 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28433704/pertussis-and-influenza-immunisation-during-pregnancy-a-landscape-review
#20
REVIEW
Bahaa Abu Raya, Kathryn M Edwards, David W Scheifele, Scott A Halperin
Immunisation during pregnancy is a relatively new strategy, and is currently limited to tetanus, pertussis, and influenza vaccines. None of these vaccines were developed specifically for use in pregnancy, but they provide an effective method of protecting mothers and young infants. In response to increases in pertussis morbidity and mortality among young infants, several countries have recommended universal tetanus, diphtheria, and acellular pertussis immunisation during pregnancy. Similarly, many countries recommend influenza immunisation during pregnancy to reduce the risk of disease for mother and infant...
July 2017: Lancet Infectious Diseases
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