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Maternal influenza

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https://www.readbyqxmd.com/read/29747736/infections-in-pregnancy-and-the-role-of-vaccines
#1
REVIEW
Kimberly B Fortner, Claudia Nieuwoudt, Callie F Reeder, Geeta K Swamy
Pregnant women are at risk for infection and may have significant morbidity or mortality. Influenza, pertussis, zika, and cytomegalovirus produce mild or asymptomatic illness in the mother, but have profound implications for her fetus. Maternal immunization can prevent or mitigate infections in pregnant women and their infants. The Advisory Committee of Immunization Practices recommends 2 vaccines during pregnancy: inactivated influenza, and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis during pregnancy...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29720076/paediatric-active-enhanced-disease-surveillance-paeds-annual-report-2015-prospective-hospital-based-surveillance-for-serious-paediatric-conditions
#2
Jocelynne E McRae, Helen E Quinn, Kristine Macartney
Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance...
September 1, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/29715051/immunization-during-pregnancy
#3
Paul Loubet, Olivia Anselem, Odile Launay
Vaccination in pregnancy has been shown to be effective for the prevention of influenza and pertussis in infants, providing support for similar strategies to prevent group B streptococcus and respiratory syncytial virus infections that represent a large burden in pediatric population. Areas covered: This review addresses the principle of maternal immunization, efficacy and safety of both pertussis and seasonal influenza vaccines and presents available data on group B streptococcus and respiratory syncytial virus that are in development for administration during pregnancy...
May 1, 2018: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29709773/midwives-knowledge-attitudes-and-learning-needs-regarding-antenatal-vaccination
#4
Annette K Regan, Yvonne Hauck, Lisa Nicolaou, Danielle Engelbrecht, Janice Butt, Donna B Mak, Rikki Priest, Ronit Cukierman, Paul V Effler
OBJECTIVE: To determine the knowledge, attitudes and learning needs of midwives regarding antenatal vaccination. DESIGN AND SETTING: A cross-sectional, paper-based survey of midwives employed at the only public tertiary maternity hospital in the Australian state of Western Australia between November 2015 and July 2016. PARTICIPANTS: 252 midwives providing care in antepartum, intrapartum, and/or postpartum settings. MEASUREMENTS: Self-reported responses to a 41-item survey...
April 10, 2018: Midwifery
https://www.readbyqxmd.com/read/29705756/cohort-profile-china-respiratory-illness-surveillance-among-pregnant-women-crisp-2015-2018
#5
Liling Chen, Suizan Zhou, Zhongwei Zhang, Yan Wang, Lin Bao, Yayun Tan, Falin Sheng, Ying Song, Ran Zhang, A Danielle Iuliano, Mark G Thompson, Carolyn M Greene, Jun Zhang
PURPOSE: We established the China Respiratory Illness Surveillance among Pregnant women (CRISP) to conduct active surveillance for influenza-associated respiratory illness during pregnancy in China from 2015 to 2018. Among annual cohorts of pregnant women, we assess the incidence of acute respiratory illness (ARI), influenza-like illness (ILI), laboratory-confirmed influenza virus infection and the seroconversion proportion during the winter influenza season. We also plan to examine the effect of influenza virus infection on adverse pregnancy, delivery and infant health outcomes with cumulative data from the three annual cohorts...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29683306/maternity-care-update-prenatal-care-and-specific-conditions
#6
Andrew Smith, Wendy B Barr, Erin Bassett-Novoa, Nicholas LeFevre
Early initiation of prenatal care is associated with improved health outcomes for women and newborns. An essential element of prenatal care is determining the estimated due date, ideally using a first-trimester ultrasound. Laboratory tests should be obtained to screen for conditions that can affect pregnancy. Routine immunizations for all pregnant women include influenza vaccine; tetanus toxoid, reduced diphtheria, acellular pertussis (Tdap) vaccine. All women should be screened for gestational diabetes mellitus in midpregnancy...
April 2018: FP Essentials
https://www.readbyqxmd.com/read/29670610/neonatal-immunization-rationale-current-state-and-future-prospects
#7
REVIEW
Elizabeth Whittaker, David Goldblatt, Peter McIntyre, Ofer Levy
Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a distinct neonatal immune system that is generally polarized against Th1 responses to many stimuli such that some vaccines that are effective in adults are not in newborns. Nevertheless, neonatal immunization could result in high-population penetration as birth is a reliable point of healthcare contact, and offers an opportunity for early protection of the young, including preterm newborns who are deficient in maternal antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29668900/burden-and-risk-factors-for-coronavirus-infections-in-infants-in-rural-nepal
#8
S M Iftekhar Uddin, Janet A Englund, Jane Kuypers, Helen Y Chu, Mark C Steinhoff, Subarna K Khatry, Steve C LeClerq, James M Tielsch, Luke C Mullany, Laxman Shrestha, Joanne Katz
Background: Knowledge of risk factors for symptomatic human coronavirus (HCoV) infections in children in community settings is limited. We estimated the disease burden and impact of birth-related, maternal, household and seasonal factors on HCoV infections among children from birth to six months old in rural Nepal. Methods: Prospective, active, weekly surveillance for acute respiratory illnesses (ARI) was conducted in infants over a period of 3 years during two consecutive, population-based randomized trials of maternal influenza immunization...
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29630014/influenza-vaccination-pregnancy-safety-and-risk-of-early-pregnancy-loss
#9
Rhoda S Sperling, Laura E Riley
Since 2004, the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists have recommended routine influenza vaccination for all pregnant women in any trimester. Maternal influenza vaccination has been shown to decrease the risk of influenza and its complications among pregnant women and their infants in the first 6 months of life. In a recent article published in Vaccine, Donahue and colleagues reported a possible association between influenza vaccination when given very early in the first trimester and spontaneous abortion...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29627238/coverage-of-recommended-vaccines-during-pregnancy-in-flanders-belgium-fairly-good-but-can-we-do-better
#10
Kirsten Maertens, Tessa Braeckman, Stéphanie Blaizot, Heidi Theeten, Mathieu Roelants, Karel Hoppenbrouwers, Elke Leuridan, Pierre Van Damme, Corinne Vandermeulen
BACKGROUND: In Flanders, Belgium, pertussis vaccination is recommended since 2013 and available free-of-charge in every pregnancy between 24 and 32 weeks of gestation. Influenza vaccination is recommended for more than 10 years with a co-payment system in the second or third trimester of pregnancy, when pregnancy coincides with the influenza season. This study aims to estimate the coverage of pertussis and influenza vaccination during pregnancy in 2016 and to determine predictors for missing vaccination...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29625766/a-follow-up-comparative-safety-analysis-of-pandemic-h1n1-vaccination-during-pregnancy-and-risk-of-infant-birth-defects-among-u-s-military-mothers
#11
Ava Marie S Conlin, Anna T Bukowinski, Jordan A Levine, Zeina G Khodr, Navjot Kaur, Susan C Farrish, Carter J Sevick
OBJECTIVE: To update a previous assessment of birth defects among infants born to active duty U.S. military mothers who received the 2009-2010 pandemic H1N1 vaccine, in comparison to the 2008-2009 seasonal influenza vaccine, during pregnancy. Here, we updated the previous comparative analyses with a more refined definition for birth defects using an additional year of follow-up data from both inpatient and outpatient medical encounters. METHODS: The study population included 15,510 live born infants born to active duty mothers vaccinated during pregnancy with either the 2009-2010 pandemic H1N1 vaccine (n = 9033) or the 2008-2009 seasonal influenza vaccine (n = 6477)...
April 3, 2018: Vaccine
https://www.readbyqxmd.com/read/29620934/factors-associated-with-lower-respiratory-tract-infections-in-hiv-exposed-uninfected-infants
#12
Adriana Weinberg, Marisa Mussi-Pinhata, Qilu Yu, Rachel A Cohen, Volia C Almeida, Fabiana R Amaral, Laura Freimanis, D Robert Harris, Christiana Smith, George Siberry
OBJECTIVES: To identify factors that predispose HIV-exposed uninfected infants (HEUs) to higher incidence of severe infections, hospitalization and death in the first 6 to 24 months of life compared with HEUs with and without lower respiratory tract infection (LRTI) in the first 6 months of life. DESIGN: Nested case-control study of 107 LRTI+ infants enrolled in the NISDI Perinatal and LILAC studies with and 140 LRTI- in the first 6 months of, matched by date and place of birth...
March 18, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29617676/glycosylation-of-human-iga-directly-inhibits-influenza-a-and-other-sialic-acid-binding-viruses
#13
Michael A Maurer, Larissa Meyer, Matteo Bianchi, Hannah L Turner, Ngoc P L Le, Marco Steck, Arkadiusz Wyrzucki, Vanessa Orlowski, Andrew B Ward, Max Crispin, Lars Hangartner
Immunoglobulin A (IgA) plays an important role in protecting our mucosal surfaces from viral infection, in maintaining a balance with the commensal bacterial flora, and in extending maternal immunity via breast feeding. Here, we report an additional innate immune effector function of human IgA molecules in that we demonstrate that the C-terminal tail unique to IgA molecules interferes with cell-surface attachment of influenza A and other enveloped viruses that use sialic acid as a receptor. This antiviral activity is mediated by sialic acid found in the complex N-linked glycans at position 459...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29609192/the-burden-of-indirect-causes-of-maternal-morbidity-and-mortality-in-the-process-of-obstetric-transition-a-cross-sectional-multicenter-study
#14
Jessica Fernandes Cirelli, Fernanda Garanhani Surita, Maria Laura Costa, Mary Angela Parpinelli, Samira Maerrawi Haddad, José Guilherme Cecatti
OBJECTIVE:  The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil. METHODS:  Secondary analysis of a multicenter cross-sectional study conducted in 27 referral obstetric units within the Brazilian Network for Surveillance of Severe Maternal Morbidity. RESULTS:  A total of 82,388 women were surveilled: 9,555 women with severe maternal morbidity were included, and 942 (9.9%) of them had indirect causes of morbidity/mortality...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29538497/incomplete-childhood-immunization-with-new-and-old-vaccines-and-associated-factors-brisa-birth-cohort-s%C3%A3-o-lu%C3%A3-s-maranh%C3%A3-o-state-northeast-brazil
#15
Francelena de Sousa Silva, Yonna Costa Barbosa, Mônica Araújo Batalha, Marizélia Rodrigues Costa Ribeiro, Vanda Maria Ferreira Simões, Maria Dos Remédios Freitas Carvalho Branco, Érika Bárbara Abreu Fonseca Thomaz, Rejane Christine de Sousa Queiroz, Waleska Regina Machado Araújo, Antônio Augusto Moura da Silva
This study estimated the percentages of incomplete immunization with new vaccines and old vaccines and associated factors in children 13 to 35 months of age belonging to a birth cohort in São Luís, the capital of Maranhão State, Brazil. The sample was probabilistic, with 3,076 children born in 2010. Information on vaccination was obtained from the Child's Health Card. The new vaccines, namely those introduced in 2010, were meningococcal C and 10-valent pneumococcal, and the old vaccines, or those already on the childhood immunization schedule, were BCG, hepatitis B, human rotavirus, polio, tetravalent (diphtheria, tetanus, pertussis, Haemophilus influenzae b), yellow fever, and triple viral (measles, mumps, rubella)...
March 12, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29519509/maternally-derived-antibodies-do-not-inhibit-swine-influenza-virus-replication-in-piglets-but-decrease-excreted-virus-infectivity-and-impair-post-infectious-immune-responses
#16
Céline Deblanc, Séverine Hervé, Stéphane Gorin, Charlie Cador, Mathieu Andraud, Stéphane Quéguiner, Nicolas Barbier, Frédéric Paboeuf, Nicolas Rose, Gaëlle Simon
Maternally-derived antibodies (MDA) reduce piglet susceptibility to swine influenza A virus, but interfere with post-infectious immune responses, raising questions about protection after waning of passive immunity. We therefore analysed the impact of different levels of residual MDA on virus excretion and immune responses in piglets born to vaccinated sows (MDA+) and infected with H1N1 at 5, 7 or 11 weeks of age, in comparison to piglets born to unvaccinated sows (MDA-). Subsequent protection against a second homologous infection occurring 4 weeks after the primo-infection was also investigated...
March 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29510698/evolution-of-h9n2-avian-influenza-virus-in-embryonated-chicken-eggs-with-or-without-homologous-vaccine-antibodies
#17
Haiyun Jin, Wan Wang, Xueqin Yang, Hailong Su, Jiawen Fan, Rui Zhu, Shifeng Wang, Huoying Shi, Xiufan Liu
BACKGROUND: Vaccines constitute a unique selective pressure, different from natural selection, drives the evolution of influenza virus. In this study, A/Chicken/Shanghai/F/1998 (H9N2) was continually passaged in specific pathogen-free embryonated chicken eggs with or without selective pressures from antibodies induced by homologous maternal antibodies. Genetic mutations, antigenic drift, replication, and pathogenicity of the passaged virus were evaluated. RESULTS: Antigenic drift of the passaged viruses occurred in the 47th generation (vF47) under selective pressure on antibodies and in the 52nd generation (nF52) without selective pressure from antibodies...
March 6, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29494274/understanding-the-barriers-to-uptake-of-antenatal-vaccination-by-women-from-culturally-and-linguistically-diverse-backgrounds-a-cross-sectional-study
#18
Sushena Krishnaswamy, Allen C Cheng, Euan M Wallace, Jim Buttery, Michelle L Giles
The role of maternal vaccination in reducing neonatal morbidity and mortality is expanding but uptake remains suboptimal. While the barriers to uptake have been well described, women from minority groups have not been well represented in previous studies. In this study we examine the facilitators and barriers to uptake of antenatal vaccination by women from culturally and linguistically diverse backgrounds in Melbourne, Australia. 537 women attending antenatal care completed a survey; 69% were born overseas...
March 1, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29485522/commentary-quantifying-the-impact-of-maternal-influenza-vaccination-beyond-laboratory-confirmed-efficacy
#19
Kathleen M Neuzil
No abstract text is available yet for this article.
May 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29483030/acceptability-of-intranasal-live-attenuated-influenza-vaccine-influenza-knowledge-and-vaccine-intent-in-the-gambia
#20
Edwin P Armitage, Janko Camara, Sulayman Bah, Alice S Forster, Ed Clarke, Beate Kampmann, Thushan I de Silva
BACKGROUND: The burden of influenza is increasingly recognised in Africa. The WHO recommends introducing influenza vaccination to high-risk groups: pregnant women, children <5 years, and the elderly. The Gambia currently has no influenza vaccination policy, but the NASIMMUNE study, a clinical trial of intranasal live attenuated influenza vaccines (LAIV) in young children provided an opportunity to study maternal attitudes towards LAIV for the first time in sub-Saharan Africa. We assess acceptability of LAIV, influenza knowledge and attitudes towards influenza vaccination in Gambian women...
March 20, 2018: Vaccine
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