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https://www.readbyqxmd.com/read/29138505/increased-complement-3a-receptor-is-associated-with-behcet-s-disease-and-vogt-koyanagi-harada-disease
#1
Chaokui Wang, Shuang Cao, Dike Zhang, Hong Li, Aize Kijlstra, Peizeng Yang
Behcet's disease (BD) and Vogt-Koyanagi-Harada disease (VKH) are systemic and recurrent autoimmune diseases associated with abnormal T cell immune response. Complement 3a receptor (C3aR) and complement 5a receptor (C5aR) have been reported to be involved in T cell mediated autoimmune disease. This study aimed to investigate the role of C3aR and C5aR in these two diseases. The C3aR expression in PBMCs was increased in patients with active BD (aBD) and active VKH (aVKH). No statistical difference was found concerning the expression of C5aR in PBMCs between patients with aBD or aVKH and normal controls...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29131059/risk-factors-and-outcomes-of-emergency-room-visits-in-intestinal-beh%C3%A3-et-s-disease
#2
Jihye Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is a chronic recurring intestinal vasculitic disorder that can lead to emergency room (ER) visits. We aimed to investigate the independent risk factors associated with intestinal BD-related ER visits. METHODS: We retrospectively reviewed 606 patients with intestinal BD registered at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea. RESULTS: One hundred eighty-five patients (30...
November 2, 2017: Digestion
https://www.readbyqxmd.com/read/29129811/transcriptome-scale-characterization-of-salt-responsive-bean-tcp-transcription
#3
Emre İlhan, İlker Büyük, Behcet İnal
TEOSINTE-BRANCHED1/CYCLOIDEA/PCF (TCP) proteins are important regulators of growth and developmental processes including branching, floral organ morphogenesis and leaf growth as well as stress response. This study identified 27 TCP genes of Phaseolus vulgaris (common bean), which were divided into three clusters based on phylogenetic relationship. In addition, this study showed that some of TCP genes such as Pvul-TCP-4 and Pvul-TCP-15 located on chromosomes 3 and 7, Pvul-TCP-7 and Pvul-TCP-20 located on chromosome 7 and 9, were segmentally duplicated...
November 9, 2017: Gene
https://www.readbyqxmd.com/read/29126538/recurrent-pulmonary-aneurysms-hughes-stovin-syndrome-on-the-spectrum-of-beh%C3%A3-et-disease
#4
Sami M Bennji, Leonard du Preez, Stephanie Griffith-Richards, Derrick P Smit, Jonathan Rigby, Coenraad F N Koegelenberg, Elvis M Irusen, Brian W Allwood
In this report, we describe a male patient who presented with recurrent life-threatening hemoptysis due to the sequential formation of multiple pulmonary aneurysms. Both pulmonary artery coil embolization and right lower lobectomy were performed, with limited success. The patient experienced extensive bilateral femoral DVT extending into the inferior vena cava, with massive hemoptysis, fulfilling the diagnosis of Hughes-Stovin syndrome. A final diagnosis of Behçet disease was made following extensive investigation, and the patient responded well to prednisone 20 mg orally and azathioprine 100 mg orally...
November 2017: Chest
https://www.readbyqxmd.com/read/29116542/the-outcomes-and-risk-factors-of-early-readmission-in-patients-with-intestinal-beh%C3%A3-et-s-disease
#5
Yong Eun Park, Jae Hee Cheon, Yehyun Park, Soo Jung Park, Tae Il Kim, Won Ho Kim
Hospital readmission rate is an integral quality of care measurement for hospitalized patients which is unknown for intestinal Behçet's disease cases. The purpose of this study was to investigate the risk factors and outcomes for patients readmitted early with intestinal Behçet's disease. We retrospectively reviewed patients with intestinal Behçet's disease who were readmitted to our hospital between 2005 and 2016. We then analyzed the risk factors and outcomes for early readmission within 3 months. Of the 204 patients who were readmitted, 103 patients (50...
November 7, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116440/parenchymal-neuro-beh%C3%A3-et-disease-with-erectile-dysfunction-and-micturition-disturbances-case-report-and-literature-review
#6
REVIEW
Ali Taylan, Merih Birlik
Parenchymal neuro-Behçet disease (NBD) is a serious clinic condition with a sub-acute or chronic disease course that results in incapability through pyramidal tract involvement. Though well-known consequences can deter a patient's life, both urinary symptoms and sexual dysfunction are underestimated complications of NBD and closely related in timing. Here, we report the case of a young male patient with parenchymal NBD who developed urinary incontinence and erectile dysfunction in addition to widespread pyramidal tract signs and symptoms...
November 7, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29116188/cxcl10-cxcr3-axis-is-associated-with-disease-activity-and-the-development-of-mucocutaneous-lesions-in-patients-with-beh%C3%A3-et-s-disease
#7
Sang Jin Lee, Shin Eui Kang, Eun Ha Kang, Byoong Yong Choi, Katherine Masek-Hammerman, Jameel Syed, Yutian Zhan, Kathleen Neff-Phillips, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song
The objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet's disease (BD) and their associations with disease activity. Blood samples were collected from 109 BD patients and 36 age- and sex-matched healthy controls (HCs). Twenty-two follow-up blood samples were collected in BD patients. Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXCL13 and CXCL16) and cell surface marker expression (CD3, CD4 and CXCR3) in peripheral blood mononuclear cells (PBMCs) were assayed...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114186/clinical-utility-of-anti-c1q-antibody-in-primary-and-secondary-vasculitic-conditions
#8
Kabeerdoss Jayakanthan, And Nikhil Gupta, John Mathew, Raheesh Ravindran, Gowri Mahasampth, Debashish Danda
Objective: Anti-C1q antibodies (Anti-C1q Ab) are seen in hypocomplementemic urticarial vasculitis syndrome (HUVS), infection-associated vasculitis such as hepatitis C virus-related vasculitis and in autoimmune diseases such as rheumatoid vasculitis, polyarteritis nodosa, giant cell arteritis, vascular Behcet's disease, and cryoglobulin associated vasculitis. Aim of this study is to evaluate the presence of Anti-C1q Ab in vasculitis and to determine if any difference exists between primary and secondary vasculitis in relation to this antibody...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29113743/-retinal-sequellae-of-beh%C3%A3-et-disease-on-ultra-wide-field-photography
#9
L Qu, A Giocanti-Aurégan
No abstract text is available yet for this article.
November 4, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29109894/vitreomacular-interface-disorders-in-beh%C3%A3-et-s-uveitis
#10
Hilal Eser Öztürk, Özlem Eşki Yücel, Yüksel Süllü
Objectives: To determine the prevalence of vitreomacular interface (VMI) disorders in patients with Behçet's uveitis and assess the relationship between VMI disorders and clinical characteristics. Materials and Methods: The macular optical coherence tomography (OCT) images of 160 eyes of 96 patients with Behçet's uveitis who were being followed in the Uvea-Behçet's clinic were assessed retrospectively for VMI disorders including posterior vitreous detachment (PVD), epiretinal membrane (ERM), vitreomacular adhesion (VMA), vitreomacular traction (VMT), full-thickness macular hole (FTMH), lamellar hole (LH) and pseudohole...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29099660/ten-year-retention-rate-of-infliximab-in-patients-with-beh%C3%A3-et-s-disease-related-uveitis
#11
Claudia Fabiani, Jurgen Sota, Antonio Vitale, Giacomo Emmi, Lorenzo Vannozzi, Daniela Bacherini, Giuseppe Lopalco, Silvana Guerriero, Vincenzo Venerito, Ida Orlando, Rossella Franceschini, Fiorella Fusco, Bruno Frediani, Mauro Galeazzi, Florenzo Iannone, Gian Marco Tosi, Luca Cantarini
PURPOSE: To evaluate the 10-year drug retention rate of infliximab (IFX) in Behçet's disease (BD)-related uveitis, the effect of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on drug survival and differences according to the lines of biologic treatment. METHODS: Cumulative survival rates were studied using the Kaplan-Meier plot, while the Log-rank (Mantel-Cox) test was used to compare survival curves. RESULTS: Forty patients (70 eyes) were eligible for analysis...
November 3, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29099052/urinary-metabolomic-profiling-to-identify-potential-biomarkers-for-the-diagnosis-of-behcet-s-disease-by-gas-chromatography-time-of-flight-mass-spectrometry
#12
Joong Kyong Ahn, Jungyeon Kim, Jiwon Hwang, Juhwan Song, Kyoung Heon Kim, Hoon-Suk Cha
Diagnosing Behcet's disease (BD) is challenging because of the lack of a diagnostic biomarker. The purposes of this study were to investigate distinctive metabolic changes in urine samples of BD patients and to identify urinary metabolic biomarkers for diagnosis of BD using gas chromatography/time-of-flight-mass spectrometry (GC/TOF-MS). Metabolomic profiling of urine samples from 44 BD patients and 41 healthy controls (HC) were assessed using GC/TOF-MS, in conjunction with multivariate statistical analysis...
November 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29096751/lps-induced-src-family-kinases-activity-mediates-il-10-production-through-activation-of-stat3-in-peripheral-blood-mononuclear-cells-of-patients-with-beh%C3%A3-et-s-disease
#13
S Irtegun Kandemir, M A Tekin, M Bozkurt, A Z Dagli, S Kalkanli-Tas
Behçet's disease (BD) is achronic inflammatory disorder characterized by recurrent oral and genital ulcers, uveitis and skin lesions. Although,the pathogenesis of BD remains poorly understood, excessive or dysregulatedcytokine production including IL-10 is associated with BD. Revealing the key molecular mechanism by which IL-10 expression is regulated is crucial to understanding the pathogenesis of BD. The aim of this study was to investigate whether Src family kinases (SFKs) are upstream mediators of STAT3/IL-10 pathway in peripheral blood mono nuclear cells(PBMCs) of active BD patients...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29095300/rare-esophageal-ulcers-related-to-beh%C3%A3-et-disease-a-case-report
#14
Ning Jia, Yanping Tang, Huayi Liu, Yang Li, Simiao Liu, Lei Liu
RATIONALE: The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. PATIENT CONCERNS: In China, BD is represented with esophageal involvement which is called esophageal BD (EBD). DIAGNOSES: A 56-year-old man diagnosed to the Gastroenterology Department of Integrated Traditional Chinese and Western Medicine Hospital, for multiple discrete, elliptical esophageal ulcers related to BD...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094181/cardiovascular-disease-in-patients-with-autoinflammatory-syndromes
#15
REVIEW
Rainer Hintenberger, Agnes Falkinger, Kathrin Danninger, Herwig Pieringer
Autoinflammatory syndromes (AIS) are characterized by recurring events of inflammation, leading to a variety of organ manifestations and fever attacks. A subgroup of AIS is commonly referred to as hereditary periodic fever syndromes (HPFS). There is substantial evidence that autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are strongly associated with cardiovascular morbidity and mortality. The link between AIS and cardiovascular disease is not that clear, even if the concept of continuous inflammation as a risk factor for cardiovascular disease is widely accepted...
November 1, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29082546/a-giant-pseudoaneurysm-of-coronary-artery-in-a-young-patient-with-beh%C3%A3-et-s-disease
#16
Lihong Pu, Rongjuan Li, Jinjie Xie, Guowen Liu, Ya Yang
As an uncommon multisystem inflammatory disease, Behçet's syndrome is characterized by mouth and genital ulcers, skin lesions, and eye inflammation, which may also affect joints, blood vessels, central nervous system, or digestive tract. However, the inflammation of coronary artery is relatively rare. We thereby reported a young male of Behçet's syndrome presenting left anterior descending artery pseudoaneurysm with myocardial infarction. Surgical resection was performed with coronary bypass grafting.
October 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/29081805/knitting-the-threads-of-silk-through-time-beh%C3%A3-et-s-disease-past-present-and-future
#17
REVIEW
Fahd Adeeb, Austin G Stack, Alexander D Fraser
Behçet's disease (BD) is a chronic relapsing vasculitis that affects vessels of all types and sizes with a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. Efforts by the scientific community to resolve the unmet needs of BD and gaps in our knowledge have been hampered by considerable challenges that primarily relate to the rare nature of the disease in many parts of the world and its heterogeneity. Controversies remain in many aspects of the disease including the diagnostic criteria, immunopathogenesis and biomarker discovery, geographical variation, and therapeutic considerations...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/29077500/behcet-s-diseasea-case-report
#18
James M Mahoney, Kelsey Millonig
Behcet's disease is a rare autoimmune systemic vasculitis. It usually presents with a symptom complex involving primarily mucocutaneous lesions, genital lesions, and uveitis. When it involves the lower extremity, venous and arterial disease predominates, and joint involvement occurs in approximately 50% of patients. We present a patient with Behcet's disease who was initially referred to us for chronic toenail pathology.
September 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29076891/a-review-of-current-management-of-vasculo-behcet-s
#19
Mira Merashli, Rozana El Eid, Imad Uthman
PURPOSE OF REVIEW: To give an overview of recently published articles about the management of vasculo-Behcet's with particular emphasis on anticoagulation. RECENT FINDINGS: Biologic agents are emerging as a potential therapeutic option in refractory vasculo-Behcet with a good safety profile. Evidence further shows that following nonpulmonary aneurysm repair, there is a reduced risk of recurrent aneurysmal formation at the operative site in patients treated with immunosuppressants in addition to their surgery, than those undergoing surgical intervention alone...
October 25, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29052573/surgical-intervention-for-behcet-s-disease-with-aorta-aneurysm-and-pseudoaneurysm-opposite-outcomes-in-two-cases
#20
Yong Chen, Jia-Shen Cui, Jian-Fei Cai, Jun Zou, Jian-Long Guan
No abstract text is available yet for this article.
October 20, 2017: Chinese Medical Journal
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