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https://www.readbyqxmd.com/read/28500272/probing-the-lithium-response-pathway-in-hipscs-implicates-the-phosphoregulatory-set-point-for-a-cytoskeletal-modulator-in-bipolar-pathogenesis
#1
Brian T D Tobe, Andrew M Crain, Alicia M Winquist, Barbara Calabrese, Hiroko Makihara, Wen-Ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D Sheridan, Ryan W Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C B Basa, Michael J McCarthy, Namrata D Udeshi, Philipp Mertins, Steven A Carr, Guy A Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J Gutierrez, Laurence M Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S Nye, Husseini Manji, Jeffrey H Price, Colleen A McClung, Hagop S Akiskal, Martin Alda, De-Maw M Chuang, Joseph T Coyle, Yang Liu, Yang D Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L Sidman, Shelley Halpain, Stephen J Haggarty, Yoshio Goshima, Evan Y Snyder
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to lithium offered unique opportunities to discern lithium's target and hence gain molecular insight into BPD. By profiling the proteomics of BDP-hiPSC-derived neurons, we found that lithium alters the phosphorylation state of collapsin response mediator protein-2 (CRMP2)...
May 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28487249/combining-tdcs-with-prismatic-adaptation-for-non-invasive-neuromodulation-of-the-motor-cortex
#2
Martina Bracco, Giuseppa Renata Mangano, Patrizia Turriziani, Daniela Smirni, Massimiliano Oliveri
BACKGROUND: Prismatic adaptation (PA) shifts visual field laterally and induces lateralized deviations of spatial attention. Recently, it has been suggested that prismatic goggles are also able to modulate brain excitability, with cognitive after-effects documented even in tasks not necessarily spatial in nature. OBJECTIVE: The aim of the present study was to test whether neuromodulatory effects obtained from tDCS and prismatic goggles could interact and induce homeostatic changes in corticospinal excitability...
May 6, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28487047/anodal-and-cathodal-electrical-stimulation-over-v5-improves-motion-perception-by-signal-enhancement-and-noise-reduction
#3
Luca Battaglini, Stefano Noventa, Clara Casco
BACKGROUND: The effect that transcranial direct current stimulation (tDCS) has on discrimination of coherent motion (CM) signals in a field of randomly moving dots (noise) can be accounted for by both noise reduction and signal enhancement. OBJECTIVE: To distinguish between noise reduction and signal enhancement, we monitored the discrimination of the correct CM direction as a function of the coherence level (using the psychophysical method of constant stimuli)...
April 28, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28472092/influence-of-slope-steepness-foot-position-and-turn-phase-on-plantar-pressure-distribution-during-giant-slalom-alpine-ski-racing
#4
Thomas Falda-Buscaiot, Frédérique Hintzy, Patrice Rougier, Patrick Lacouture, Nicolas Coulmy
The purpose of this study was to investigate the evolution of ground reaction force during alpine skiing turns. Specifically, this study investigated how turn phases and slope steepness affected the whole foot normal GRF pattern while performing giant slalom turns in a race-like setting. Moreover, the outside foot was divided into different plantar regions to see whether those parameters affected the plantar pressure distribution. Eleven skiers performed one giant slalom course at race intensity. Runs were recorded synchronously using a video camera in the frontal plane and pressure insoles under both feet's plantar surface...
2017: PloS One
https://www.readbyqxmd.com/read/28460250/measurement-of-root-surface-area-of-permanent-teeth-in-a-chinese-population
#5
Y Gu, Q Zhu, Y Tang, Y Zhang, X Feng
OBJECTIVES: The aim of this study was to investigate the relation between the remaining area of periodontal attachment and the attachment levels for each type of permanent teeth in a Chinese population by using micro-computed tomography (micro-CT) scans. DESIGN: A total of 440 extracted permanent teeth (including each tooth type except for the third molars) were collected from a Chinese population and scanned using a micro-CT. The CT data were input into Mimics 15...
April 21, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28422528/effect-of-psychopharmacotherapy-on-body-mass-index-among-children-and-adolescents-with-bipolar-disorders
#6
Ayush Patel, Wenyaw Chan, Rajender R Aparasu, Melissa Ochoa-Perez, Jeff T Sherer, Rohan Medhekar, Hua Chen
OBJECTIVE: To assess the long-term effect of all treatment options for pediatric bipolar disorders on body mass index (BMI) and to explore individual characteristics associated with less BMI increase during psychotropic medication exposures. METHODS: A retrospective cohort study was conducted by using the 1995 to 2010 General Electric Electronic Medical Record database. Individuals aged 18 years or younger who had a new bipolar disorder episode were identified. Treatment exposure was defined based on the medication regimens patients received, which include atypical antipsychotic (AT) monotherapy, mood stabilizer (MS) monotherapy, antidepressant (AD) monotherapy, AT+MS polytherapy, AT+AD polytherapy, MS+AD polytherapy, and no treatment...
May 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28402791/survey-of-corticioid-fungi-in-north-american-pinaceous-forests-reveals-hyperdiversity-underpopulated-sequence-databases-and-species-that-are-potentially-ectomycorrhizal
#7
Lisa M Rosenthal, Karl-Henrik Larsson, Sara Branco, Judy A Chung, Sydney I Glassman, Hui-Ling Liao, Kabir G Peay, Dylan P Smith, Jennifer M Talbot, John W Taylor, Else C Vellinga, Rytas Vilgalys, Thomas D Bruns
The corticioid fungi are commonly encountered, highly diverse, ecologically important, and understudied. We collected specimens in 60 pine and spruce forests across North America to survey corticioid fungal frequency and distribution and to compile an internal transcribed spacer (ITS) database for the group. Sanger sequences from the ITS region of vouchered specimens were compared with sequences on GenBank and UNITE, and with high-throughput sequence data from soil and roots taken at the same sites. Out of 425 high-quality Sanger sequences from vouchered specimens, we recovered 223 distinct operational taxonomic units (OTUs), the majority of which could not be assigned to species by matching to the BLAST database...
2017: Mycologia
https://www.readbyqxmd.com/read/28388853/psychometrically-equivalent-bisyllabic-words-for-speech-recognition-threshold-testing-in-vietnamese
#8
Richard W Harris, David L McPherson, Claire M Hanson, Dennis L Eggett
OBJECTIVE: This study identified, digitally recorded, edited and evaluated 89 bisyllabic Vietnamese words with the goal of identifying homogeneous words that could be used to measure the speech recognition threshold (SRT) in native talkers of Vietnamese. DESIGN: Native male and female talker productions of 89 Vietnamese bisyllabic words were recorded, edited and then presented at intensities ranging from -10 to 20 dBHL. Logistic regression was used to identify the best words for measuring the SRT...
April 7, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28386922/technical-descriptions-of-four-hemispherectomy-approaches-from-the-pediatric-epilepsy-surgery-meeting-at-gothenburg-2014
#9
James E Baumgartner, Jeffrey P Blount, Thomas Blauwblomme, P Sarat Chandra
Hemispherectomy is a complex multistep procedure with a steep learning curve. Several surgical approaches have been developed, but each requires considerable practice to master. Four experienced pediatric neurosurgeons, who participated in the 2014 Gothenburg Pediatric Epilepsy Surgery Meeting, provided succinct technical summaries of four hemispherectomy approaches: modified functional hemispherectomy, peri-insular hemispherotomy, parasagittal hemispherotomy, and endoscopic-assisted hemispherotomy. No clinical or outcome data are included...
April 2017: Epilepsia
https://www.readbyqxmd.com/read/28371805/restitution-slope-is-principally-determined-by-steady-state-action-potential-duration
#10
Michael J Shattock, Kyung Chan Park, Hsiang-Yu Yang, Angela W C Lee, Steven Niederer, Kenneth T MacLeod, James Winter
Aims: The steepness of the action potential duration (APD) restitution curve and local tissue refractoriness are both thought to play important roles in arrhythmogenesis. Despite this, there has been little recognition of the apparent association between steady-state APD and the slope of the restitution curve. The objective of this study was to test the hypothesis that restitution slope is determined by APD and to examine the relationship between restitution slope, refractoriness and susceptibility to VF...
June 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28349665/steeper-change-in-body-mass-across-four-decades-predicts-poorer-cardiometabolic-outcomes-at-midlife
#11
Hong Xian, Terrie Vasilopoulos, Weijian Liu, Richard L Hauger, Kristen C Jacobson, Michael J Lyons, Matthew Panizzon, Chandra A Reynolds, Eero Vuoksimaa, William S Kremen, Carol E Franz
OBJECTIVE: This study examined patterns of change in adiposity across four decades starting in young adulthood as well as associations between change and midlife cardiometabolic outcomes. METHODS: BMI was assessed at ages 20, 40, 56, and 62 years in 977 male veterans from the Vietnam Era Twin Study of Aging. Age 62 (range 56-66) cardiometabolic outcomes included hypertension, diabetes, dyslipidemia, inflammation, and ischemic heart disease. Analyses included latent growth modeling (LGM), latent class growth modeling (LCGM), and logistic regression models...
April 2017: Obesity
https://www.readbyqxmd.com/read/28344912/the-topography-of-a-continental-indenter-the-interplay-between-crustal-deformation-erosion-and-base-level-changes-in-the-eastern-southern-alps
#12
J Robl, B Heberer, G Prasicek, F Neubauer, S Hergarten
The topography of the eastern Southern Alps (ESA) reflects indenter tectonics causing crustal shortening, surface uplift, and erosional response. Fluvial drainages were perturbed by Pleistocene glaciations that locally excavated alpine valleys. The Late Miocene desiccation of the Mediterranean Sea and the uplift of the northern Molasse Basin led to significant base level changes in the far field of the ESA and the Eastern Alps (EA), respectively. Among this multitude of mechanisms, the processes that dominate the current topographic evolution of the ESA and the ESA-EA drainage divide have not been identified...
January 2017: Journal of Geophysical Research. Earth Surface
https://www.readbyqxmd.com/read/28336970/a-steep-slope-transistor-combining-phase-change-and-band-to-band-tunneling-to-achieve-a-sub-unity-body-factor
#13
Wolfgang A Vitale, Emanuele A Casu, Arnab Biswas, Teodor Rosca, Cem Alper, Anna Krammer, Gia V Luong, Qing-T Zhao, Siegfried Mantl, Andreas Schüler, A M Ionescu
Steep-slope transistors allow to scale down the supply voltage and the energy per computed bit of information as compared to conventional field-effect transistors (FETs), due to their sub-60 mV/decade subthreshold swing at room temperature. Currently pursued approaches to achieve such a subthermionic subthreshold swing consist in alternative carrier injection mechanisms, like quantum mechanical band-to-band tunneling (BTBT) in Tunnel FETs or abrupt phase-change in metal-insulator transition (MIT) devices...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331933/conformation-of-the-proximal-tibia-and-cranial-cruciate-ligament-disease-in-small-breed-dogs
#14
Jan Janovec, Michal Kyllar, Duncan Midgley, Martin Owen
OBJECTIVES: To investigate the conformation of the proximal tibia in small breed dogs with and without cranial cruciate ligament disease (CCLD) and to identify morphologic abnormalities that may predispose to development of CCLD. METHODS: Mediolateral radiographs of the entire tibia of dogs <15 kg with surgically confirmed CCLD were retrospectively evaluated. Proximal tibial width (PTW), tibial plateau length (TPL), tibial plateau angle as described by Slocum and Slocum (sTPA), proximal tibial tuberosity angle (PTTA), tibial plateau angle as described by Inauen and colleagues (nTPA), and diaphyseal tibial width (DTW) were measured...
March 23, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28318454/infant-stranger-fear-trajectories-predict-anxious-behaviors-and-diurnal-cortisol-rhythm-during-childhood
#15
Carol A Van Hulle, Mollie N Moore, Kathryn Lemery-Chalfant, H Hill Goldsmith, Rebecca J Brooker
Although a robust literature has linked stable, high levels of fear across childhood to increased risk for anxiety problems, less is known about alternative pathways to anxiety. We tested two putatively normative developmental pathways of early fearfulness for their distinct associations with behavioral (anxiety-related behaviors and symptoms) and biological (diurnal cortisol) markers of anxiety risk in middle childhood in a community-based sample (n = 107). Steeper increases in fear from 6 to 36 months predicted more parent-reported anxiety symptoms at age 8 years...
March 20, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28306291/new-paradigm-for-turbulent-transport-across-a-steep-gradient-in-toroidal-plasmas
#16
H S Xie, Y Xiao, Z Lin
First principles gyrokinetic simulation of the edge turbulent transport in toroidal plasmas finds a reverse trend in the turbulent transport coefficients under strong gradients. It is found that there exist both linear and nonlinear critical gradients for the nonmonotonicity of transport characteristics. The discontinuity of the transport flux slope around the turning gradient shows features of a second order phase transition. Under a strong gradient the most unstable modes are in nonground eigenstates with unconventional mode structures, which significantly reduces the effective correlation length and thus reverse the transport trend...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28303142/nitrogen-use-efficiency-of-coffee-at-the-vegetative-stage-as-influenced-by-fertilizer-application-method
#17
Alveiro Salamanca-Jimenez, Timothy A Doane, William R Horwath
Nitrogen (N) is the most limiting nutrient for coffee production in Colombia. An adequate supply is especially important during the vegetative period of growth, since any deficiency during this short period is known to have lasting effects on subsequent coffee bean production. Urea fertilizer is commonly applied on the soil surface since steep slopes hamper incorporation into soil, a practice which increases the risk of N volatilization. Little information is available on N recovery during early growth stages under different fertilizer application practices...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28295107/self-wrapping-of-an-ouzo-drop-induced-by-evaporation-on-a-superamphiphobic-surface
#18
Huanshu Tan, Christian Diddens, Michel Versluis, Hans-Jürgen Butt, Detlef Lohse, Xuehua Zhang
Evaporation of multi-component drops is crucial to various technologies and has numerous potential applications because of its ubiquity in nature. Superamphiphobic surfaces, which are both superhydrophobic and superoleophobic, can give a low wettability not only for water drops but also for oil drops. In this paper, we experimentally, numerically and theoretically investigate the evaporation process of millimetric sessile ouzo drops (a transparent mixture of water, ethanol, and trans-anethole) with low wettability on a superamphiphobic surface...
April 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28260600/trends-in-population-blood-pressure-and-determinant-factors-for-population-blood-pressure
#19
Ulla Overgaard Andersen
Strategies to reduce the burden of blood pressure attributable diseases require knowledge of secular trend in PBP and its determinants. The issues were investigated in the Copenhagen City Heart Study. The design of CCHS is a repeated measures study. Such designs are uniquely suited to studying changes of an outcome and what risk factors may be associated with that outcome. Repeated measures studies are very well suited for trend analysis by using mixed effect analyses. SBP decreased about 2 mmHg in 25 years...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28255568/association-between-lateral-posterior-tibial-slope-body-mass-index-and-acl-injury-risk
#20
Katherine M Bojicic, Mélanie L Beaulieu, Daniel Y Imaizumi Krieger, James A Ashton-Miller, Edward M Wojtys
BACKGROUND: While body mass index (BMI), a modifiable parameter, and knee morphology, a nonmodifiable parameter, have been identified as risk factors for anterior cruciate ligament (ACL) rupture, the interaction between them remains unknown. An understanding of this interaction is important because greater compressive axial force (perhaps due to greater BMI) applied to a knee that is already at an increased risk because of its geometry, such as a steep lateral posterior tibial slope, could further increase the probability of ACL injury...
February 2017: Orthopaedic Journal of Sports Medicine
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