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https://www.readbyqxmd.com/read/28428796/expression-profiling-coupled-with-in-silico-mapping-identifies-candidate-genes-for-reducing-aflatoxin-accumulation-in-maize
#1
Ramesh Dhakal, Chenglin Chai, Ratna Karan, Gary L Windham, William P Williams, Prasanta K Subudhi
Aflatoxin, produced by Aspergillus flavus, is hazardous to health of humans and livestock. The lack of information about large effect QTL for resistance to aflatoxin accumulation is a major obstacle to employ marker-assisted selection for maize improvement. The understanding of resistance mechanisms of the host plant and the associated genes is necessary for improving resistance to A. flavus infection. A suppression subtraction hybridization (SSH) cDNA library was made using the developing kernels of Mp715 (resistant inbred) and B73 (susceptible inbred) and 480 randomly selected cDNA clones were sequenced to identify differentially expressed genes (DEGs) in response to A...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28425426/production-of-red-tilapia-oreochromis-spp-in-floating-cages-in-the-mekong-delta-vietnam-mortality-and-health-management
#2
Annette S Boerlage, Tu Thanh Dung, Tran Thi Hoa, Jeffrey Davidson, Henrik Stryhn, K Larry Hammell
The Mekong Delta in Vietnam is one of the most productive aquaculture regions in the world, in which the red tilapia (Oreochromis spp.) industry is a small-scale industry that mainly supplies local markets in the delta region. Little is known about the frequency of mortality events and health management in this sector. We describe red tilapia floating cage production systems in the Mekong Delta, Vietnam, for the purposes of quantifying mortality and associated production factors, and describing practices that may influence pathogen introduction and spread to and from farms...
April 20, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28421098/fine-mapping-the-branching-habit-trait-in-cultivated-peanut-by-combining-bulked-segregant-analysis-and-high-throughput-sequencing
#3
Galya Kayam, Yael Brand, Adi Faigenboim-Doron, Abhinandan Patil, Ilan Hedvat, Ran Hovav
The growth habit of lateral shoots (also termed "branching habit") is an important descriptive and agronomic character of peanut. Yet, both the inheritance of branching habit and the genetic mechanism that controls it in this crop remain unclear. In addition, the low degree of polymorphism among cultivated peanut varieties hinders fine-mapping of this and other traits in non-homozygous genetic structures. Here, we combined high-throughput sequencing with a well-defined genetic system to study these issues in peanut...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28419352/dermatophytes-and-dermatophytosis-in-the-eastern-and-southern-parts-of-africa
#4
E I Nweze, I E Eke
Dermatophytosis is currently a disease of global importance and a public health burden. It is caused by dermatophytes, which attack and grow on dead animal keratin. Dermatophytes belong to three genera, namely, Epidermophyton, Microsporum, and Trichophyton. The predominant clinical forms and causative agents vary from one region of the world to another. Poor socioeconomic status, high population densities, and poor sanitary conditions are some of the factors responsible for the high prevalence of dermatophytosis in many developing countries, which include countries in southern and eastern Africa, the focus of this review...
April 17, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28412013/investigation-of-the-imaging-characteristics-of-the-albira-ii-small-animal-pet-system-for-18-f-68-ga-and-64-cu
#5
Ali Asgar Attarwala, Yvonne Wanjiku Karanja, Deni Hardiansyah, Chiara Romanó, Mareike Roscher, Björn Wängler, Gerhard Glatting
AIM: In this study the performance characteristics of the Albira II PET sub-system and the response of the system for the following radionuclides (18)F, (68)Ga and (64)Cu was analyzed. MATERIALS AND METHODS: The Albira II tri-modal system (Bruker BioSpin MRI GmbH, Ettlingen, Germany) is a pre-clinical device for PET, SPECT and CT. The PET sub-system uses single continuous crystal detectors of lutetium yttrium orthosilicate (LYSO). The detector assembly consists of three rings of 8 detector modules...
April 12, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28394651/reference-thresholds-for-the-ten-hl-test-for-people-with-normal-hearing
#6
Andreas S Hansen, Øyvind Raen, Brian C J Moore
OBJECTIVE: To estimate normative values and repeatability of thresholds for the TEN(HL) test for diagnosing dead regions in the cochlea, as a function of signal frequency, TEN(HL) level, age and gender. DESIGN: The TEN(HL) test was administered twice for each ear of each participant using signal frequencies from 0.5 to 4 kHz and TEN(HL) levels of 30, 50 and 70 dB HL/ERBN. STUDY SAMPLE: In all, 29 young participants and 8 older participants were tested...
April 10, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28392030/an-unusual-exit-wound-as-a-result-of-a-shotgun-suicide-to-the-head
#7
S N Kunz
The location of a gunshot entrance wound as well as the wound path trajectory are the main findings that help to determine the position from which a weapon was fired and thus distinguish firearm suicides from homicides and accidents. We present a case of a 28-year old man, who was found dead in his car. Because of an unusual position of the firearm, which was clamped into the steering wheel, and an unclear entrance/exit wound, an autopsy was performed. The deceased showed typical signs of a contact shotgun wound to the head with an entrance wound in the right temporal region and an exit wound in the midface...
March 30, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28381285/new-oligonucleotide-microarray-for-rapid-diagnosis-of-avian-viral-diseases
#8
Kulyaisan T Sultankulova, Nurlan S Kozhabergenov, Vitaliy M Strochkov, Yerbol D Burashev, Kamshat A Shorayeva, Olga V Chervyakova, Nurkuisa M Rametov, Nurlan T Sandybayev, Abylay R Sansyzbay, Mukhit B Orynbayev
BACKGROUND: We developed a new oligonucleotide microarray comprising 16 identical subarrays for simultaneous rapid detection of avian viruses: avian influenza virus (AIV), Newcastle disease virus (NDV), infection bronchitis virus (IBV), and infectious bursal disease virus (IBDV) in single- and mixed-virus infections. The objective of the study was to develop an oligonucleotide microarray for rapid diagnosis of avian diseases that would be used in the course of mass analysis for routine epidemiological surveillance owing to its ability to test one specimen for several infections...
April 5, 2017: Virology Journal
https://www.readbyqxmd.com/read/28381228/mesocarnivores-and-macroparasites-altitude-and-land-use-predict-the-ticks-occurring-on-red-foxes-vulpes-vulpes
#9
Attila D Sándor, Gianluca D'Amico, Călin M Gherman, Mirabela O Dumitrache, Cristian Domșa, Andrei Daniel Mihalca
BACKGROUND: The red fox Vulpes vulpes is the most common mesocarnivore in Europe and with a wide geographical distribution and a high density in most terrestrial habitats of the continent. It is fast urbanising species, which can harbor high numbers of different tick species, depending on the region. Here we present the results of a large-scale study, trying to disentangle the intricate relationship between environmental factors and the species composition of ectoparasites in red foxes...
April 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28379507/impact-of-male-fertility-status-on-the-transcriptome-of-the-bovine-epididymis
#10
Christine Légaré, Ayodélé Akintayo, Patrick Blondin, Ezequiel Calvo, Robert Sullivan
STUDY QUESTION: Can region-specific transcriptional profiling of the epididymis from fertile and sub-fertile bulls predict the etiology of fertility/sub-fertility in males? SUMMARY ANSWER: The highly regulated gene expression along the bovine epididymis is affected by the fertility status of bulls used for artificial insemination. WHAT IS KNOWN ALREADY: In mammals, sperm maturation and storage occur in the epididymis. Each epididymal segment has his own transcriptomic signature that modulates the intraluminal composition and consequently governs sequential modifications of the maturing male gamete...
April 3, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28378782/global-evolutionary-history-and-spatio-temporal-dynamics-of-dengue-virus-type-2
#11
Kaifa Wei, Yuhan Li
DENV-2 spread throughout the tropical and subtropical regions globally, which is implicated in deadly outbreaks of DHF and DSS. Since dengue cases have grown dramatically in recent years, about half of the world's population is now at risk. Our timescale analysis indicated that the most recent common ancestor existed about 100 years ago. The rate of nucleotide substitution was estimated to be 8.94 × 10(-4) subs/site/year. Selection pressure analysis showed that two sites 160 and 403 were under positive selection, while E gene is mainly shaped by stronger purifying selection...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28373109/modelling-the-bronchial-barrier-in-pulmonary-drug-delivery-a-human-bronchial-epithelial-cell-line-supplemented-with-human-tracheal-mucus
#12
Xabi Murgia, Hanzey Yasar, Cristiane Carvalho-Wodarz, Brigitta Loretz, Sarah Gordon, Konrad Schwarzkopf, Ulrich Schaefer, Claus-Michael Lehr
The airway epithelium together with the mucus layer coating it forms a protective system that efficiently filters and removes potentially harmful particles contained in inhaled air. The same mechanism, however, serves to entrap particulate drug carriers, precluding their interaction with their target. The mucus barrier is often neglected in in vitro testing setups employed for the assessment of pulmonary drug delivery strategies. Therefore, our aim was to more accurately model the bronchial barrier, by developing an in vitro system comprising a tight epithelial cell layer which may be optionally supplemented with a layer of human tracheal mucus...
April 1, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28365882/proteus-a-random-forest-classifier-to-predict-disorder-to-order-transitioning-binding-regions-in-intrinsically-disordered-proteins
#13
Sankar Basu, Fredrik Söderquist, Björn Wallner
The focus of the computational structural biology community has taken a dramatic shift over the past one-and-a-half decades from the classical protein structure prediction problem to the possible understanding of intrinsically disordered proteins (IDP) or proteins containing regions of disorder (IDPR). The current interest lies in the unraveling of a disorder-to-order transitioning code embedded in the amino acid sequences of IDPs/IDPRs. Disordered proteins are characterized by an enormous amount of structural plasticity which makes them promiscuous in binding to different partners, multi-functional in cellular activity and atypical in folding energy landscapes resembling partially folded molten globules...
April 1, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28363052/teratoma-of-the-ovary-in-a-free-ranging-japanese-raccoon-dog-nyctereutes-procyonoides-viverrinus
#14
Hisashi Yoshimura, Masami Yamamoto, Maiko Moriya, Tomohiko Endo, Natsuko Sugiura, Takuya Kato, Yoko Matsuda, Toshiyuki Ishiwata, Hiroshi Kajigaya, Shinji Kamiya
A young adult, female, free-ranging Japanese raccoon dog ( Nyctereutes procyonoides viverrinus) with scabies infection was found dead as a result of traumatic injuries presumed to reflect vehicular trauma. Necropsy showed a large solid mass located on the left ovarian region, occupying a third of the abdominal cavity. Histologically, the mass contained complex tissues derived from three germinal layers, with areas of cuboidal or columnar epithelium, keratinized squamous epithelium, bone, cartilage, and adipose tissue...
March 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28349246/suicide-patterns-in-children-and-adolescents-a-review-from-a-pediatric-institution-in-england
#15
Khairul Zainum, Marta C Cohen
Suicide is a catastrophic event to both families and communities yet it is potentially preventable. This study aims to determine incidence and patterns of suicide in children and young adolescents in our region, raise awareness of this entity as a potentially preventable cause of death in this age group, and identify its possible associated risk factors. We retrospectively reviewed suicide cases presenting as sudden unexpected death in children and adolescents that underwent coronial post-mortems at our institution...
March 27, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28348210/myosin-1e-interacts-with-fak-proline-rich-region-1-to-induce-fibronectin-type-matrix
#16
Joel B Heim, Edwin J Squirewell, Ancilla Neu, Georg Zocher, Sindhuja Sominidi-Damodaran, Saranya P Wyles, Ekaterina Nikolova, Nille Behrendt, Ditte M Saunte, Jorgen Lock-Andersen, Krutika S Gaonkar, Huihuang Yan, Jann N Sarkaria, Mira Krendel, Jan van Deursen, Remco Sprangers, Thilo Stehle, Ralph T Böttcher, Jeong-Heon Lee, Tamas Ordog, Alexander Meves
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase involved in development and human disease, including cancer. It is currently thought that the four-point one, ezrin, radixin, moesin (FERM)-kinase domain linker, which contains autophosphorylation site tyrosine (Y) 397, is not required for in vivo FAK function until late midgestation. Here, we directly tested this hypothesis by generating mice with FAK Y397-to-phenylalanine (F) mutations in the germline. We found that Y397F embryos exhibited reduced mesodermal fibronectin (FN) and osteopontin expression and died during mesoderm development akin to FAK kinase-dead mice...
March 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28348086/the-dead-box-rna-helicase-ddx41-is-a-novel-repressor-of-p21-waf1-cip1-translation
#17
Dominik Peters, Claudia Radine, Alina Reese, Wilfried Budach, Dennis Sohn, Reiner U Jänicke
The cyclin-dependent kinase inhibitor p21 is an important player in stress pathways exhibiting both tumor-suppressive and oncogenic functions. Thus, expression of p21 has to be tightly controlled, which is achieved by numerous mechanisms at the transcriptional, translational and post-translational level. Performing immunoprecipitations of bromouridine (BrU)-labeled p21 mRNAs that had been incubated before with cytoplasmic extracts of untreated HCT116 colon carcinoma cells, we identified the DEAD-box RNA helicase DDX41 as a novel regulator of p21 expression...
March 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28337775/effectiveness-and-safety-assessment-of-citrate-anticoagulation-during-albumin-dialysis-in-comparison-to-other-methods-of-anticoagulation
#18
Agnieszka Dyla, Wojciech Mielnicki, Joanna Bartczak, Tomasz Zawada, Piotr Garba
Liver failure is a serious and often deadly disease often requiring MARS (Molecular Adsorbent Recirculating System) therapy. Choosing the safe and effective method of anticoagulation during artificial liver support systems seems to be very difficult and extremely important. The aim of this study was to assess effectiveness and safety of regional anticoagulation with citrate in liver failure patients during MARS. We used a single center observational study. We analyzed 158 MARS sessions performed in 65 patients: 105 (66...
March 23, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28333083/divergent-expression-patterns-and-function-implications-of-four-nanos-genes-in-a-hermaphroditic-fish-epinephelus-coioides
#19
Zhi-Hui Sun, Yang Wang, Wei-Jia Lu, Zhi Li, Xiao-Chun Liu, Shui-Sheng Li, Li Zhou, Jian-Fang Gui
Multiple nanos genes have been characterized in several fishes, but the functional implications of their various expression patterns remain unclear. In this study, we identified and characterized four nanos genes from a hermaphroditic fish orange-spotted grouper, Epinephelus coioides. Ecnanos1a and Ecnanos1b show divergent expression patterns, and the dynamic expression change of Ecnanos1a in pituitaries during sex change is associated with testis differentiation and spermatogenesis. Ecnanos2 and Ecnanos3 might be germline stem cells (GSCs) and primordial germ cells (PGCs)-specific markers, respectively...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28327807/ultrastructural-study-of-morphological-changes-in-schistosoma-mansoni-after-in-vitro-exposure-to-the-monoterpene-rotundifolone
#20
Thiago José Matos-Rocha, Marília Gabriela Dos Santos Cavalcanti, José Maria Barbosa-Filho, Ana Silvia Suassuna Carneiro Lúcio, Dyana Leal Veras, Márcia Ortiz Mayo Marques, Luiz Carlos Alves, Fábio André Brayner
INTRODUCTION: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. METHODS: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
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