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https://www.readbyqxmd.com/read/27895795/growth-differentiating-factor-15-gdf-15-a-potential-biomarker-and-therapeutic-target-for-cancer-associated-weight-loss
#1
Lorena Lerner, Jeno Gyuris, Richard Nicoletti, James Gifford, Brian Krieger, Aminah Jatoi
Growth differentiating factor-15 (GDF-15), also known as macrophage inhibiting factor-1, is a member of the transforming growth factor-β superfamily, which has been implicated in cancer-associated weight loss. The present study investigated the association between cancer-associated weight loss and plasma GDF-15 concentration, as well as other biomarkers, in patients with metastatic lung or exocrine pancreatic cancer. A total of 218 patients were enrolled over a 1-year period. The patient cohort included 152 patients with incurable lung cancer and 66 patients with incurable pancreatic cancer...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27879019/screening-for-alk-abnormalities-in-central-nervous-system-metastases-of-non-small-cell-lung-cancer-alk-abnormalities-in-cns-metastases-of-nsclc
#2
Marcin Nicoś, Bożena Jarosz, Paweł Krawczyk, Kamila Wojas-Krawczyk, Tomasz Kucharczyk, Marek Sawicki, Juliusz Pankowski, Tomasz Trojanowski, Janusz Milanowski
Anaplastic lymphoma kinase (ALK) gene rearrangement was reported in 3-7% of primary non-small-cell lung cancer (NSCLC) and its presence is commonly associated with adenocarcinoma (AD) type and non-smoking history. ALK tyrosine kinase inhibitors (TKIs) such as crizotinib, alectinib and ceritinib showed efficiency in patients with primary NSCLC harboring ALK gene rearrangement. Moreover, response to ALK TKIs was observed in central nervous system (CNS) metastatic lesions of NSCLC. However, there are no reports concerning the frequency of ALK rearrangement in CNS metastases...
November 23, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27861515/involvement-of-igf1r-in-bronchiolar-epithelial-regeneration-role-during-repair-kinetics-after-selective-club-cell-ablation
#3
Icíar P López, Sergio Piñeiro-Hermida, Rosete S Pais, Raquel Torrens, Andreas Hoeflich, José G Pichel
Regeneration of lung epithelium is vital for maintaining airway function and integrity. An imbalance between epithelial damage and repair is at the basis of numerous chronic lung diseases such as asthma, COPD, pulmonary fibrosis and lung cancer. IGF (Insulin-like Growth Factors) signaling has been associated with most of these respiratory pathologies, although their mechanisms of action in this tissue remain poorly understood. Expression profiles analyses of IGF system genes performed in mouse lung support their functional implication in pulmonary ontogeny...
2016: PloS One
https://www.readbyqxmd.com/read/27843633/scoring-of-pd-l1-expression-intensity-on-pulmonary-adenocarcinomas-and-the-correlations-with-clinicopathological-factors
#4
Tomoyuki Igarashi, Koji Teramoto, Mitsuaki Ishida, Jun Hanaoka, Yataro Daigo
INTRODUCTION: The contribution of programmed cell death ligand-1 (PD-L1) immune checkpoint molecule toward progression of non-small cell lung cancer (NSCLC) has not yet been elucidated, in part, because of lack of a standardised method to evaluate PD-L1 expression. In this study, we developed a novel method for the evaluation of PD-L1 expression on NSCLC cells and examined its correlation with clinicopathological characteristics. METHODS: After immunohistochemical examination of PD-L1 expression for surgically resected pulmonary adenocarcinomas (n=106), based on the findings that PD-L1 are consistently expressed on alveolar macrophages, PD-L1 staining intensity of tumour cells was classified into four levels relative to PD-L1 staining intensity in alveolar macrophages; PD-L1 expression scores (range, 0-300) were semiquantitatively assessed...
2016: ESMO Open
https://www.readbyqxmd.com/read/27825563/resveratrol-inhibits-lung-cancer-growth-by-suppressing-m2-like-polarization-of-tumor-associated-macrophages
#5
Liwei Sun, Bonian Chen, Rong Jiang, Jinduo Li, Bin Wang
In cancer, tumor associated macrophages (TAMs) play an important role in the cancer progression, evasion of immunity and dissemination of cancer cells. Inhibition of the activation or the M2 polarization of TAMs is an effective therapy for cancer. In the present study, we investigated the ability of resveratrol (RES) to inhibit lung cancer growth using in vitro and in vivo studies, and examined the underlying mechanisms. We demonstrated that M2 polarization of human monocyte derived macrophage (HMDMs) induced by the lung cancer cells conditioned medium was inhibited by RES...
November 2, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27822063/the-accumulation-of-macrophages-attenuates-the-effect-of-recombinant-human-endostatin-on-lung-cancer
#6
Yanyang Liu, Li Tu, Li Wang, Jianlin Long, Jiantao Wang, Yuyi Wang, Feng Luo, Dan Cao
BACKGROUND: Although anti-angiogenic therapy is widely applied clinically, its efficacy has been less than expected. Screening for regulatory factors and sensitive indicators to define the effectiveness of these drugs is required. Through a retrospective study of clinical data, we found that patients with a higher peripheral monocyte-to-lymphocyte ratio (MLR) obtained less benefit from recombinant human endostatin (rhES, Endostar(®)), an anti-angiogenic drug, in lung cancer. Because MLR is positively correlated with macrophage count in tumors, this result suggests that macrophages may influence the effectiveness of rhES therapy in lung cancer...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27793775/systemic-and-tumor-th1-and-th2-inflammatory-profile-and-macrophages-in-lung-cancer-influence-of-underlying-chronic-respiratory-disease
#7
Mercè Mateu-Jimenez, Víctor Curull, Lara Pijuan, Albert Sánchez-Font, Hugo Rivera-Ramos, Alberto Rodríguez-Fuster, Rafael Aguiló, Joaquim Gea, Esther Barreiro
INTRODUCTION: Chronic respiratory conditions, especially chronic obstructive pulmonary disease (COPD), and inflammatory events underlie lung cancer (LC). We hypothesized that profiles of T helper 1 and T helper 2 cytokines and type 1 and type 2 macrophages (M1 and M2) are differentially expressed in lung tumors and blood of patients with NSCLC with and without COPD and that the ratio M1/M2 specifically may influence their survival. METHODS: In blood, inflammatory cytokines (determined by enzyme-linked immunosorbent assay) were quantified in 80 patients with LC (60 with LC and COPD [the LC-COPD group] and 20 with LC only [the LC-only group]) and lung specimens (tumor and nontumor) from those undergoing thoracotomy (20 in the LC-COPD group and 20 in the LC-only group)...
October 25, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27788479/laurus-nobilis-leaf-extract-mediated-green-synthesis-of-zno-nanoparticles-characterization-and-biomedical-applications
#8
Sekar Vijayakumar, Baskaralingam Vaseeharan, Balasubramanian Malaikozhundan, Malaikkarasu Shobiya
The present study reports the green synthesis of zinc oxide nanoparticles using the aqueous leaf extract of Laurus nobilis (Ln-ZnO NPs) by co-precipitation method. The synthesized Ln-ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, XRD, TEM, SEM and EDX. Ln-ZnO NPs were crystalline in nature, flower like and have hexagonal wurtzite structure with a mean particle size of 47.27nm. The antibacterial activity of Ln-ZnO NPs was greater against Gram positive (Staphylococcus aureus) bacteria than Gram negative (Pseudomonas aeruginosa) bacteria...
October 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27785783/the-absence-of-hla-class-i-expression-in-non-small-cell-lung-cancer-correlates-with-the-tumor-tissue-structure-and-the-pattern-of-t-cell-infiltration
#9
Francisco Perea, Mónica Bernal, Abel Sánchez-Palencia, Javier Carretero, Cristina Torres, Clara Bayarri, Mercedes Gómez-Morales, Federico Garrido, Francisco Ruiz-Cabello
We wanted to analyze whether tumor HLA class I (HLA-I) expression influences the pattern of the immune cell infiltration and stromal cell reaction in the tumor microenvironment. Tumor tissues obtained from 57 patients diagnosed with lung carcinomas were analyzed for HLA expression and leukocyte infiltration. 28 patients out of the 57 were completely negative for HLA class I (HLA-I) expression (49.1%) or showed a selective HLA-A locus downregulation (3 patients, 5.2%). In 26 out of 57 tumors (47.8%) we detected a positive HLA-I expression but with a percentage of HLA-I negative cells between 10 and 25%...
October 27, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27775991/irradiated-vegf164-modified-tumor-cell-vaccine-protected-mice-from-the-parental-tumor-challenge
#10
Bing Kan, Li Yang, Yan-Jun Wen, Jin-Rong Yang, Ting Niu, Jiong Li, Hong-Xin Deng, Wei Wei, Li-Gong Chen, Quan Zhang, Wei Wang, Yu-Quan Wei
Vascular endothelial growth factor (VEGF) is an important regulating molecule of angiogenesis in tumor formation and progression. Cancer cells always secrete VEGF to stimulate angiogenesis that facilitate growth and invasion of the tumor. In this study, we established a VEGF164 overexpressing LL/2 lung cancer cell model and found that the postirradiated VEGF164-modified tumor cells protected the host against the challenge with LL/2 wild-type tumor cells. Histochemical assay showed that there were large areas of tumor necrosis with macrophage infiltration in the mice vaccinated with the VEGF164-modified tumor vaccine...
October 21, 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27736957/high-potency-vegfrs-met-fms-triple-blockade-by-tas-115-concomitantly-suppresses-tumor-progression-and-bone-destruction-in-tumor-induced-bone-disease-model-with-lung-carcinoma-cells
#11
Hidenori Fujita, Akira Gomori, Yayoi Fujioka, Yuki Kataoka, Kenji Tanaka, Akihiro Hashimoto, Takamasa Suzuki, Kenjiro Ito, Tomonori Haruma, Hiromi Yamamoto-Yokoi, Naomoto Harada, Motomu Sakuragi, Nobuyuki Oda, Kenichi Matsuo, Masaki Inada, Kazuhiko Yonekura
Approximately 25-40% of patients with lung cancer show bone metastasis. Bone modifying agents reduce skeletal-related events (SREs), but they do not significantly improve overall survival. Therefore, novel therapeutic approaches are urgently required. In this study, we investigated the anti-tumor effect of TAS-115, a VEGFRs and HGF receptor (MET)-targeted kinase inhibitor, in a tumor-induced bone disease model. A549-Luc-BM1 cells, an osteo-tropic clone of luciferase-transfected A549 human lung adenocarcinoma cells (A549-Luc), produced aggressive bone destruction associated with tumor progression after intra-tibial (IT) implantation into mice...
2016: PloS One
https://www.readbyqxmd.com/read/27697073/cigarette-smoke-mediated-perturbations-of-the-immune-response-a-new-therapeutic-approach-with-natural-compounds
#12
Thea Magrone, Emilio Jirillo
Cigarette smoke (CS) accounts for the outcome of several pathologies, even including lung cancer, cardiovascular disease and chronic obstructive pulmonary disease (COPD). Under healthy conditions, lung immune system becomes tolerant in response to various external stimuli. CS exposure alters the pulmonary immune equilibrium, thus leading to a condition of hyper activation of the local innate and adaptive immunity. COPD is one of the major complications of chronic CS exposure where a pro-inflammatory profile of the pulmonary and systemic immunity is predominant...
September 27, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27668795/iron-oxide-nanoparticles-inhibit-tumour-growth-by-inducing-pro-inflammatory-macrophage-polarization-in-tumour-tissues
#13
Saeid Zanganeh, Gregor Hutter, Ryan Spitler, Olga Lenkov, Morteza Mahmoudi, Aubie Shaw, Jukka Sakari Pajarinen, Hossein Nejadnik, Stuart Goodman, Michael Moseley, Lisa Marie Coussens, Heike Elisabeth Daldrup-Link
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast agents for magnetic resonance imaging and as drug carriers. Here, we show an intrinsic therapeutic effect of ferumoxytol on the growth of early mammary cancers, and lung cancer metastases in liver and lungs. In vitro, adenocarcinoma cells co-incubated with ferumoxytol and macrophages showed increased caspase-3 activity. Macrophages exposed to ferumoxytol displayed increased mRNA associated with pro-inflammatory Th1-type responses...
November 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27660431/neutral-sphingomyelinase-2-acid-sphingomyelinase-and-ceramide-levels-in-copd-patients-compared-to-controls
#14
Simon R Lea, Hannah J Metcalfe, Jonathan Plumb, Christian Beerli, Chris Poll, Dave Singh, Katharine H Abbott-Banner
BACKGROUND: Increased pulmonary ceramide levels are suggested to play a causative role in lung diseases including COPD. Neutral sphingomyelinase-2 (nSMase-2) and acid SMase (aSMase), which hydrolyze sphingomyelin to produce ceramide, are activated by a range of cellular stresses, including inflammatory cytokines and pathogens, but notably cigarette smoke appears to only activate nSMase-2. Our primary objective was to investigate nSMase-2 and aSMase protein localization and quantification in lung tissue from nonsmokers (NS), smokers (S), and COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27659803/complete-resection-for-pleomorphic-lung-cancer-with-a-high-serum-il-6-level-a-case-report
#15
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Hidetaka Uramoto, Fumihiro Tanaka
BACKGROUND: Pleomorphic lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. Recently, the autonomous production of hematopoietic cytokines (granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF], and interleukin-6 [IL-6]) was observed in some of these patients. CASE PRESENTATION: We herein report a case of complete resection of right pleomorphic lung cancer producing IL-6. The patient had a high-grade fever before surgery, and a blood examination showed high IL-6 and CRP levels in the serum...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27647974/endostatin-enhances-antitumor-effect-of-tumor-antigen-pulsed-dendritic-cell-therapy-in-mouse-xenograft-model-of-lung-carcinoma
#16
Jing Liang, Xiaolin Liu, Qi Xie, Guoling Chen, Xingyu Li, Yanrui Jia, Beibei Yin, Xun Qu, Yan Li
OBJECTIVE: To investigate the antitumor effect of endostatin combined with tumor antigen-pulsed dendritic cell (DC)-T cell therapy on lung cancer. METHODS: Transplanted Lewis lung cancer (LLC) models of C57BL/6 mice were established by subcutaneous injection of LLC cells in left extremity axillary. Tumor antigen-pulsed DC-T cells from spleen cells and bone of mice were cultured in vitro. Tumor-bearing mice were randomly divided into three groups, including DC-T+endostatin group, DC-T group, and phosphate-buffered saline (PBS) control group...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27636991/oxidized-macrophage-migration-inhibitory-factor-is-a-potential-new-tissue-marker-and-drug-target-in-cancer
#17
Alexander Schinagl, Michael Thiele, Patrice Douillard, Dirk Völkel, Lukas Kenner, Zahra Kazemi, Michael Freissmuth, Friedrich Scheiflinger, Randolf J Kerschbaumer
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, which was shown to be upregulated in cancers and to exhibit tumor promoting properties. Unlike other cytokines, MIF is ubiquitously present in the circulation and tissue of healthy subjects. We recently described a previously unrecognized, disease-related isoform of MIF, designated oxMIF, which is present in the circulation of patients with different inflammatory diseases. In this article, we report that oxMIF is also linked to different solid tumors as it is specifically expressed in tumor tissue from patients with colorectal, pancreatic, ovarian and lung cancer...
September 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27630310/local-concentrations-of-cc-chemokine-ligand-18-correlate-with-tumor-size-in-non-small-cell-lung-cancer-and-are-elevated-in-lymph-node-positive-disease
#18
Severin Schmid, Uyen-Thao LE, Benedikt Haager, Olga Mayer, Irene Dietrich, Mirjam Elze, Lars Johann Kemna, Gernot Zissel, Bernward Passlick
BACKGROUND: The tumor microenvironment plays a critical role in tumor growth and spreading. Tumor-associated macrophages (TAM) make up a large proportion of the tumor mass and are one of the main producers of CC-chemokine ligand 18 (CCL18), which is believed to carry out important functions in the immunological interactions that promote tumor progression. MATERIALS AND METHODS: Cytokines/chemokines were measured in bronchoalveolar lavage (BAL) from the tumor site and serum before and after resection in patients with proven non-small cell lung cancer (NSCLC)...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27595749/fdg-pet-in-the-evaluation-of-response-to-nivolumab-in-recurrent-non-small-cell-lung-cancer
#19
Mitsunori Higuchi, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Takeo Hasegawa, Hiroyuki Suzuki
BACKGROUND: Nivolumab, an immune checkpoint inhibitor, is recently clinically applied to non-small cell lung cancer (NSCLC) treatment, and this causes T cell activation and T cell infiltration to tumor tissue through the blockade of the interaction between programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1). 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) sometimes shows false positive because of the recruitment of neutrophils, lymphocytes, and macrophages...
September 5, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27584018/multi-modal-imaging-in-a-mouse-model-of-orthotopic-lung-cancer
#20
Priya Patel, Tatsuya Kato, Hideki Ujiie, Hironobu Wada, Daiyoon Lee, Hsin-Pei Hu, Kentaro Hirohashi, Jin Young Ahn, Jinzi Zheng, Kazuhiro Yasufuku
BACKGROUND: Investigation of CF800, a novel PEGylated nano-liposomal imaging agent containing indocyanine green (ICG) and iohexol, for real-time near infrared (NIR) fluorescence and computed tomography (CT) image-guided surgery in an orthotopic lung cancer model in nude mice. METHODS: CF800 was intravenously administered into 13 mice bearing the H460 orthotopic human lung cancer. At 48 h post-injection (peak imaging agent accumulation time point), ex vivo NIR and CT imaging was performed...
2016: PloS One
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