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"lung cancer", "interleukin 17"

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https://www.readbyqxmd.com/read/27872514/the-role-of-interleukin-17-in-lung-cancer
#1
REVIEW
Feng Wu, Juanjuan Xu, Qi Huang, Jieli Han, Limin Duan, Jinshuo Fan, Zhilei Lv, Mengfei Guo, Guorong Hu, Lian Chen, Shuai Zhang, Xiaonan Tao, Wanli Ma, Yang Jin
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27866241/elevated-regulatory-t-cells-surface-and-intracellular-ctla-4-expression-and-interleukin-17-in-the-lung-cancer-microenvironment-in-humans
#2
Iwona Kwiecien, Anna Stelmaszczyk-Emmel, Malgorzata Polubiec-Kownacka, Dariusz Dziedzic, Joanna Domagala-Kulawik
Regulatory T cells (Tregs) play an important role in the suppression of the immune response in lung cancer. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) expressed on T lymphocytes is capable of downregulating cytotoxic T cells and is constitutively expressed on Tregs. Little is known about the population of Tregs with two forms of CTLA-4: surface (s) and intracellular (in) in the lung cancer environment. Th17 cells defined by production of IL-17 have pleiotropic functions in anticancer immune response. Our aim was to detect the elements of immune response regulation in lung cancer in three compartments: by analysis of bronchoalveolar lavage fluid (BALF) from the lung affected by cancer (clBALF), healthy symmetrical lung (hlBALF) and peripheral blood (PB) from the same patient...
November 19, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27819281/il-17-promotes-angiogenic-factors-il-6-il-8-and-vegf-production-via-stat1-in-lung-adenocarcinoma
#3
Qi Huang, Limin Duan, Xin Qian, Jinshuo Fan, Zhilei Lv, Xiuxiu Zhang, Jieli Han, Feng Wu, Mengfei Guo, Guorong Hu, Jiao Du, Caiyun Chen, Yang Jin
Inflammation and angiogenesis are two hallmarks of carcinoma. The proinflammatory cytokine interleukin-17 (IL-17) facilitates angiogenesis in lung cancer; however, the underlying mechanism is not fully understood. In this study, tumour microvessel density (MVD) was positively associated with IL-17, interleukin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial cell growth factor (VEGF) expression in human lung adenocarcinoma tissues, and it was increased in tumour tissues of A549-IL-17 cell-bearing nude mice...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27468622/-interleukin-17-expression-and-clinical-significance-in-the-lung-tissue-of-patients-with-stable-chronic-obstructive-pulmonary-disease
#4
X Chen, J Cao, B Y Chen
OBJECTIVE: To observe the interleukin-17 (IL-17) expression in lung tussiue of patients with stable chronic obstructive pulmonary disease (COPD) and investigate the clinical significance. METHODS: A total of 50 patients receiving lung resections in General Hospital, Tianjin Medical University for lung cancer from October 2010 to October 2011 were included and divided into non-smoking COPD group (NS group), smoking non-COPD group (S group), smoking COPD group (COPD group) according to smoking status and 2013 COPD diagnosis standard...
July 12, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27375020/interleukin-17-promotes-prostate-cancer-via-mmp7-induced-epithelial-to-mesenchymal-transition
#5
Q Zhang, S Liu, K R Parajuli, W Zhang, K Zhang, Z Mo, J Liu, Z Chen, S Yang, A R Wang, L Myers, Z You
Chronic inflammation has been associated with a variety of human cancers including prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been demonstrated to promote development of prostate cancer, colon cancer, skin cancer, breast cancer, lung cancer and pancreas cancer. IL-17 promotes prostate adenocarcinoma with a concurrent increase of matrix metalloproteinase 7 (MMP7) expression in mouse prostate. Whether MMP7 mediates IL-17's action and the underlying mechanisms remain unknown...
July 4, 2016: Oncogene
https://www.readbyqxmd.com/read/26805737/-role-of-interleukin-17-in-lung-carcinogenesis-and-lung-cancer-progression
#6
Jiandong Mei, Lunxu Liu
Interleukin 17 (IL-17) is an important pro-inflammatory cytokine. It plays a critical role in mediating pathogen defense reactions, and the pathological inflammation of autoimmune diseases. IL-17 is also involved in various inflammation-related carcinogenesis. Cigarette smoking is one of the most important risk factors of lung cancer. Chronic inflammation caused by smoking and other factors is accompanied with overexpression of IL-17 within the airway, which reveals a potential relationship between IL-17 and lung carcinogenesis...
January 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/26708832/interleukin-17-potently-increases-non-small-cell-lung-cancer-growth
#7
Lei Wei, Hui Wang, Fen Yang, Qi Ding, Jianhua Zhao
The aim of the present study was to explore the effects of interleukin (IL)-17 on the growth and metastasis of tumors that were subcutaneously implanted into C57BL/6 mice. Lewis lung carcinoma (LLC) cells were subcutaneously injected into C57BL/6 mice followed by intraperitoneal injection of mouse recombinant IL-17 protein (IL-17 groups) or phosphate-buffered saline (control groups). Tumor growth and metastasis were assessed by measuring the size and weight of tumors and cervical lymph nodes, respectively. Cytokine expression in tumor masses was quantified by reverse transcription-quantitative polymerase chain reaction and western blotting, respectively...
February 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26524953/interleukin-17-promotes-angiogenesis-by-stimulating-vegf-production-of-cancer-cells-via-the-stat3-giv-signaling-pathway-in-non-small-cell-lung-cancer
#8
Bo Pan, Jing Shen, Jingyan Cao, Yongxu Zhou, Lihua Shang, Shi Jin, Shoubo Cao, Dehai Che, Fang Liu, Yan Yu
The presence of IL-17-positive cells is observed in a variety of inflammatory associated cancers and IL-17 has been found to be involved in angiogenesis. However, it remains unclear how IL-17 might contribute to tumor angiogenesis. In our study, IL-17 enhanced the formation of vessel-like tubes in HUVECs both directly (when HUVECs were incubated with IL-17) and indirectly (when HUVECs were incubated in conditioned cell media (CCM) from IL-17-treated cancer cells). Our results from experiments using siRNA-mediated knockdowns of STAT3 and GIV suggest that the effects of IL-17 were mediated by activating STAT3/GIV signaling in NSCLC cells and subsequently up-regulating its downstream target VEGF...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26379842/prognostic-significance-of-interleukin-17-in-solid-tumors-a-meta-analysis
#9
Yunhui Zeng, Qiongwen Zhang, Hong Wang, Minxun Lu, Hongyu Kong, Yingyi Zhang, Huashan Shi
BACKGROUND: The prognostic significance of intratumoral and peripheral interleukin-17 (IL-17) in tumors has been studied worldwide during these years, providing un-uniformed conclusions. METHODS: We conducted a meta-analysis of published literatures that evaluated the correlation between IL-17 and clinical staging, overall survival (OS) and/or disease free survival (DFS). RESULTS: A total of 28 studies enrolling 2902 patients were included...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26301881/interleukin-17-levels-correlate-with-poor-prognosis-and-vascular-endothelial-growth-factor-concentration-in-the-serum-of-patients-with-non-small-cell-lung-cancer
#10
Bo Pan, Dehai Che, Jingyan Cao, Jing Shen, Shi Jin, Yongxu Zhou, Fang Liu, Kuo Gu, Yingchun Man, Lihua Shang, Yan Yu
OBJECTIVE: The aim of this study was to explore the clinical role of serum interleukin-17 in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHOD: IL-17 expression and microvessel density (MVD) were measured via immunohistochemistry in 58 NSCLC tissues. Serum IL-17 and VEGF levels in NSCLC patients (n = 43) and healthy controls (n = 37) were analyzed via enzyme-linked immunosorbent assay. RESULTS: Serum IL-17 was elevated and the levels positively correlated with VEGF concentration in NSCLC patients...
2015: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/26165685/prognostic-value-of-serum-il-17-and-vegf-levels-in-small-cell-lung-cancer
#11
Qunying Lin, Lei Xue, Tian Tian, Bo Zhang, Lijing Guo, Guosheng Lin, Zhiwei Chen, Kexing Fan, Xiaobin Gu
OBJECTIVE: To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). MATERIALS AND METHODS: IL-17 and VEGF levels were determined by a commercially available ELISA method. RESULTS: Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p<0.001 and p<0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF...
October 2015: International Journal of Biological Markers
https://www.readbyqxmd.com/read/26045995/interleukin-17-induced-emt-promotes-lung-cancer-cell-migration-and-invasion-via-nf-%C3%AE%C2%BAb-zeb1-signal-pathway
#12
Kuo Gu, Ming-Ming Li, Jing Shen, Fang Liu, Jing-Yan Cao, Shi Jin, Yan Yu
Inflammatory cytokine interleukin-17 (IL-17) has been associated with the risk of progressive cancers including lung cancer. However, it remains unclear how IL-17 may contribute to the invasion and development of these inflammation-associated malignancies. Here we aimed to investigate the role of IL-17 in lung cancer cell development. Epithelial-mesenchymal transition (EMT) has been recently proposed as a developmental process which plays an important role in cancer progression and metastases. Here we show that IL-17 might promote EMT in lung cancer cells by inducing the transcriptional repressor ZEB1...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/25469655/interleukin-17a-genetic-variations-and-susceptibility-to-non-small-cell-lung-cancer
#13
Qin-Yun Ma, Ji Chen, Shao-Hua Wang, Ning Wu, Zhen-Hua Hao, Xiao-Feng Chen
Lung cancer is the leading cause of cancer-related death, in which non-small cell lung cancer (NSCLC) is the most common type. Evidence have shown that interleukin 17 (IL-17) greatly involves in human immune responses. In this study, we investigated the effect of IL-17 on NSCLC by examining the association between IL-17A genetic polymorphisms and the susceptibility to NSCLC. IL-17A -420A/G and IL-17A -73G/A polymorphisms were detected in 330 NSCLC patients and 382 healthy controls. We found that subjects carrying -73GA genotype or AA genotype had 2...
March 2015: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/25374205/association-between-polymorphisms-of-interleukin-17a-and-interleukin-17f-genes-and-silicosis-susceptibility-in-chinese-han-people
#14
COMPARATIVE STUDY
Ying Chen, Xue-Yun Fan, Yu-Lan Jin, San-Qiao Yao, Xiang Yun, Zheng-Bing Hua, Fu-Hai Shen
BACKGROUND: To explore the relationship between polymorphisms of interleukin17 (IL-17) gene(A-832G 7488A/G) and the susceptibility to silicosis, a risk factor for lung cancer. MATERIALS AND METHODS: A total of 113 silicosis patients and 116 workers without silicosis were enrolled in the case-control study. IL-17A A-832G and IL-17F 7488A/G polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The frequencies of AA,GG and AG of IL-17A A-832G locus in the case and control groups were 46...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25289477/interleukin-17a-polymorphism-elevates-gene-expression-and-is-associated-with-increased-risk-of-nonsmall-cell-lung-cancer
#15
Sensen Cheng, Zhulin Shao, Xiuchun Liu, Liangjun Guo, Xia Zhang, Qinyun Na, Xiaofeng Chen, Yuan Ma, Jinsong Zheng, Bao Song, Jie Liu
Interleukin 17 (IL-17), also known as IL-17A, is a proinflammatory cytokine and plays critical roles in tumor immunity. Nonsmall cell lung cancer (NSCLC) is the most common type of lung cancers. The aim of this study was to investigate the correlation between IL-17A genetic polymorphisms and susceptibility to NSCLC. Two single nucleotide polymorphisms (SNPs) in IL-17A gene, rs3819024A/G and rs8193037G/A, were detected in 322 NSCLC patients and 366 healthy donors. Data revealed that prevalence of IL-17A rs8193037GA and AA genotypes were significantly higher in the patients than in controls (odds ratio [OR]: 2...
January 2015: DNA and Cell Biology
https://www.readbyqxmd.com/read/25038765/interleukin-17-indirectly-promotes-m2-macrophage-differentiation-through-stimulation-of-cox-2-pge2-pathway-in-the-cancer-cells
#16
Qingli Li, Lunxu Liu, Qiuyang Zhang, Sen Liu, Dongxia Ge, Zongbing You
PURPOSE: Interleukin-17 (IL-17) is a proinflammatory cytokine that plays important roles in inflammation, autoimmunity, and cancer. The purpose of this study was to determine if IL-17 indirectly regulates macrophage differentiation through up-regulation of cyclooxygenase-2 (COX-2) expression in the cancer cell lines. MATERIALS AND METHODS: Human cervical cancer HeLa, human lung cancer A549, and mouse prostate cancer Myc-CaP/CR cell lines were treated with recombinant IL-17; Western blot analysis, enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction analysis were utilized to examine the cellular responses...
July 2014: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/24887477/elevated-pleural-effusion-il-17-is-a-diagnostic-marker-and-outcome-predictor-in-lung-cancer-patients
#17
ChunHua Xu, LiKe Yu, Ping Zhan, Yu Zhang
BACKGROUND: Interleukin 17 (IL-17) is a proinflammatory cytokine produced mainly by CD4(+) T-lymphocytes and may be important in tumor cell growth and progression. In this study, we aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of IL-17 in lung cancer patients with malignant pleural effusion (MPE). METHODS: Pleural effusion samples were collected from 78 lung cancer patients with MPE and from 45 patients with nonmalignant pleural effusion...
2014: European Journal of Medical Research
https://www.readbyqxmd.com/read/24861949/inflammatory-cytokines-and-vegf-measured-in-exhaled-breath-condensate-are-correlated-with-tumor-mass-in-non-small-cell-lung-cancer
#18
Luisa Brussino, Beatrice Culla, Caterina Bucca, Roberto Giobbe, Monica Boita, Giancarlo Isaia, Enrico Heffler, Alberto Oliaro, Pierluigi Filosso, Giovanni Rolla
Inflammation mediated by the immune system is known to be important in carcinogenesis and, specifically, T helper 17 cells have been reported to play a role in tumor progression by promoting neo-angiogenesis. The aim of this study was to investigate whether inflammatory cytokines and vascular endothelial growth factor (VEGF) levels in exhaled breath condensate (EBC) and in serum were related to tumor size in patients with non-small cell lung cancer (NSCLC). Il-6, IL-17, TNF-α and VEGF levels were measured in EBC and serum of 15 patients with stage I-IIA NSCLC and in 30 healthy controls by immunoassay...
June 2014: Journal of Breath Research
https://www.readbyqxmd.com/read/24789737/lung-tumours-reprogram-pulmonary-dendritic-cell-immunogenicity-at-the-microrna-level
#19
Lotte Pyfferoen, Pieter Mestdagh, Karl Vergote, Nancy De Cabooter, Jo Vandesompele, Bart N Lambrecht, Karim Y Vermaelen
Lung cancer arises in a context of tumour-induced immune suppression. Dendritic cells (DCs) are central players in the induction of anti-tumoural immunity, providing critical signals that drive the induction of cytotoxic T-cell responses. Meanwhile, microRNAs are associated with tumour development as well as immune regulation. We postulated that lung tumours escape immune control by reprogramming DC immunogenicity at the microRNA level. Using an orthotopic model of lung cancer, we first identified the DC population responsible for transport and cross-presentation of lung tumour-derived antigens to naïve T cells in the draining mediastinal lymph nodes (LNs)...
December 15, 2014: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24768708/erlotinib-promotes-endoplasmic-reticulum-stress-mediated-injury-in-the-intestinal-epithelium
#20
Lu Fan, Lingna Hu, Baofang Yang, Xianying Fang, Zhe Gao, Wanshuai Li, Yang Sun, Yan Shen, Xuefeng Wu, Yongqian Shu, Yanhong Gu, Xudong Wu, Qiang Xu
Erlotinib, a popular drug for treating non-small cell lung cancer (NSCLC), causes diarrhea in approximately 55% of patients receiving this drug. In the present study, we found that erlotinib induced barrier dysfunction in rat small intestine epithelial cells (IEC-6) by increasing epithelial permeability and down-regulating E-cadherin. The mRNA levels of various pro-inflammatory cytokines (Il-6, Il-25 and Il-17f) were increased after erlotinib treatment in IEC-6 cells. Erlotinib concentration- and time-dependently induced apoptosis and endoplasmic reticulum (ER) stress in both IEC-6 and human colon epithelial cells (CCD 841 CoN)...
July 1, 2014: Toxicology and Applied Pharmacology
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