M Hachenberger, M Yeniguen, L Suenner, D Hinchliffe, C Mueller, A Wietelmann, T Gerriets, M Tschernatsch, M Juenemann, S T Gerner, T R Doeppner, H B Huttner, T Braun
Cerebral sinus venous thrombosis (CSVT) is an uncommon disease that is usually treated with anticoagulation (heparin, low-molecular heparin, or vitamin K-antagonists). We compared treatment with edoxaban, an oral factor Xa-antagonist, that has not been approved in patients with CSVT, with enoxaparin, a well-established therapy, in a rat model of CSVT. Fifty male Wistar rats were randomized into 5 groups (10 animals each) and subjected to aluminum chloride (AlCl3)-induced thrombosis of the superior sagittal sinus (SSS) or sham procedure...
June 1, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology