Read by QxMD icon Read


Alexander Drofa, Evgueni Kouznetsov, Stephen Tomek, Matthew Wiisanen, Michael Manchak, Timothy Lindley, Steven Mitchell, Ferdinand Hui, Dane Breker
Cerebral sinus venous thrombosis (CSVT) is a recognized cause of childhood and neonatal stroke. More than 50% of neonates have a poor outcome, and mortality is high. Coma is a predictor of death in neonatal CSVT. We present the case of a 9-day-old infant, who presented in coma and was treated successfully with a combination of mechanical thrombectomy using the MindFrame System via the right jugular vein, local infusion of recombinant tissue plasminogen activator and abciximab, as well as anticoagulation. In this case, aggressive thrombectomy and thrombolysis achieved complete neurologic restoration safely and quickly...
2016: Pediatric Neurosurgery
Melissa G Chung
Investigators from Erasmus University Hospital in Belgium and Gustave-Dron Hospital and Roger-Salengro Hospital in France studied the clinical and neuroradiologic characteristics of cerebral sinovenous thrombosis (CSVT) in neonates and children.
March 2016: Pediatric neurology briefs
Chiara Carducci, Giovanna Stefania Colafati, Lorenzo Figà-Talamanca, Daniela Longo, Tommaso Lunardi, Francesco Randisi, Bruno Bernardi
Cerebral sinovenous thrombosis (CSVT) is a relatively uncommon and potentially life-threatening condition in childhood, occurring in various clinical settings. Nowadays, however, it is increasingly diagnosed as related to many causes, likely due to greater clinical awareness and improvement of neuroradiologic techniques. The prompt diagnosis is an important goal to significantly reduce the risk of acute complications and long-term sequelae. The purpose of this narrative overview is to provide a useful educational tool in daily clinical practice for radiologists with a broad perspective of CSVT including a discussion of more common potential pitfalls related to misinterpretation of images in children...
May 2016: La Radiologia Medica
Valentina Lolli, Francesco Molinari, Jean-Pierre Pruvo, Gustavo Soto Ares
BACKGROUND AND PURPOSE: Cerebral sinovenous thrombosis (CSVT) represents an increasingly recognized cause of pediatric stroke. Our purpose was to assess gender and age differences in the etiology, clinical presentation, and imaging features of CSVT in neonates and older children. METHODS: Subjects aged newborn to 18 years diagnosed with CSVT at the Lille university hospital between 2011 and 2014 were included. RESULTS: Eleven neonates and 16 non-neonates constituted the study population...
July 2016: Journal of Neuroradiology. Journal de Neuroradiologie
Aashim Bhatia, Sumit Pruthi
Despite being as common as brain tumors in children, lack of awareness of pediatric stroke presents unique challenges, both in terms of diagnosis and management. Due to diverse and overlapping risk factors, as well as variable clinical presentations, the diagnosis can be either missed or frequently delayed. Early recognition and treatment of pediatric stroke is however critical in optimizing long-term functional outcomes, reducing morbidity and mortality, and preventing recurrent stroke. Neuroimaging plays a vital role in achieving this goal...
September 2016: Indian Journal of Pediatrics
C Herweh, M Griebe, C Geisbüsch, K Szabo, E Neumaier-Probst, M G Hennerici, M Bendszus, P A Ringleb, S Nagel
BACKGROUND AND PURPOSE: The temporal course of recanalization and its association with clinical outcome were analysed in our patients with cerebral sinus and/or venous thrombosis (CSVT) and follow-up magnetic resonance imaging (MRI). METHODS: Between January 1998 and September 2014 all patients from our institutions with CSVT were systematically analysed. Baseline data, treatment characteristics and follow-up MRI were retrospectively recorded. The status of recanalization was assessed as complete (CRec), partial (PRec) or failed recanalization...
April 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Ornit Giladi, David M Steinberg, Kobi Peleg, David Tanne, Adi Givon, Ehud Grossman, Yoram Klein, Shirli Avigdori, Gahl Greenberg, Rachel Katz, Varda Shalev, Ophira Salomon
BACKGROUND: Cerebral sinus vein thrombosis (CSVT) is a rare disease with significant neurological sequelae and high mortality rate. Incidence of CSVT diagnosis in the western world has increased despite the reduced occurrence of infections. AIM: To identify risk factors that may explain the predisposition to site specific thrombosis. METHODS: Ninety consecutive patients diagnosed with acute CSVT in tertiary hospital. As a control group we used the data extracted from the National Trauma Registry and Healthcare Services...
January 2016: Thrombosis Research
Sarah H O'Brien
Stroke is more likely to occur in the perinatal period than any other time in childhood, and these events can lead to a lifetime of intellectual and motor disabilities, epilepsy, and behavioral challenges. This review describes the epidemiology and natural history of perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT), risk factors for these complications, recent evidence regarding treatment strategies, and current gaps in knowledge. Existing evidence demonstrates the multifactorial etiology of symptomatic ischemic stroke in neonates, which includes a combination of maternal, delivery, and neonatal factors...
2015: Hematology—the Education Program of the American Society of Hematology
Amihai Rottenstreich, Keren Machol, Eli M Eisenstein, Shai Padeh, Aharon Klar, Avi Livneh, Yackov Berkun
OBJECTIVES: Central nervous system (CNS) involvement, one of the most severe manifestations of Behçet's disease (BD), is uncommon in children. Because it is rare, the clinical features of this disease in children are not well characterised. Here we describe a teenager with BD which was disclosed following an episode of cerebral sinus vein thrombosis (CSVT) and review the available literature on children with CSVT associated with BD. METHODS: A 12-year-old boy who presented with CSVT is described and the relevant literature, based on a Medline search from 1966 to January 2015 is reviewed...
November 2015: Clinical and Experimental Rheumatology
Omer Selvitop, Andrea Poretti, Thierry Agm Huisman, Matthias W Wagner
Pediatric cerebral sinovenous thrombosis (CSVT) is associated with high morbidity and mortality. Severe long-term sequelae are reported in up to 48% of children. The most frequent location of CSVT in children is the superficial venous system. We present the neuroimaging findings using both computed tomography and magnetic resonance imaging (MRI) in a 10-year-old child with extensive superficial CSVT. Our report aims to stress the importance of awareness of risk factors in suspecting and rapidly diagnosing CSVT...
June 2015: Neuroradiology Journal
Hossein Eslamiyeh, Farah Ashrafzadeh, Javad Akhondian, Mehran Beiraghi Toosi
Objective Homocystinuria is an inborn error of amino acid metabolism caused by cystathionine beta-synthase deficiency that affects methionine metabolism. The clinical features are heterogeneous ranging from mental retardation, ectopia lentis, and osteoporosis to vascular events such as deep vein thrombosis, sagital sinus thrombosis, and myocardial infarction. Cerebral sinovenous thrombosis (CVST) is an unusual disorder in children and requires prompt and accurate management. Some causal factors for the development of CVST differ between children and adults...
2015: Iranian Journal of Child Neurology
Mesut Yenigün, Martin Jünemann, Tibo Gerriets, Erwin Stolz
Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young patients. CVST represents with 0.5-3% of stroke cases a relatively rare disease. CVST affects 3-4 cases per 1 million overall and 7 cases per 1 million children and neonates. Typical clinical symptoms include headache, visual deficits and seizures. Beside the main condition associated with CVST in women in pregnancy and puerperium, the most frequently identified risk factors are oral hormonal contraceptives in combination with coagulation disorders...
June 2015: Annals of Translational Medicine
R Tatapudi, M Tripurasundari, K Asra, N L N Moothi
INTRODUCTION: The posterior reversible encephalopathy syndrome-PRES is recognised as the neuro radiologic abnormality in Eclampsia and with prompt treatment and delivery is usually reversible. OBJECTIVES: To study neuro radiological and biochemical abnormalities in severe preeclampsia and eclampsia and their reversibility following delivery. METHODS: 100 Women with severe pre-eclampsia and eclampsia admitted to High risk unit at Gandhi Hospital, Secunderabad were studied between September 2008 and September 2010...
July 2012: Pregnancy Hypertension
J Hobbs, A Tekes, J Klein, M Lemmon, R J Felling, R Chavez-Valdez
We report the case of a 1-month old, 28-week gestational age infant who presented with acute paraplegia after cardiopulmonary arrest. Later imaging confirms cerebral sinovenous thrombosis (CSVT) and a suspected infarction in the conus medullaris of the spinal cord. A prothrombotic state may explain the numerous areas of infarction visualized on neuroimaging. To our knowledge this is the first case report of acute and persistent paraplegia in an infant with CSVT and conus medullaris injury, which may be due to venous infarction of the spinal cord...
June 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
Oded Shamriz, Dan Engelhard, Violeta Temper, Shoshana Revel-Vilk, Shmuel Benenson, Rebecca Brooks, Ariel Tenenbaum, Polina Stepensky, Benjamin Koplewitz, Michal Kaufmann, Diana Averbuch
PURPOSE: This study aimed at reviewing our experience with infections caused by Fusobacterium in children. METHODS: A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom Fusobacterium spp. was identified in any specimen. RESULTS: A total of 22 patients (males = 12) at a mean ± SE age of 5 ± 1 (range 1-17) years, were identified. The most common complication was abscess formation (n = 11, 50 %)...
December 2015: Infection
Agnese Suppiej, Chiara Gentilomo, Paola Saracco, Stefano Sartori, Manuela Agostini, Rossana Bagna, Bianca Bassi, Paola Giordano, Massimo Grassi, Andrea Guzzetta, Donatella Lasagni, Matteo Luciani, Angelo C Molinari, Antonella Palmieri, Maria Caterina Putti, Luca Antonelli Ramenghi, Lidia Luciana Rota, Domenico Sperlì, Anna Maria Laverda, Paolo Simioni
Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral thrombotic events of the R...
June 2015: Thrombosis and Haemostasis
Matthias W Wagner, Thangamadhan Bosemani, Alexander Oshmyansky, Andrea Poretti, Thierry A G M Huisman
PURPOSE: Pediatric cerebral sinovenous thrombosis (CSVT) is a potentially life-threatening condition which is usually diagnosed by MRI. We analyzed the signal changes of the thrombus over time and the role of diffusion-weighted/tensor imaging (DWI/DTI) in the diagnosis of CSVT. METHODS: Clinical histories were reviewed for risk factors for CSVT, neurologic manifestation, and interval from onset of symptoms related to CSVT to the neuroimaging diagnosis. MRI studies were retrospectively evaluated for the appearance of thrombi on T1- and T2-weighted, fluid-attenuated inversion recovery (FLAIR), DWI/DTI, susceptibility-weighted imaging (SWI), and magnetic resonance venography (MRV) images...
May 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Eva Terni, Nicola Giannini, Alberto Chiti, Gino Gialdini, Giovanni Orlandi, Vincenzo Montano, Daniele Orsucci, Marco Brondi, Ubaldo Bonuccelli, Michelangelo Mancuso
Cerebral sinus venous thrombosis (CSVT) is a rare condition representing the 0.5-1% of all stroke cases which can have serious consequences. Early diagnosis and complete screening for acquired or inherited risk factors is crucial for decreasing morbidity and mortality. We have investigated clinical and aetiological factors in an Italian cohort of 43 patients with cerebral sinus venous thrombosis. Common presentation complaints were headache (81.4%), focal signs (20.9%), vomiting (11.6%) and seizures (6.9%)...
July 2015: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
M P De Carolis, S Salvi, A Botta, C Cocca, C Garufi, A Lanzone, S De Carolis
Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production of de novo antibodies by the neonate. However, few cases of neonatal APS are reported in the literature, especially regarding arterial thrombotic events. In particular, only two cases of neonatal aPL related isolated cerebral sinovenous thrombosis (CSVT) are described in the literature...
March 2015: Lupus
Andrea Andrade, Ivanna Yau, Mahendranath Moharir
Stroke is a relatively rare but rather significant cause of short- and long-term morbidity and mortality in children. It can be divided into three categories: arterial ischemic stroke (AIS), hemorrhagic stroke (HS) and cerebral sinovenous thrombosis (CSVT). This review focuses on AIS. The etiologies of pediatric AIS are diverse and different from those in adult stroke, chief among these being congenital heart disease, vasculopathies, hematological disorders and prothrombotic states. Additional factors might be related to the age group, ethnicity and geographic factors...
February 2015: Indian Journal of Pediatrics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"