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https://www.readbyqxmd.com/read/28340255/massive-gastric-juvenile-polyposis%C3%A2-a-clinicopathologic-study-using-smad4-immunohistochemistry
#1
Margaret E Lawless, Daniel L Toweill, Kim D Jewell, Dhanpat Jain, Laura Lamps, Alyssa M Krasinskas, Paul E Swanson, Melissa P Upton, Matthew M Yeh
Objectives: Juvenile polyps involving the stomach are uncommon. Massive gastric juvenile polyposis is even rarer. Methods: We describe the clinicopathologic features of nine cases of massive gastric juvenile polyposis. Results: All patients had anemia; four had hypoalbuminemia. The polyps were composed predominantly of dilated crypts lined by columnar epithelium and abundant edematous stroma with mixed inflammatory infiltrates. One patient had a poorly differentiated adenocarcinoma, arising in juvenile polyp-associated intraepithelial neoplasia...
March 18, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28325193/management-of-non-neoplastic-gastric-lesions
#2
REVIEW
Ryan K Schmocker, Anne O Lidor
Benign gastric lesions represent various pathologic entities and management considerations. Upper endoscopy serves as the primary diagnostic modality for gastric lesions. Persistent or giant gastric ulcers represent unique subtypes of ulcers, requiring investigation of the underlying cause. Medical management remains the mainstay of treatment; however, indications for surgical intervention remain. Gastric polyps also represent diverse etiologies, and accurate diagnosis requires pertinent information and tissue samples...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28325192/endoscopic-management-of-early-gastric-adenocarcinoma-and-preinvasive-gastric-lesions
#3
REVIEW
Saowanee Ngamruengphong, Seiichiro Abe, Ichiro Oda
Early gastric cancer (ECG) can be difficult to diagnose endoscopically. Endoscopists should be familiar with subtle changes and endoscopic features of EGC. Chromoendoscopy and image-enhanced endoscopy improve diagnostic accuracy and facilitate endoscopic resection. Endoscopic submucosal dissection is a preferred endoscopic technique for resection of EGC and offers a comparable overall survival to surgical resection. Endoscopic management of benign gastric epithelial polyps (fundic gland polyps, hyperplastic polyps, and gastric adenoma) depends on patient symptomatology, patient's comorbidities (eg, familial syndromes), lesions' characteristics, and risk of malignant transformation...
April 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28315903/reconsideration-of-the-primary-and-secondary-diagnostic-criteria-of-meckel-s-diverticulum-scintigraphy-a-study-of-93-confirmed-cases
#4
Ha Wu, Xiaofei Zhao, Yiwei Li, Ruifang Zhao
OBJECTIVE: Meckel's diverticulum scintigraphy (MDS) is a common method for diagnosing ectopic gastric mucosa (EGM), but atypical images are difficult to diagnose. This study aimed to improve the understanding of the existing diagnostic criteria through a review of confirmed cases. SUBJECTS AND METHODS: A total of 352 patients underwent MDS. Among 120 patients with a positive diagnosis, 106 underwent surgery. This study analyzed the imaging presentation, surgical records, and pathological results...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28303455/duodenal-cancer-in-a-young-patient-with-peuts-jeghers-syndrome-harboring-an-entire-deletion-of-the-stk11-gene
#5
Satoshi Teramae, Koichi Okamoto, Kumiko Tanaka, Reika Matsumoto, Shinji Kitamura, Tetsuo Kimura, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yoshimi Bando, Mitsuo Shimada, Tetsuji Takayama
A 21-year-old woman with Peuts-Jeghers syndrome (PJS) was referred to our hospital for gastrointestinal surveillance. She had been diagnosed as having PJS from a young age based on her family history and the presence of mucocutaneous pigmentation on her lips and oral mucosa. Her mother and brother had PJS harboring an entire deletion of the STK11 gene. She had tetralogy of Fallot, atrial tachycardia, sick sinus syndrome, and mental retardation in her past history. Esophagogastroduodenoscopy identified a protruded lesion with a depressed area that occupied the lumen half-circumferentially in the duodenal second portion and also showed a 10-mm protruded lesion on the anterior wall of the lower gastric body...
March 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28285810/-gastric-adenoma-of-pyloric-type-associated-with-familial-adenomatous-polyposis-a-rare-histological-type-not-to-be-overlooked
#6
Jérôme Didier, Peggy Dartigues, Ranya Soufan, David Malka, Pascal Burtin, Jean-Yves Scoazec
We report here two cases of gastric adenomas of pyloric type diagnosed during the follow-up of familial adenomatous polyposis (FAP). This rare histological lesion has been only recently described in this particular context and its clinical and pathological spectrum remains to be evaluated. Our two cases were very different in their clinical and endoscopic presentation. In the first patient, the lesion was diagnosed late during the evolution of FAP; it was very large and protruded above the adjacent mucosa; because of its large size, its treatment proved to be difficult...
March 9, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/28284066/successful-treatment-of-proton-pump-inhibitor-induced-sporadic-fundic-gland-polyps-with-an-argon-plasma-coagulator-in-a-patient-with-polycythaemia-vera
#7
Kazuya Kato, Yoshiaki Iwasaki, Masahiko Taniguchi, Kazuhiko Onodera, Takako Kawakami, Minoru Matsuda, Mineko Higuchi, Kimitaka Kato, Yurina Kato, Susumu Tamakawa, Hiroyuki Furukawa
INTRODUCTION: Proton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC). PRESENTATION OF CASE: We present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years...
February 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28271094/clinical-outcomes-of-gastric-polyps-and-neoplasms-in-patients-with-familial-adenomatous-polyposis
#8
Keiko Nakamura, Satoru Nonaka, Takeshi Nakajima, Tatsuo Yachida, Seiichiro Abe, Taku Sakamoto, Haruhisa Suzuki, Shigetaka Yoshinaga, Ichiro Oda, Takahisa Matsuda, Shigeki Sekine, Yukihide Kanemitsu, Hitoshi Katai, Yutaka Saito, Seiichi Hirota
Background and study aims Familial adenomatous polyposis (FAP) is an autosomal dominant syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene, characterized by the presence of more than 100 adenomatous polyps in the colorectum. The upper gastrointestinal tract is an extracolonic site for malignancy in patients with FAP. The frequency of death in Japanese patients with FAP because of gastric cancer is 2.8 % and that because of colon cancer is 60.6 %. Few studies have reported upper gastrointestinal diseases in patients with FAP...
March 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28270877/hematemesis-with-gastric-laceration-after-tattooing-a-polyp-with-purified-carbon-a-review-of-the-literature
#9
Ana Isabel Gonzalez-Tallon, Miguel Rivero-Fernandez, Irina Calvo-Ramos, Antonio Diaz-Sanchez, Maria Del Rosario Gonzalez-Alonso, Elsa De la Fuente-Briongos, Rebeba Manzano-Fernandez, Eloisa Moya-Valverde, Jose Maria Riesco-Lopez, Rocio Campos-Cantero
Endoscopic tattooing is a simple and effective technique for marking small lesions, so they can be localized during surgery or in later endoscopies. Various agents can be used such as India ink or a solution of purified carbon particles. The number of complications from tattooing is relatively small, but not rare. The majority of the literature on the subject refers to complications in the colon. We present a case of gastric bleeding secondary to a laceration following tattooing with purified carbon, and a literature review...
February 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28257791/safety-and-efficacy-of-cap-assisted-endoscopic-mucosal-resection-for-sporadic-nonampullary-duodenal-adenomas
#10
Laith H Jamil, Amir Kashani, Neiveen Peter, Simon K Lo
BACKGROUND AND AIMS: Eradication of sporadic non-ampullary duodenal adenomas (SNADAs) is essential due to their high rate of malignant transformation. Endoscopic mucosal resection (EMR) techniques are the alternative to the traditional surgical treatments of SNADAs. There are very limited data on the safety and efficacy of cap-assisted EMR (C-EMR) in the treatment of SNADA. METHODS: The medical records of patients who underwent C-EMR for SNADAs between July 2002 and April 2013 were retrospectively reviewed...
February 28, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28222897/gastric-polyps-retrospective-analysis-of-41-253-upper-endoscopies
#11
Lidia Argüello Viúdez, Henry Córdova, Hugo Uchima, Cristina Sánchez-Montes, Àngels Ginès, Isis Araujo, Begoña González-Suárez, Oriol Sendino, Josep Llach, Gloria Fernández-Esparrach
INTRODUCTION: Gastric polyps are usually asymptomatic lesions incidentally discovered during endoscopy. OBJECTIVE: To study the frequency of different types of gastric polyps in our population and their possible association with other factors. PATIENTS AND METHODS: Retrospective study of gastroscopies performed in a tertiary hospital over a ten-year period. Demographics, medical history, indication for gastroscopy and morphological and histological characteristics of polyps were collected...
February 17, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28206938/a-review-of-sleeve-gastrectomy-specimen-histopathology
#12
Luke A Kinsinger, James C Garber, Oliver Whipple
With the increasing popularity of sleeve gastrectomy, many stomach specimens are being evaluated. Understanding the significance and treatment for unexpected pathology is important. This study examines the incidence of relevant histopathology of sleeve gastrectomy specimens. It evaluates previous data for each histopathology and provides recommendations for treatment. In this study, a retrospective review was performed for 241 patients who underwent sleeve gastrectomy from 2009 to 2014 at a single institution...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28199735/novel-gastric-mucosal-findings-in-association-with-proton-pump-inhibitors
#13
EDITORIAL
Hajime Isomoto, Hiroki Kurumi
Proton pump inhibitors (PPIs) are prescribed worldwide as the treatment of choice for gastroesophageal reflux disease, and are known to exert preventive effects for upper gastrointestinal injuries due to aspirin or non-steroidal anti-inflammatory drugs. On the other hand, the long-term use of PPIs may cause such adverse events as fractures and enteric infections. Recently, they have been associated with mucosal changes including parietal cell protrusions, oxyntic gland dilatations and fundic gland polyps (FGPs)...
February 15, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28192107/gastrointestinal-complications-of-obesity
#14
Michael Camilleri, Harmeet Malhi, Andres Acosta
Obesity is usually associated with morbidity related to diabetes mellitus and cardiovascular diseases. However, there are many gastrointestinal and hepatic diseases for which obesity is the direct cause [e.g. non-alcoholic fatty liver diseases (NAFLD)] or is a significant risk factor, such as reflux esophagitis and gallstones. When obesity is a risk factor, it may interact with other mechanisms and result in earlier presentation or complicated diseases. There are increased odds ratios or relative risks of several gastrointestinal complications of obesity: gastroesophageal reflux disease (GERD), erosive esophagitis, Barrett's esophagus, esophageal adenocarcinoma, erosive gastritis, gastric cancer, diarrhea, colonic diverticular disease, polyps, cancer, liver disease including NAFLD, cirrhosis, hepatocellular carcinoma, gallstones, acute pancreatitis, and pancreatic cancer...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28190361/ball-valve-syndrome-caused-by-a-giant-gastric-vanek-s-tumor
#15
Cláudio Rodrigues Martins, Élia Gamito, Ana Paula Oliveira
Inflammatory fibroid polyps (Vanek's tumor) are rare, accounting for 0.1% of all gastric polyps. This letter describes an unusual case of an intermittent gastric outlet obstruction by a large Vanek's tumor.
February 13, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28188442/patients-with-mccune-albright-syndrome-have-a-broad-spectrum-of-abnormalities-in-the-gastrointestinal-tract-and-pancreas
#16
Laura D Wood, Michaël Noë, Wenzel Hackeng, Lodewijk A A Brosens, Feriyl Bhaijee, Marija Debeljak, Jun Yu, Masaya Suenaga, Aatur D Singhi, Atif Zaheer, Alison Boyce, Cemre Robinson, James R Eshleman, Michael G Goggins, Ralph H Hruban, Michael T Collins, Anne Marie Lennon, Elizabeth A Montgomery
McCune-Albright Syndrome (MAS) is a rare sporadic syndrome caused by post-zygotic mutations in the GNAS oncogene, leading to constitutional mosaicism for these alterations. Somatic activating GNAS mutations also commonly occur in several gastrointestinal and pancreatic neoplasms, but the spectrum of abnormalities in these organs in patients with MAS has yet to be systematically described. We report comprehensive characterization of the upper gastrointestinal tract in seven patients with MAS and identify several different types of polyps, including gastric heterotopia/metaplasia (7/7), gastric hyperplastic polyps (5/7), fundic gland polyps (2/7), and a hamartomatous polyp (1/7)...
February 10, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28185118/gastric-cancer-in-fap-a-concerning-rise-in-incidence
#17
Gautam Mankaney, Pamela Leone, Michael Cruise, Lisa LaGuardia, Margaret O'Malley, Amit Bhatt, James Church, Carol A Burke
The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal, and thyroid for which surveillance is recommended. Nearly all patients with FAP have gastric fundic gland polyposis (FGP), but gastric cancers are rarely reported with a similar incidence as the general population. We describe a recent, sudden increase in the incidence of gastric cancer in FAP. Seven of the ten cases were diagnosed in the last 20 months. Comparing our population to the SEER database for gastric cancer, the standardized incidence ratio is 140...
February 9, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28181701/primary-gastric-choriocarcinoma-developed-in-a-helicobacter-pylori-negative-patient
#18
Taro Iwatsubo, Noriya Uedo, Kazunobu Ishibashi
A woman in her fifties underwent esophagogastroduodenoscopy, which revealed a whitish large laterally spreading lesion with reddish nodule at the greater curvature (Fig. 1). The patient had no history of Helicobacter pylori (H. pylori) eradication therapy. Anti-H. pylori antibody was negative (<3 U/mL) and no H. pylori-like organism was detected in any of the biopsy specimens. Fundic-gland polyps were seen in the non-atrophic gastric mucosa. No lymph node and distant metastases were found by computed tomography scan...
February 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28168076/coexistence-of-juvenile-like-polyp-with-neurofibroma-at-the-gastroesophageal-junction-in-an-adult-with-neurofibromatosis-type-i
#19
Namrah Aijaz, Peter Draganov, Atif Iqbal, Xiuli Liu
A 23-year-old Caucasian male with Neurofibromatosis Type I (NF-I) was found to have a submucosal nodule at the gastroesophageal junction (GEJ) and underwent endoscopic submucosal dissection. Histological examination revealed two different lesions within the nodule. The dominant lesion was inflammatory/hyperplastic (juvenile-like) polyp with obliterative vasculopathy while the smaller lesion was a neurofibroma. Gastric/GEJ lesions in NF-I are very rare with only seven cases reported in the literature. Three cases of juvenile-like gastric polyps (located in the antrum, greater curvature, and fundus) have been reported in adult NF-I patients...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28163952/unintended-targeting-of-dmp1-cre-reveals-a-critical-role-for-bmpr1a-signaling-in-the-gastrointestinal-mesenchyme-of-adult-mice
#20
Joohyun Lim, Joseph Burclaff, Guangxu He, Jason C Mills, Fanxin Long
Cre/loxP technology has been widely used to study cell type-specific functions of genes. Proper interpretation of such data critically depends on a clear understanding of the tissue specificity of Cre expression. The Dmp1-Cre mouse, expressing Cre from a 14-kb DNA fragment of the mouse Dmp1 gene, has become a common tool for studying gene function in osteocytes, but the presumed cell specificity is yet to be fully established. By using the Ai9 reporter line that expresses a red fluorescent protein upon Cre recombination, we find that in 2-month-old mice, Dmp1-Cre targets not only osteocytes within the bone matrix but also osteoblasts on the bone surface and preosteoblasts at the metaphyseal chondro-osseous junction...
2017: Bone Research
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