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https://www.readbyqxmd.com/read/28740967/incidental-gastrointestinal-stromal-tumor-at-a-gastroscopic-polypectomy-specimen-a-case-report-and-review-of-literature
#1
Dursun Özgür Karakaş, Özgür Dandin, Ahmet Ziya Balta, Yavuz Özdemir, İsmail Yılmaz, İlker Sücüllü
Although gastrointestinal stromal tumors (GISTs) comprise less than 1% of all gastrointestinal (GI) tract tumors, they are the most common mesenchymal tumors of the GI tract. Gastrointestinal stromal tumors can occur anywhere along the GI tract, but the stomach and small intestine are the most frequently involved sites. Gastrointestinal stromal tumors are frequently asymptomatic, and one-third of all cases are found incidentally. Endoscopy, endoscopic ultrasonography, and computed tomography are useful tools in the diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28717077/gastric-hyperplastic-polyps-associated-with-proton-pump-inhibitor-use-in-a-case-without-a-history-of-helicobacter-pylori-infection
#2
Shuichi Miyamoto, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Kanako C Hatanaka, Izumi Tsunematsu, Naoya Sakamoto
A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28710883/an-atypical-type-i-gastric-neuroendocrine-tumor
#3
Andrada-Viorela Gheorghe, Mihai Rimbas, Octav Ginghina, Andrada Spanu, Theodor Alexandru Voiosu
BACKGROUND: Gastric neuroendocrine tumors(GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring. CASE REPORT: We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena...
July 14, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28706179/nilotinib-induced-recurrent-gastric-polyps-case-report-and-review-of-literature
#4
Nancy Kassem, Omar M Ismail, Halima Elomri, Mohamad A Yassin
BACKGROUND Tyrosine kinase inhibitors (TKIs) are currently an important targeted drug class in the treatment of chronic myeloid leukemia (CML). Imatinib was the first approved TKI for CML in 2001. Nilotinib is a second-generation TKI, approved in 2007; it inhibits BCR-ABL, PDGFR, and c-KIT, and is 30 times more potent than imatinib. Tyrosine kinase enzymes are expressed in multiple tissues and are involved in several signaling pathways; they have been shown to have several off-target side effects. CASE REPORT We report a case of an elderly male with CML and no history of gastrointestinal diseases, treated with nilotinib, and developed recurrent gastric polyps after three years of treatment...
July 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28695877/endoscopic-gastric-polypectomy-assisted-by-laparoscopy-for-giant-gastric-and-duodenal-lesion-treatment-case-series-from-two-centres
#5
Luis Alberto Topete-Gonzalez, Morris E Franklin, Jorge Ernesto Balli-Martinez, Jan Lammel-Lindemann, Sofia Perez-Banuet-Farell, Orestes Valles-Guerra, Eduardo Flores-Villalba
BACKGROUND: Endoscopy has developed rapidly, generating new challenges. Today, there are several procedures done endoscopically with very good results. In the past, the assisted laparoscopic colon polypectomy has been described, reducing the morbidity of a bigger procedure. Nonetheless, little has been said about the use of hybrid surgery in the management of gastric or duodenal polyps. OBJECTIVES: Evaluating the safety and efficacy of the assisted laparoscopic gastric endoscopic polypectomy...
July 7, 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28675538/the-frequency-and-risk-factors-of-colorectal-adenoma-in-patients-with-early-gastric-cancer
#6
Hyun Hee Chung, Kyeong Ok Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
BACKGROUND/AIMS: The authors aimed to determine the clinical value of colonoscopy by evaluating the frequency of colorectal neoplasm detection in patients with early gastric cancer (EGC) as compared with healthy controls and analyzed the risk factors of advanced colorectal neoplasm in patients with EGC. METHODS: The medical records of 201 patients diagnosed as EGC and age and gender matched healthycontrols were retrospectively reviewed. Frequencies and clinical features of colorectal polyps of patients and controls were compared...
July 4, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28670238/clinical-characteristics-of-patients-with-serrated-polyposis-syndrome-in-korea-comparison-with-western-patients
#7
Eun Ran Kim, Jaryong Jeon, Jin Hee Lee, Yoon Jung Lee, Sung Noh Hong, Dong Kyung Chang, Young-Ho Kim
BACKGROUND/AIMS: Serrated polyposis syndrome (SPS) has been shown to increase the risk of colorectal cancer (CRC). However, little is known about the characteristics of Asian patients with SPS. This study aimed to identify the clinicopathological features and risk of CRC in Korean patients with SPS as well as the differences between Korean and Western patients based on a literature review. METHODS: This retrospective study included 30 patients with SPS as defined by World Health Organization classification treated at Samsung Medical Center, Korea, between March 1999 and May 2011...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28660530/hemorrhagic-polyps-formed-like-fundic-gland-polyps-during-long-term-proton-pump-inhibitor-administration
#8
Tsutomu Takeda, Daisuke Asaoka, Yuzuru Tajima, Kenshi Matsumoto, Naoto Takeda, Takahumi Hiromoto, Shoki Okubo, Hiroaki Saito, Tomonori Aoyama, Tomoyoshi Shibuya, Naoto Sakamoto, Mariko Hojo, Taro Osada, Akihito Nagahara, Takashi Yao, Sumio Watanabe
We report a rare case of hemorrhagic gastric polyps resulting in anemia during long-term proton pump inhibitor (PPI) administration that endoscopically looked like a fundic gland polyp (FGP). A 44-year-old man presented complaining of anemia and tarry stools. Esophagogastroduodenoscopy (EGD) demonstrated multiple white edematous polyps in the corpus and antrum, which were considered to be FGPs. We attempted endoscopic hemostasis but hemorrhaging increased because of hemorrhagic polyps and vulnerable gastric mucosa...
June 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28643319/-progress-of-the-application-of-optical-coherence-tomography-in-gastrointestinal-tumor-surgery
#9
Yongsheng Li, Hao Liu, Haipeng Huang, Yu Zhu, Haijun Deng, Jiang Yu, Site Luo, Li Huo, Li Lin, Huikai Xie, Guoxin Li
Optical coherence tomography (OCT) is a real-time, cross-sectional optical imaging technology. It is analogous to ultrasonography, except that OCT uses light waves instead of sound waves, and can provide three-dimensional morphological images of living tissues with a micrometer resolution. Through the use of endoscopes, needles, catheters and laparoscopes, OCT has demonstrated tremendous imaging potential in tumor surgery. The current studies suggest that OCT has potential for clinical applications in the following fields of gastrointestinal tumor surgery: (1) Early tumor detection and diagnosis: OCT can distinguish differences between polyp tissue, normal tissue and malignant tissue...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28591245/agreement-between-different-pathologists-in-histopathologic-diagnosis-of-128-gastric-polyps
#10
Sérgio Henrique Brito Barbosa, Geraldo Cezário de Lázaro, Luciano Monteiro Franco, José Telmo Valença, Miguel Ângelo Nobre E Souza, Marcellus Henrique Loiola Ponte Souza
BACKGROUND: - Gastric polyps are elevated mucosal lesions. Most of them are less than 1 cm and when larger than 2 cm, has a high malignancy probability. The histopathological types are mainly fundic gland polyps, hyperplastic polyps and adenomatous polyps. OBJECTIVE: - To evaluate the agreement between three different pathologists in the histopathological diagnosis of 128 biopsied gastric polyps in Digestive Endoscopy Unit from Walter Cantídeo University Hospital, between May 2010 to May 2012...
May 25, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28550623/malignant-tumors-associated-with-juvenile-polyposis-syndrome-in-japan
#11
REVIEW
Hideyuki Ishida, Keiichiro Ishibashi, Takeo Iwama
PURPOSE: The risk of malignant tumors developing in association with juvenile polyposis syndrome (JPS) was evaluated to explore the optimal treatment for this rare disease. METHODS: We reviewed the data on JPS cases reported in Japan between January, 1971 and March, 2016. RESULTS: A total of 171 cases were evaluable. Of these 171 patients, 83 (48.5%) were female and the median age at diagnosis was 28 years (range 1-80 years). The polyps were located in the stomach alone (n = 62; 36...
May 26, 2017: Surgery Today
https://www.readbyqxmd.com/read/28494511/the-ethnic-distribution-of-sessile-serrated-polyps-in-the-united-states-is-inversely-associated-with-h-pylori-prevalence
#12
Amnon Sonnenberg, Kevin O Turner, Robert M Genta
BACKGROUND: Little is known about the epidemiology of sessile serrated polyps (SSP). Our study was aimed to investigate the influence of H. pylori gastritis and demographic patient characteristics (age, sex, ethnicity) on the prevalence of sessile serrated polyps, using a large national database of patients undergoing bi-directional endoscopy. METHODS: De-identified patient data were extracted from the Miraca Life Sciences electronic database of histopathologic reports...
May 11, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28487084/application-of-oral-contrast-trans-abdominal-ultrasonography-for-initial-screening-of-gastric-cancer-in-rural-areas-of-china
#13
Li Shen, Chenfei Zhou, Lan Liu, Li Zhang, Dianyuan Lu, Jianrong Cai, Liying Zhao, Rongrong Chu, Junyu Zhou, Jun Zhang
BACKGROUND: The present study is aimed at assessing the efficacy of oral contrast trans-abdominal ultrasonography (OCTU) as an initial screening tool for gastric cancer in rural areas of China. METHODS: All subjects that were enrolled from Chongming County, Shanghai, China. Subjects in the symptomatic group underwent both OCTU and gastroscopic biopsy. OCTU was performed by experienced ultrasonic physicians in a blinded fashion. RESULTS: In the symptomatic group, 643 patients were enrolled; diagnoses included low risk diseases gastritis (68...
August 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28485638/endoscopic-findings-of-the-gastric-mucosa-during-long-term-use-of-proton-pump-inhibitor-a-multicenter-study
#14
Mariko Kiso, Masanori Ito, Tomoyuki Boda, Takahiro Kotachi, Kazuhiko Masuda, Kosaku Hata, Atsunori Sasaki, Toru Kawamura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: It is clinically important to diagnose drug-induced gastric lesions correctly. Recently, the use of proton pump inhibitors (PPI) has increased worldwide. The histological features induced by PPI have been reported; however, few reports have described endoscopic findings induced by PPI. Therefore, we aimed to clarify the characteristic endoscopic features in PPI users and associated pathogenic factors. METHODS: We prospectively registered 1007 consecutive participants (70 PPI users and 937 nonusers) who underwent endoscopic examination for cancer screening in three hospitals/clinics...
May 9, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28483019/clinical-endoscopic-and-pathologic-features-of-36-patients-with-gastric-neuroendocrine-neoplasms
#15
Chunsaier Wang, Tianming Xu, Jingnan Li, Aiming Yang, Jiaming Qian, Xi Wu
Objective To explore the clinical features of gastric neuroendocrine neoplasms (GNENs). Methods A total of 36 patients with GNENs who were diagnosed between October 2005 and October 2015 at Peking Union Medical College Hospital were retrospectively analyzed. The demographic characteristics,clinical manifestations,endoscopic findings,and pathologic features as well as the treatments of GNENs were collected and analyzed. Results The average age of 36 patients was (55.8±11.1) years and the male to female ratio was 0...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28462913/a-clinicopathologic-evaluation-of-incidental-fundic-gland-polyps-with-dysplasia-implications-for-clinical-management
#16
Isaac E Lloyd, Wendy K Kohlmann, Keith Gligorich, Amy Hall, Elaine Lyon, Erinn Downs-Kelly, Wade S Samowitz, Mary P Bronner
OBJECTIVES: Fundic gland polyps (FGPs) can rarely exhibit dysplasia of the surface epithelium. Based on retrospective data, FGPs with dysplasia (FGPDs) are thought to be a strong marker for familial adenomatous polyposis (FAP), although sporadic, non-syndromic FGPDs also occur. Owing to the significant syndromic association, diagnosis of an apparently sporadic FGPD may prompt clinical evaluation for FAP, especially its attenuated variant. We sought to evaluate the positive predictive value of incidental FGPDs for FAP...
July 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28439498/gastric-and-duodenal-polyps-in-familial-adenomatous-polyposis-patients-conventional-endoscopy-vs-virtual-chromoendoscopy-fujinon-intelligent-color-enhancement-in-dysplasia-evaluation
#17
Gabriele Lami, Andrea Galli, Giuseppe Macrì, Emanuele Dabizzi, Maria Rosa Biagini, Mirko Tarocchi, Luca Messerini, Rosa Valanzano, Stefano Milani, Simone Polvani
AIM: To test the fujinon intelligent color enhancement (FICE) in identifying dysplastic or adenomatous polyps in familial adenomatous polyposis (FAP) patients. METHODS: Seventy-six consecutive FAP patients, already treated by colectomy and members of sixty-five families, were enrolled. A FICE system for the upper gastro-intestinal tract with an electronic endoscope system and a standard duodenoscope (for side-viewing examination) were used by two expert examiners...
April 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28430953/gastric-proteins-muc5ac-and-tff1-as-potential-diagnostic-markers-of-colonic-sessile-serrated-adenomas-polyps
#18
Magomed Khaidakov, Keith K Lai, D Roudachevski, Julietta Sargsyan, Hannah E Goyne, Rish K Pai, Laura W Lamps, Curt H Hagedorn
Objectives: A subset of colon cancers originates from sessile serrated adenomas/polyps (SSA/Ps). Our goal was to identify markers for SSA/Ps that could aid in distinguishing them from hyperplastic polyps (HPs). Methods: We performed immunostaining for gastric proteins MUC5AC and TFF1 in formalin-fixed, paraffin-embedded (FFPE) samples of HPs (n = 47), SSA/Ps (n = 37), and normal colon (n = 30). Results: Control mucosa expressed only trace amounts of MUC5AC and TFF1...
November 1, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28429649/fundic-gland-polyps-in-the-pediatric-population
#19
Amy Coffey, Kalyani Patel, Norma Quintanilla, Richard Kellermayer, Hao Wu
We retrospectively studied the clinical and histologic features of pediatric fundic gland polyps (FGPs) in 16 patients. FGPs had an endoscopic prevalence of 0.25% in 8527 pediatric gastric biopsies. Five patients had familial adenomatous polyposis (FAP). The median age of onset was 17.7 years in FAP and 17.3 years in sporadic patients. All syndromic patients were asymptomatic and FGPs were identified during surveillance for existing or concurrent colon polyps. They did not take antacids. In comparison, all 11 sporadic FGPs were identified during evaluation of symptomatic patients who had taken antacids (median duration 21 months)...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28394803/hpv-negative-gastric-type-adenocarcinoma-in-situ-of-the-cervix-a-spectrum-of-rare-lesions-exhibiting-gastric-and-intestinal-differentiation
#20
Karen L Talia, Colin J R Stewart, Brooke E Howitt, Marisa R Nucci, W Glenn McCluggage
In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium...
August 2017: American Journal of Surgical Pathology
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