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https://www.readbyqxmd.com/read/28727416/in-situ-electrochemical-sensing-and-real-time-monitoring-live-cells-based-on-freestanding-nanohybrid-paper-electrode-assembled-from-3d-functionalized-graphene-framework
#1
Yan Zhang, Jian Xiao, Qi-Ying Lv, Lu Wang, Xulin Dong, Muhammad Asif, Jinghua Ren, Wenshan He, Yimin Sun, Fei Xiao, Shuai Wang
In this work, we develop a new type of freestanding nanohybrid paper electrode assembled from 3D ionic liquid (IL) functionalized graphene framework (GF) decorated by gold nanoflowers (AuNFs), and explore its practical application in in-situ electrochemical sensing of live breast cell samples by real-time tracking biomarker H2O2 released from cells. The AuNFs modified IL functionalized GF (AuNFs/IL-GF) was synthesized via a facile and efficient dopamine assisted one-pot self-assembly strategy. The as-obtained nanohybrid assembly exhibits a typical 3D hierarchical porous structure, where the highly active electrocatalyst AuNFs are well dispersed on IL-GF scaffold...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28723155/inhibiting-the-fibrillation-of-serum-albumin-proteins-in-presence-of-surface-active-ionic-liquids-sails-at-low-ph-a-spectroscopic-and-microscopic-study
#2
Sangita Kundu, Chiranjib Banerjee, Nilmoni Sarkar
One of the key necessary steps to prevent human neurological disorders is the efficient disruption of protein aggregation or amyloid fibril. In this article, we have explored the effect of three amphiphilic surface active ionic liquids (SAILs) namely 1-methyl-3-octylimidazolium chloride ([C8mim]Cl), 1-dodecyl-3-methyllimidazolium chloride ([C12mim]Cl) and 1-hexadecyl-3-methyllimidazolium chloride ([C16mim]Cl) having concentration of 5.8 mM, 0.29 mM and 0.08 mM respectively on bovine serum albumin (BSA) and human serum albumin (HSA) fibril...
July 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28722688/spin-dependent-seebeck-effects-in-a-graphene-superlattice-p-n-junction-with-different-shapes
#3
Benhu Zhou, Benliang Zhou, Yagang Yao, Guanghui Zhou, Ming Hu
We theoretically calculate spin-dependent transmission probability and spin Seebeck coefficient for a zigzagedge graphene nanoribbon (ZGNR) p-n junction with periodically attached stubs under a perpendicular magnetic field and a ferromagnetic insulator. By using the nonequilibrium Green's function (NEGF) method combining with the tight-binding Hamiltonian, it is demonstrated that, the spin-dependent transmission probability and spin Seebeck coefficient for two types of superlattices can be modulated by the potential drop, the magnetization strength, the number of periods of the superlattice, the strength of the perpendicular magnetic field, and the Anderson disorder strength...
July 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#4
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28716609/oxytocin-reduces-alcohol-consumption-in-prairie-voles
#5
J R Stevenson, S M Wenner, D M Freestone, C C Romaine, M C Parian, S M Christian, A E Bohidar, J R Ndem, I R Vogel, C M O'Kane
Alcohol use disorder (AUD) negatively affects millions of people every year in the United States, and effective treatments for AUD are still needed. The neuropeptide oxytocin has shown promise for reducing alcohol drinking in mice and rats. Because oxytocin also plays a key role in complex prosocial behaviors like bonding and attachment, we tested the effect of oxytocin on alcohol drinking in prairie voles, a species that both consumes high amounts of alcohol and forms oxytocin dependent social bonds in a manner similar to humans...
July 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28715704/oxytocin-receptor-gene-polymorphisms-attachment-and-ptsd-results-from-the-national-health-and-resilience-in-veterans-study
#6
Lauren M Sippel, Shizhong Han, Laura E Watkins, Ilan Harpaz-Rotem, Steven M Southwick, John H Krystal, Miranda Olff, Richard Sherva, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter, Robert H Pietrzak
The human oxytocin system is implicated in social behavior and stress recovery. Polymorphisms in the oxytocin receptor gene (OXTR) may interact with attachment style to predict stress-related psychopathology like posttraumatic stress disorder (PTSD). The objective of this study was to examine independent and interactive effects of the OXTR single nucleotide polymorphism (SNP) rs53576, which has been associated with stress reactivity, support-seeking, and PTSD in prior studies, and attachment style on risk for PTSD in a nationally representative sample of 2163 European-American (EA) U...
July 8, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28709671/mechanism-and-properties-of-positive-allosteric-modulation-of-n-methyl-d-aspartate-receptors-by-6-alkyl-2-naphthoic-acid-derivatives
#7
Kiran Sapkota, Mark W Irvine, Guangyu Fang, Erica S Burnell, Neil Bannister, Arturas Volianskis, Georgia R Culley, Shashank M Dravid, Graham L Collingridge, David E Jane, Daniel T Monaghan
The theory that N-methyl-d-aspartate receptor (NMDAR) hypofunction is responsible for the symptoms of schizophrenia is well supported by many pharmacological and genetic studies. Accordingly, positive allosteric modulators (PAMs) that augment NMDAR signaling may be useful for treating schizophrenia. Previously we have identified several NMDAR PAMs containing a carboxylic acid attached to naphthalene, phenanthrene, or coumarin ring systems. In this study, we describe several functional and mechanistic properties of UBP684, a 2-naphthoic acid derivative, which robustly potentiates agonist responses at each of the four GluN1a/GluN2 receptors and at neuronal NMDARs...
July 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28704829/prevalence-of-and-risk-factors-for-secondary-traumatization-in-interpreters-for-refugees-a-cross-sectional-study
#8
David Kindermann, Carolin Schmid, Cassandra Derreza-Greeven, Daniel Huhn, Rupert Maria Kohl, Florian Junne, Maritta Schleyer, Judith K Daniels, Beate Ditzen, Wolfgang Herzog, Christoph Nikendei
BACKGROUND: A substantial proportion of refugees, fleeing persecution, torture, and war, are estimated to suffer from psychological traumatization. After being sheltered in reception centers, the refugees come in close contact with different occupational groups, e.g., physicians, social workers, and interpreters. Previous studies ascertained that such interpreters themselves often suffer from primary psychological traumatization. Moreover, through translating refugees' potentially traumatic depictions, the interpreters are in danger of developing a so-called secondary traumatization...
July 14, 2017: Psychopathology
https://www.readbyqxmd.com/read/28701967/a-novel-integrating-virtual-reality-approach-for-the-assessment-of-the-attachment-behavioral-system
#9
Irene Alice Chicchi Giglioli, Gabriella Pravettoni, Dolores Lucia Sutil Martín, Elena Parra, Mariano A Raya
Virtual reality (VR) technology represents a novel and powerful tool for behavioral research in psychological assessment. VR provides simulated experiences able to create the sensation of undergoing real situations. Users become active participants in the virtual environment seeing, hearing, feeling, and actuating as if they were in the real world. Currently, the most psychological VR applications concern the treatment of various mental disorders but not the assessment, that it is mainly based on paper and pencil tests...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28698488/dementia-at-the-end-of-life-and-family-partners-a-symbolic-interactionist-perspective-on-communication
#10
Christopher Johnson, Jordan Kelch, Roxanna Johnson
People with dementia are not dying; they are experiencing changes in the brain. This paper utilizes a symbolic interaction theoretical perspective to outline communicative alternatives to polypharmacy. There is a growing interest in sociological interventions to untangle the "disordered discourses" associated with dementia. Such practices challenge common stigmas attached to dementia as an "ongoing funeral" or "death certificate." Changing the expectations, attitudes and communication patterns of family care partners can positively impact them and the person living with dementia at the end of life...
July 9, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28693401/formulating-autism-systemically-part-1-a-review-of-the-published-literature-and-case-assessments
#11
Patricia M Crittenden
Autism is a psychiatric disorder of unknown aetiology. In this article, the literature on genetic, neurological, psychological, relational and cultural causes of autism is reviewed, beginning with the 2014 review of Crittenden, Dallos, Landini et al. (pp. 64-70) up to and including recent publications in 2017. Some of the findings were unexpected; others led to new questions. The unexpected findings were the minimal contribution of genes to autism, the extremely evident neurological differences, the interpersonal quality of the psychological findings (that lacked evidence of parents' behaviour), the relational evidence that mothers' childhood trauma, perinatal stress and marital stress increased the risk of autism, and the reciprocal relation between funding for treatment of autism and diagnoses of autism...
July 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28691843/associations-of-borderline-personality-disorder-traits-with-stressful-events-and-emotional-reactivity-in-women-with-bulimia-nervosa
#12
Carolyn M Pearson, Jason M Lavender, Li Cao, Stephen A Wonderlich, Ross D Crosby, Scott G Engel, James E Mitchell, Carol B Peterson, Scott J Crow
Borderline personality disorder (BPD) traits are common among those with bulimia nervosa (BN). However, how these traits impact the state experience of precipitants of BN behavior, such as stressful events and emotional reactivity, has not been determined. Thus, the purpose of this naturalistic study was to examine this trait-state association in BN. Women with DSM-IV BN (N = 133) completed a baseline measure of personality pathology traits, and subsequently recorded their affective state and the frequency and perception of 3 types of stressful events (interpersonal, work/environment, and daily hassles) several times per day for 2 weeks using ecological momentary assessment (EMA)...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28686560/-hoarding-disorder-in-dsm-5-clinical-description-and-cognitive-approach
#13
L Kalogeraki, I Michopoulos
Hoarding disorder is characterized by difficulty discarding or parting with possessions regardless their actual value as well as, in most cases, persistent acquisition of objects. Possessions are accumulated in large numbers that fill up and clutter active living space to the extent that its intended use is no longer possible resulting to significant functional impairment and/or distress. Saving and difficulty discarding appear to be associated to subjective beliefs about the instrumental, sentimental or intrinsic value of objects...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28686162/-the-etiology-of-obsessive-compulsive-disorder-from-the-aspects-of-attachment-theory-with-special-regard-to-perceived-parental-treatment-attachment-patterns-and-emotion-regulation-difficulties
#14
Nóra Rejtô, Gábor Papp, Judit Molnár
BACKGROUND AND AIMS: The focus of our study was the etiology of obsessive-compulsive disorder from attachment aspects. Our aim was to examine the representations of perceived parental treatment, attachment patterns and the level of emotion regulation of people who suffer from obsessive-compulsive disorder. METHOD: 223 people participated in our study. The clinical group consisted of 92 persons with obsessive-compulsive symptoms, while the control group involved 131 people without OC symptoms...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28684192/involvement-of-sphingosine-kinase-sphingosine-1-phosphate-metabolic-pathway-in-spondyloarthritis
#15
Carole Bougault, Alaeddine El Jamal, Anne Briolay, Saida Mebarek, Marie-Astrid Boutet, Thomas Garraud, Benoit Le Goff, Fréderic Blanchard, David Magne, Leyre Brizuela
Spondyloarthritis (SpA) is a relatively common chronic inflammatory joint disorder, with a prevalence of about 0.2-0.5% worldwide. The primary target of the pathological process is the enthesis, where tendons and ligaments attach to underlying bone. These insertion sites are hotspots of bone formation (enthesophytes), which can lead to ankylosis. Unfortunately, the mechanisms causing the onset and progression of entheseal ossification remain largely unknown. Sphingosine 1-phosphate (S1P), a lipid generated after sphingosine phosphorylation by sphingosine kinases 1 and 2 (SK1/2), plays important roles in cell proliferation, differentiation and survival...
July 3, 2017: Bone
https://www.readbyqxmd.com/read/28680639/subtypes-of-borderline-personality-disorder-patients-a-cluster-analytic-approach
#16
Maaike L Smits, Dine J Feenstra, Dawn L Bales, Jasmijn de Vos, Zwaan Lucas, Roel Verheul, Patrick Luyten
BACKGROUND: The borderline personality disorder (BPD) population is notably heterogeneous, and this has potentially important implications for intervention. Identifying distinct subtypes of patients may represent a first step in identifying which treatments work best for which individuals. METHODS: A cluster-analysis on dimensional personality disorder (PD) features, as assessed with the SCID-II, was performed on a sample of carefully screened BPD patients (N = 187) referred for mentalization-based treatment...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28670988/-the-relationship-of-attachment-features-and-multi-impulsive-symptoms-in-eating-disorders
#17
Tamás Dömötör Szalai
INTRODUCTION: Attachment dysfunctions determine borderline personality disorder, which is a frequent background factor of multi-impulsivity; however, the relationship between attachment and multi-impulsive eating disorders is almost unexplored. AIM: To compare attachment features of multi-impulsive and classical eating disorder patients with individuals without eating disorders, and to test attachment as a predictor of multi-impulsivity. METHOD: A cross-sectional survey (148 females, mean age: 30...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28670707/radiosynthesis-and-evaluation-of-1-substituted-3-2-3-dihydro-1h-inden-2-yl-6-1-ethylpropyl-3r-6r-2-5-piperazinedione-derivatives-as-pet-tracers-for-imaging-the-central-oxytocinergic-system
#18
Carmine Marzano, Steen Jacobsen, Cristian Salinas, Sac Pham Tang, Dirk Bender, Jan Passchier, Christophe Plisson
Oxytocin is known to be implicated in a variety of functions, such as learning, stress, anxiety, feeding and pain perception. Oxytocin is also important for social memory and attachment, human bonding, sexual and maternal behaviour, and aggression. Human disorders characterized by aberrant social interactions, such as autism and schizophrenia, may also involve abnormal oxytocin levels. GSK712043, GSK711320 and GSK664004, three antagonists exhibiting sub-nanomolar affinity for the human oxytocin receptor (hOTR) and high selectivity over vasopressin receptors were successfully labelled with carbon-11 with suitable yields (0...
July 3, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28665521/traumatic-stress-in-patients-with-acute-leukemia-a-prospective-cohort-study
#19
Gary Rodin, Amy Deckert, Eryn Tong, Lisa W Le, Anne Rydall, Aaron Schimmer, Charles R Marmar, Chris Lo, Camilla Zimmermann
OBJECTIVE: Acute leukemia (AL) is associated with an immediate threat to life, an unpredictable clinical course, and substantial physical suffering. Traumatic stress symptoms that may meet criteria for acute stress disorder (ASD) may be common and disabling in this context, but have received little clinical attention. We investigated the incidence over time and risk factors for traumatic stress symptoms and ASD in the 3 months following diagnosis or relapse of AL. METHODS: Individuals with AL were recruited at a tertiary cancer centre in Canada within one month of diagnosis or relapse...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28664328/timeline-of-intergenerational-child-maltreatment-the-mind-brain-body-interplay
#20
REVIEW
Marija Mitkovic Voncina, Milica Pejovic Milovancevic, Vanja Mandic Maravic, Dusica Lecic Tosevski
PURPOSE OF REVIEW: Still obscure mechanisms of intergenerational child maltreatment (ITCM) have been investigated partially, from various psychological and biological perspectives and from various time perspectives. This review is aimed at integrating the findings on different temporal ITCM pathways, emphasizing the mind-brain-body interplay. RECENT FINDINGS: Psychological mediators of ITCM involve attachment, mentalization, dissociation, social information processing, personality traits, and psychiatric disorders...
August 2017: Current Psychiatry Reports
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