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https://www.readbyqxmd.com/read/28915904/tiga-cub-manualised-psychoanalytic-child-psychotherapy-versus-treatment-as-usual-for-children-aged-5-11-years-with-treatment-resistant-conduct-disorders-and-their-primary-carers-study-protocol-for-a-randomised-controlled-feasibility-trial
#1
Elizabeth Edginton, Rebecca Walwyn, Kayleigh Burton, Robert Cicero, Liz Graham, Sadie Reed, Sandy Tubeuf, Maureen Twiddy, Alex Wright-Hughes, Lynda Ellis, Dot Evans, Tom Hughes, Nick Midgley, Paul Wallis, David Cottrell
BACKGROUND: The National Institute for Health and Care Excellence (NICE) recommends evidence-based parenting programmes as a first-line intervention for conduct disorders (CD) in children aged 5-11 years. As these are not effective in 25-33% of cases, NICE has requested research into second-line interventions. Child and Adolescent Psychotherapists (CAPTs) address highly complex problems where first-line treatments have failed and there have been small-scale studies of Psychoanalytic Child Psychotherapy (PCP) for CD...
September 15, 2017: Trials
https://www.readbyqxmd.com/read/28915376/psychometric-properties-of-the-postpartum-bonding-questionnaire-and-correlates-of-mother-infant-bonding-impairment-in-italian-new-mothers
#2
Alessandra Busonera, Stefania Cataudella, Jessica Lampis, Marco Tommasi, Giulio Cesare Zavattini
OBJECTIVE: impaired maternal bonding is a risk factor for problems with infant well-being and development. The investigation of perinatal variables related to disorders of the mother-infant relationship as well as the administration of reliable and valid screening tools to new mothers in the postpartum can help identify early signs of a disturbed mother-child relationship. The Postpartum Bonding Questionnaire (PBQ) has been shown to be a valid screening instrument, but its dimensional structure is still controversial...
September 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28912798/comparative-genomic-analysis-of-the-human-gut-microbiome-reveals-a-broad-distribution-of-metabolic-pathways-for-the-degradation-of-host-synthetized-mucin-glycans-and-utilization-of-mucin-derived-monosaccharides
#3
Dmitry A Ravcheev, Ines Thiele
The colonic mucus layer is a dynamic and complex structure formed by secreted and transmembrane mucins, which are high-molecular-weight and heavily glycosylated proteins. Colonic mucus consists of a loose outer layer and a dense epithelium-attached layer. The outer layer is inhabited by various representatives of the human gut microbiota (HGM). Glycans of the colonic mucus can be used by the HGM as a source of carbon and energy when dietary fibers are not sufficiently available. Both commensals and pathogens can utilize mucin glycans...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28905880/mutations-in-rars-cause-a-hypomyelination-disorder-akin-to-pelizaeus-merzbacher-disease
#4
Michael Nafisinia, Nara Sobreira, Lisa Riley, Wendy Gold, Birgit Uhlenberg, Claudia Weiß, Corinne Boehm, Kristina Prelog, Robert Ouvrier, John Christodoulou
Pelizaeus-Merzbacher disease (PMD) is a rare Mendelian disorder characterised by central nervous system hypomyelination. PMD typically manifests in infancy or early childhood and is caused by mutations in proteolipid protein-1 (PLP1). However, variants in several other genes including gap junction protein gamma 2 (GJC2) can also cause a similar phenotype and are referred to PMD-like disease (PMLD). Whole-exome sequencing in two siblings presenting with clinical symptoms of PMD revealed a homozygous variant in the arginyl-tRNA synthetase (RARS) gene: NM_002887...
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28903103/change-of-unresolved-attachment-in-borderline-personality-disorder-rct-study-of-transference-focused-psychotherapy
#5
Anna Buchheim, Susanne Hörz-Sagstetter, Stephan Doering, Michael Rentrop, Peter Schuster, Peter Buchheim, Dan Pokorny, Melitta Fischer-Kern
No abstract text is available yet for this article.
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28899753/precise-gene-editing-of-chicken-na-h-exchange-type-1-chnhe1-confers-resistance-to-avian-leukosis-virus-subgroup-j-alv-j
#6
Hong Jo Lee, Kyung Youn Lee, Kyung Min Jung, Kyung Je Park, Ko On Lee, Jeong-Yong Suh, Yongxiu Yao, Venugopal Nair, Jae Yong Han
Avian leukosis virus subgroup J (ALV-J), first isolated in the late 1980s, has caused economic losses to the poultry industry in many countries. As all chicken lines studied to date are susceptible to ALV infection, there is enormous interest in developing resistant chicken lines. The ALV-J receptor, chicken Na(+)/H(+) exchange 1 (chNHE1) and the critical amino acid sequences involved in viral attachment and entry have already been characterized. However, there are no reported attempts to induce resistance to the virus by targeted genome modification of the receptor sequences...
September 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28895183/self-concept-in-institutionalized-children-with-disturbed-attachment-the-mediating-role-of-exploratory-behaviours
#7
V S Vacaru, P S Sterkenburg, C Schuengel
BACKGROUND: Self-concept is seen as both an outcome of sociocognitive and emotional development, and a factor in social and mental health outcomes. Although the contribution of attachment experiences to self-concept has been limited to quality of primary attachment relationships, little is known of the effects of disturbed attachment on self-concept in institutionalized children. Thus, the current study examined associations between disturbed attachment behaviours in institutionalized children and self-concept, testing limited exploration as an explanatory factor...
September 11, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28883918/predicting-intolerance-of-uncertainty-in-individuals-with-eating-disorder-symptoms
#8
Lot C Sternheim, Martin Fisher, Amy Harrison, Rosamond Watling
BACKGROUND: Intolerance of Uncertainty (IU) is recognized for its contribution to various psychopathologies, in particular anxiety and depression. Studies highlight the relevance of IU for Eating Disorders (EDs) however, potential factors contributing to IU in EDs remain unstudied. METHODS: Three hundred and forty-nine women with ED symptoms and 214 individuals without ED symptoms were recruited and compared on levels of IU, insecure (anxious and avoidant) attachment styles, extraversion and openness...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28882085/psychotherapeutic-and-vocational-interventions-among-young-adults-with-work-disability-due-to-mental-disorders-in-finland
#9
Pauliina Mattila-Holappa, Matti Joensuu, Kirsi Ahola, Teija Kivekäs, Mika Kivimäki, Aki Koskinen, Marianna Virtanen
Backround: Little is known about treatment and rehabilitation received and planned among young adults with work disability due to a mental disorder. AIMS: To examine the implemented psychotherapeutic and vocational interventions and treatment plans among young adults with work disability due to a mental disorder. MATERIAL AND METHODS: Data were collected from medical records of young Finnish adults aged 18-34 with a long-term work disability history due to a mental disorder (N = 1163)...
September 7, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28880415/pregnant-substance-abusers-in-voluntary-and-coercive-treatment-in-norway-therapists-reflections-on-change-processes-and-attachment-experiences
#10
Siv Merete Myra, Edle Ravndal, Vigdis Wie Torsteinsson, Anne Kyong Sook Øfsti
AIMS AND OBJECTIVES: To explore therapists' discourses on treatment processes, when working with pregnant substance abusers in voluntary and coercive treatment, and looking for the clinical implications of these discourses. BACKGROUND: Treatment of Substance Use Disorder (SUDs) faces many challenges. One is pregnancy and motherhood, which are vulnerable and complex processes. The literature emphasizes lack of optimal and knowledge-based treatment for this group...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28877484/effect-of-a-paramagnetic-spin-label-on-the-intrinsically-disordered-peptide-ensemble-of-amyloid-%C3%AE
#11
Sukanya Sasmal, James Lincoff, Teresa Head-Gordon
Paramagnetic relaxation enhancement is an NMR technique that has yielded important insight into the structure of folded proteins, although the perturbation introduced by the large spin probe might be thought to diminish its usefulness when applied to characterizing the structural ensembles of intrinsically disordered proteins (IDPs). We compare the computationally generated structural ensembles of the IDP amyloid-β42 (Aβ42) to an alternative sequence in which a nitroxide spin label attached to cysteine has been introduced at its N-terminus...
September 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28870203/the-dlgap-family-neuronal-expression-function-and-role-in-brain-disorders
#12
REVIEW
Andreas H Rasmussen, Hanne B Rasmussen, Asli Silahtaroglu
The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing...
September 4, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28867131/posterior-vitreous-detachment-and-the-posterior-hyaloid-membrane
#13
Gregory S Fincham, Sean James, Carl Spickett, Michael Hollingshead, Christopher Thrasivoulou, Arabella V Poulson, Annie McNinch, Allan Richards, David Snead, Gloria A Limb, Martin P Snead
PURPOSE: Despite posterior vitreous detachment being a common ocular event affecting most individuals in an aging population, there is little consensus regarding its precise anatomic definition. We investigated the morphologic appearance and molecular composition of the posterior hyaloid membrane to determine whether the structure clinically observed enveloping the posterior vitreous surface after posterior vitreous detachment is a true basement membrane and to postulate its origin. Understanding the relationship between the vitreous (in both its attached and detached state) and the internal limiting membrane of the retina is essential to understanding the cause of rhegmatogenous retinal detachment and vitreoretinal interface disorders, as well as potential future prophylactic and treatment strategies...
August 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28863607/effect-of-level-difference-between-left-and-right-vocal-folds-on-phonation-physical-experiment-and-theoretical-study
#14
Isao T Tokuda, Ryo Shimamura
As an alternative factor to produce asymmetry between left and right vocal folds, the present study focuses on level difference, which is defined as the distance between the upper surfaces of the bilateral vocal folds in the inferior-superior direction. Physical models of the vocal folds were utilized to study the effect of the level difference on the phonation threshold pressure. A vocal tract model was also attached to the vocal fold model. For two types of different models, experiments revealed that the phonation threshold pressure tended to increase as the level difference was extended...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28851636/sle-autoantibodies-are-well-recognized-by-peroxynitrite-modified-hsa-its-implications-in-the-pathogenesis-of-sle
#15
Zarina Arif, Km Neelofar, Akhlas Tarannum, Mir Yasir Arfat, Shafeeque Ahmad, Asif Zaman, Mohd Adnan Khan, Asim Badar, Shireen Naaz Islam, Mohammad Arif Iqubal
Systemic lupus erythematosus (SLE) is an autoimmune disorder where the role of inflammatory processes in the etiopathogenesis is well documented. Despite extensive research, the trigger for initiation of the disease has not been identified. Peroxynitrite, a strong nitrating/oxidizing agent has been reported in SLE and other autoimmune diseases. In this study, human serum albumin (HSA) was exposed to peroxynitrite for 30min at 37°C. The structure of HSA was grossly perturbed when examined by various physico-chemical techniques...
August 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28841921/growing-up-hiv-positive-in-uganda-psychological-immunodeficiency-a-qualitative-study
#16
Birthe Loa Knizek, James Mugisha, Joseph Osafo, Eugene Kinyanda
BACKGROUND: This study is part of a longitudinal study among children and adolescents with HIV in both urban and rural Uganda: 'Mental health among HIV infected CHildren and Adolescents in KAmpala and Masaka, Uganda (CHAKA)'. METHOD: The study is constructed of both quantitative and qualitative components. In this article we report a qualitative study on the experiences of 21 adolescents (twelve to seventeen years) living with HIV in Uganda. The purpose of the study was to investigate both the protective and the risk factors in HIV-infected adolescents' care environment in order to understand what might contribute to negative outcomes and what might provide a protective buffer against harmful life events...
August 25, 2017: BMC Psychology
https://www.readbyqxmd.com/read/28841475/reflective-function-mediates-the-relationship-between-emotional-maltreatment-and-borderline-pathology-in-adolescents-a-preliminary-investigation
#17
Jeremy Quek, Louise K Newman, Clair Bennett, Michael S Gordon, Naysun Saeedi, Glenn A Melvin
Deficits in mentalizing, particularly within the context of attachment relationships i.e., reflective function (RF), are posited to result from childhood maltreatment and to influence the development of borderline personality disorder (BPD). Whilst a mentalization-based model of BPD provides a theoretical explanation, direct empirical support for this model, in linking childhood maltreatment to borderline pathology remains limited. This study examined the interrrelationships between childhood maltreatment, RF, and borderline pathology in a mixed adolescent sample, consisting of adolescents with BPD (n=26) and a group of non-clinical adolescents (n=25)...
August 22, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28835066/-attaching-importance-to-molecular-imaging-techniques-and-promoting-precision-diagnosis-in-burns
#18
Y M Yu, X Peng
The explosive growth and advancement of computer science in recent decades have prompted the rapid development and wide applications of imaging techniques in life science, which have brought about revolutionary changes in modern medicine. Nowadays, it is possible to visualize multiple physiological and disease processes, precisely and non-invasively, in a living human body. Modern medicine has even started"reading the mind", to diagnose psychology, behavior and degenerative disorders of human brain. The border between the organic and inorganic diseases in old dogma is disappearing because imaging techniques have"visualized"the neurological and tissue changes of inorganic disorders...
August 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28833940/taking-tests-in-the-magnet-brain-mapping-standardized-tests
#19
David C Rubin, Dawei Li, Shana A Hall, Philip A Kragel, Dorthe Berntsen
Standardized psychometric tests are sophisticated, well-developed, and consequential instruments; test outcomes are taken as facts about people that impact their lives in important ways. As part of an initial demonstration that human brain mapping techniques can add converging neural-level evidence to understanding standardized tests, our participants completed items from standardized tests during an fMRI scan. We compared tests for diagnosing posttraumatic stress disorder (PTSD) and the correlated measures of Neuroticism, Attachment, and Centrality of Event to a general-knowledge baseline test...
August 18, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28831948/social-and-psychological-consequences-of-not-crying-possible-associations-with-psychopathology-and-therapeutic-relevance
#20
Dale C Hesdorffer, Ad J J M Vingerhoets, Michael R Trimble
OBJECTIVE: Emotional crying is hypothesized to serve intra- and interpersonal functions. Intrapersonal functions are assumed to facilitate the capacity to recover from emotional distress, thus promoting well-being. Interpersonal functions are postulated to have a major impact on social functioning. We hypothesized that non-criers would have lower well-being and poorer social functioning than criers. METHODS: Study participants included 475 people who reportedly lost the capacity to cry and 179 "normal" control criers...
August 23, 2017: CNS Spectrums
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