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JOURNAL ARTICLE
Enrico De Lorenzis, Silvia Laura Bosello, Francesco Varone, Giacomo Sgalla, Lucio Calandriello, Gerlando Natalello, Bruno Iovene, Giuseppe Cicchetti, Laura Gigante, Lucrezia Verardi, Elisa Gremese, Luca Richeldi, Anna Rita Larici
Multidisciplinary team (MDT) discussion is the gold standard in the management of interstitial lung disease (ILD). The rheumatologist is not routinely involved in MDT, even if up to 20% of ILD are related to systemic autoimmune rheumatic diseases (SARD). The study aims to assess the agreement and its variation over time between rheumatologists and pulmonologists in the screening of SARD and between rheumatologists and an MDT extended to rheumatologists (eMDT) in evaluating the progression of SARD. We computed the agreement between the pulmonologist and rheumatologist in the identification of red flags for SARDs of 81 ILD cases and between the rheumatologist alone and eMDT in the confirmation of 70 suspected SARD-ILD progressions...
September 2, 2020: Diagnostics
#22
JOURNAL ARTICLE
Francesco Varone, Ludovica Friello, Chiara Di Blasi, Giacomo Sgalla, Marco Luigetti, Bruno Iovene, Luca Richeldi, Giacomo Della Marca, Valerio Brunetti
OBJECTIVE: Sleep disorders have a high prevalence among patients with idiopathic pulmonary fibrosis (IPF). The prevalence of restless legs syndrome (RLS) is not known in these patients, neither is its clinical impact as a comorbidity. We investigated the association of RLS with IPF and characterized the clinical features of RLS in a cohort of IPF patients. METHODS: Fifty patients with diagnosis of IPF were prospectively enrolled. RLS was diagnosed using the validated 5-item RLS criteria...
August 2020: Respiratory Medicine
#23
JOURNAL ARTICLE
Teresa Bruni, Francesco Varone
Nintedanib shows a statistically significant effect on lung function decay in patients with ILD secondary to systemic sclerosis, but no effect on skin fibrosis and on health-related quality of life https://bit.ly/2vfJRj7.
June 2020: Breathe
#24
JOURNAL ARTICLE
Francesco Varone, Giacomo Sgalla, Bruno Iovene, Luca Richeldi
No abstract text is available yet for this article.
October 2020: Annals of the American Thoracic Society
#25
REVIEW
Francesco Varone, Bruno Iovene, Giacomo Sgalla, Mariarosaria Calvello, Angelo Calabrese, Anna Rita Larici, Luca Richeldi
Fibrotic hypersensitivity pneumonitis is a complex interstitial lung disease that is not entirely understood. In its chronic and fibrotic form, hypersensitivity pneumonitis is one of the main mimickers of idiopathic pulmonary fibrosis (IPF). Distinguishing between these two conditions is challenging but is of particular clinical relevance. Two approved therapies are available for IPF, and a considerable number of clinical trials are now exploring newer pharmacological options. This impressive research effort is a consequence of new pathogenetic understanding, updated diagnostic criteria and a long history of pharmacological trials...
June 2020: Lung
#26
MULTICENTER STUDY
Giacomo Sgalla, Erminia Lo Greco, Mariarosaria Calvello, Francesco Varone, Bruno Iovene, Stefania Cerri, Pierluigi Donatelli, Ada Vancheri, Mauro Pavone, Fabrizio Luppi, Carlo Vancheri, Luca Richeldi
BACKGROUND AND OBJECTIVE: In clinical practice, a working diagnosis of IPF may be performed to provide effective antifibrotic treatment to patients who cannot undergo SLB. In this study, we compared the disease course across IPF diagnostic categories in a real-life clinical setting to clarify the appropriateness of a working diagnosis of IPF and treatment initiation in these patients. METHODS: Longitudinal data from IPF patients receiving antifibrotic treatment (pirfenidone or nintedanib) were retrospectively collected at three tertiary centres in Italy...
November 2020: Respirology: Official Journal of the Asian Pacific Society of Respirology
#27
JOURNAL ARTICLE
Jens Kattge, Gerhard Bönisch, Sandra Díaz, Sandra Lavorel, Iain Colin Prentice, Paul Leadley, Susanne Tautenhahn, Gijsbert D A Werner, Tuomas Aakala, Mehdi Abedi, Alicia T R Acosta, George C Adamidis, Kairi Adamson, Masahiro Aiba, Cécile H Albert, Julio M Alcántara, Carolina Alcázar C, Izabela Aleixo, Hamada Ali, Bernard Amiaud, Christian Ammer, Mariano M Amoroso, Madhur Anand, Carolyn Anderson, Niels Anten, Joseph Antos, Deborah Mattos Guimarães Apgaua, Tia-Lynn Ashman, Degi Harja Asmara, Gregory P Asner, Michael Aspinwall, Owen Atkin, Isabelle Aubin, Lars Baastrup-Spohr, Khadijeh Bahalkeh, Michael Bahn, Timothy Baker, William J Baker, Jan P Bakker, Dennis Baldocchi, Jennifer Baltzer, Arindam Banerjee, Anne Baranger, Jos Barlow, Diego R Barneche, Zdravko Baruch, Denis Bastianelli, John Battles, William Bauerle, Marijn Bauters, Erika Bazzato, Michael Beckmann, Hans Beeckman, Carl Beierkuhnlein, Renee Bekker, Gavin Belfry, Michael Belluau, Mirela Beloiu, Raquel Benavides, Lahcen Benomar, Mary Lee Berdugo-Lattke, Erika Berenguer, Rodrigo Bergamin, Joana Bergmann, Marcos Bergmann Carlucci, Logan Berner, Markus Bernhardt-Römermann, Christof Bigler, Anne D Bjorkman, Chris Blackman, Carolina Blanco, Benjamin Blonder, Dana Blumenthal, Kelly T Bocanegra-González, Pascal Boeckx, Stephanie Bohlman, Katrin Böhning-Gaese, Laura Boisvert-Marsh, William Bond, Ben Bond-Lamberty, Arnoud Boom, Coline C F Boonman, Kauane Bordin, Elizabeth H Boughton, Vanessa Boukili, David M J S Bowman, Sandra Bravo, Marco Richard Brendel, Martin R Broadley, Kerry A Brown, Helge Bruelheide, Federico Brumnich, Hans Henrik Bruun, David Bruy, Serra W Buchanan, Solveig Franziska Bucher, Nina Buchmann, Robert Buitenwerf, Daniel E Bunker, Jana Bürger, Sabina Burrascano, David F R P Burslem, Bradley J Butterfield, Chaeho Byun, Marcia Marques, Marina C Scalon, Marco Caccianiga, Marc Cadotte, Maxime Cailleret, James Camac, Jesús Julio Camarero, Courtney Campany, Giandiego Campetella, Juan Antonio Campos, Laura Cano-Arboleda, Roberto Canullo, Michele Carbognani, Fabio Carvalho, Fernando Casanoves, Bastien Castagneyrol, Jane A Catford, Jeannine Cavender-Bares, Bruno E L Cerabolini, Marco Cervellini, Eduardo Chacón-Madrigal, Kenneth Chapin, F Stuart Chapin, Stefano Chelli, Si-Chong Chen, Anping Chen, Paolo Cherubini, Francesco Chianucci, Brendan Choat, Kyong-Sook Chung, Milan Chytrý, Daniela Ciccarelli, Lluís Coll, Courtney G Collins, Luisa Conti, David Coomes, Johannes H C Cornelissen, William K Cornwell, Piermaria Corona, Marie Coyea, Joseph Craine, Dylan Craven, Joris P G M Cromsigt, Anikó Csecserits, Katarina Cufar, Matthias Cuntz, Ana Carolina da Silva, Kyla M Dahlin, Matteo Dainese, Igor Dalke, Michele Dalle Fratte, Anh Tuan Dang-Le, Jirí Danihelka, Masako Dannoura, Samantha Dawson, Arend Jacobus de Beer, Angel De Frutos, Jonathan R De Long, Benjamin Dechant, Sylvain Delagrange, Nicolas Delpierre, Géraldine Derroire, Arildo S Dias, Milton Hugo Diaz-Toribio, Panayiotis G Dimitrakopoulos, Mark Dobrowolski, Daniel Doktor, Pavel Dřevojan, Ning Dong, John Dransfield, Stefan Dressler, Leandro Duarte, Emilie Ducouret, Stefan Dullinger, Walter Durka, Remko Duursma, Olga Dymova, Anna E-Vojtkó, Rolf Lutz Eckstein, Hamid Ejtehadi, James Elser, Thaise Emilio, Kristine Engemann, Mohammad Bagher Erfanian, Alexandra Erfmeier, Adriane Esquivel-Muelbert, Gerd Esser, Marc Estiarte, Tomas F Domingues, William F Fagan, Jaime Fagúndez, Daniel S Falster, Ying Fan, Jingyun Fang, Emmanuele Farris, Fatih Fazlioglu, Yanhao Feng, Fernando Fernandez-Mendez, Carlotta Ferrara, Joice Ferreira, Alessandra Fidelis, Bryan Finegan, Jennifer Firn, Timothy J Flowers, Dan F B Flynn, Veronika Fontana, Estelle Forey, Cristiane Forgiarini, Louis François, Marcelo Frangipani, Dorothea Frank, Cedric Frenette-Dussault, Grégoire T Freschet, Ellen L Fry, Nikolaos M Fyllas, Guilherme G Mazzochini, Sophie Gachet, Rachael Gallagher, Gislene Ganade, Francesca Ganga, Pablo García-Palacios, Verónica Gargaglione, Eric Garnier, Jose Luis Garrido, André Luís de Gasper, Guillermo Gea-Izquierdo, David Gibson, Andrew N Gillison, Aelton Giroldo, Mary-Claire Glasenhardt, Sean Gleason, Mariana Gliesch, Emma Goldberg, Bastian Göldel, Erika Gonzalez-Akre, Jose L Gonzalez-Andujar, Andrés González-Melo, Ana González-Robles, Bente Jessen Graae, Elena Granda, Sarah Graves, Walton A Green, Thomas Gregor, Nicolas Gross, Greg R Guerin, Angela Günther, Alvaro G Gutiérrez, Lillie Haddock, Anna Haines, Jefferson Hall, Alain Hambuckers, Wenxuan Han, Sandy P Harrison, Wesley Hattingh, Joseph E Hawes, Tianhua He, Pengcheng He, Jacob Mason Heberling, Aveliina Helm, Stefan Hempel, Jörn Hentschel, Bruno Hérault, Ana-Maria Hereş, Katharina Herz, Myriam Heuertz, Thomas Hickler, Peter Hietz, Pedro Higuchi, Andrew L Hipp, Andrew Hirons, Maria Hock, James Aaron Hogan, Karen Holl, Olivier Honnay, Daniel Hornstein, Enqing Hou, Nate Hough-Snee, Knut Anders Hovstad, Tomoaki Ichie, Boris Igić, Estela Illa, Marney Isaac, Masae Ishihara, Leonid Ivanov, Larissa Ivanova, Colleen M Iversen, Jordi Izquierdo, Robert B Jackson, Benjamin Jackson, Hervé Jactel, Andrzej M Jagodzinski, Ute Jandt, Steven Jansen, Thomas Jenkins, Anke Jentsch, Jens Rasmus Plantener Jespersen, Guo-Feng Jiang, Jesper Liengaard Johansen, David Johnson, Eric J Jokela, Carlos Alfredo Joly, Gregory J Jordan, Grant Stuart Joseph, Decky Junaedi, Robert R Junker, Eric Justes, Richard Kabzems, Jeffrey Kane, Zdenek Kaplan, Teja Kattenborn, Lyudmila Kavelenova, Elizabeth Kearsley, Anne Kempel, Tanaka Kenzo, Andrew Kerkhoff, Mohammed I Khalil, Nicole L Kinlock, Wilm Daniel Kissling, Kaoru Kitajima, Thomas Kitzberger, Rasmus Kjøller, Tamir Klein, Michael Kleyer, Jitka Klimešová, Joice Klipel, Brian Kloeppel, Stefan Klotz, Johannes M H Knops, Takashi Kohyama, Fumito Koike, Johannes Kollmann, Benjamin Komac, Kimberly Komatsu, Christian König, Nathan J B Kraft, Koen Kramer, Holger Kreft, Ingolf Kühn, Dushan Kumarathunge, Jonas Kuppler, Hiroko Kurokawa, Yoko Kurosawa, Shem Kuyah, Jean-Paul Laclau, Benoit Lafleur, Erik Lallai, Eric Lamb, Andrea Lamprecht, Daniel J Larkin, Daniel Laughlin, Yoann Le Bagousse-Pinguet, Guerric le Maire, Peter C le Roux, Elizabeth le Roux, Tali Lee, Frederic Lens, Simon L Lewis, Barbara Lhotsky, Yuanzhi Li, Xine Li, Jeremy W Lichstein, Mario Liebergesell, Jun Ying Lim, Yan-Shih Lin, Juan Carlos Linares, Chunjiang Liu, Daijun Liu, Udayangani Liu, Stuart Livingstone, Joan Llusià, Madelon Lohbeck, Álvaro López-García, Gabriela Lopez-Gonzalez, Zdeňka Lososová, Frédérique Louault, Balázs A Lukács, Petr Lukeš, Yunjian Luo, Michele Lussu, Siyan Ma, Camilla Maciel Rabelo Pereira, Michelle Mack, Vincent Maire, Annikki Mäkelä, Harri Mäkinen, Ana Claudia Mendes Malhado, Azim Mallik, Peter Manning, Stefano Manzoni, Zuleica Marchetti, Luca Marchino, Vinicius Marcilio-Silva, Eric Marcon, Michela Marignani, Lars Markesteijn, Adam Martin, Cristina Martínez-Garza, Jordi Martínez-Vilalta, Tereza Mašková, Kelly Mason, Norman Mason, Tara Joy Massad, Jacynthe Masse, Itay Mayrose, James McCarthy, M Luke McCormack, Katherine McCulloh, Ian R McFadden, Brian J McGill, Mara Y McPartland, Juliana S Medeiros, Belinda Medlyn, Pierre Meerts, Zia Mehrabi, Patrick Meir, Felipe P L Melo, Maurizio Mencuccini, Céline Meredieu, Julie Messier, Ilona Mészáros, Juha Metsaranta, Sean T Michaletz, Chrysanthi Michelaki, Svetlana Migalina, Ruben Milla, Jesse E D Miller, Vanessa Minden, Ray Ming, Karel Mokany, Angela T Moles, Attila Molnár, Jane Molofsky, Martin Molz, Rebecca A Montgomery, Arnaud Monty, Lenka Moravcová, Alvaro Moreno-Martínez, Marco Moretti, Akira S Mori, Shigeta Mori, Dave Morris, Jane Morrison, Ladislav Mucina, Sandra Mueller, Christopher D Muir, Sandra Cristina Müller, François Munoz, Isla H Myers-Smith, Randall W Myster, Masahiro Nagano, Shawna Naidu, Ayyappan Narayanan, Balachandran Natesan, Luka Negoita, Andrew S Nelson, Eike Lena Neuschulz, Jian Ni, Georg Niedrist, Jhon Nieto, Ülo Niinemets, Rachael Nolan, Henning Nottebrock, Yann Nouvellon, Alexander Novakovskiy, Kristin Odden Nystuen, Anthony O'Grady, Kevin O'Hara, Andrew O'Reilly-Nugent, Simon Oakley, Walter Oberhuber, Toshiyuki Ohtsuka, Ricardo Oliveira, Kinga Öllerer, Mark E Olson, Vladimir Onipchenko, Yusuke Onoda, Renske E Onstein, Jenny C Ordonez, Noriyuki Osada, Ivika Ostonen, Gianluigi Ottaviani, Sarah Otto, Gerhard E Overbeck, Wim A Ozinga, Anna T Pahl, C E Timothy Paine, Robin J Pakeman, Aristotelis C Papageorgiou, Evgeniya Parfionova, Meelis Pärtel, Marco Patacca, Susana Paula, Juraj Paule, Harald Pauli, Juli G Pausas, Begoña Peco, Josep Penuelas, Antonio Perea, Pablo Luis Peri, Ana Carolina Petisco-Souza, Alessandro Petraglia, Any Mary Petritan, Oliver L Phillips, Simon Pierce, Valério D Pillar, Jan Pisek, Alexandr Pomogaybin, Hendrik Poorter, Angelika Portsmuth, Peter Poschlod, Catherine Potvin, Devon Pounds, A Shafer Powell, Sally A Power, Andreas Prinzing, Giacomo Puglielli, Petr Pyšek, Valerie Raevel, Anja Rammig, Johannes Ransijn, Courtenay A Ray, Peter B Reich, Markus Reichstein, Douglas E B Reid, Maxime Réjou-Méchain, Victor Resco de Dios, Sabina Ribeiro, Sarah Richardson, Kersti Riibak, Matthias C Rillig, Fiamma Riviera, Elisabeth M R Robert, Scott Roberts, Bjorn Robroek, Adam Roddy, Arthur Vinicius Rodrigues, Alistair Rogers, Emily Rollinson, Victor Rolo, Christine Römermann, Dina Ronzhina, Christiane Roscher, Julieta A Rosell, Milena Fermina Rosenfield, Christian Rossi, David B Roy, Samuel Royer-Tardif, Nadja Rüger, Ricardo Ruiz-Peinado, Sabine B Rumpf, Graciela M Rusch, Masahiro Ryo, Lawren Sack, Angela Saldaña, Beatriz Salgado-Negret, Roberto Salguero-Gomez, Ignacio Santa-Regina, Ana Carolina Santacruz-García, Joaquim Santos, Jordi Sardans, Brandon Schamp, Michael Scherer-Lorenzen, Matthias Schleuning, Bernhard Schmid, Marco Schmidt, Sylvain Schmitt, Julio V Schneider, Simon D Schowanek, Julian Schrader, Franziska Schrodt, Bernhard Schuldt, Frank Schurr, Galia Selaya Garvizu, Marina Semchenko, Colleen Seymour, Julia C Sfair, Joanne M Sharpe, Christine S Sheppard, Serge Sheremetiev, Satomi Shiodera, Bill Shipley, Tanvir Ahmed Shovon, Alrun Siebenkäs, Carlos Sierra, Vasco Silva, Mateus Silva, Tommaso Sitzia, Henrik Sjöman, Martijn Slot, Nicholas G Smith, Darwin Sodhi, Pamela Soltis, Douglas Soltis, Ben Somers, Grégory Sonnier, Mia Vedel Sørensen, Enio Egon Sosinski, Nadejda A Soudzilovskaia, Alexandre F Souza, Marko Spasojevic, Marta Gaia Sperandii, Amanda B Stan, James Stegen, Klaus Steinbauer, Jörg G Stephan, Frank Sterck, Dejan B Stojanovic, Tanya Strydom, Maria Laura Suarez, Jens-Christian Svenning, Ivana Svitková, Marek Svitok, Miroslav Svoboda, Emily Swaine, Nathan Swenson, Marcelo Tabarelli, Kentaro Takagi, Ulrike Tappeiner, Rubén Tarifa, Simon Tauugourdeau, Cagatay Tavsanoglu, Mariska Te Beest, Leho Tedersoo, Nelson Thiffault, Dominik Thom, Evert Thomas, Ken Thompson, Peter E Thornton, Wilfried Thuiller, Lubomír Tichý, David Tissue, Mark G Tjoelker, David Yue Phin Tng, Joseph Tobias, Péter Török, Tonantzin Tarin, José M Torres-Ruiz, Béla Tóthmérész, Martina Treurnicht, Valeria Trivellone, Franck Trolliet, Volodymyr Trotsiuk, James L Tsakalos, Ioannis Tsiripidis, Niklas Tysklind, Toru Umehara, Vladimir Usoltsev, Matthew Vadeboncoeur, Jamil Vaezi, Fernando Valladares, Jana Vamosi, Peter M van Bodegom, Michiel van Breugel, Elisa Van Cleemput, Martine van de Weg, Stephni van der Merwe, Fons van der Plas, Masha T van der Sande, Mark van Kleunen, Koenraad Van Meerbeek, Mark Vanderwel, Kim André Vanselow, Angelica Vårhammar, Laura Varone, Maribel Yesenia Vasquez Valderrama, Kiril Vassilev, Mark Vellend, Erik J Veneklaas, Hans Verbeeck, Kris Verheyen, Alexander Vibrans, Ima Vieira, Jaime Villacís, Cyrille Violle, Pandi Vivek, Katrin Wagner, Matthew Waldram, Anthony Waldron, Anthony P Walker, Martyn Waller, Gabriel Walther, Han Wang, Feng Wang, Weiqi Wang, Harry Watkins, James Watkins, Ulrich Weber, James T Weedon, Liping Wei, Patrick Weigelt, Evan Weiher, Aidan W Wells, Camilla Wellstein, Elizabeth Wenk, Mark Westoby, Alana Westwood, Philip John White, Mark Whitten, Mathew Williams, Daniel E Winkler, Klaus Winter, Chevonne Womack, Ian J Wright, S Joseph Wright, Justin Wright, Bruno X Pinho, Fabiano Ximenes, Toshihiro Yamada, Keiko Yamaji, Ruth Yanai, Nikolay Yankov, Benjamin Yguel, Kátia Janaina Zanini, Amy E Zanne, David Zelený, Yun-Peng Zhao, Jingming Zheng, Ji Zheng, Kasia Ziemińska, Chad R Zirbel, Georg Zizka, Irié Casimir Zo-Bi, Gerhard Zotz, Christian Wirth
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling...
January 2020: Global Change Biology
#28
REVIEW
Francesco Varone, Yoshikazu Inoue, Luca Richeldi
No abstract text is available yet for this article.
January 2020: Respirology: Official Journal of the Asian Pacific Society of Respirology
#29
JOURNAL ARTICLE
Leonello Fuso, Francesco Varone, Daniele Magnini, Mariarosaria Calvello, Erminia Lo Greco, Luca Richeldi
No abstract text is available yet for this article.
March 2019: Respiratory Care
#30
REVIEW
Luca Richeldi, Francesco Varone, Miguel Bergna, Joao de Andrade, Jeremy Falk, Robert Hallowell, Stéphane Jouneau, Yasuhiro Kondoh, Lee Morrow, Winfried Randerath, Mary Strek, Gabriela Tabaj
A proportion of patients with interstitial lung diseases (ILDs) are at risk of developing a progressive-fibrosing phenotype, which is associated with a deterioration in lung function and early mortality. In addition to idiopathic pulmonary fibrosis (IPF), fibrosing ILDs that may present a progressive phenotype include idiopathic nonspecific interstitial pneumonia, connective tissue disease-associated ILDs, hypersensitivity pneumonitis, unclassifiable idiopathic interstitial pneumonia, ILDs related to other occupational exposures and sarcoidosis...
December 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
#31
JOURNAL ARTICLE
Riccardo Inchingolo, Francesco Varone, Giacomo Sgalla, Luca Richeldi
Idiopathic pulmonary fibrosis (IPF) is a chronic, debilitating, fibrotic lung disease leading to respiratory failure, and ultimately to death. It is characterized by marked heterogeneity regarding its clinical course. Despite significant progress in the understanding of its pathogenesis, the course of the disease and the response to treatment of an individual patient cannot be reliably predicted today. Areas covered: Non-invasive biomarkers, in particular serum biomarkers, for the (early) diagnosis, differential diagnosis, prognosis, and prediction of therapeutic response are described...
January 2019: Expert Review of Respiratory Medicine
#32
JOURNAL ARTICLE
Daniele Magnini, Leonello Fuso, Francesco Varone, Ettore D'Argento, Maurizio Martini, Antonietta Pecoriello, Vincenzo Di Noia, Damiano Arciuolo, Guido Fadda, Guido Rindi, Luca Richeldi
PURPOSE: Cytological endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimens of mediastinal lymph node metastasis are frequently used to perform concomitant diagnosis, staging and genetic testing in non-small-cell lung cancer (NSCLC). The purposes of this single-center retrospective study were to evaluate EBUS-TBNA samples' adequacy for molecular testing of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), and to analyze the concordance between the cell block method and liquid-based cytology (LBC) in appraising the sample cellularity and in detecting EGFR mutation...
December 2018: Molecular Diagnosis & Therapy
#33
REVIEW
Francesca Graziani, Francesco Varone, Filippo Crea, Luca Richeldi
Heart failure with preserved ejection fraction (HFpEF) has a poor prognosis, and an effective treatment is currently lacking. Increasing evidence suggests a prevailing pathogenic role of cardiac fibrosis in HFpEF, which generates the possibility of a mechanistic overlap with pulmonary fibrosis. Indeed, cardiac and pulmonary fibrosis share some characteristics and molecular pathways, such as that of transforming growth factor-β. If pulmonary and cardiac fibrosis share common pathways, we can hypothesize a beneficial effect of anti-fibrotic drugs used in idiopathic pulmonary fibrosis on cardiac outcomes...
October 2018: European Journal of Heart Failure
#34
REVIEW
Leonello Fuso, Francesco Varone, Daniele Magnini, Mariarosaria Calvello, Erminia Lo Greco, Luca Richeldi
In the everyday practice of respiratory physicians, ultrasound techniques play a key role by enabling several diagnostic and interventional procedures. The application of ultrasound to endoscopic procedures allows both a visualization and a guided sampling of mediastinal and hilar lymph nodes. Endobronchial ultrasound can be combined with transbronchial needle aspiration, and, similarly, endoscopic ultrasound can be combined with fine-needle aspiration to sample virtually all mediastinal nodal stations from the airways and the esophagus...
November 2018: Respiratory Care
#35
JOURNAL ARTICLE
Leonello Fuso, Francesco Varone, Daniele Magnini
No abstract text is available yet for this article.
April 2018: Journal of Bronchology & Interventional Pulmonology
#36
REVIEW
Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone, Luca Richeldi
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor prognosis. This review will present the substantial advances achieved in the understanding of IPF pathogenesis and in the therapeutic options that can be offered to patients, and will address the issues regarding diagnosis and management that are still open. MAIN BODY: Over the last two decades much has been clarified about the pathogenic pathways underlying the development and progression of the lung scarring in IPF...
February 22, 2018: Respiratory Research
#37
REVIEW
Francesco Varone, Giacomo Sgalla, Bruno Iovene, Teresa Bruni, Luca Richeldi
Idiopathic Pulmonary Fibrosis (IPF) is an interstitial lung disease characterized by the progressive loss of pulmonary function, ultimately leading to respiratory failure and death. Two novel compounds, nintedanib and pirfenidone, have shown efficacy in reducing the rate of decline of lung function in IPF patients. The multiple tyrosine kinase inhibitor nintedanib has extensively being studied as a potential angiogenesis inhibitor in clinical against various neoplastic disorders. Afterwards, this compound was successfully tested in IPF...
February 2018: Expert Opinion on Pharmacotherapy
#38
REVIEW
Simone Scarlata, Lello Fuso, Gabriele Lucantoni, Francesco Varone, Daniele Magnini, Raffaele Antonelli Incalzi, Gianni Galluccio
More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in advanced cancerous lesions and cure of early lung cancer. Bronchoscopic management is also indicated for all those patients suffering from benign or minimally invasive neoplasm who are not suitable for surgery due to their clinical conditions...
August 2017: Journal of Thoracic Disease
#39
REVIEW
Francesco Varone, Giuliano Montemurro, Francesco Macagno, Mariarosaria Calvello, Emanuele Conte, Enrica Intini, Bruno Iovene, Paolo Maria Leone, Pier-Valerio Mari, Luca Richeldi
IPF is a specific form of chronic fibrosing interstitial pneumonia of unknown cause, characterized by progressive worsening in lung function and an unfavorable prognosis. Current concepts on IPF pathogenesis are based on a dysregulated wound healing response, leading to an over production of extracellular matrix. Based on recent research however, several other mechanisms are now proposed as potential targets for novel therapeutic strategies. Areas covered: This review analyzes the current investigational strategies targeting extracellular matrix deposition, tyrosine-kinase antagonism, immune and autoimmune response, and cell-based therapy...
September 2017: Expert Opinion on Investigational Drugs
#40
JOURNAL ARTICLE
Leonello Fuso, Francesco Varone, Daniele Magnini, Antonietta Pecoriello, Giuliano Montemurro, Giulia Angeletti, Salvatore Valente
BACKGROUND: The diagnostic yield of conventional transbronchial needle aspiration (TBNA) is characterized by a learning effect. The aim of this retrospective study was to verify whether a learning curve similarly affected the yield of endobronchial ultrasound-guided (EBUS)-TBNA. To this end, we evaluated the sensitivity and diagnostic accuracy of EBUS-TBNA during the first 3 years of activity. METHODS: EBUS-TBNA was performed by 2 operators with no previous experience in this technique...
July 2017: Journal of Bronchology & Interventional Pulmonology
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