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Varone Francesco

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https://www.readbyqxmd.com/read/27322356/pulmonary-fibrolysis-in-a-patient-with-idiopathic-pulmonary-fibrosis-improvement-of-clinical-and-radiological-pattern-after-treatment-with-pirfenidone
#1
Francesco Varone, Annelisa Mastrobattista, Paola Franchi, Luca Viglietta, Venerino Poletti, Sara Tomassetti, Alessandra Dubini, Linda Tagliaboschi, Lucio Calandriello, Alessandra Farchione, Anna Rita Larici
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high-resolution computed tomography pattern of "definite UIP" is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis...
June 20, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/26753560/incidence-and-management-of-post-lobectomy-and-pneumonectomy-bronchopleural-fistula
#2
Leonello Fuso, Francesco Varone, Dania Nachira, Ilaria Leli, Ivano Salimbene, Maria Teresa Congedo, Stefano Margaritora, Pierluigi Granone
INTRODUCTION: Bronchopleural fistula is a rare but potentially fatal complication of pulmonary resections and proper management is essential for its resolution. In this study, we analyzed the incidence of fistula after pulmonary resection and reported data about endoscopic and conservative treatments of this complication. METHODS: From January 2003 to December 2013, 835 patients underwent anatomic lung resections: 786 (94.1 %) had a lobectomy and 49 (5.9 %) a pneumonectomy...
April 2016: Lung
https://www.readbyqxmd.com/read/26351968/usefulness-of-conventional-transbronchial-needle-aspiration-for-sampling-of-mediastinal-lymph-nodes-in-lung-cancer
#3
Leonello Fuso, Francesco Varone, Andrea Smargiassi, Daniele Magnini, Sara Colella, Alessandro Di Marco Berardino, Roberta Marra, Antonino Mulè, Guido Rindi, Riccardo Inchingolo
BACKGROUND: Transbronchial needle aspiration (TBNA) is recognized as a valuable tool for the sampling of mediastinal lymph nodes. In this study, we report data about the diagnostic yield of conventional TBNA in the diagnosis and staging of lung cancer. METHODS: All patients with suspected lung cancer who underwent bronchoscopy with conventional TBNA in the years 2008 to 2012 were evaluated. TBNA was performed on mediastinal lymph nodes enlarged at chest computed tomography scan and/or with increased fluorodeoxyglucose uptake on positron emission tomography/computed tomography scan...
October 2015: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/23639784/role-of-ultrasound-guided-transbronchial-biopsy-in-the-diagnosis-of-peripheral-pulmonary-lesions
#4
Leonello Fuso, Francesco Varone, Daniele Magnini, Fabiana Baldi, Guido Rindi, Gabriella Pagliari, Riccardo Inchingolo, Andrea Smargiassi
INTRODUCTION: Endobronchial ultrasound (EBUS) can be used as an alternative to fluoroscopy to visualize a peripheral pulmonary lesion (PPL) and to provide an image guidance for transbronchial biopsy (TBB). The aim of this study was to verify the accuracy of EBUS-guided TBB in the diagnosis of PPLs. METHODS: All the patients with CT-scan evidence of PPL who underwent bronchoscopy with EBUS in the period between 2008 and 2011 were retrospectively evaluated. EBUS was performed using a radial-type miniature ultrasound probe...
July 2013: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/23351275/husband-and-wife-with-sarcoidosis-possible-environmental-factors-involved
#5
Ilaria Leli, Ivano Salimbene, Francesco Varone, Leonello Fuso, Salvatore Valente
Sarcoidosis is a granulomatous multisystem disorder of unclear etiology that involves any organ, most commonly the lung and the lymph nodes. It is hypothesized that the disease derives from the interaction between single or multiple environmental factors and genetically determined host factors. Multiple potential etiologic agents for sarcoidosis have been proposed without any definitive demonstration of causality.We report the case of two patients, husband (57 years old) and wife (55 years old), both suffering from sarcoidosis...
2013: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/23127376/mitral-valve-repair-or-replacement-for-ischemic-mitral-regurgitation-the-italian-study-on-the-treatment-of-ischemic-mitral-regurgitation-istimir
#6
MULTICENTER STUDY
Roberto Lorusso, Sandro Gelsomino, Enrico Vizzardi, Antonio D'Aloia, Giuseppe De Cicco, Fabiana Lucà, Orlando Parise, Gian Franco Gensini, Pierluigi Stefàno, Ugolino Livi, Igor Vendramin, Davide Pacini, Roberto Di Bartolomeo, Antonio Miceli, Egidio Varone, Mattia Glauber, Alessandro Parolari, Francesco Giuseppe Arlati, Francesco Alamanni, Filiberto Serraino, Attilio Renzulli, Antonio Messina, Giovanni Troise, Giovanni Mariscalco, Marzia Cottini, Cesare Beghi, Francesco Nicolini, Tiziano Gherli, Valentino Borghetti, Alessandro Pardini, Philippe-Primo Caimmi, Ezio Micalizzi, Carlo Fino, Paolo Ferrazzi, Michele Di Mauro, Antonio Maria Calafiore
OBJECTIVE: It is uncertain whether mitral valve replacement is really inferior to mitral valve repair for the treatment of chronic ischemic mitral regurgitation. This multicenter study aimed at providing a contribution to this issue. METHODS: Of 1006 patients with chronic ischemic mitral regurgitation and impaired left ventricular function (ejection fraction < 40%) operated on at 13 Italian institutions between 1996 and 2011, 298 (29.6%) underwent mitral valve replacement whereas 708 (70...
January 2013: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/22958751/rationale-and-clinical-benefits-of-an-intensive-long-term-pulmonary-rehabilitation-program-after-oesophagectomy-preliminary-report
#7
Filippo Lococo, Alfredo Cesario, Silvia Sterzi, Giovanni Magrone, Valentina Dall'armi, Francesca Mattei, Francesco Varone, Venanzio Porziella, Stefano Margaritora, Pierluigi Granone
Patients who undergo oesophagectomy for oesophagealcancer (OC) usually have an overall poor prognosis and, still more preoccupying, an unsatisfactory quality of life (QoL). Considering that, as already noted, post-operative pulmonary function has a strong correlation with the long-term outcome and QoL after surgery, we have assumed and speculated on the clinical benefits of an intensive long-term pulmonary post-operative rehabilitation program in this particular subset of patients.Herein, we report the preliminary results of a comparative retrospective analysis in a series of 58 patients who underwent radical oesophagectomy and post-operative chest physical therapy (CPT) under two different protocols, from October 2006 to January 2011...
2012: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/22271438/reduced-respiratory-muscle-strength-and-endurance-in-type-2-diabetes-mellitus
#8
Leonello Fuso, Dario Pitocco, Anna Longobardi, Francesco Zaccardi, Chiara Contu, Carmen Pozzuto, Salvatore Basso, Francesco Varone, Giovanni Ghirlanda, Raffaele Antonelli Incalzi
BACKGROUND: A restrictive lung function pattern is frequently observed in patients with diabetes mellitus (DM) and has been related to respiratory muscle dysfunction in type 1 DM or in mixed population. We aimed to verify whether such a relationship applies also to type 2 DM patients. METHODS: The respiratory muscle function was explored in 75 non-smoking patients with type 2 DM without pulmonary or cardiac diseases and compared with that of 40 healthy non-smoking control subjects matched by age and sex...
May 2012: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/21801327/bronchoalveolar-lavage-fluid-and-progression-of-scleroderma-interstitial-lung-disease
#9
Maria De Santis, Silvia Laura Bosello, Giusy Peluso, Michela Pinnelli, Stefano Alivernini, Gaetano Zizzo, Mario Bocci, Annunziata Capacci, Giuseppe La Torre, Alice Mannocci, Gabriella Pagliari, Francesco Varone, Roberto Pistelli, Francesco Maria Danza, Gianfranco Ferraccioli
INTRODUCTION: So far no clinical or experimental evidences clearly explain how and which systemic sclerosis (SSc) patients will experience a functional and radiological progression of interstitial lung disease (ILD). OBJECTIVES: The aim of the study was to investigate whether any bronchoalveolar lavage fluid (BALF) characteristic, compared with clinical, functional and radiological parameters, is associated with the risk of progression of ILD and worse survival in SSc patients...
January 2012: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/21314931/%C3%AE-thymosins-and-interstitial-lung-disease-study-of-a-scleroderma-cohort-with-a-one-year-follow-up
#10
Maria De Santis, Rosanna Inzitari, Silvia L Bosello, Giusy Peluso, Chiara Fanali, Federica Iavarone, Gaetano Zizzo, Mario Bocci, Tiziana Cabras, Irene Messana, Leo Fuso, Francesco Varone, Gabriella Pagliari, Massimo Castagnola, Gianfranco Ferraccioli
BACKGROUND: β-thymosins play roles in cytoskeleton rearrangement, angiogenesis, fibrosis and reparative process, thus suggesting a possible involvement in the pathogenesis of systemic sclerosis. The aim of the study was to investigate the presence of thymosins β4, β4 sulfoxide, and β10 in bronchoalveolar lavage fluid of scleroderma patients with interstitial lung disease and the relation of these factors with pulmonary functional and radiological parameters. METHODS: β-thymosins concentrations were determined by reverse phase-high performance liquid chromatography-electrospray-mass spectrometry in the bronchoalveolar lavage fluid of 46 scleroderma patients with lung involvement and of 15 controls...
2011: Respiratory Research
https://www.readbyqxmd.com/read/20031930/effects-of-mycophenolate-mofetil-on-acute-ischaemia-reperfusion-injury-in-rats-and-its-consequences-in-the-long-term
#11
Massimo Sabbatini, Francesco Uccello, Vittorio Serio, Giancarlo Troncone, Valeria Varone, Michele Andreucci, Teresa Faga, Antonio Pisani
BACKGROUND: Renal ischaemia-reperfusion injury (IRI) acutely decreases glomerular filtration rate (GFR) and impairs kidney function in the long term. Pre-treatment with chaetomellic acid (KM), an inhibitor of membrane-bound Ha-Ras, has demonstrated beneficial effects on acute renal ischaemia. METHODS: We tested whether mycophenolate mofetil (MMF, 20 mg/day for 4 days before IRI), an immunosuppressor with anti-inflammatory properties, improved renal outcome in uninephrectomized rats after IRI (45 min of renal ischaemia), alone or in combination with KM...
May 2010: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/14681881/infantile-spinal-muscular-atrophy-with-respiratory-distress-type-1-smard1
#12
Katja Grohmann, Raymonda Varon, Piroschka Stolz, Markus Schuelke, Catrin Janetzki, Enrico Bertini, Kate Bushby, Francesco Muntoni, Robert Ouvrier, Lionel Van Maldergem, Nathalie M L A Goemans, Hanns Lochmüller, Stephan Eichholz, Coleen Adams, Friedrich Bosch, Padraic Grattan-Smith, Carmen Navarro, Heidemarie Neitzel, Tilman Polster, Haluk Topaloğlu, Christina Steglich, Ulf P Guenther, Klaus Zerres, Sabine Rudnik-Schöneborn, Christoph Hübner
Autosomal recessive spinal muscular atrophy with respiratory distress type 1 (SMARD1) is the second anterior horn cell disease in infants in which the genetic defect has been defined. SMARD1 results from mutations in the gene encoding the immunoglobulin micro-binding protein 2 (IGHMBP2) on chromosome 11q13. Our aim was to review the clinical features of 29 infants affected with SMARD1 and report on 26 novel IGHMBP2 mutations. Intrauterine growth retardation, weak cry, and foot deformities were the earliest symptoms of SMARD1...
December 2003: Annals of Neurology
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