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Francesco Macagno

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https://www.readbyqxmd.com/read/27815354/cytokine-induced-killer-cells-kill-chemo-surviving-melanoma-cancer-stem-cells
#1
Dario Sangiolo, Loretta Gammaitoni, Lidia Giraudo, Marco Macagno, Valeria Leuci, Giulia Mesiano, Ramona Rotolo, Francesco Sassi, Martina Sanlorenzo, Alessandro Zaccagna, Alberto Pisacane, Rebecca Senetta, Michela Cangemi, Giulia Cattaneo, Valentina Martin, Valentina Coha, Susanna Gallo, Ymera Pignochino, Anna Sapino, Giovanni Grignani, Fabrizio Carnevale-Schianca, Massimo Aglietta
PURPOSE: The MHC-unrestricted activity of cytokine-induced killer (CIK) cells against chemo-surviving melanoma cancer stem cells (mCSCs) was explored, as CSCs are considered responsible for chemo-resistance and relapses. EXPERIMENTAL DESIGN: Putative mCSCs were visualized by engineering patient-derived melanoma cells (MCs) with a lentiviral-vector encoding eGFP under expression control by stemness gene promoter oct4. Their stemness potential was confirmed in vivo by limiting dilution assays...
November 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26693732/electronic-nose-and-exhaled-breath-nmr-based-metabolomics-applications-in-airways-disease
#2
Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni, Paolo Montuschi
Breathomics, the multidimensional molecular analysis of exhaled breath, includes analysis of exhaled breath with gas-chromatography/mass spectrometry (GC/MS) and electronic noses (e-noses), and metabolomics of exhaled breath condensate (EBC), a non-invasive technique which provides information on the composition of airway lining fluid, generally by high-resolution nuclear magnetic resonance (NMR) spectroscopy or MS methods. Metabolomics is the identification and quantification of small molecular weight metabolites in a biofluid...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26190466/on-the-edge-of-language-acquisition-inherent-constraints-on-encoding-multisyllabic-sequences-in-the-neonate-brain
#3
Alissa L Ferry, Ana Fló, Perrine Brusini, Luigi Cattarossi, Francesco Macagno, Marina Nespor, Jacques Mehler
To understand language, humans must encode information from rapid, sequential streams of syllables - tracking their order and organizing them into words, phrases, and sentences. We used Near-Infrared Spectroscopy (NIRS) to determine whether human neonates are born with the capacity to track the positions of syllables in multisyllabic sequences. After familiarization with a six-syllable sequence, the neonate brain responded to the change (as shown by an increase in oxy-hemoglobin) when the two edge syllables switched positions but not when two middle syllables switched positions (Experiment 1), indicating that they encoded the syllables at the edges of sequences better than those in the middle...
May 2016: Developmental Science
https://www.readbyqxmd.com/read/24656639/liquid-chromatography-mass-spectrometry-measurement-of-leukotrienes-in-asthma-and-other-respiratory-diseases
#4
REVIEW
Paolo Montuschi, Giuseppe Santini, Salvatore Valente, Chiara Mondino, Francesco Macagno, Paola Cattani, Gina Zini, Nadia Mores
Leukotrienes (LTs), including cysteinyl-LTs (LTC4, LTD4 and LTE4) and LTB4, are potent inflammatory lipid mediators which have been involved in the pathophysiology of respiratory diseases. LC-MS/MS techniques for measuring LT concentrations in sputum supernatants, serum, urine and exhaled breath condensate (EBC) have been developed. In asthmatic adults, reported LTB4 and LTE4 concentrations in sputum range from 79 to 7,220 pg/ml and from 11.9 to 891 pg/ml, respectively. Data on sputum LT concentrations in healthy subjects are not available...
August 1, 2014: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/23536167/increased-morbidity-and-mortality-in-very-preterm-vlbw-infants-with-congenital-heart-disease
#5
Angelo Polito, Simone Piga, Paola E Cogo, Carlo Corchia, Virgilio Carnielli, Monica Da Frè, Domenico Di Lallo, Isabella Favia, Luigi Gagliardi, Francesco Macagno, Silvana Miniaci, Marina Cuttini
PURPOSE: To study the association between congenital heart diseases (CHD) and in-hospital mortality and morbidity of very preterm/very low birth weight (VLBW) infants. METHODS: The area-based prospective cohort study ACTION included all infants with gestational age (GA) 22-31 weeks or birth weight <1,500 g admitted to neonatal care between July 2003 and June 2005 in six Italian regions (n = 3,684). CHD were coded according to ICD9-CM. Cluster multivariable logistic regression analyses were used to assess the relationship between CHD and mortality and selected morbidities [neonatal infection, ultrasound brain abnormalities, retinopathy of prematurity (ROP), and bronchopulmonary dysplasia (BPD)] adjusting for potential confounders...
June 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23493168/pregnancy-disorders-leading-to-very-preterm-birth-influence-neonatal-outcomes-results-of-the-population-based-action-cohort-study
#6
Luigi Gagliardi, Franca Rusconi, Monica Da Frè, Giorgio Mello, Virgilio Carnielli, Domenico Di Lallo, Francesco Macagno, Silvana Miniaci, Carlo Corchia, Marina Cuttini
Background:We examined the relationships between -pregnancy disorders leading to very preterm birth -(spontaneous preterm labor, prelabor premature rupture of -membranes (PPROM), hypertension/preeclampsia, -intrauterine growth restriction (IUGR), antenatal hemorrhage, and maternal -infection), both in isolation and grouped together as -"disorders of placentation" (hypertensive disorders and IUGR) vs. -"presumed infection/inflammation" (all the others), and several unfavorable neonatal outcomes.Methods:We examined a population-based prospective cohort of 2,085 singleton infants of 23-31 wk gestational age (GA) born in six Italian regions (the Accesso alle Cure e Terapie Intensive Ostetriche e Neonatali (ACTION) study)...
June 2013: Pediatric Research
https://www.readbyqxmd.com/read/23337093/cause-specific-mortality-of-very-preterm-infants-and-antenatal-events
#7
Carlo Corchia, Pierpaolo Ferrante, Monica Da Frè, Domenico Di Lallo, Luigi Gagliardi, Virgilio Carnielli, Silvana Miniaci, Simone Piga, Francesco Macagno, Marina Cuttini
OBJECTIVE: To assess the relationship between antenatal factors and cause-specific risk of death in a large area-based cohort of very preterm infants. STUDY DESIGN: The ACTION (Accesso alle Cure e Terapie Intensive Ostetriche e Neonatali) study recruited during an 18-month period all infants 22-31 weeks' gestational age admitted to neonatal care in 6 Italian regions (n=3040). We analyzed the data of 2974 babies without lethal or acutely life-threatening malformations...
June 2013: Journal of Pediatrics
https://www.readbyqxmd.com/read/23071325/newborn-s-brain-activity-signals-the-origin-of-word-memories
#8
Silvia Benavides-Varela, Jean-Rémy Hochmann, Francesco Macagno, Marina Nespor, Jacques Mehler
Recent research has shown that specific areas of the human brain are activated by speech from the time of birth. However, it is currently unknown whether newborns' brains also encode and remember the sounds of words when processing speech. The present study investigates the type of information that newborns retain when they hear words and the brain structures that support word-sound recognition. Forty-four healthy newborns were tested with the functional near-infrared spectroscopy method to establish their ability to memorize the sound of a word and distinguish it from a phonetically similar one, 2 min after encoding...
October 30, 2012: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/22087327/memory-in-the-neonate-brain
#9
Silvia Benavides-Varela, David M Gómez, Francesco Macagno, Ricardo A H Bion, Isabelle Peretz, Jacques Mehler
BACKGROUND: The capacity to memorize speech sounds is crucial for language acquisition. Newborn human infants can discriminate phonetic contrasts and extract rhythm, prosodic information, and simple regularities from speech. Yet, there is scarce evidence that infants can recognize common words from the surrounding language before four months of age. METHODOLOGY/PRINCIPAL FINDINGS: We studied one hundred and twelve 1-5 day-old infants, using functional near-infrared spectroscopy (fNIRS)...
2011: PloS One
https://www.readbyqxmd.com/read/20540801/high-prevalence-of-minor-neurologic-deficits-in-a-long-term-neurodevelopmental-follow-up-of-children-with-severe-persistent-pulmonary-hypertension-of-the-newborn-a-cohort-study
#10
COMPARATIVE STUDY
Anna Berti, Augusta Janes, Riccardo Furlan, Francesco Macagno
BACKGROUND: Persistent pulmonary hypertension of the newborn (PPHN) is a severe condition that determines a profound brain hypoxia. Inhaled nitric oxide was approved for the treatment of PPHN since the end of the 1990s. The debate upon the long term outcome of these children is still open. Our aim was to investigate the incidence of minor long-term neurodevelopmental problems in a cohort of children affected by severe PPHN. METHODS: All neonates with severe PPHN treated with inhaled nitric oxide in our facility between 01...
2010: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/18768785/the-neonate-brain-detects-speech-structure
#11
Judit Gervain, Francesco Macagno, Silvia Cogoi, Marcela Peña, Jacques Mehler
What are the origins of the efficient language learning abilities that allow humans to acquire their mother tongue in just a few years very early in life? Although previous studies have identified different mechanisms underlying the acquisition of auditory and speech patterns in older infants and adults, the earliest sensitivities remain unexplored. To address this issue, we investigated the ability of newborns to learn simple repetition-based structures in two optical brain-imaging experiments. In the first experiment, 22 neonates listened to syllable sequences containing immediate repetitions (ABB; e...
September 16, 2008: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/16717116/a-cyanobacterial-lps-antagonist-prevents-endotoxin-shock-and-blocks-sustained-tlr4-stimulation-required-for-cytokine-expression
#12
Annalisa Macagno, Monica Molteni, Andrea Rinaldi, Francesco Bertoni, Antonio Lanzavecchia, Carlo Rossetti, Federica Sallusto
Toll-like receptors (TLRs) function as primary sensors that elicit coordinated innate immune defenses through recognition of microbial products and induction of immune and proinflammatory genes. Here we report the identification and biological characterization of a lipopolysaccharide (LPS)-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (cyanobacterial product [CyP]) that is not stimulatory per se but acts as a potent and selective antagonist of bacterial LPS. CyP binds to MD-2 and efficiently competes with LPS for binding to the TLR4-MD-2 receptor complex...
June 12, 2006: Journal of Experimental Medicine
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