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Scott D Boden, James Kang, Harvinder Sandhu, John G Heller
STUDY DESIGN: A prospective randomized clinical study was conducted. OBJECTIVE: To determine whether the dose and carrier that were successful in rhesus monkeys could induce consistent radiographic spine fusion in humans. SUMMARY OF BACKGROUND DATA: Preclinical studies have demonstrated that recombinant human bone morphogenetic protein-2 (rhBMP-2), an osteoinductive bone morphogenetic protein, is successful at generating spine fusion in rabbits and rhesus monkeys...
December 1, 2002: Spine
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