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https://www.readbyqxmd.com/read/29223005/the-emerging-role-of-systems-biology-for-engineering-protein-production-in-cho-cells
#1
REVIEW
Chih-Chung Kuo, Austin Wt Chiang, Isaac Shamie, Mojtaba Samoudi, Jahir M Gutierrez, Nathan E Lewis
To meet the ever-growing demand for effective, safe, and affordable protein therapeutics, decades of intense efforts have aimed to maximize the quantity and quality of recombinant proteins produced in CHO cells. Bioprocessing innovations and cell engineering efforts have improved product titer; however, uncharacterized cellular processes and gene regulatory mechanisms still hinder cell growth, specific productivity, and protein quality. Herein, we summarize recent advances in systems biology and data-driven approaches aiming to unravel how molecular pathways, cellular processes, and extrinsic factors (e...
December 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29222841/evaluation-of-an-ovary-on-a-chip-in-large-mammalian-models-species-specificity-and-influence-of-follicle-isolation-status
#2
J Nagashima, R El Assal, N Songsasen, U Demirci
The ability to grow oocytes from immature ovarian follicles in vitro has significant potential for fertility preservation; yet, it has proved challenging in large mammalian species due to the complex metabolic needs and long-term culture requirements. Currently, follicular incubations are based on a 'static' system with manual exchange of medium. Despite the numerous advantages of conventional culturing approaches, recapitulating the native microenvironment and supporting the survival of ovarian follicles still represent challenges...
December 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29222458/serendipity-and-strategy-in-rapid-innovation
#3
T M A Fink, M Reeves, R Palma, R S Farr
Innovation is to organizations what evolution is to organisms: it is how organizations adapt to environmental change and improve. Yet despite advances in our understanding of evolution, what drives innovation remains elusive. On the one hand, organizations invest heavily in systematic strategies to accelerate innovation. On the other, historical analysis and individual experience suggest that serendipity plays a significant role. To unify these perspectives, we analysed the mathematics of innovation as a search for designs across a universe of component building blocks...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222231/al-amyloidosis-from-molecular-mechanisms-to-targeted-therapies
#4
REVIEW
Giampaolo Merlini
Systemic amyloidosis is caused by misfolding and extracellular deposition of circulating proteins as amyloid fibrils, resulting in the dysfunction of vital organs. The most common systemic amyloidosis, light-chain (AL) amyloidosis, is caused by misfolded light chains produced by a small, dangerous B-cell clone. The process of amyloid formation, organ targeting, and damage is multifaceted and, after disease initiation, the complexity of the downstream pathogenic cascade increases, rendering its control a challenge...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221765/advances-in-fetal-echocardiography
#5
REVIEW
Helena M Gardiner
The development of fetal echocardiography and success in prenatal cardiac screening programs over the past 30 years has been driven by technical innovation and influenced by the different approaches of the various specialties practicing it. Screening for congenital heart defects no longer focuses on examining a limited number of pregnant women thought to be at increased risk, but instead forms an integrated part of a high-quality anatomical ultrasound performed in the second trimester using the 'five-transverse view' protocol...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29221625/population-health-for-ckd-and-diabetes-lessons-from%C3%A2-the-indian-health-service
#6
Andrew Narva
Despite extensive clinical guidelines, innovative efforts to improve care, and well-funded efforts to raise awareness, limited progress has been made in reducing the burden of kidney disease in the United States, and the prevalence continues to increase worldwide. The Indian Health Service and the Centers for Disease Control and Prevention recently reported a 54% decrease in the incidence of kidney failure among American Indian and Alaska Native people with diabetes. This decrease in end-stage renal disease incidence was associated with a population health approach to diabetes care based in the community and the primary clinical setting...
December 5, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29221448/next-generation-sequencing-recent-applications-to-the-analysis-of-colorectal-cancer
#7
REVIEW
Filippo Del Vecchio, Valentina Mastroiaco, Antinisca Di Marco, Chiara Compagnoni, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, Edoardo Alesse, Alessandra Tessitore
Since the establishment of the Sanger sequencing method, scientists around the world focused their efforts to progress in the field to produce the utmost technology. The introduction of next-generation sequencing (NGS) represents a revolutionary step and promises to lead to massive improvements in our understanding on the role of nucleic acids functions. Cancer research began to use this innovative and highly performing method, and interesting results started to appear in colorectal cancer (CRC) analysis. Several studies produced high-quality data in terms of mutation discovery, especially about actionable or less frequently mutated genes, epigenetics, transcriptomics...
December 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29221030/optical-camera-with-liquid-crystal-autofocus-lens
#8
T Galstian, O Sova, K Asatryan, V Presniakov, A Zohrabyan, M Evensen
A mobile phone camera with an innovative electrically tunable liquid crystal lens (TLCL) concept is demonstrated. We first report the comparative theoretical and experimental analyses of the performance of a traditional "modal control" TLCL versus a TLCL using a floating (unpowered) transparent electrode (FTE). It is shown that the appropriate choice of voltage and frequency values of the driving electric signal may improve significantly (almost twice) the optical quality of the lens using the FTE. Exceptionally low spherical aberrations of the lens (< λ/10 for up to 10 diopters of optical power) and high modulation transfer functions of a mobile phone camera (using those lenses for autofocus function) are demonstrated in a very simple operation mode (frequency tuning of the lens' optical power at a fixed driving voltage)...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29219844/amine-treatment-induced-perovskite-nanowire-network-in-perovskite-solar-cells-efficient-surface-passivation-and-carrier-transport
#9
Ke Xiao, Can Cui, Peng Wang, Ping Lin, Yaping Qiang, Lingbo Xu, Jiangsheng Xie, Zhengrui Yang, Xiaodong Zhu, Xuegong Yu, Deren Yang
In the fabrication of high efficiency organic-inorganic metal halide perovskite solar cells (PSCs), an additional interface modifier is usually applied for enhancing the interface passivation and carrier transport. In this paper, we develop an innovative method with in-situ growth of one-dimensional perovskite nanowire (1D PNW) network triggered by Lewis amine over the perovskite films. To our knowledge, this is the first time to fabricate PSCs with shape-controlled perovskite surface morphology, which improved power conversion efficiency (PCE) from 14...
December 8, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29218885/democratizing-health-data-for-translational-research
#10
Philip R O Payne, Nigam H Shah, Jessica D Tenenbaum, Lara Mangravite
There is an expanding and intensive focus on the accessibility, reproducibility, and rigor of basic, clinical, and translational research. This focus complements the need to identify sustainable ways to generate actionable research results that improve human health. The principles and practices of open science offer a promising path to address both issues by facilitating: 1) increased transparency of data and methods which promotes research reproducibility and rigor; and 2) cumulative efficiencies wherein research tools and the output of research are combined to accelerate the delivery of new knowledge...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218714/using-a-service-design-model-to-develop-the-passport-to-safer-birth-in-nigeria-and-uganda
#11
Mariana Salgado, Melanie Wendland, Damaris Rodriguez, Meghan A Bohren, Olufemi T Oladapo, Olubunmi A Ojelade, Adebimpe A Olalere, Ronald Luwangula, Kidza Mugerwa, Bukola Fawole
OBJECTIVE: To demonstrate how a human-centered service design approach can generate practical tools for good-quality childbirth care in low-resource settings. METHODS: As part of the WHO "Better Outcomes in Labour Difficulty" (BOLD) project, a service design approach was used in eight Ugandan and Nigerian health facilities and communities to develop the "Passport to Safer Birth." There are three phases: Research for Design, Concept Design, and Detail Design. These generated design principles, design archetype personas, and Passport prototypes...
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29217503/impact-of-an-electronic-health-record-integrated-personal-health-record-on-patient-participation-in-health-care-development-and-randomized-controlled-trial-of-myhealthkeeper
#12
Borim Ryu, Nari Kim, Eunyoung Heo, Sooyoung Yoo, Keehyuck Lee, Hee Hwang, Jeong-Whun Kim, Yoojung Kim, Joongseek Lee, Se Young Jung
BACKGROUND: Personal health record (PHR)-based health care management systems can improve patient engagement and data-driven medical diagnosis in a clinical setting. OBJECTIVE: The purpose of this study was (1) to demonstrate the development of an electronic health record (EHR)-tethered PHR app named MyHealthKeeper, which can retrieve data from a wearable device and deliver these data to a hospital EHR system, and (2) to study the effectiveness of a PHR data-driven clinical intervention with clinical trial results...
December 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29217168/the-stories-of-women-who-are-transferred-due-to-threat-of-preterm-birth
#13
Lyn Woodhart, Jessica Goldstone, Donna Hartz
BACKGROUND: Women at risk of preterm birth before 32 weeks gestation are routinely transferred to facilitate birth at a hospital that has Neonatal Intensive Care. The clinical outcomes of being 'in-born" improves newborn and neonatal outcomes is well documented. However little is known about the women's experiences when such a complication occurs. METHOD: Using the NSW Agency for Clinical Innovation Patient and Carer stories method, 10 women were purposively invited and consented to tell their stories...
December 4, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29216874/factors-influencing-the-experience-of-sexual-and-reproductive-healthcare-for-female-adolescents-with-perinatally-acquired-hiv-a-qualitative-case-study
#14
Gertrude Mwalabu, Catrin Evans, Sarah Redsell
BACKGROUND: Young people living with perinatally-acquired HIV require age-appropriate support regarding sex and relationships as they progress towards adulthood. HIV affects both genders but evidence suggests that young women are particularly vulnerable to sexual abuse and more prone to engaging in sexual behaviours to meet their daily survival needs. This can result in poor sexual and reproductive health (SRH) outcomes. HIV services in Malawi provide support for young women's HIV-related clinical needs, but it is unclear whether there is sufficient provision for their SRH needs as they become adults...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216071/features-of-the-non-collinear-one-phonon-anomalous-light-scattering-controlled-by-elastic-waves-with-elevated-linear-losses-potentials-for-multi-frequency-parallel-spectrum-analysis-of-radio-wave-signals
#15
Alexandre S Shcherbakov, Adan Omar Arellanes
During subsequent development of the recently proposed multi-frequency parallel spectrometer for precise spectrum analysis of wideband radio-wave signals, we study potentials of new acousto-optical cells exploiting selected crystalline materials at the limits of their capabilities. Characterizing these wide-aperture cells is non-trivial due to new features inherent in the chosen regime of an advanced non-collinear one-phonon anomalous light scattering by elastic waves with significantly elevated acoustic losses...
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29215404/quality-and-safety-in-health-care-part-xxxiv-coronary-artery-disease-secondary-prevention-medications
#16
Jay A Harolds
There is an important opportunity for improvement in the care of cardiology outpatients by having greater compliance with published guidelines, and the PINNACLE (Practice Innovation and Clinical Excellence) Registry seeks to do that. One of the major areas studied by this registry is the use of secondary prevention medications for patients with coronary artery disease. Appropriate use of these medications decreases later myocardial infarctions and death from a cardiac cause.
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29215402/quality-and-safety-in-health-care-part-xxxiv-the-pinnacle-registry
#17
Jay A Harolds
The PINNACLE (Practice INNovation And Clinical Excellence) program was started in 2008 by the American College of Cardiology and its National Cardiovascular Data Registry. This was the first and now the largest countrywide prospective registry to improve care quality for cardiac outpatients. The registry focuses on reporting about the adherence to guidelines in treating individuals with high blood pressure, atrial fibrillation, coronary artery disease, and/or cardiac failure.
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29214575/health-technology-assessment-and-appraisal-of-therapies-for-rare-diseases
#18
Georgi Iskrov, Tsonka Miteva-Katrandzhieva, Rumen Stefanov
Innovative rare disease therapies and health technology assessment (HTA) share a lot of similarities. Both represent cases of interaction of epidemiology and health economics. Both are relatively new topics in public health practice. And both pose a lot of challenges to rare disease stakeholders who are currently looking for tools to support the timely access to innovative treatments while putting budget spending in order. This is why optimisation of assessment and appraisal of new rare disease therapies is a fundamental issue in rare disease health policy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29214021/a-pilot-study-with-early-adolescents-dealing-with-diet-tobacco-and-air-pollution-using-practical-experiences-and-biological-markers
#19
Chiara Marabelli, Elena Munarini, Micaela Lina, Roberto Mazza, Roberto Boffi, Cinzia De Marco, Ario Ruprecht, Giorgia Angellotti, Chiara Veronese, Paolo Pozzi, Eleonora Bruno, Giuliana Gargano, Adalberto Cavalleri, Giulia Garrone, Franco Berrino
Background: Tobacco use and the Western diet are two of the most important and investigated topics in relation to adolescents' health. In addition, air pollution is a crucial subject for future generations. School is a key social environment that should promote healthy behaviors in children and adolescents. In this field many different programs have been conducted, with mixed results and effectiveness. Research data suggest that comprehensive and multicomponent approaches may have a greater effect on tobacco use and diet, especially when integrated into a community-wide approach...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29213212/implementation-and-feasibility-of-the-stroke-nursing-guideline-in-the-care-of-patients-with-stroke-a-mixed-methods-study
#20
Ingibjörg Bjartmarz, Helga Jónsdóttir, Thóra B Hafsteinsdóttir
Background: Nurses often have difficulties with using interdisciplinary stroke guidelines for patients with stroke as they do not focus sufficiently on nursing. Therefore, the Stroke Nursing Guideline (SNG) was developed and implemented. The aim of this study was to determine the implementation and feasibility of the SNG in terms of changes in documentation and use of the guideline in the care of stroke patients on Neurological and Rehabilitation wards, barriers and facilitators, and nurses' and auxiliary nurses' view of the implementation...
2017: BMC Nursing
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