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https://www.readbyqxmd.com/read/28544960/anti-biofilm-effect-of-dihydromyricetin-loaded-nanocapsules-on-urinary-catheter-infected-by-pseudomonas-aeruginosa
#1
A J F Dalcin, C G Santos, S S Gündel, I Roggia, R P Raffin, A F Ourique, R C V Santos, P Gomes
Nosocomial infections associated with biofilm formation on urinary catheters are among the leading causes of complications due to biofilm characteristics and high antimicrobial resistance. An interesting alternative are natural products, such as Dihydromyricetin (DMY), a flavonoid which presents several pharmacological properties, including strong antimicrobial activity against various microorganisms. However, DMY, has low aqueous solubility and consequently low bioavailability. Nanoencapsulation can contribute to the improvement of characteristics of some drugs, by increasing the apparent solubility and sustained release has been reported among other advantages...
May 15, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28544378/concise-review-induced-pluripotent-stem-cell-based-drug-discovery-for-mitochondrial-disease
#2
REVIEW
Gizem Inak, Carmen Lorenz, Pawel Lisowski, Annika Zink, Barbara Mlody, Alessandro Prigione
High attrition rates and loss of capital plague the drug discovery process. This is particularly evident for mitochondrial disease that typically involves neurological manifestations and is caused by nuclear or mitochondrial DNA defects. This group of heterogeneous disorders is difficult to target because of the variability of the symptoms among individual patients and the lack of viable modeling systems. The use of induced pluripotent stem cells (iPSCs) might significantly improve the search for effective therapies for mitochondrial disease...
May 22, 2017: Stem Cells
https://www.readbyqxmd.com/read/28542651/cellular-migration-transition-and-interaction-during-regeneration-of-the-sponge-hymeniacidon-heliophila
#3
Cristiano C Coutinho, Ivone de Andrade Rosa, John Douglas de Oliveira Teixeira, Leonardo R Andrade, Manoel Luis Costa, Claudia Mermelstein
Sponges have a high capacity for regeneration and this process improves biomass production in some species, thus contributing to a solution for the biomass supply problem for biotechnological applications. The aim of this work is to characterize the dynamics of cell behavior during the initial stages of sponge regeneration, using bright-field microscopy, confocal microscopy and SEM. We focused on the first 20 h of regeneration, during which blastema formation and epithelium initialization occur. An innovative sponge organotypic culture of the regenerating internal region is described and investigated by confocal microscopy, cell transplantation and vital staining...
2017: PloS One
https://www.readbyqxmd.com/read/28542539/a-leishmania-secretion-system-for-the-expression-of-major-ampullate-spidroin-mimics
#4
Todd A Lyda, Elizabeth L Wagner, Andre X Bourg, Congyue Peng, Golnaz Najaf Tomaraei, Delphine Dean, Marian S Kennedy, William R Marcotte
Spider major ampullate silk fibers have been shown to display a unique combination of relatively high fracture strength and toughness compared to other fibers and show potential for tissue engineering scaffolds. While it is not possible to mass produce native spider silks, the potential ability to produce fibers from recombinant spider silk fibers could allow for an increased innovation rate within tissue engineering and regenerative medicine. In this pilot study, we improved upon a prior fabrication route by both changing the expression host and additives to the fiber pulling precursor solution to improve the performance of fibers...
2017: PloS One
https://www.readbyqxmd.com/read/28541119/treatment-of-opioid-use-disorder-with-ibogaine-detoxification-and-drug-use-outcomes
#5
Thomas Kingsley Brown, Kenneth Alper
BACKGROUND: Ibogaine is a monoterpene indole alkaloid used in medical and nonmedical settings for the treatment of opioid use disorder. Its mechanism of action is apparently novel. There are no published prospective studies of drug use outcomes with ibogaine. OBJECTIVES: To study outcomes following opioid detoxification with ibogaine. METHODS: In this observational study, 30 subjects with DSM-IV Opioid Dependence (25 males, 5 females) received a mean total dose of 1,540 ± 920 mg ibogaine HCl...
May 25, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28540641/evaluation-of-penicillin-allergy-in-the-hospitalized-patient-opportunities-for-antimicrobial-stewardship
#6
REVIEW
Justin R Chen, David A Khan
PURPOSE OF REVIEW: Penicillin allergy is often misdiagnosed and is associated with adverse consequences, but testing is infrequently done in the hospital setting. This article reviews historical and contemporary innovations in inpatient penicillin allergy testing and its impact on antimicrobial stewardship. RECENT FINDINGS: Adoption of the electronic medical record allows rapid identification of admitted patients carrying a penicillin allergy diagnosis. Collaboration with clinical pharmacists and the development of computerized clinical guidelines facilitates increased testing and appropriate use of penicillin and related β-lactams...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28540125/project-heaven-preoperative-training-in-virtual-reality
#7
Kiratipath Iamsakul, Alexander V Pavlovcik, Jesus I Calderon, Lance M Sanderson
A cephalosomatic anastomosis (CSA; also called HEAVEN: head anastomosis venture) has been proposed as an option for patients with neurological impairments, such as spinal cord injury (SCI), and terminal medical illnesses, for which medicine is currently powerless. Protocols to prepare a patient for life after CSA do not currently exist. However, methods used in conventional neurorehabilitation can be used as a reference for developing preparatory training. Studies on virtual reality (VR) technologies have documented VR's ability to enhance rehabilitation and improve the quality of recovery in patients with neurological disabilities...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28540121/comprehensive-preoperative-staging-system-for-endoscopic-single-and-multicorridor-approaches-to-juvenile-nasal-angiofibromas
#8
Trichy N Janakiram, Shilpee B Sharma, Ekkehard Kasper, Onkar Deshmukh, Iype Cherian
BACKGROUND: Juvenile nasal angiofibromas (JNA) is a benign lesion with high vascularity and propensity of bone erosion leading to skull base invasion and intracranial extension. It is known to involve multiple compartments, which are often surgically difficult to access. With evolution in surgical expertise and technical innovations, endoscopic and endoscopic-assisted management has become the preferred choice of surgical management. Over the last four decades, various staging systems have been proposed, which are largely based on the extent of nasal angiofibroma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28540068/serendipity-and-innovation-history-and-evolution-of-transthoracic-echocardiography
#9
REVIEW
Antonino Di Franco, Lucas B Ohmes, Mario Gaudino, Lisa Q Rong, Leonard N Girardi, Filippo M Sarullo, Ylenia Salerno, Silvia Sarullo, Jonathan W Weinsaft, Jiwon Kim
The history of echocardiography is sprinkled with many interesting episodes and anecdotes showing that devoting your life to the pursuit of one goal is praiseworthy, and that at the same time, a little luck goes a long way. Transthoracic echocardiography (TTE) has led to dramatic improvements in cardiovascular medicine, and is now the most widely used diagnostic cardiac test after electrocardiography (ECG). The present review pays tribute to the pioneering efforts of those who believed in this innovative technology despite mounted skepticism and briefly describes the evolution of TTE from its early days to the most recent developments...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28539745/effect-of-tamarindus-indica-l-and-manihot-esculenta-extracts-on-antibiotic-resistant-bacteria
#10
Zenon Machado Lima, Lenilson Santos da Trindade, Genelane Cruz Santana, Francine Ferreira Padilha, Marcelo da Costa Mendonça, Luiz Pereira da Costa, Jorge A López, Maria Lucila Hernández Macedo
BACKGROUND: The chemical composition of plants used in traditional medicine exhibits biologically active compounds, such as tannins, flavonoids, and alkaloids and becomes a promising approach to treat microbial infections, mainly with drug-resistant bacteria. OBJECTIVE: The aim of the present study was to evaluate the hydroethanolic leaf extracts of Tamarindus indica (tamarind) and Manihot esculenta (cassava) as antimicrobial potential against Pseudomonas aeruginosa clinical isolated and Methicillin-resistant Staphylococcus aureus...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539080/keeping-candles-lit-the-role-of-concierge-medicine-in-the-future-of-primary-care
#11
Rocco Palumbo
Universal coverage and financial sustainability are two competing aims in primary care. Patient empowerment and patient engagement have been suggested as essential ingredients of the recipe for innovative primary care models aimed at sustaining universal coverage. Concierge medicine is achieving a growing popularity among both scholars and practitioners as a direct primary care practice which allows to bridge the gap between patient empowerment and patient engagement. However, ethical and legal concerns hinder the diffusion of concierge models in the current primary care practices...
May 2017: Health Services Management Research
https://www.readbyqxmd.com/read/28538709/minimal-invasive-cystometry-and-intra-abdominal-pressure-assessments-in-rodents-a-novel-animal-study
#12
Yafei Yang, Jin Yang, Lin Chen, Jianyun Hu, Shasha Xing, Bastian Amend, Arnulf Stenzl, Xin Wei, Haifeng Hu
BACKGROUND The abdominal straining pattern can act as a novel parameter for improving the prediction of bladder outlet obstruction (BOO). To preserve detrusor function in the early stage of urinary system impairment, such as BOO, we establish a novel method for cystometry and Intra-abdominal pressure (IAP) assessments in rodents without cystostomy. MATERIAL AND METHODS Twenty mice and rats were divided into three groups (control, sham-operated and BOO group) respectively. The cystometry and IAP assessments were measured by the pediatric venous indwelling sheath and coronary dilatation catheter connected to Laborie urodynamic system on postoperative day 7...
May 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28538247/the-positive-predictive-value-of-an-ambulance-prealert-for-stroke-and-transient-ischaemic-attack
#13
Craig W Brown, Mary J Macleod
OBJECTIVE: Therapeutic options for ischaemic stroke, such as thrombolysis or thrombectomy, are time sensitive. Multiple innovations have been established to reduce the symptom-to-needle time. One such innovation is the prealerting of emergency department (ED) or stroke unit staff by prehospital personnel of suspected stroke patients. The diagnosis of stroke can sometimes be difficult, with stroke mimics being a recognized issue. The prealert mobilizes ED, stroke and imaging personnel, which, for a true-positive, improves door-to-needle times...
May 19, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28538239/how-to-save-1-million-lives-in-a-year-in-low-and-middle-income-countries
#14
Colm P Travers, Wally A Carlo
Despite major improvements in reducing childhood mortality worldwide, over 5 million pregnancies per year end in stillbirths or neonatal deaths. The vast majority of these deaths occur in low- and middle-income countries. Many of these deaths are preventable with readily available evidence-based care practices. This review focuses on educational programs developed to reduce preventable deaths in newborn infants in low- and middle-income countries, including Essential Newborn Care and Helping Babies Breathe, a simplified version of the Neonatal Resuscitation Program...
2017: Neonatology
https://www.readbyqxmd.com/read/28538233/enewborn-the-information-technology-revolution-and-challenges-for-neonatal-networks
#15
Dominique Haumont, Cuong NguyenBa, Neena Modi
Among preterm infants, 1-2% are born before 32 weeks of gestation or have a birth weight below 1,500 g. They contribute disproportionately to the burden of mortality and morbidity related to preterm birth, whether in the neonatal period or later in life. They are the target population studied in neonatal networks. Improving neonatal care and later outcome is a major issue in public health. Neonatologists, health care providers, public authorities, parents and families, industry, and all organizations dedicated to infant health must bring their efforts together and dedicate their actions in order to do so...
2017: Neonatology
https://www.readbyqxmd.com/read/28538021/global-surgery-current-evidence-for-improving-surgical-care
#16
Jennifer C Fuller, David A Shaye
PURPOSE OF REVIEW: The field of global surgery is undergoing rapid transformation, owing to several recent prominent reports positioning it as a cost-effective means of relieving global disease burden. The purpose of this article is to review the recent advances in the field of global surgery. RECENT FINDINGS: Efforts to grow the global surgical workforce and procedural capacity have focused on innovative methods to increase surgeon training, enhance international collaboration, leverage technology, optimize existing health systems, and safely implement task-sharing...
May 19, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28537961/the-affordable-care-act-and-cancer-care-delivery
#17
Gabriel A Brooks, J Russell Hoverman, Carrie H Colla
The Affordable Care Act (ACA) has reformed US health care delivery through insurance coverage expansion, experiments in payment design, and funding for patient-centered clinical and health care delivery research. The impact on cancer care specifically has been far reaching, with new ACA-related programs that encourage coordinated, patient-centered, cost-effective care. Insurance expansions through private exchanges and Medicaid, along with preexisting condition clauses, have helped more than 20 million Americans gain health care coverage...
May 2017: Cancer Journal
https://www.readbyqxmd.com/read/28537786/designing-a-community-based-population-health-model
#18
Christopher J Durovich, Peter W Roberts
The pace of change from volume-based to value-based payment in health care varies dramatically among markets. Regardless of the ultimate disposition of the Affordable Care Act, employers and public-private payers will continue to increase pressure on health care providers to assume financial risk for populations in the form of shared savings, bundled payments, downside risk, or even capitation. This article outlines a suggested road map and practical considerations for health systems that are building or planning to build population health capabilities to meet the needs of their local markets...
May 24, 2017: Population Health Management
https://www.readbyqxmd.com/read/28537207/indirect-effect-of-management-support-on-users-compliance-behaviour-towards-information-security-policies
#19
Norshima Humaidi, Vimala Balakrishnan
BACKGROUND: Health information systems are innovative products designed to improve the delivery of effective healthcare, but they are also vulnerable to breaches of information security, including unauthorised access, use, disclosure, disruption, modification or destruction, and duplication of passwords. Greater openness and multi-connectedness between heterogeneous stakeholders within health networks increase the security risk. OBJECTIVE: The focus of this research was on the indirect effects of management support (MS) on user compliance behaviour (UCB) towards information security policies (ISPs) among health professionals in selected Malaysian public hospitals...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28537089/federated-health-information-architecture-enabling-healthcare-providers-and-policymakers-to-use-data-for-decision-making
#20
Manish Kumar, Javed Mostafa, Rohit Ramaswamy
Health information systems (HIS) in India, as in most other developing countries, support public health management but fail to enable healthcare providers to use data for delivering quality services. Such a failure is surprising, given that the population healthcare data that the system collects are aggregated from patient records. An important reason for this failure is that the health information architecture (HIA) of the HIS is designed primarily to serve the information needs of policymakers and program managers...
January 1, 2017: HIM Journal
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