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https://www.readbyqxmd.com/read/28088695/deep-metabolome-annotation-in-natural-products-research-towards-a-virtuous-cycle-in-metabolite-identification
#1
REVIEW
Pierre-Marie Allard, Grégory Genta-Jouve, Jean-Luc Wolfender
Natural products (NPs) research is changing and rapidly adopting cutting-edge tools, which radically transform the way to characterize extracts and small molecules. With the innovations in metabolomics, early integration of deep metabolome annotation information allows to efficiently guide the isolation of valuable NPs only and, in parallel, to generate massive metadata sets for the study of given extracts under various perspectives. This is the case for chemotaxonomy studies where common biosynthetic traits among species can be evidenced, but also for drug discovery purpose where such traits, in combination with bioactivity studies on extracts, may evidence bioactive molecules even before their isolation...
January 12, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28088691/stability-effect-of-cholesterol-poly-acrylic-acid-in-a-stimuli-responsive-polymer-liposome-complex-obtained-from-soybean-lecithin-for-controlled-drug-delivery
#2
M G Simões, P Alves, Manuela Carvalheiro, P N Simões
The development of polymer-liposome complexes (PLCs), in particular for biomedical applications, has grown significantly in the last decades. The importance of these studies comes from the emerging need in finding intelligent controlled release systems, more predictable, effective and selective, for applications in several areas, such as treatment and/or diagnosis of cancer, neurological, dermatological, ophthalmic and orthopedic diseases, gene therapy, cosmetic treatments, and food engineering. This work reports the development and characterization of a pH sensitive system for controlled release based on PLCs...
January 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28088438/a-snapshot-of-urban-adolescent-women-s-contraceptive-knowledge-at-the-onset-of-a-community-larc-promotion-initiative
#3
K B Greenberg, S C Jenks, N G Piazza, B R Malibiran, C A Aligne
STUDY OBJECTIVE: To contextualize young women's knowledge and attitudes regarding contraception at the outset of an intervention promoting long-acting reversible contraceptives (LARC) for teen pregnancy prevention. DESIGN: and Setting: Our intervention is based on diffusion of innovation theory, and at the outset we were interested in likely early adopters' existing knowledge and attitudes towards contraception. This mixed methods study consists of focus groups within positive youth development programs in Rochester, New York; we discussed young women's knowledge and sources of information for all FDA-approved contraceptive methods...
January 11, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28087483/cell-number-per-spheroid-and-electrical-conductivity-of-nanowires-influence-the-function-of-silicon-nanowired-human-cardiac-spheroids
#4
Yu Tan, Dylan Richards, Robert C Coyle, Jenny Yao, Ruoyu Xu, Wenyu Gou, Hongjun Wang, Donald R Menick, Bozhi Tian, Ying Mei
: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide an unlimited cell source to treat cardiovascular diseases, the leading cause of death worldwide. However, current hiPSC-CMs retain an immature phenotype that leads to difficulties for integration with adult myocardium after transplantation. To address this, we recently utilized electrically conductive silicon nanowires (e-SiNWs) to facilitate self-assembly of hiPSC-CMs to form nanowired hiPSC cardiac spheroids...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28086925/partnerships-in-mental-healthcare-service-delivery-in-low-resource-settings-developing-an-innovative-network-in-rural-nepal
#5
Bibhav Acharya, Duncan Maru, Ryan Schwarz, David Citrin, Jasmine Tenpa, Soniya Hirachan, Madhur Basnet, Poshan Thapa, Sikhar Swar, Scott Halliday, Brandon Kohrt, Nagendra P Luitel, Erick Hung, Bikash Gauchan, Rajeev Pokharel, Maria Ekstrand
BACKGROUND: Mental illnesses are the largest contributors to the global burden of non-communicable diseases. However, there is extremely limited access to high quality, culturally-sensitive, and contextually-appropriate mental healthcare services. This situation persists despite the availability of interventions with proven efficacy to improve patient outcomes. A partnerships network is necessary for successful program adaptation and implementation. PARTNERSHIPS NETWORK: We describe our partnerships network as a case example that addresses challenges in delivering mental healthcare and which can serve as a model for similar settings...
January 13, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28086808/a-quiet-harvest-linkage-between-ritual-seed-selection-and-the-historical-use-of-the-finger-bladed-knife-as-a-traditional-plant-breeding-tool-in-ifugao-philippines
#6
REVIEW
Kevin M Murphy
The transverse harvest knife, also commonly called the finger or finger-bladed knife, has been utilized by rice farmers in southeast Asia for many centuries. The finger knife persisted in many traditional cultures long after the introduction of the sickle, a tool which provided farmers with the means to execute a much faster harvest. Several theories in interpretative archaeology have attempted to account for this rejection of more modern technological innovations. These theories, which include community-based social organization ideas and practical reasons for the continued use of the finger knife, are presented in this paper...
January 13, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28081561/a-novel-richardson-lucy-model-with-dictionary-basis-and-spatial-regularization-for-isolating-isotropic-signals
#7
Tiantian Xu, Yuanjing Feng, Ye Wu, Qingrun Zeng, Jun Zhang, Jianzhong He, Qichuan Zhuge
Diffusion-weighted magnetic resonance imaging is a non-invasive imaging method that has been increasingly used in neuroscience imaging over the last decade. Partial volume effects (PVEs) exist in sampling signal for many physical and actual reasons, which lead to inaccurate fiber imaging. We overcome the influence of PVEs by separating isotropic signal from diffusion-weighted signal, which can provide more accurate estimation of fiber orientations. In this work, we use a novel response function (RF) and the correspondent fiber orientation distribution function (fODF) to construct different signal models, in which case the fODF is represented using dictionary basis function...
2017: PloS One
https://www.readbyqxmd.com/read/28081557/student-led-intervention-to-innovate-hand-hygiene-practice-in-auckland-region-s-medical-students-the-no-hharms-study
#8
Nathanael Cc Lucas, Carl G Hume, Abdal Al-Chanati, William Diprose, Sally Roberts, Josh Freeman, Vernon Mogol, David Hoskins, Richard Hamblin, Chris Frampton, Warwick Bagg, Alan F Merry
BACKGROUND: Hand hygiene is important in reducing healthcare-associated infections. The World Health Organization has defined 'five moments' when hand hygiene compliance is required. During 2013, New Zealand national data showed poor compliance with these moments by medical students. AIM: To improve medical students' compliance with the five moments. METHODS: In this prospective student-led quality improvement initiative, student investigators developed, implemented and evaluated a multi-modal intervention comprising a three-month social media campaign, a competition and an entertaining educational video...
January 13, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28080208/a-research-program-for-the-socioeconomic-impacts-of-gene-editing-regulation
#9
Agustina I Whelan, Martin A Lema
Gene editing technologies are a group of recent innovations in plant breeding using molecular biology, which have in common the capability of introducing a site-directed mutation or deletion in the genome. The first cases of crops improved with these technologies are approaching the market; this has raised an international debate regarding if they should be regulated as genetically modified crops or just as another form of mutagenesis under conventional breeding. This dilemma for policymakers not only entails issues pertaining safety information and legal/regulatory definitions...
January 12, 2017: GM Crops & Food
https://www.readbyqxmd.com/read/28079719/feasibility-of-using-hiv-care-continuum-outcomes-to-identify-geographic-areas-for-targeted-hiv-testing
#10
Amanda D Castel, Irene Kuo, Meriam Mikre, Toni Young, Meredith Haddix, Suparna Das, Geoffrey Maugham, Carol Reisen
BACKGROUND: Improved detection and linkage to care of previously undiagnosed HIV infections require innovative approaches to testing. We sought to determine the feasibility of targeted HIV testing in geographic areas, defined by continuum of care parameters, to identify HIV-infected persons needing linkage or engagement in care. METHODS: Using HIV surveillance data from Washington, DC, we identified census tracts that had an HIV prevalence >1% and were either above (higher risk areas-HRAs) or below (lower risk areas-LRAs) the median for 3 indicators: monitored viral load, proportion of persons out of care (OOC), and never in care...
February 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28078528/reducing-stress-among-mothers-in-drug-treatment-a-description-of-a-mindfulness-based-parenting-intervention
#11
Vanessa L Short, Meghan Gannon, Wendy Weingarten, Karol Kaltenbach, Marianna LaNoue, Diane J Abatemarco
Background Parenting women with substance use disorder could potentially benefit from interventions designed to decrease stress and improve overall psychosocial health. In this study we assessed whether a mindfulness based parenting (MBP) intervention could be successful in decreasing general and parenting stress in a population of women who are in treatment for substance use disorder and who have infants or young children. Methods MBP participants (N = 59) attended a two-hour session once a week for 12 weeks...
January 11, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28078186/soluble-receptor-for-advanced-glycation-end-products-improves-stromal-cell-derived-factor-1-activity-in-model-diabetic-environments
#12
Melissa Przyborowski Olekson, Renea A Faulknor, Henry C Hsia, Ann Marie Schmidt, François Berthiaume
Objective: In diabetes, hyperglycemia causes the accumulation of advanced glycation end products (AGEs) that trigger reactive oxygen species (ROS) generation through binding the receptor for AGEs (RAGE). Because exogenous growth factors have had little success in enhancing chronic wound healing, we investigated whether hyperglycemia-induced AGEs interfere with cellular responses to extracellular signals. We used stromal cell-derived factor-1 (SDF-1), an angiogenic chemokine also known to promote stem cell recruitment in skin wounds...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28077896/study-of-scientific-production-of-community-medicines-department-indexed-in-isi-citation-databases
#13
Mohammad Khademloo, Ali Akbar Khaseh, Hasan Siamian, Kobra Aligolbandi, Mahsoomeh Latifi, Mousa Yaminfirooz
BACKGROUND: In the scientometric, the main criterion in determining the scientific position and ranking of the scientific centers, particularly the universities, is the rate of scientific production and innovation, and in all participations in the global scientific development. One of the subjects more involved in repeatedly dealt with science and technology and effective on the improvement of health is medical science fields. In this research using scientometric and citation analysis, we studied the rate of scientific productions in the field of community medicine, which is the numbers of articles published and indexed in ISI database from 2000 to 2010...
October 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077586/redeploying-%C3%AE-lactam-antibiotics-as-a-novel-antivirulence-strategy-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-infections
#14
Elaine M Waters, Justine K Rudkin, Simone Coughlan, Geremy C Clair, Joshua N Adkins, Suzanna Gore, Guoqing Xia, Nikki S Black, Tim Downing, Eoghan O'Neill, Aras Kadioglu, James P O'Gara
Innovative approaches to the use of existing antibiotics is an important strategy in efforts to address the escalating antimicrobial resistance crisis. We report a new approach to the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections by demonstrating that oxacillin can be used to significantly attenuate the virulence of MRSA despite the pathogen being resistant to this drug. Using mechanistic in vitro assays and in vivo models of invasive pneumonia and sepsis, we show that oxacillin-treated MRSA strains are significantly attenuated in virulence...
January 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28077232/evidence-for-underuse-of-effective-medical-services-around-the-world
#15
REVIEW
Paul Glasziou, Sharon Straus, Shannon Brownlee, Lyndal Trevena, Leonila Dans, Gordon Guyatt, Adam G Elshaug, Robert Janett, Vikas Saini
Underuse-the failure to use effective and affordable medical interventions-is common and responsible for substantial suffering, disability, and loss of life worldwide. Underuse occurs at every point along the treatment continuum, from populations lacking access to health care to inadequate supply of medical resources and labour, slow or partial uptake of innovations, and patients not accessing or declining them. The extent of underuse for different interventions varies by country, and is documented in countries of high, middle, and low-income, and across different types of health-care systems, payment models, and health services...
January 6, 2017: Lancet
https://www.readbyqxmd.com/read/28077030/mortality-rates-in-oecd-countries-converged-during-the-period-1990-2010
#16
Sven G Bremberg
AIMS: Since the scientific revolution of the 18th century, human health has gradually improved, but there is no unifying theory that explains this improvement in health. Studies of macrodeterminants have produced conflicting results. Most studies have analysed health at a given point in time as the outcome; however, the rate of improvement in health might be a more appropriate outcome. METHODS: Twenty-eight OECD member countries were selected for analysis in the period 1990-2010...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28076989/improvement-of-patient-eligibility-with-the-use-of-new-generation-endografts-for-the-treatment-of-abdominal-aortic-aneurysms-a-comparison-study-among-currently-used-endografts-and-literature-review
#17
Nikolaos Kontopodis, George Papadopoulos, Nikolaos Galanakis, Dimitrios Tsetis, Christos V Ioannou
AIM: Newer generation devices have attempted to accommodate a wider range of aortoiliac anatomies offering endovascular aneurysm repair (EVAR) to more patients with abdominal aortic aneurysms (AAAs). We aim to examine the anatomic suitability for the ultra-low profile Ovation endograft in our AAA patients and to compare them with other contemporary devices. RESEARCH DESIGN AND METHODS: 158 consecutive AAA patients treated with EVAR or open surgical repair (OSR) were tested for EVAR eligibility according to the most commonly used endografts' instructions for use...
January 11, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28076371/meta-analysis-of-the-long-term-success-rate-of-different-interventions-in-benign-biliary-strictures
#18
Orsolya Huszár, Bálint Kokas, Péter Mátrai, Péter Hegyi, Erika Pétervári, Áron Vincze, Gabriella Pár, Patrícia Sarlós, Judit Bajor, József Czimmer, Dóra Mosztbacher, Katalin Márta, Csaba Zsiborás, Péter Varjú, Ákos Szücs
BACKGROUND: Benign biliary stricture is a rare condition and the majority of the cases are caused by operative trauma or chronic inflammation based on various etiology. Although the initial results of endoscopic, percutaneous and surgical treatment are impressive, no comparison about long term stricture resolution is available. AIMS: The goal of this study was to compare the long term disease free survival in benign biliary strictures with various etiology after surgery, percutaneous transhepatic-and endoscopic treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28075641/the-transgender-women-of-color-initiative-implementing-and-evaluating-innovative-interventions-to-enhance-engagement-and-retention-in-hiv-care
#19
Gregory Rebchook, JoAnne Keatley, Robert Contreras, Judy Perloff, Luis Freddy Molano, Cathy J Reback, Kelly Ducheny, Tooru Nemoto, Royce Lin, Jeffrey Birnbaum, Tiffany Woods, Jessica Xavier
To improve health outcomes among transgender women of color living with HIV, the Health Resources and Services Administration's Special Programs of National Significance program funded the Enhancing Engagement and Retention in Quality HIV Care for Transgender Women of Color Initiative in 2012. Nine demonstration projects in four US urban areas implemented innovative, theory-based interventions specifically targeting transgender women of color in their jurisdictions. An evaluation and technical assistance center was funded to evaluate the outcomes of the access to care interventions, and these findings will yield best practices and lessons learned to improve the care and treatment of transgender women of color living with HIV infection...
February 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28074569/screening-brief-intervention-and-referral-to-treatment-implications-of-samhsa-s-sbirt-initiative-for-substance-abuse-policy-and-practice
#20
Thomas F Babor, Frances Del Boca, Jeremy W Bray
AIMS: This paper describes the major findings and public health implications of a cross-site evaluation of a national Screening, Brief Intervention and Referral to Treatment (SBIRT) demonstration program funded by the US Substance Abuse and Mental Health Services Administration (SAMHSA). METHODS: Eleven multi-site programs in two cohorts of SAMHSA grant recipients were each funded for 5 years to promote the adoption and sustained implementation of SBIRT. The SBIRT cross-site evaluation used a multi-method evaluation design to provide comprehensive information on the processes, outcomes and costs of SBIRT as implemented in a variety of medical and community settings...
February 2017: Addiction
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