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https://www.readbyqxmd.com/read/29782704/profiling-of-new-psychoactive-substances-nps-by-using-stable-isotope-ratio-mass-spectrometry-irms-study-on-the-synthetic-cannabinoid-5f-pb-22
#1
S Münster-Müller, N Scheid, T Holdermann, S Schneiders, M Pütz
In this paper results of a pilot study on the profiling of the synthetic cannabinoid receptor agonist 5F-PB-22 (5F-QUPIC, pentylfluoro-1H-indole-3-carboxylic acid-8-quinolinyl ester) via isotope ratio mass spectrometry are presented. It is focused on δ13 C, δ15 N and δ2 H isotope ratios, which are determined using elemental analyser (EA) and high temperature elemental analyser (TC/EA) coupled to an isotope ratio mass spectrometer (IRMS). By means of a sample of pure material of 5F-PB-22 it is shown that the extraction of 5F-PB-22 from herbal material, a rapid clean-up procedure, or preparative column chromatography had no influences on the isotope ratios...
May 21, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29777946/screening-method-for-rapid-classification-of-psychoactive-substances-in-illicit-tablets-using-mid-infrared-spectroscopy-and-pls-da
#2
Leandro S A Pereira, Fernanda L C Lisboa, José Coelho Neto, Frederico N Valladão, Marcelo M Sena
Several new psychoactive substances (NPS) have reached the illegal drug market in recent years, and ecstasy-like tablets are one of the forms affected by this change. Cathinones and tryptamines have increasingly been found in ecstasy-like seized samples as well as other amphetamine type stimulants. A presumptive method for identifying different drugs in seized ecstasy tablets (n=92) using ATR-FTIR (attenuated total reflectance - Fourier transform infrared spectroscopy) and PLS-DA (partial least squares discriminant analysis) was developed...
May 9, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29775956/typology-of-new-psychoactive-substance-use-among-the-general-australian-population
#3
Rachel Sutherland, Amy Peacock, Amanda Roxburgh, Monica J Barratt, Lucinda Burns, Raimondo Bruno
AIM: The aim of this study was to examine the typology of Australian illicit drug consumers to determine whether those who use new psychoactive substances (NPS) differ from those using other illicit substances. METHODS: Data were from the 2013 National Drug Strategy Household Survey, a representative population study; analyses were limited to participants reporting past year illicit drug use (including NPS; n = 3309). Latent class analysis identified groups based on past year substance use, and a weighted multivariable, multinomial regression model was used to examine characteristics associated with group membership...
May 3, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29773359/-psychoactive-substances-use-in-r%C3%A3-union-island-and-mayotte-french-departments-in-indian-ocean
#4
Amélie Daveluy, Françoise Haramburu
INTRODUCTION: The government plan for the fight against drugs and addictive behaviors 2013-2017 includes several actions concerning French overseas territories, in particular to strengthen information on drug addiction. The Interministerial mission for combating drugs and addictive behaviors (MILD&CA) has commissioned the Bordeaux addictovigilance center to strengthen exchanges on addictovigilance with Réunion Island and Mayotte and to make an inventory of problematic drug use in these two French departments of Indian Ocean...
February 27, 2018: Thérapie
https://www.readbyqxmd.com/read/29768112/-marvin-the-paranoid-android-the-case-of-an-alpha-pvp-user-in-the-expanding-galaxy-of-nps
#5
Simonato Pierluigi, Bulsis Laura, Negri Attilio, Bansal Gurjeet K, Pessa Gloria, Mioni Davide, Giuseppe Borgherini, Martinotti Giovanni, Schifano Fabrizio, Giulia Perini, Corazza Ornella
Alpha-PVP can be defined as a novel psychoactive substance (NPS)-more specifically, a novel synthetic cathinone with unpredictable stimulant effects in humans. "Marvin" arrived at a Dual Diagnosis Unit at Parco dei Tigli, Italy. He underwent a 30-day rehabilitation program to overcome his problematic Alpha-PVP use as a psychonaut. We conducted an online search to understand the properties of Alpha-PVP and its presence in scientific literature, reviewing official reports and the online drug market (e...
May 16, 2018: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/29760666/candyflipping-and-other-combinations-identifying-drug-drug-combinations-from-an-online-forum
#6
Michael Chary, David Yi, Alex F Manini
Novel psychoactive substances (NPS) refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades. Case reports suggest that users combine substances to achieve desired psychotropic experiences while reducing dysphoria and unpleasant somatic effects. However, the pattern of combining NPS has not been studied on a large scale. Here, we show that posts discussing NPS describe combining nootropics with sedative-hypnotics and stimulants with plant hallucinogens or psychiatric medications...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29757600/dark-classics-in-chemical-neuroscience-morphine
#7
Andrea L Devereaux, Susan L Mercer, Christopher W Cunningham
As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chemists seeking to disentangle pharmacologically beneficial analgesic effects from addiction, tolerance, and dependence liabilities. In this review, we will detail the history of morphine, from the first extraction and isolation by Sertürner in 1804 to the illicit use of morphine and proliferation of opioid use and abuse disorders currently ravaging the United States...
May 14, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29757475/rapid-analysis-of-fentanyls-and-other-novel-psychoactive-substances-nps-in-substance-use-disorder-patient-urine-using-paper-spray-mass-spectrometry
#8
Joseph H Kennedy, Jan Palaty, Chris G Gill, Justin M Wiseman
RATIONALE: Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies to identify and quantitate NPS. METHODS: Paper spray tandem mass spectrometry and high-resolution mass spectrometry were used to identify and measure fentanyl analogs as well as common drugs of abuse in urine samples from substance use disorder clinics. Ten-microliter urine samples were deposited directly on paper spray cartridges previously loaded with internal standards, dried, and analyzed with no other sample treatment...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29757104/rehabilitation-of-drug-abusers-the-roles-of-perceptions-relationships-and-family-supports
#9
Samuel Ojima Adejoh, Olusegun M Temilola, Funmilayo F Adejuwon
The increase in the use, abuse and misuse of psychoactive substances is not just of concern to national government of different countries but poses a big problem to the international community as well as of a global public health challenge. The study explored the perceived influence of perceptions, relationships and family support on rehabilitation of drug abusers undergoing rehabilitation in a rehabilitation centre. The non-experimental study design was used. The study population was that of drug abuse patients undergoing rehabilitation in the Neuropsychiatric Hospital in Lagos...
May 14, 2018: Social Work in Public Health
https://www.readbyqxmd.com/read/29755353/importance-of-toxicokinetics-to-assess-the-utility-of-zebrafish-larvae-as-model-for-psychoactive-drug-screening-using-meta-chlorophenylpiperazine-mcpp-as-example
#10
Krishna Tulasi Kirla, Ksenia J Groh, Michael Poetzsch, Rakesh Kumar Banote, Julita Stadnicka-Michalak, Rik I L Eggen, Kristin Schirmer, Thomas Kraemer
The number of new psychoactive substances (NPS) increases rapidly, harming society and fuelling the need for alternative testing strategies. These should allow the ever-increasing number of drugs to be tested more effectively for their toxicity and psychoactive effects. One proposed strategy is to complement rodent models with zebrafish ( Danio rerio ) larvae. Yet, our understanding of the toxicokinetics in this model, owing to the waterborne drug exposure and the distinct physiology of the fish, is incomplete...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29750237/oral-health-of-youth-housed-in-socio-educational-centers-of-the-juvenile-penal-area-of-the-province-of-c%C3%A3-rdoba-argentina
#11
María M Barnetche, Lila S Cornejo
The purpose of this research was to analyze the oral health status of youth housed in socio-educational centers of the Juvenile Penal Area of the Province of Córdoba, Argentina of corrections by considering clinical evaluation and the main sociodemographic data. Socio-demographics, healthy and unhealthy habits of self-care, and dental clinical profile were assessed for this purpose. An exploratory cross-sectional study was carried out on 70 14- to 18-year-olds who had been institutionalized for at least six months...
December 2017: Acta Odontológica Latinoamericana: AOL
https://www.readbyqxmd.com/read/29745328/a-case-of-acute-intoxication-due-to-the-assumption-of-the-new-psychoactive-substance-nps-u-47700-identification-in-urine-blood-and-pubic-hair-by-liquid-chromatography-high-resolution-mass-spectrometry
#12
Donata Favretto, Vogliardi Susanna, Stocchero Giulia, Maietti Sergio, Tucci Marianna, Nalesso Alessandro, Snenghi Rossella
BACKGROUND/OBJECTIVE: We report on a case of severe intoxication after insufflation of U-47700, a synthetic opioid that acts as a selective agonist of the µ-opioid receptor, several times more potent than morphine. A man in his 30s was found irresponsive in his apartment and was brought to the emergency department of a local hospital. A comatous state and severe respiratory depression were diagnosed. Anamnesis revealed that the patient could have taken the substance named "U-47700", bought in the Internet...
May 9, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29744945/understanding-the-development-of-a-regulated-market-approach-to-new-psychoactive-substances-nps-in-new-zealand-using-punctuated-equilibrium-theory
#13
Marta Rychert, Chris Wilkins
BACKGROUND AND AIMS: The short-lived regulated legal market for new psychoactive substances (NPS) in New Zealand marked a radical departure from the traditional prohibition-based approach. This paper aimed to enhance understanding of this policy change using Punctuated Equilibrium Theory (PET). METHODS: The analysis draws on three years of evaluative research, including interviews with key stakeholders, analysis of legislation and policy documents and academic and grey literature...
May 9, 2018: Addiction
https://www.readbyqxmd.com/read/29742236/attendance-of-children-and-adolescents-with-psychoactive-substance-use-disorders-performed-by-psychosocial-care-centers-in-brazil-2008-2012
#14
Déborah Santos Conceição, Sérgio Baxter Andreoli, Monique Azevedo Esperidião, Darci Neves Dos Santos
OBJECTIVE: to describe the profile of care for children and adolescents withpsychoactive substance use disorders performed by the Brazilian Psychosocial Care Centers (Centros de Atenção Psicossocial - CAPS) from 2008 to 2012. METHODS: a descriptive study with data from the SUS Outpatient Information System (Sistema de Informações Ambulatoriais do Sistema Único de Saúde - SIA/SUS) and the system of National Registration of Health Establishments (Cadastro Nacional de Estabelecimentos de Saúde - CNES)...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29737425/haemorrhagic-stroke-related-to-the-use-of-4-fluoroamphetamine
#15
C H W Wijers, M C Visser, R T H van Litsenburg, R J M Niesink, R B Willemse, Esther A Croes
INTRODUCTION: The use of the new psychoactive substance 4-fluoroamphetamine (4-FA) and the number of 4-FA-related intoxications substantially increased in The Netherlands in recent years. We describe two patients with severe 4-FA-related complications and the characteristics of a large sample of 4-FA-intoxicated patients. METHODS: Information on patients with 4-FA-related intoxications between January 2009 and June 2017 was available from the Monitor Drug-related Incidents...
May 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29726116/phase-i-metabolism-of-the-carbazole-derived-synthetic-cannabinoids-eg-018-eg-2201-and-mdmb-chmczca-and-detection-in-human-urine-samples
#16
Lukas Mogler, Florian Franz, Maurice Wilde, Laura M Huppertz, Sebastian Halter, Verena Angerer, Bjoern Moosmann, Volker Auwärter
Synthetic cannabinoids (SCs) are a structurally diverse class of new psychoactive substances. Most SCs used for recreational purposes are based on indole or indazole core structures. EG-018 (naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone), EG-2201 ((9-(5-fluoropentyl)-9H-carbazol-3-yl)(naphthalen-1-yl)methanone) and MDMB-CHMCZCA (methyl 2-(9-(cyclohexylmethyl)-9H-carbazole-3-carboxamido)-3,3-dimethylbutanoate) are three representatives of a structural subclass of SCs, characterized by a carbazole core system...
May 4, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29718282/suspected-driving-under-the-influence-case-involving-mitragynine
#17
Trista H Wright
Mitragynine is a novel psychoactive substance (NPS) that has emerged as a designer opioid being distributed on the street. Mitragynine, also known as kratom, has dose-dependent pharmacological effects and possesses both stimulant-like and sedative effects due to dual-binding of α-adrenergic and μ-opioid receptors. This herbal remedy readily available online has caused adverse effects including tachycardia, agitation, tremors, hallucination and death; however, this is the first reported suspected driving under the influence case involving mitragynine...
April 27, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29709847/big-data-on-a-big-new-market-insights-from-washington-state-s-legal-cannabis-market
#18
Jonathan P Caulkins, Yilun Bao, Steve Davenport, Imane Fahli, Yutian Guo, Krista Kinnard, Mary Najewicz, Lauren Renaud, Beau Kilmer
INTRODUCTION: Voters in eight U.S. states have passed initiatives to legalize large-scale commercial production of cannabis for non-medical use. All plan or require some form of "seed-to-sale" tracking systems, which provide a view of cannabis market activity at a heretofore unimagined level of detail. Legal markets also create a range of new matters for policy makers to address. DATA: Publicly available data were obtained on approximately 45 million individually priced items purchased in the 35 million retail transactions that took place during the first two and a half years of Washington State's legal cannabis market...
April 27, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29709048/coping-with-stress-by-mothers-of-children-and-adolescents-with-cystic-fibrosis
#19
Renata Zubrzycka
INTRODUCTION: Studies of coping with stress of parents of children with cystic fibrosis (CF) are relatively rare and their results are inconsistent. The aim of the work was to determine the strategies of coping with stress of Polish mothers of children and adolescents with CF. MATERIAL AND METHODS: The research was conducted in the group of 89 Polish mothers of children with CF (0-18) and used the Brief COPE by Carver in the Polish adaptation by Juczyński and Ogińska-Bulik (2009)...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29704411/are-suicide-risk-factors-gender-specific
#20
Joanna Maria Pawlak, Izabela Miechowicz, Monika Dmitrzak-Węglarz, Aleksandra Szczepankiewicz, Dorota Zaremba, Paweł Kapelski, Aleksandra Rajewska-Rager, Piotr Czerski, Maria Skibińska, Joanna Hauser
OBJECTIVES: Suicide is an important clinical problem in psychiatric patients. The highest risk of suicide attempts is noted in affective disorders. In this study we tested 20 factors described in the literature (sociodemographic and clinical factors as well as family burden) in association with suicidal behavior and we analyzed whether the significance of those factors differs between males and females. METHODS: In the study we included patients with major depressive disorder (MDD; n = 249) and bipolar affective disorder (BP; n = 582)...
February 28, 2018: Psychiatria Polska
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