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Asthma marker

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https://www.readbyqxmd.com/read/29792201/cerium-dioxide-nanoparticles-exacerbate-house-dust-mite-induced-type-ii-airway-inflammation
#1
Kirsty Meldrum, Sarah B Robertson, Isabella Römer, Tim Marczylo, Lareb S N Dean, Andrew Rogers, Timothy W Gant, Rachel Smith, Terry D Tetley, Martin O Leonard
BACKGROUND: Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2 NPs) have the ability to modify disease outcome but have not been investigated for their effect on models of asthma and inflammatory lung disease. The aim of this study was to examine the impact of CeO2 NPs in a house dust mite (HDM) induced murine model of asthma. RESULTS: Repeated intranasal instillation of CeO2 NPs in the presence of HDM caused the induction of a type II inflammatory response, characterised by increased bronchoalveolar lavage eosinophils, mast cells, total plasma IgE and goblet cell metaplasia...
May 23, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29778504/solitary-chemosensory-cells-are-a-primary-epithelial-source-of-interleukin-25-in-chronic-rhinosinusitis-with-nasal-polyps
#2
Michael A Kohanski, Alan D Workman, Neil N Patel, Li-Yin Hung, Julie P Shtraks, Bei Chen, Mariel Blasetti, Laurel Doghramji, David W Kennedy, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen
BACKGROUND: IL-25 can function as an early signal for the respiratory Type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human airway epithelial IL-25 has remained elusive. OBJECTIVE: In this study, we sought to determine if the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the sinonasal epithelium...
May 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29777682/inhibition-of-bet-bromodomains-restores-corticosteroid-responsiveness-in-a-mixed-granulocytic-mouse-model-of-asthma
#3
Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Nahid Siddiqui, Khalid E Ibrahim, Sabry M Attia
Asthma is a heterogeneous disease characterized by different endotypes/phenotypes. Th2/Th17 driven mixed granulocytic asthma is one of them and shows resistance to corticosteroid therapy. Bromodomain and extra-terminal (BET) proteins are required for differentiation of Th17 cells which play a pivotal role in neutrophilic inflammation. Therefore, we sought to characterize the differential effects of BET inhibitor versus corticosteroids, and their potential synergism in cockroach allergen extract (CE)-induced mixed granulocytic (eosinophilic and neutrophilic) mouse model of asthma having Th2/Th17 endotype...
May 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29775222/abca1-inhibits-pdgf-induced-proliferation-and-migration-of-rat-airway-smooth-muscle-cell-through-blocking-tlr2-nf-%C3%AE%C2%BAb-nfatc1-signaling
#4
Wei Cheng, Kun Yan, Yanni Chen, Wen Zhang, Zongzheng Ji, Chengxue Dang
Airway remodeling is a key feature of asthma, characterized by abnormal proliferation and migration of airway smooth muscle cells (ASMCs). ABCA1, a member of the ATP-binding cassette family of active transporters, plays an essential role in the progression of lung diseases. However, the contributions of ABCA1 in ASMCs remain to be explored. The purpose of the present study was to investigate the functional role and potential molecular mechanism of ABCA1 in platelet derived growth factor (PDGF)-induced primary rat ASMC proliferation and migration...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#5
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29746003/ige-sensitisation-to-food-allergens-and-airborne-allergens-in-relation-to-biomarkers-of-type-2-inflammation-in-asthma
#6
A Patelis, K Alving, R Middelveld, A James, J Ono, S Ohta, K Izuhara, M P Borres, B Forsberg, C Janson, A Malinovschi
BACKGROUND: We have recently reported that sensitisation to food allergens and sensitisation to airborne allergens had independent associations with increased fraction of exhaled nitric oxide (FeNO) and blood eosinophils in middle-aged adults and in young subjects with asthma. OBJECTIVE: To investigate the relation between IgE sensitisation and several type 2 inflammation biomarkers in adult asthmatics. METHODS: FeNO, urinary eosinophil-derived neurotoxin (U-EDN), serum eosinophil cationic protein (S-ECP) and periostin were measured in 396 asthmatics, aged 17-76 years, from the Swedish GA2LEN study...
May 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29737044/a-clinical-follow-up-of-omalizumab-in-routine-treatment-of-allergic-asthma-monitored-by-cd-sens
#7
S Gunnar O Johansson, Gunnar Lilja, Jenny Hallberg, Anna Nopp
INTRODUCTION: Omalizumab has been available for treatment of allergic asthma for more than a decade and thus, its efficacy in routine treatment was of interest to evaluate. Basophil allergen threshold sensitivity (CD-sens) has been shown to correlate with the bronchial allergen threshold sensitivity and can be used to objectively measure omalizumab treatment efficacy. We aimed to evaluate the effect of omalizumab treatment of allergic asthma by CD-sens, as an objective marker of the IgE-mediated inflammation, and related to SPT, spirometry, FeNO, Asthma Control Questionnaire (ACQ), and Global Evaluation of Treatment Effectiveness (GETE)...
May 7, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29729177/clinical-and-pathogenetic-features-of-nonalcoholic-steatohepatitis-for-comorbidity-with-bronchial-asthma-on-the-background-of-obesity
#8
Oksana S Khukhlina, Alona A Antoniv, Olha Ye Mandryk, Olha Yе Hryniuk, Svitlana V Kovalenko, Victoria Yu Drozd, Zoriana Ia Kotsiubiichuk
OBJECTIVE: Introduction: The comorbid flow of non-alcoholic steatohepatitis (NASH) and bronchial asthma (BA) on the background of obesity is often recently drawn to the attention of both practitioners and researchers . The aim of our study was to study the changes in the functional state of the liver and the dependence of the external respiration function in patients with non-alcoholic steatohepatitis in combination with bronchial asthma and obesity. PATIENTS AND METHODS: Materials and methods: The study was attended by 50 people aged from 30 to 50 years (average age 42 years), of which 40% were men and 60% women...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29729167/the-dependence-of-the-endothelial-function-on-comorbid-states-in-patients-with-asthma
#9
Galyna V Yeryomenko
OBJECTIVE: Introduction: the purpose of the research consisted in the study of the functional state of the endothelium in patients having persistent asthma (A) with an uncontrolled course in combination with diabetes mellitus type 2 (DM2T) and obesity (O) The aim: on the basis of a complex study of nitric oxide metabolites (nitrosothiols, S-NO), von Willebrand factor (VWF) and endothelin-1 (EТ-1). PATIENTS AND METHODS: Materials and methods: The study involved 90 A patients with comorbid states, who were divided into 3 groups...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29728628/chronic-features-of-allergic-asthma-are-enhanced-in-the-absence-of-resistin-like-molecule-beta
#10
Kim S LeMessurier, Maneesha Palipane, Meenakshi Tiwary, Brian Gavin, Amali E Samarasinghe
Asthma is characterized by inflammation and architectural changes in the lungs. A number of immune cells and mediators are recognized as initiators of asthma, although therapeutics based on these are not always effective. The multifaceted nature of this syndrome necessitate continued exploration of immunomodulators that may play a role in pathogenesis. We investigated the role of resistin-like molecule-beta (RELM-β), a gut antibacterial, in the development and pathogenesis of Aspergillus-induced allergic airways disease...
May 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29724254/radical-containing-combustion-derived-particulate-matter-enhance-pulmonary-th17-inflammation-via-the-aryl-hydrocarbon-receptor
#11
Sridhar Jaligama, Vivek S Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R Mancuso, Tammy R Dugas, Stephania A Cormier
BACKGROUND: Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke, cigarette smoke, etc.). Our previous studies demonstrated that acute exposure to EPFRs results in dendritic cell maturation and Th17-biased pulmonary immune responses. Further, in a mouse model of asthma, these responses were enhanced suggesting exposure to EPFRs as a risk factor for the development and/or exacerbation of asthma...
May 3, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29719412/acute-effects-of-smoke-exposure-on-airway-and-systemic-inflammation-in-forest-firefighters
#12
Niki Gianniou, Charilena Giannakopoulou, Efrossini Dima, Matina Kardara, Paraskevi Katsaounou, Alexandros Tsakatikas, Charis Roussos, Nikolaos Koulouris, Nikoletta Rovina
Introduction: The aim of this study was to assess respiratory health and airway and systemic inflammation in professional forest firefighters post firefighting. Methods: A total of 60 firefighters who participated in forest firefighting operations in Greece during 2008 were included in the study. A questionnaire consisting of symptoms and exposure, pulmonary function, atopy, bronchial hyperresponsiveness, and markers of inflammation in induced sputum, serum, and bronchoalveolar lavage (BAL) fluid was assessed...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29717106/role-of-clusterin-progranulin-in-toluene-diisocyanate-induced-occupational-asthma
#13
Gil-Soon Choi, Hoang Kim Tu Trinh, Eun-Mi Yang, Young-Min Ye, Yoo Seob Shin, Seung-Hyun Kim, Hae-Sim Park
Toluene diisocyanate (TDI) exposure induces oxidative stress and epithelial cell-derived inflammation, which affect the pathogenesis of TDI-induced occupational asthma (TDI-OA). Recent studies suggested a role for clusterin (CLU) and progranulin (PGRN) in oxidative stress-mediated airway inflammation. To evaluate CLU and PGRN involvement in airway inflammation in TDI-OA, we measured their serum levels in patients with TDI-OA, asymptomatic exposed controls (AECs), and unexposed healthy normal controls (NCs)...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29715561/low-blood-eosinophil-counts-are-not-always-a-reliable-marker-of-clinical-response-to-mepolizumab-in-severe-asthma
#14
Iñigo Ojanguren, Simone Chaboillez, Catherine Lemiere
No abstract text is available yet for this article.
April 28, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29709643/development-of-a-tool-predicting-severity-of-allergic-reaction-during-peanut-challenge
#15
R Sharon Chinthrajah, Natasha Purington, Sandra Andorf, Jaime S Rosa, Kaori Mukai, Robert Hamilton, Bridget Marie Smith, Ruchi Gupta, Stephen J Galli, Manisha Desai, Kari C Nadeau
BACKGROUND: Reliable prognostic markers for predicting severity of allergic reactions during oral food challenges (OFC) have not been established. OBJECTIVE: We sought to develop a predictive algorithm of a food challenge severity score (CSS) to identify those at higher risk for severe reactions to a standardized peanut OFC. METHODS: Medical history and allergy tests were obtained for 120 peanut-allergic participants who underwent double-blind, placebo-controlled food challenges (DBPCFCs)...
April 27, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29705122/measurement-of-endocrine-disrupting-and-asthma-associated-chemicals-in-hair-products-used-by-black-women
#16
Jessica S Helm, Marcia Nishioka, Julia Green Brody, Ruthann A Rudel, Robin E Dodson
BACKGROUND: Personal care products are a source of exposure to endocrine disrupting and asthma-associated chemicals. Because use of hair products differs by race/ethnicity, these products may contribute to exposure and disease disparities. OBJECTIVE: This preliminary study investigates the endocrine disrupting and asthma-associated chemical content of hair products used by U.S. Black women. METHODS: We used gas chromatography/mass spectrometry (GC/MS) to test 18 hair products in 6 categories used by Black women: hot oil treatment, anti-frizz/polish, leave-in conditioner, root stimulator, hair lotion, and relaxer...
April 24, 2018: Environmental Research
https://www.readbyqxmd.com/read/29694255/serum-prolactin-level-in-chronic-urticaria-is-promocriptine-inducing-remission-in-chronic-urticaria
#17
Mohamed Soliman, Fathia M Khattab, Mohamad Nasr
BACKGROUND: Chronic urticaria (CU) is a disturbing disease with a negative impact on quality of life. Despite of several clinical studies on CU patients, its pathogenesis is poorly understood. Prolactin (PRL) is peptide hormone has immunomodulatory effects in some immune inflammatory skin diseases. AIM: To elucidate any possible relationship between the immunomodulatory effects of Prolactin (PRL) and CU. Besides, the study aims to investigate the crucial role of antiprolactin drugs in the management of CU patients...
April 25, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29692764/the-virome-and-its-major-component-anellovirus-a-convoluted-system-molding-human-immune-defenses-and-possibly-affecting-the-development-of-asthma-and-respiratory-diseases-in-childhood
#18
REVIEW
Giulia Freer, Fabrizio Maggi, Massimo Pifferi, Maria E Di Cicco, Diego G Peroni, Mauro Pistello
The microbiome, a thriving and complex microbial community colonizing the human body, has a broad impact on human health. Colonization is a continuous process that starts very early in life and occurs thanks to shrewd strategies microbes have evolved to tackle a convoluted array of anatomical, physiological, and functional barriers of the human body. Cumulative evidence shows that viruses are part of the microbiome. This part, called virome, has a dynamic composition that reflects what we eat, how and where we live, what we do, our genetic background, and other unpredictable variables...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29691706/low-concentrations-of-25-hydroxyvitamin-d-and-long-term-prognosis-of-copd-a-prospective-cohort-study
#19
Gitte Færk, Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard
Role and importance of vitamin D deficiency in long-term prognosis of chronic obstructive pulmonary disease (COPD) still remains undetermined. We tested the hypothesis that among individuals with COPD, those with low concentrations of 25-hydroxyvitamin D have a poorer prognosis compared to those with normal concentrations. We studied 35,153 individuals from the general population aged 20-100 years with 25-hydroxyvitamin D measurements and spirometry, the Copenhagen City Heart Study [median follow-up 21 years (range 13 days-36 years)] and the Copenhagen General Population Study [7...
April 24, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29677923/profiling-databases-to-facilitate-comparison-of-child-health-systems-across-europe-using-standardised-quality-markers
#20
Harshana Liyanage, Stacy Shinneman, Uy Hoang, Filipa Ferreira, Denise Alexander, Michael Rigby, Mitch Blair, Simon de Lusignan
Models of child primary health care vary across Europe. There are three categories, primary care paediatricians, general practitioner based, or mixed. This paper describes the metadata schema used in the profiling process of candidate data sources for appraisal for the Models of Child Health Appraised (MOCHA) project using the MOCHA International Research Opportunity Instrument (MIROI). The ten clinical indicators included: asthma, antibiotic stewardship, immunisation, rickets, diarrhea, epilepsy, depression, ADHD, enuresis and care of women during pregnancy...
2018: Studies in Health Technology and Informatics
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