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Asthma marker

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https://www.readbyqxmd.com/read/29150068/sensitization-to-staphylococcus-aureus-enterotoxins-in-smokers-with-asthma
#1
Tadao Nagasaki, Hisako Matsumoto, Tsuyoshi Oguma, Isao Ito, Hideki Inoue, Toshiyuki Iwata, Tomoko Tajiri, Yoshihiro Kanemitsu, Yumi Izuhara, Chie Morimoto, Yumi Ishiyama, Hironobu Sunadome, Akio Niimi, Toyohiro Hirai
BACKGROUND: Sensitization to Staphylococcus aureus enterotoxins (SEs) augments eosinophilic inflammation in asthma. Recent epidemiologic studies demonstrate that sensitization to SEs is increased in healthy smokers; however, there is no evidence on the association between sensitization to SEs and eosinophilic inflammation in smokers with asthma. OBJECTIVE: To clarify the role of SEs on clinical indexes, including eosinophilic inflammation and lung function in smokers with asthma...
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29144419/air-pollution-and-dispensed-medications-for-asthma-and-possible-effect-modifiers-related-to-mental-health-and-socio-economy-a-longitudinal-cohort-study-of-swedish-children-and-adolescents
#2
Anna Oudin, Lennart Bråbäck, Daniel Oudin Åström, Bertil Forsberg
It has been suggested that children that are exposed to a stressful environment at home have an increased susceptibility for air pollution-related asthma. The aim here was to investigate the association between air pollution exposure and asthma, and effect modification by mental health and by socio-economic status (as markers of a stressful environment). All individuals under 18 years of age in four Swedish counties during 2007 to 2010 (1.2 million people) were included. The outcome was defined as dispensing at least two asthma medications during follow up...
November 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29141605/an-intronic-single-nucleotide-polymorphism-rs13217795-in-foxo3-is-associated-with-asthma-and-allergic-rhinitis-a-case-case-control-study
#3
Justin Z Amarin, Randa G Naffa, Haya H Suradi, Yousof M Alsaket, Nathir M Obeidat, Tareq M Mahafza, Malek A Zihlif
BACKGROUND: Asthma and allergic rhinitis are respiratory diseases with a significant global burden. Forkhead box O3 (FOXO3) is a gene involved in the etiology of a number of respiratory diseases. The objective of this study is to assess the association of rs13217795, an intronic FOXO3 single-nucleotide polymorphism, with asthma and allergic rhinitis. METHODS: In this case-case-control genetic association study, genotyping was conducted using the PCR-RFLP method...
November 15, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29139062/tools-in-asthma-evaluation-and-management-when-and-how-to-use-them
#4
REVIEW
Anna Mulholland, Alana Ainsworth, Naveen Pillarisetti
The goals of asthma management are accurate diagnosis, prompt initiation of treatment and monitoring of disease progression to limit potential morbidity and mortality. While the diagnosis and management is largely based on history taking and clinical examination, there are an increasing number of tools available that could be used to aid diagnosis, define phenotypes, monitor progress and assess response to treatment. Tools such as the Asthma Predictive Index could help in making predictions about the possibility of asthma in childhood based on certain clinical parameters in pre-schoolers...
November 15, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29133222/physical-activity-and-exercise-capacity-in-severe-asthma-key-clinical-associations
#5
Laura Cordova-Rivera, Peter G Gibson, Paul A Gardiner, Heather Powell, Vanessa M McDonald
BACKGROUND: Physical inactivity and sedentary time are distinct behaviors that may be more prevalent in severe asthma, contributing to poor disease outcomes. Physical activity and sedentary time in severe asthma however have not been extensively examined. OBJECTIVE: We aimed to objectively measure physical activity and sedentary time in people with severe asthma compared with age-matched control participants, describing the associations of these behaviors with clinical and biological outcomes...
November 10, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29130617/dendritic-cell-phenotype-in-severe-asthma-reflects-clinical-responsiveness-to-glucocorticoids
#6
Emma S Chambers, Alexandra M Nanzer, Paul E Pfeffer, David F Richards, Adrian R Martineau, Christopher J Griffiths, Christopher J Corrigan, Catherine M Hawrylowicz
BACKGROUND: Subsets of patients with severe asthma remain symptomatic despite prolonged, high dosage glucocorticoid therapy. We hypothesised that the clinical glucocorticoid sensitivity of these asthmatics is reflected in differences in peripheral blood dendritic cell subsets. OBJECTIVE: To compare peripheral blood leukocyte populations using flow cytometry at baseline and after 2 weeks of systemic glucocorticoid (steroid) treatment to identify immunological differences between steroid sensitive (SS) and steroid resistant (SR) asthmatics...
November 11, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29128708/childhood-brain-tumours-early-infections-and-immune-stimulation-a-pooled-analysis-of-the-escale-and-estelle-case-control-studies-sfce-france
#7
Judith E Lupatsch, Helen D Bailey, Brigitte Lacour, Christelle Dufour, Anne-Isabelle Bertozzi, Pierre Leblond, Cécile Faure-Conter, Isabelle Pellier, Claire Freycon, François Doz, Stéphanie Puget, Stéphane Ducassou, Laurent Orsi, Jacqueline Clavel
BACKGROUND: Few studies have investigated whether early infections and factors potentially related to early immune stimulation might be involved in the aetiology of childhood brain tumours (CBT). In this study, we investigated the associations between CBT with early day-care attendance, history of early common infections, atopic conditions (asthma/wheezing, eczema, allergic rhinitis), early farm residence/visits and contact with animals. METHODS: We pooled data from two nationwide French case-control studies, the ESCALE and ESTELLE studies...
November 10, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29120994/inhaled-corticosteroids-in-asthma-promoting-or-protecting-against-atherosclerosis
#8
Michał Podgórski, Maciej Kupczyk, Piotr Grzelak, Małgorzata Bocheńska-Marciniak, Michał Polguj, Piotr Kuna, Ludomir Stefańczyk
BACKGROUND Bronchial asthma is an inflammatory disease of the respiratory system. However, it may also induce systemic effects. Although reports suggest patients with asthma are at increased risk of cardiovascular events, the association between asthma and atherosclerosis is unclear. The aim of the present study was to compare the progression of atherosclerosis between patients with asthma treated with inhaled corticosteroids and healthy controls. MATERIAL AND METHODS In 102 adult patients with asthma, markers of arterial stiffness (pulse wave velocity and augmentation index) were evaluated by applanation tonometry...
November 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29110960/the-clinical-role-of-fractional-exhaled-nitric-oxide-in-asthma-control
#9
Suguru Sato, Junpei Saito, Atsuro Fukuhara, Manabu Uematsu, Yasuhito Suzuki, Ryuichi Togawa, Yuki Sato, Takefumi Nikaido, Xintao Wang, Yoshinori Tanino, Mitsuru Munakata
BACKGROUND: The potential role and characteristics of fractional exhaled nitric oxide (FeNO) remain unclear in the treatment of asthma. OBJECTIVE: To explore the clinical role of FeNO in asthmatic treatment. METHODS: We evaluated whether the mean or change of FeNO levels in the treatment period is associated with other conventional control parameters and predicted some clinical outcomes of asthma. We retrospectively analyzed the mean and percentage change of FeNO levels in the first 5 measurements at our hospital...
October 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29105205/enhanced-antigen-presenting-and-t-cell-functions-during-late-phase-allergic-responses-in-the-lung
#10
Mark C Liu, HuiQing Xiao, Linda Breslin, Bruce Bochner, John Schroeder
BACKGROUND: Allergic inflammation is a common feature of asthma and may contribute to both development and perpetuation of disease. The interaction of antigen presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines may determine the inflammatory response. Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional studies in humans have been limited. OBJECTIVE: This study examined the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge (SAC)...
November 3, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29103994/sputum-cell-interleukin-1-receptor-expression-level-is-a-marker-of-airway-neutrophilia-and-airflow-obstruction-in-asthma
#11
Michael D Evans, Stephane Esnault, Loren C Denlinger, Nizar N Jarjour
BACKGROUND: Various clinical, biologic or physiologic markers of asthma have been used to identify patient clusters and potential targets for therapy. However, these identifiers frequently overlap among the different asthma groups. For instance, both eosinophils and neutrophils are often increased in the airway of asthma patients despite their typical association with type-2 and type-17 immune response, respectively. OBJECTIVES: To determine whether inflammatory gene expressions are related to patterns of airway inflammation and lung function, and identify molecular markers for neutrophilic asthma...
November 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29083971/patient-outcomes-health-care-resource-use-and-costs-associated-with-high-versus-low-hedis-asthma-medication-ratio
#12
Allan T Luskin, Evgeniya N Antonova, Michael S Broder, Eunice Chang, Karina Raimundo, Paul G Solari
BACKGROUND: The Healthcare Effectiveness Data and Information Set (HEDIS) quality measures for asthma include the asthma medication ratio (AMR) as a marker of quality of care for patients with asthma. Few data are available to describe the association between health care use and costs in patients with high versus low AMR. OBJECTIVE: To characterize health care use and costs associated with high versus low AMR in patients participating in commercial health plans...
November 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29076426/swertia-chirata-a-comprehensive-review-with-recent-advances
#13
Nupur Jauhari, Navneeta Bharadvaja, Neelam Sharma
BACKGROUND: Swertia chirata, an ethnomedicinal plant, is renowned for its diverse medicinal properties. The plant produces large number of therapeutic phytochemicals responsible for remedial effect against various ailments mainly chronic fever, malaria, bronchial asthma, liver disorders, certain type of mental disorder, blood purification and diabetes. Recently reported anticancer effect of S. chirata has amplified its importance in the scientific community. OBJECTIVE: The aim of the review is to deliver the pharmaceutical importance of S...
October 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29073174/asthma-is-associated-with-atherosclerotic-artery-changes
#14
COMPARATIVE STUDY
Izabela Tuleta, Dirk Skowasch, Florian Aurich, Nicolas Eckstein, Robert Schueler, Carmen Pizarro, Nadjib Schahab, Georg Nickenig, Christian Schaefer, Simon Pingel
Asthma is a chronic airway inflammation with a potential systemic impact. Atherosclerosis is a chronic inflammatory artery disease. The aim of our study was to prove if there is a correlation between the occurrence of asthma and increased atherosclerotic vessel disorders. Vessel status was compared between mild-to-moderate, severe allergic asthma and matched controls. Measurements of artery stiffness were calculated by central pulse wave velocity, ultrasonographic strain imaging and ankle-brachial index. Atherosclerotic plaque burden was assessed by colour-coded duplex sonography...
2017: PloS One
https://www.readbyqxmd.com/read/29068321/relationship-between-total-serum-immunoglobulin-e-levels-fractional-exhaled-breath-nitric-oxide-levels-and-absolute-blood-eosinophil-counts-in-atopic-and-non-atopic-asthma-a-controlled-comparative-study
#15
Sanjeet Krishna Shrestha, Arne Drews, Lucky Sharma, Subash Pant, Sanjeev Shrestha, Arpana Neopane
ABSTRACT Introduction Asthma is a prevalent non communicable disease both in low and high income countries, including Nepal. Total serum immunoglobulin E levels and peripheral blood absolute eosinophil counts are known inflammatory markers of asthma. And Fractional Exhaled Nitric Oxide measure in breath has also been proposed as a non-invasive biomarker to assess eosinophilic airway inflammation. This study explores the correlation between these three variables with intent that one may replace the other in resource limited setup...
October 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29064792/anti-inflammatory-and-endothelium-protective-effect-of-long-term-pioglitazone-intake-in-patients-suffering-from-bronchial-asthma-concurrent-with-ischemic-heart-disease
#16
Oksana V Byelan, Tetiana V Mamontova, Liudmyla E Vesnina, Oksana A Borzykh, Igor P Kaidashev
INTRODUCTION: Treatment of co-morbidities, including bronchial asthma (BA) and coronary heart disease (CHD), is a relevant issue of modern therapy. The aim of the research is to study the impact of long-term intake of pioglitazone on the development of inflammation and ED in patients with BA concurrent with CHD. MATERIAL AND METHODS: The clinical study involved 50 people aged 40-75 who suffered from asthma concurrent with CHD. On the first day of the study, blood samples were collected and clinical examinations were performed, after which patients were randomized and divided into the control group who continued to receive only the standard therapy, and the study group, who received pioglitazone (Pioglar, Ranbaxy, India) 15 mg once a day along with comprehensive therapy...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29064281/interferon-stimulated-gene-expression-type-2-inflammation-and-endoplasmic-reticulum-stress-in-asthma
#17
Nirav R Bhakta, Stephanie A Christenson, Srilaxmi Nerella, Owen D Solberg, Christine P Nguyen, David F Choy, Kyle L Jung, Suresh Garudadri, Luke R Bonser, Joshua L Pollack, Lorna T Zlock, David J Erle, Charles Langelier, Joseph L Derisi, Joseph R Arron, John V Fahy, Prescott G Woodruff
RATIONALE: Quantification of type-2 inflammation provided a molecular basis for heterogeneity in asthma. Non-type-2 pathways that contribute to asthma pathogenesis are not well understood. OBJECTIVES: To identify dysregulated pathways beyond type-2 inflammation. METHODS: We applied RNA sequencing to airway epithelial brushings obtained from stable mild asthmatics not on corticosteroids (n=19) and healthy controls (n=16). Sequencing reads were mapped to human and viral genomes...
October 24, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29062802/modulation-of-lung-inflammation-and-immune-markers-in-asthmatic-rats-treated-by-portulaca-oleracea
#18
Mahsa Kaveh, Akram Eidi, Ali Nemati, Mohammad Hossein Boskabady
OBJECTIVE: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2 (PLA2) and IgE in sensitized rats were examined. MATERIALS AND METHODS: Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of P...
September 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29059515/effectiveness-of-germination-on-protein-hydrolysis-as-a-way-to-reduce-adverse-reactions-to-wheat
#19
Fatma Boukid, Barbara Prandi, Sofie Buhler, Stefano Sforza
In this work, the aim is to study the effectiveness of germination on wheat protein degradation, with a specific focus on proteins involved in adverse reactions to wheat. The effects of 8 days of germination at 25 °C on the chemical composition and the protein profile were determined. Germination did not have a significant effect on starch, protein, lipid, and ash contents. General protein profile, as indicated by SDS-PAGE analysis, revealed that germination induced a relevant degradation in protein fraction...
November 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29058773/the-role-of-innate-lymphoid-cells-in-health-and-disease
#20
REVIEW
Hamed Mohammadi, Nadia Sharafkandi, Maryam Hemmatzadeh, Gholamreza Azizi, Mohammad Karimi, Farhad Jadidi-Niaragh, Behzad Baradaran, Zohreh Babaloo
Innate lymphoid cells (ILCs) are kind of innate immune cells which can be divided into three main subsets according to their cytokine release profile, transcription factors, and surface markers. ILCs affect the initial stages of immunity in response to microbes and participate in immunity, inflammation and tissue repair. ILCs modulate immunity through resistance to the pathogens and regulation of autoimmune inflammation and metabolic homeostasis. Therefore dysregulation of ILCs may lead to chronic pathologies such as allergies (i...
October 23, 2017: Journal of Cellular Physiology
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