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Asthma marker

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https://www.readbyqxmd.com/read/28804539/mir-371-mir-138-mir-544-mir-145-and-mir-214-could-modulate-th1-th2-balance-in-asthma-through-the-combinatorial-regulation-of-runx3
#1
Yu-Ying Qiu, Ying-Wei Zhang, Xiu-Fen Qian, Tao Bian
Asthma is tightly related to the imbalance of Th1/Th2 cells, and Runx3 plays a pivotal role in the differentiation of T helper cells. The present study aimed to investigate dysregulated microRNAs that may target Runx3 in CD4(+) T cells from asthmatic patients and reveal Runx3 function in Th1/Th2 balance regulation. We detected the levels of Th1- and Th2-related cytokines by ELISA and analyzed the differentiation marker gene of T helper cells by qRT-PCR. Results indicated that an imbalance of Th1/Th2 cells was present in our asthmatic subject...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28797075/arginine-metabolic-endotypes-related-to-asthma-severity
#2
Weiling Xu, Suzy A A Comhair, Allison J Janocha, Abigail Lara, Lori A Mavrakis, Carole D Bennett, Satish C Kalhan, Serpil C Erzurum
AIMS: Arginine metabolism via inducible nitric oxide synthase (iNOS) and arginase 2 (ARG2) is higher in asthmatics than in healthy individuals. We hypothesized that a sub-phenotype of asthma might be defined by the magnitude of arginine metabolism categorized on the basis of high and low fraction of exhaled nitric oxide (FENO). METHODS: To test this hypothesis, asthmatics (n = 52) were compared to healthy controls (n = 51) for levels of FENO, serum arginase activity, and airway epithelial expression of iNOS and ARG2 proteins, in relation to clinical parameters of asthma inflammation and airway reactivity...
2017: PloS One
https://www.readbyqxmd.com/read/28795218/atopy-and-prostate-cancer-is-there-a-link-between-circulating-levels-of-ige-and-psa-in-humans
#3
Mieke Van Hemelrijck, Sophia N Karagiannis, Sabine Rohrmann
BACKGROUND: Atopy has been investigated as a potential risk factor for prostate cancer. IgE antibodies may be major players in protective responses against tumours, through engendering antigen presentation and enhancing adaptive immune responses targeted towards a specific allergen, but potentially also against tumour-associated antigens such as prostate-specific antigen (PSA). We therefore cross-sectionally investigated associations between circulating levels of PSA and IgE in the National Health and Nutrition Examination Survey 2005-2006...
August 9, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28791839/a-comparative-study-of-strem-1-il-6-and-il-13-concentration-in-bronchoalveolar-lavage-fluid-in-asthma-and-copd-a-preliminary-study
#4
Małgorzata Proboszcz, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Katarzyna Górska, Rafał Krenke
BACKGROUND: Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is a cell-surface receptor presented on neutrophils, macrophages and monocytes. Elevated sTREM-1 levels are a marker of acute microbial infections, and have also been reported in chronic lung diseases. IL-6 and IL-13 are effective markers in distinguishing these diseases. IL-6 has been shown to play an important role in chronic obstructive pulmonary disease (COPD), while IL-13 is described as one of the key mediators of allergic asthma...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28760578/pre-birth-origins-of-allergy-and-asthma
#5
REVIEW
K L Gatford, A L Wooldridge, K L Kind, R Bischof, V L Clifton
Allergy is a chronic disease that can develop as early as infancy, suggesting that early life factors are important in its aetiology. Variable associations between size at birth, a crude marker of the fetal environment, and allergy have been reported in humans and require comprehensive review. Associations between birth weight and allergy are however confounded in humans, and we and others have therefore begun exploring the effects of early life events on allergy in experimental models. In particular, we are using ovine models to investigate whether and how a restricted environment before birth protects against allergy, whether methyl donor availability contributes to allergic protection in IUGR, and why maternal asthma during pregnancy is associated with increased risks of allergic disease in children...
July 20, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28759272/determination-of-asthma-control-using-administrative-data-regarding-short-acting-beta-agonist-inhaler-purchase
#6
Dekel Shlomi, Irit Katz, Michael J Segel, Bernice Oberman, Nir Peled
BACKGROUND: Symptom control is a primary goal in asthma. We hypothesized that administrative data regarding rescue inhaler purchases may correlate with asthma symptom control. METHODS: We identified all patients who purchased SABA inhalers during the course of one year in the database of an Health Maintenance Organization (HMO). Primary physicians identified asthma patients and classified their asthma symptom control into 3 groups according to GINA guidelines. Asthma patients were asked to answer symptom questionnaires and grade their asthma control...
July 31, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28759088/the-effects-of-treatment-in-patients-with-childhood-asthma-on-the-elastic-properties-of-the-aorta
#7
Osman Bektaş, Zeki Yüksel Günaydin, Ahmet Karagöz, Recep Akgedik, Adil Bayramoğlu, Ahmet Kaya
INTRODUCTION: The study aimed to investigate the effects of treatment in patients with childhood asthma on the elastic properties of the aorta and cardiovascular risk. METHODS: The study was performed in 66 paediatric patients diagnosed with bronchial asthma (BA). All patients were administered the β2 agonist, salbutamol, for seven days, followed by one month of montelukast and six months of inhaled steroid treatment. All patients underwent conventional transthoracic echocardiographic imaging before and after treatment...
May 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28755730/is-decreased-mean-platelet-volume-in-allergic-airway-diseases-associated-with-extent-of-the-inflammation-area
#8
Recep Akgedik, Yasin Yağız
OBJECTIVE: The aim of this study was to determine the relationship between mean platelet volume (MPV) level and the extent of airway inflammation in allergic airway diseases and in subgroups by comparison of inflammatory markers. MATERIALS AND METHODS: A retrospective examination was made of 250 patients with allergic airway disease in the symptomatic phase, who had been newly diagnosed or who had abandoned treatment for at least 6 months. These patients were separated into 3 groups of asthma without allergic rhinitis (A - AR, n = 107), asthma with allergic rhinitis (A + AR, n = 83) and allergic rhinitis without asthma (AR - A, n = 60)...
July 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28752551/point-of-care-instruments-need-to-offer-high-levels-of-accuracy
#9
Malgorzata Karawajczyk, Anders Larsson
We appreciate the interest shown by Heffler et al in our paper on the HemoCue WBC DIFF instrument (1). Considering the return of eosinophils as markers in asthma monitoring (eosinophilia) or in sepsis (eosinopenia) it is important to remind ourselves how the levels of measured blood cells are influenced by the performance of an analytical instrument. We fully agree with Heffler et al (2) that the HemoCue WBC DIFF's results should be interpreted in the context of the clinical setting or medical condition of the patient...
July 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28737966/effect-of-obesity-on-sinonasal-disease-in-asthma
#10
S Kanagalingam, S S Shehab, D A Kaminsky, R A Wise, J E Lang, A E Dixon
Sinonasal disease can contribute to poor asthma control. There are reports that link obesity with an increased prevalence of sinonasal disease, but no studies evaluating the severity of sinonasal disease in obese asthmatics, and how this impacts asthma control. The purpose of the current study was to determine if obesity is associated with increased severity of sinonasal disease, and/or affects response to nasal corticosteroid treatment in asthma. METHODS: This study included 236 adults participating in a 24-week randomized, double-masked, placebo-controlled study of nasal mometasone for the treatment of poorly controlled asthma...
July 24, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28732802/carica-papaya-ameliorates-allergic-asthma-via-down-regulation-of-il-4-il-5-eotaxin-tnf-%C3%AE-nf-%C3%A4-b-and-inos-levels
#11
Asma Inam, Muhammad Shahzad, Arham Shabbir, Hira Shahid, Khadija Shahid, Aqeel Javeed
BACKGROUND: Natural products have a prime importance as an essential source for new drug discovery. Carica papaya leaves (CPL) have been used to treat inflammation in traditional system of medicine. AIM/HYPOTHESIS: Current study evaluates the anti-inflammatory and immunomodulatory effects of CPL extract using mouse model of ovalbumin- (OVA) induced allergic asthma. METHODS: All the mice were intraperitoneally sensitized and subsequently given intranasal challenge with OVA except the control group...
August 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28729226/solanum-paniculatum-l-decreases-levels-of-inflammatory-cytokines-by-reducing-nfkb-tbet-and-gata3-gene-expression-in-vitro
#12
Raimon Rios, Hugo Bernardino Ferreira da Silva, Norma Vilany Queiroz Carneiro, Anaque de Oliveira Pires, Tamires Cana Brasil Carneiro, Ryan Dos Santos Costa, Cintia Rodrigues Marques, Marta Santos Serafim Machado, Eudes da Silva Velozo, Telma M G da Silva, Tania M S da Silva, Adilva de Souza Conceição, Neuza Maria Alcântara-Neves, Camila Alexandrina Figueiredo
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey in "Todos os Santos" Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28727997/therapeutic-intranasal-instillation-of-allergen-loaded-microbubbles-suppresses-experimental-allergic-asthma-in-mice
#13
Blaise Corthésy, Gilles Bioley
Despite proven efficiency, subcutaneous immunotherapy for aeroallergens is impaired by the duration of the protocol, the repeated injections and potential side-effects associated with the doses of allergen administered. Intranasal delivery of immunotherapeutic agents may overcome several of these drawbacks, provided that an efficient allergen delivery vehicle can be identified. This study evaluates whether intranasally delivered gas-filled microbubble (MB)-associated ovalbumin (OVA), used as a model allergen, can serve as a therapeutic treatment in a mouse model of established allergic asthma...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28709779/bronchial-hyper-responsiveness-after-preterm-birth
#14
REVIEW
Hege H Clemm, Merete Engeseth, Maria Vollsæter, Sailesh Kotecha, Thomas Halvorsen
Being born preterm often adversely affects later lung function. Airway obstruction and bronchial hyperresponsiveness (BHR) are common findings. Respiratory symptoms in asthma and in lung disease after preterm birth might appear similar, but clinical experience and studies indicate that symptoms secondary to preterm birth reflect a separate disease entity. BHR is a defining feature of asthma, but can also be found in other lung disorders and in subjects without respiratory symptoms. We review different methods to assess BHR, and findings reported from studies that have investigated BHR after preterm birth...
June 20, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28702854/gastroesophageal-reflux-disease-and-pulmonary-diseases-associated-with-aspergillosis-is-there-a-connection
#15
Maria N Gamaletsou, David W Denning
INTRODUCTION: We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. BACKGROUND: Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. METHODS: We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD...
July 12, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28696802/correlation-of-induced-sputum-eosinophil-levels-with-clinical-parameters-in-mild-and-moderate-persistent-asthma-in-children-aged-7-18%C3%A2-years
#16
Prachi Kansal, Devki Nandan, Sheetal Agarwal, Neha Patharia, Narendra Arya
BACKGROUND: Treatment decisions in asthma are currently based on clinical assessment and spirometry. Sputum eosinophil, being a marker of airway inflammation, can serve as a tool for assessing severity and response to treatment in asthma patients. OBJECTIVES: To measure eosinophil percentage in induced sputum in children with asthma and correlate it with clinical asthma parameters. METHODS: A prospective observational study was performed at tertiary care hospital on 91 children aged 7-18 years with newly diagnosed mild or moderate persistent asthma...
July 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28696336/perspectives-on-exhaled-nitric-oxide
#17
Fabio Luigi Massimo Ricciardolo, Philip E Silkoff
The history of nitric oxide (NO) in respiratory field dates back to the beginning of '90s with the ancestral study by Lars Gustafsson et al. describing the presence of endogenous NO in the exhaled breath of human beings. Soon after, independent studies showed that exhaled NO concentrations (FENO) is higher in asthmatics than in normal subjects. Not all asthmatics demonstrate a high FENO reflecting heterogeneity of asthma. High values of FENO are associated with over-expression of corticosteroid-sensitive iNOS isoform and allergic/eosinophilic inflammation...
July 11, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28687933/cellular-zinc-homeostasis-modulates-polarization-of-thp-1-derived-macrophages
#18
Laura Dierichs, Veronika Kloubert, Lothar Rink
PURPOSE: Polarization of macrophages by environmental stimuli leads to the characteristic of different phenotypes that exhibit distinct functions, ranging in a continuous spectrum from pro-inflammatory M1 up to immunoregulatory and wound-healing M2 macrophages. Diseases like cancer, allergic asthma or diabetes are associated with an M1/M2 imbalance. Owing to the importance of the essential trace element zinc for the immune system and its involvement in signal transduction as a second messenger, we investigated the impact of zinc on M1 and M2 polarization of macrophages in vitro...
July 7, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28675761/estimating-the-causal-effect-of-body-mass-index-on-hay-fever-asthma-and-lung-function-using-mendelian-randomization
#19
T Skaaby, A E Taylor, B H Thuesen, R K Jacobsen, N Friedrich, L T Møllehave, S Hansen, S C Larsen, U Völker, M Nauck, H Völzke, T Hansen, O Pedersen, T Jørgensen, L Paternoster, M Munafò, N Grarup, A Linneberg
BACKGROUND: Observational studies have shown that body mass index (BMI) is positively associated with asthma. However, observational data are prone to confounding and reverse causation. In Mendelian randomization, genetic variants are used as unconfounded markers of exposures to examine causal effects. We examined the causal effect of BMI on asthma, hay fever, allergic sensitization, serum total immunoglobulin E (IgE), forced expiratory volume in one-second (FEV1) and forced vital capacity (FVC)...
July 4, 2017: Allergy
https://www.readbyqxmd.com/read/28674387/activation-of-the-mtor-signaling-pathway-is-required-for-asthma-onset
#20
Yanli Zhang, Ying Jing, Junying Qiao, Bin Luan, Xiufang Wang, Li Wang, Zhe Song
The mTOR pathway has been implicated in immune functions; however, its role in asthma is not well understood. We found that patients experiencing an asthma attack, when compared with patients in asthma remission, showed significantly elevated serum mTOR pathway activation, increased Th17 cells and IL-4, and decreased Treg cells and IFN-γ. In patients experiencing asthma, mTOR activation was positively correlated with the loss of Th17/Treg and Th1/Th2 balance. The role of mTOR in asthma was further confirmed using an ovalbumin-induced asthmatic mouse model...
July 3, 2017: Scientific Reports
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