Maria Calderon-Dominguez, Eva Trejo-Gutierrez, Almudena González-Rovira, Lucía Beltrán-Camacho, Marta Rojas-Torres, Sara Eslava-Alcón, Daniel Sanchez-Morillo, Juan Calderon-Dominguez, Mª Pilar Martinez-Nicolás, Estibaliz Gonzalez-Beitia, Mª Dolores Nieto-Martín, Teresa Trujillo-Soto, Manuel A Rodríguez-Iglesias, Juan A Moreno, Rafael Moreno-Luna, Mª Carmen Durán-Ruiz
Despite the extraordinary advances achieved to beat COVID-19 disease, many questions remain unsolved, including the mechanisms of action of SARS-CoV-2 and which factors determine why individuals respond so differently to the viral infection. Herein, we performed an in silico analysis to identify host microRNA targeting ACE2 , TMPRSS2 , and/or RAB14, all genes known to participate in viral entry and replication. Next, the levels of six microRNA candidates previously linked to viral and respiratory-related pathologies were measured in the serum of COVID-19-negative controls (n = 16), IgG-positive COVID-19 asymptomatic individuals (n = 16), and critical COVID-19 patients (n = 17)...
September 13, 2022: Molecular Therapy. Nucleic Acids