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fractional excretion of sodium

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https://www.readbyqxmd.com/read/29784554/renal-stress-and-kidney-injury-biomarkers-in-response-to-endurance-cycling-in-the-heat-with-and-without-ibuprofen
#1
Brendon P McDermott, Cody R Smith, Cory L Butts, Aaron R Caldwell, Elaine C Lee, Jakob L Vingren, Colleen X Munoz, Laura J Kunces, Keith Williamson, Matthew S Ganio, Lawrence E Armstrong
Exercise, especially in the heat, can contribute to acute kidney injury, which can expedite chronic kidney disease onset. The additional stress of ibuprofen use is hypothesized to increase renal stress. OBJECTIVES: To observe the effects of endurance cycling in the heat on renal function. Secondarily, we investigated the effect of ibuprofen ingestion on kidney stress. DESIGN: Randomized, placebo controlled and observational methods were utilized. METHODS: Forty cyclists (52±9y, 21...
May 16, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29770972/fractional-excretion-of-electrolytes-in-volume-responsive-and-intrinsic-acute-kidney-injury-in-dogs-diagnostic-and-prognostic-implications
#2
Roberta Troìa, Marta Gruarin, Chiara Grisetti, Federica Serafini, Luca Magna, Erika Monari, Massimo Giunti, Francesco Dondi
BACKGROUND: The value of fractional excretion (FE) of electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs. OBJECTIVES: To evaluate the diagnostic and prognostic roles of FE of electrolytes in dogs with AKI. ANIMALS: Dogs (n = 135) with AKI treated with standard care (February 2014-December 2016). METHODS: Prospective study. Clinical and laboratory variables including FE of electrolytes, were measured upon admission...
May 17, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29736405/renal-evaluation-in-common-variable-immunodeficiency
#3
Giovany Gomes Capistrano, Gdayllon Cavalcante Meneses, Fernanda Macedo de Oliveira Neves, Renata de Almeida Leitão, Alice Maria Costa Martins, Alexandre Braga Libório
Introduction: Common variable immunodeficiency (CVID) comprises a heterogeneous group of disorders characterized by impaired antibody production. Kidney involvement in CVID is described in isolated and sporadic case reports. The objective of this study was to study the renal function pattern in CVID patients through glomerular and tubular function tests. Methods: Study of 12 patients with CVID diagnosis and 12 healthy control individuals. Glomerular filtration rate (GFR), fractional excretion of sodium (FENa+ ) and potassium (FEK+ ), urinary concentration, and acidification capacity were measured...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29686776/vanadate-induced-renal-camp-and-malondialdehyde-accumulation-suppresses-alpha-1-sodium-potassium-adenosine-triphosphatase-protein-levels
#4
Somchit Eiam-Ong, Yuyen Nakchui, Mookda Chaipipat, Somchai Eiam-Ong
It has been demonstrated that vanadate causes nephrotoxicity. Vanadate inhibits renal sodium potassium adenosine triphosphatase (Na, K-ATPase) activity and this is more pronounced in injured renal tissues. Cardiac cyclic adenosine monophosphate (cAMP) is enhanced by vanadate, while increased cAMP suppresses Na, K-ATPase action in renal tubular cells. There are no in vivo data collectively demonstrating the effect of vanadate on renal cAMP levels; on the abundance of the alpha 1 isoform (α1 ) of the Na, K-ATPase protein or its cellular localization; or on renal tissue injury...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29669331/previous-exercise-effects-in-cisplatin-induced-renal-lesions-in-rats
#5
Heloísa D C Francescato, Lucas F Almeida, Natany G Reis, Camila M Faleiros, Marcelo Papoti, Roberto S Costa, Terezila M Coimbra
BACKGROUND/AIMS: Physical training has beneficial effects on endothelial function and can influence the regeneration of the endothelial cell. We investigated the effect of physical training on cisplatin (CP)-induced acute kidney injury and assessed the impact of training on endothelial structure and function, and on the inflammatory processes in rats. METHODS: We injected male Wistar rats subjected to previous physical training in treadmill running (trained, TR) or not (sedentary, SED) with CP (5 mg/kg) (TR+CP and SED+CP groups, respectively)...
April 13, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29667913/ubiquitin-c-terminal-hydrolase-l1-deletion-is-associated-with-urinary-%C3%AE-klotho-deficiency-and-perturbed-phosphate-homeostasis
#6
Naomi C Boisvert, Chet E Holterman, Alexey Gutsol, Josee Coulombe, Wanling Pan, R Todd Alexander, Douglas A Gray, Chris R Kennedy
Loss of ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated the mechanisms underlying the phosphate imbalance in Uchl1-/- mice. Interestingly, phosphaturia was not a result of lower renal brush border membrane sodium-phosphate cotransporter expression as sodium-phosphate cotransporter 2a and 2c expression levels were similar to wild type levels...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29657194/association-of-brucellosis-with-renal-tubular-and-glomerular-damage-in-children-in-turkey
#7
Secil Conkar, Muhammed Kosker, Saliha Cevik, Muzeyyen Ay
Brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations. Until now, no studies have been performed on renal tubular disorders in patients with brucellosis. The present study aims to investigate renal tubular disorders in patients with brucellosis. This prospective case-control study includes a total of 31 brucellosis patients (Group 1) and 30 healthy controls (Group 2) matched for age and sex. Renal tubular functions of children who were diagnosed as having brucellosis in outpatient pediatric clinics were evaluated...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29617893/serum-cortisol-and-cortisone-as-potential-biomarkers-of-partial-11%C3%AE-hydroxysteroid-dehydrogenase-type-2-deficiency
#8
Cristian A Carvajal, Alejandra Tapia-Castillo, Carolina P Valdivia, Fidel Allende, Sandra Solari, Carlos F Lagos, Carmen Campino, Alejandro Martínez-Aguayo, Andrea Vecchiola, Constanza Pinochet, Claudia Godoy, Virginia Iturrieta, Rene Baudrand, Carlos E Fardella
Background: Pathogenic variations in HSD11B2 gene triggers the apparent mineralocorticoid excess syndrome (AME). There is scarce information regarding the phenotypes of subjects carrying heterozygous pathogenic variants in HSD11B2 gene. We investigated if serum cortisol/cortisone(F/E) ratio and cortisone are useful for identifying partial 11βHSD2 deficiency in those heterozygous subjects. Methods: We studied two patients diagnosed with AME and their families carrying either D223N or R213C mutation...
March 30, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29599129/5-aminoisoquinoline-improves-renal-function-and-fibrosis-during-recovery-phase-of-cisplatin-induced-acute-kidney-injury-in-rats
#9
Andrés Quesada, Francisco O'Valle, Sebastián Montoro-Molina, Mercedes Gómez-Morales, Mercedes Caba-Molina, Juan Francisco González, María C de Gracia, Antonio Osuna, Félix Vargas, Rosemary Wangensteen
The aim of this study is to analyze the effects of 5-aminoisoquinoline (5-AIQ), a poly(ADP-ribose) polymerase-1 (PARP1) inhibitor, over renal dysfunction and fibrosis during recovery phase of cisplatin-induced acute kidney injury (AKI) in rats. Male Wistar rats were distributed in three groups (n=8 each group): control, cisplatin (CisPt) and CisPt+5-AIQ. Control and CisPt groups received a subcutaneous injection of either saline or 7 mg/kg cisplatin, respectively. CisPt+5-AIQ group received two intraperitoneal injections of 10 mg/kg 5-AIQ 2 hours before and 24 hours after cisplatin treatment...
March 29, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29575360/effects-of-fenoldopam-on-kidney-function-parameters-and-its-therapeutic-efficacy-in-the-management-of-acute-kidney-injury-in-dogs-with-heatstroke
#10
Gilad Segev, Yaron Bruchim, Noga Berl, Adar Cohen, Itamar Aroch
BACKGROUND: Acute kidney injury (AKI) is common in dogs, but evidence of efficacy of its treatment is lacking. OBJECTIVE: To evaluate the efficacy of fenoldopam in the management of AKI. ANIMALS: Forty dogs with naturally occurring heatstroke. METHODS: Dogs were prospectively enrolled and divided into treatment and the placebo groups (fenoldopam, constant rate infusion [CRI] of 0.1 µg/kg/min or saline, respectively)...
March 25, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29556693/urinary-composition-predicts-diuretic-efficiency-of-hypertonic-saline-solution-with-furosemide-therapy-and-heart-failure-prognosis
#11
Tomotaka Ando, Yoshitaka Okuhara, Yoshiyuki Orihara, Koichi Nishimura, Kyoko Yamamoto, Tohru Masuyama, Shinichi Hirotani
Recently, we and other group have reported that furosemide administration along with hypertonic saline solution enhanced diuretic efficiency of furosemide. However, little is known about factors which associated with high diuretic efficiency by hypertonic saline solution with furosemide therapy. To identify predictors of diuretic efficiency in the hypertonic saline solution with furosemide therapy, we recruited 30 consecutive hospitalized heart failure (HF) patients with volume overload (77 ± 10 years, systolic blood pressure > 90 mmHg, and estimated glomerular filtration rate > 15 ml/min/1...
March 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29483574/elevated-fgf23-levels-in-mice-lacking-the-thiazide-sensitive-nacl-cotransporter-ncc
#12
Ganesh Pathare, Manuel Anderegg, Giuseppe Albano, Florian Lang, Daniel G Fuster
Fibroblast growth factor 23 (FGF23) participates in the orchestration of mineral metabolism by inducing phosphaturia and decreasing the production of 1,25(OH)2 D3 . It is known that FGF23 release is stimulated by aldosterone and extracellular volume depletion. To characterize this effect further in a model of mild hypovolemia, we studied mice lacking the thiazide sensitive NaCl cotransporter (NCC). Our data indicate that NCC knockout mice (KO) have significantly higher FGF23, PTH and aldosterone concentrations than corresponding wild type (WT) mice...
February 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29483040/pharmacodynamic-assessment-of-diuretic-efficacy-and-braking-in-a-furosemide-continuous-infusion-model
#13
D Adin, C Atkins, M G Papich
INTRODUCTION: Diuretic failure is a potential life-ending event but is unpredictable and poorly understood. The objectives of this study were to evaluate pharmacodynamic markers of furosemide-induced diuresis and to investigate mechanisms of diuretic braking in dogs receiving constant rate infusion (CRI) of furosemide. ANIMALS: Six healthy male dogs. METHODS: Raw data and stored samples from one arm of a previously published study were further analyzed to mechanistically investigate causes of diuretic braking in these dogs...
April 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29479578/n-ethyl-n-nitrosourea-induced-adaptor-protein-2-sigma-subunit-1-ap2s1-mutations-establish-ap2s1-loss-of-function-mice
#14
Caroline M Gorvin, Angela Rogers, Michelle Stewart, Anju Paudyal, Tertius A Hough, Lydia Teboul, Sara Wells, Steve Dm Brown, Roger D Cox, Rajesh V Thakker
The adaptor protein-2 sigma subunit (AP2σ), encoded by AP2S1 , forms a heterotetrameric complex, with AP2α, AP2β, and AP2μ subunits, that is pivotal for clathrin-mediated endocytosis, and AP2σ loss-of-function mutations impair internalization of the calcium-sensing receptor (CaSR), a G-protein-coupled receptor, and cause familial hypocalciuric hypercalcemia type-3 (FHH3). Mice with AP2σ mutations that would facilitate investigations of the in vivo role of AP2σ, are not available, and we therefore embarked on establishing such mice...
May 2, 2017: JBMR Plus
https://www.readbyqxmd.com/read/29377609/use-of-the-fractional-excretion-of-urea-in-an-azotemic-nonoliguric-state-type-1-cardiorenal-syndrome
#15
James B Diskin, Christopher Brandon Walker, Michael D Oberle, Charles J Diskin
The fractional excretion of urea is a useful tool to evaluate renal function in oliguric states; however, it remains unexplored in nonoliguric states. We evaluated its use to predict responses in patients with type 1 cardiorenal syndrome. This was a prospective observational study of 116 patients with type 1 cardiorenal syndrome referred over a 4-year period. Fractional excretion of urea and sodium, ejection fraction, mean arterial pressure, age, sex, diabetes, brain natriuretic peptide (BNP), serum sodium and blood urea nitrogen were analyzed for effects upon serum creatinine and survival...
January 26, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29372301/effect-of-variations-in-dietary-pi-intake-on-intestinal-pi-transporters-napi-iib-pit-1-and-pit-2-and-phosphate-regulating-factors-pth-fgf-23-and-mepe
#16
Tatiana Martins Aniteli, Flávia Ramos de Siqueira, Luciene Machado Dos Reis, Wagner Vasques Dominguez, Elizabeth Maria Costa de Oliveira, Patrícia Castelucci, Rosa Maria Affonso Moysés, Vanda Jorgetti
Hyperphosphatemia is a common condition in patients with chronic kidney disease (CKD) and can lead to bone disease, vascular calcification, and increased risks of cardiovascular disease and mortality. Inorganic phosphate (Pi ) is absorbed in the intestine, an important step in the maintenance of homeostasis. In CKD, it is not clear to what extent Pi absorption is modulated by dietary Pi . Thus, we investigated 5/6 nephrectomized (Nx) Wistar rats to test whether acute variations in dietary Pi concentration over 2 days would alter hormones involved in Pi metabolism, expression of sodium-phosphate cotransporters, apoptosis, and the expression of matrix extracellular phosphoglycoprotein (MEPE) in different segments of the small intestine...
April 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29363324/chronic-nicotine-exposure-reduces-klotho-expression-and-triggers-different-renal-and-hemodynamic-responses-in-klotho-haploinsufficient-mice
#17
Fernanda Oliveira Coelho, Lecticia Barbosa Jorge, Ana Carolina de Bragança Viciana, Talita Rojas Sanches, Fernando Dos Santos, Claudia Maria B Helou, Maria Claudia Irigoyen, Makoto Kuro-O, Lucia Andrade
The klotho gene, which encodes a single-pass transmembrane protein and a secreted protein, is expressed predominantly by the distal renal tubules and is related to calcium-phosphorus metabolism, ion channel regulation, intracellular signaling pathways, and longevity. Klotho deficiency aggravates acute kidney injury and renal fibrosis. Exposure to nicotine also worsens kidney injury. Here, we investigated renal klotho expression in a mouse model of chronic (28-day) nicotine exposure, in which mice received nicotine or vehicle (saccharine) in drinking water, comparing wild-type (klotho+/+) mice, klotho-haploinsufficient (klotho+/-) mice, and their respective controls, in terms of the effects of that exposure...
January 24, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29341461/effect-of-immediate-and-prolonged-glp-1-receptor-agonist-administration-on-uric-acid-and-kidney-clearance-post-hoc-analyses-of-four-clinical-trials
#18
Lennart Tonneijck, Marcel H A Muskiet, Mark M Smits, Petter Bjornstad, Mark H H Kramer, Michaela Diamant, Ewout J Hoorn, Jaap A Joles, Daniël H van Raalte
AIMS: To determine the effects of glucagon-like peptide (GLP)-1 receptor agonists (RA) on uric acid (UA) levels and kidney UA clearance. MATERIAL AND METHODS: This study involved post-hoc analyses of 4 controlled clinical trials, which assessed actions of GLP-1RA administration on kidney physiology. The immediate effects of GLP-1RA exenatide infusion vs placebo were determined in 9 healthy overweight men (Study-A) and in 52 overweight T2DM patients (Study-B). The effects of 12 weeks of long-acting GLP-1RA liraglutide vs placebo in 36 overweight T2DM patients (Study-C) and of 8 weeks of short-acting GLP-1RA lixisenatide vs once-daily titrated insulin glulisine in 35 overweight T2DM patients (Study-D) were also examined...
January 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29341028/ameliorative-effects-of-zataria-multiflora-hydro-alcoholic-extract-on-gentamicin-induced-nephrotoxicity-in-rats
#19
Saeed Hajihashemi, Tahereh Jafarian, Mahboubeh Ahmadi, Ali Rahbari, Fatemeh Ghanbari
BACKGROUND: Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim of this study was to investigate the therapeutic effects of Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity. METHODS: Twenty-eight male Wistar rats categorized into four groups: 1) the control group without injection, 2) the gentamicin treated group (100 mg/kg, i.p) 3) the gentamicin and Z. Multiflora treated group; Z. Multiflora extract(0...
January 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29299437/the-protective-effect-of-hydroalcoholic-extract-of-ginger-zingiber-officinale-rosc-against-iron-induced-functional-and-histological-damages-in-rat-liver-and-kidney
#20
Firouzeh Gholampour, Fatemeh Behzadi Ghiasabadi, Seyed Mohammad Owji, Jaafar Vatanparast
Objective: Iron overload in the body is related with toxic effects and threatens the health. The aim of this study was to evaluate the protective role of hydroalcoholic extract of ginger ( Zingiber officinale ) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and Methods: The rats were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G...
November 2017: Avicenna Journal of Phytomedicine
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