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dendritic cell cigarette smoke

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https://www.readbyqxmd.com/read/27586551/cigarette-smoke-induced-chronic-obstructive-pulmonary-disease-is-attenuated-by-ccl20-blocker-a-rat-model
#1
Desheng Sun, Yao Ouyang, Yanhui Gu, Xiansheng Liu
AIM: To evaluate whether the effect of dendritic cells (DCs) on chronic obstructive pulmonary disease (COPD) can be relieved by blocking CCL20. METHODS: 30 Wistar rats were randomly divided into three groups: control, COPD, and COPD treated with CCL20 monoclonal antibody. In the latter two groups, COPD was induced by four-week cigarette smoke exposure and trachea injection of lipopolysaccharide solution on two occasions. CCL20 monoclonal antibody was injected intraperitoneally on the first day...
August 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27460220/cigarette-smoke-alters-the-ability-of-human-dendritic-cells-to-promote-anti-streptococcus-pneumoniae-th17-response
#2
Olivier Le Rouzic, Bachirou Koné, Jerome Kluza, Philippe Marchetti, Florence Hennegrave, Cécile Olivier, Gwenola Kervoaze, Eva Vilain, Clémence Mordacq, Nicolas Just, Thierry Perez, Nathalie Bautin, Muriel Pichavant, Philippe Gosset
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading to bacteria-induced exacerbation of the disease. A defect in Th17 cytokines in response to Streptococcus pneumoniae, a bacteria associated with COPD exacerbations, has been recently reported. Dendritic cells (DC) are professional antigen presenting cells that drive T-cells differentiation and activation. In this study, we hypothesized that exposure to cigarette smoke, the main risk factor of COPD, might altered the pro-Th17 response to S...
2016: Respiratory Research
https://www.readbyqxmd.com/read/27448664/dendritic-cells-induce-tc1-cell-differentiation-via-the-cd40-cd40l-pathway-in-mice-after-exposure-to-cigarette-smoke
#3
Liang-Jian Kuang, Ting-Ting Deng, Qin Wang, Shi-Lin Qiu, Yi Liang, Zhi-Yi He, Jian-Quan Zhang, Jing Bai, Mei-Hua Li, Jing-Min Deng, Guang-Nan Liu, Ji-Feng Liu, Xiao-Ning Zhong
Dendritic cells and CD8(+) T cells participate in the pathology of chronic obstructive pulmonary disease, including emphysema, but little is known of the involvement of the CD40/CD40L pathway. We investigated the role of the CD40/CD40L pathway in Tc1 cell differentiation induced by dendritic cells in a mouse model of emphysema, and in vitro. C57BL/6J wild-type and CD40(-/-) mice were exposed to cigarette smoke (CS) or not (control), for 24 wk. In vitro experiments involved wild-type and CD40(-/-) dendritic cells treated with CS extract (CSE) or not...
September 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27058955/cigarette-smoke-decreases-the-maturation-of-lung-myeloid-dendritic-cells
#4
COMPARATIVE STUDY
Elena Arellano-Orden, Carmen Calero-Acuña, Nicolás Moreno-Mata, Lourdes Gómez-Izquierdo, Verónica Sánchez-López, Cecilia López-Ramírez, Daniela Tobar, José Luis López-Villalobos, Cesar Gutiérrez, Ana Blanco-Orozco, José Luis López-Campos
BACKGROUND: Conflicting data exist on the role of pulmonary dendritic cells (DCs) and their maturation in patients with chronic obstructive pulmonary disease (COPD). Herein, we investigated whether disease severity and smoking status could affect the distribution and maturation of DCs in lung tissues of patients undergoing elective pneumectomy or lobectomy for suspected primary lung cancer. MATERIALS AND METHODS: A total of 75 consecutive patients were included...
2016: PloS One
https://www.readbyqxmd.com/read/26728371/-depressive-effect-of-cigarette-smoke-extracts-on-dendritic-cells-inducing-differentiation-of-cd4-t-cells-into-cd4-cd25-foxp3-tregs
#5
Yi Liang, Guang Zhou, Longju Zhang, Jifeng Liu, Xiaoning Zhong
OBJECTIVE: To explore the impact of both cigarette smoke extracts (CSE) and CD40-CD40L pathway blocking on mouse myeloid dendritic cells (DCs) inducing CD4(+)T cells differentiation into CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). METHODS :A combination of recombinant mouse granulocyte-macrophage colony stimulating factor (rmGM-CSF, 40 ng/mL) and recombinant mouse IL-4 (rmIL-4, 10 ng/mL) was applied in vitro to induce the differentiation of BALB/c mouse myeloid monocytes into DCs...
January 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/26498483/cigarette-smoke-differentially-modulates-dendritic-cell-maturation-and-function-in-time
#6
Masoumeh Ezzati Givi, Gert Folkerts, Gerry T M Wagenaar, Frank A Redegeld, Esmaeil Mortaz
BACKGROUND: Dendritic cells (DCs) as professional antigen presenting cells (APCs) play a critical role in the regulation of host immune responses. DCs evolve from immature, antigen-capturing cells, to mature antigen-presenting cells. The relative contribution of DCs to cigarette smoke-induced inflammation is not well documented. In the current study, we investigated a modulatory effect of cigarette smoke extract (CSE) on differentiation, maturation and function of DCs. METHODS: Primary murine DCs were grown from bone marrow cells with GM-CSF...
2015: Respiratory Research
https://www.readbyqxmd.com/read/26475733/dendritic-cells-inversely-regulate-airway-inflammation-in-cigarette-smoke-exposed-mice
#7
Masoumeh Ezzati Givi, Peyman Akbari, Louis Boon, Vladimir S Puzovic, Gillina F G Bezemer, Fabio L M Ricciardolo, Gert Folkerts, Frank A Redegeld, Esmaeil Mortaz
The recruitment and activation of inflammatory cells into the respiratory system is considered a crucial feature in the pathophysiology of chronic obstructive pulmonary disease (COPD). Because dendritic cells (DCs) have a pivotal role in the onset and regulation of immune responses, we investigated the effect of modulating DC subsets on airway inflammation by acute cigarette smoke (CS) exposure. CS-exposed mice (5 days) were treated with fms-like tyrosine kinase 3 ligand (Flt3L) and 120g8 antibody to increase total DC numbers and deplete plasmacytoid DCs (pDCs), respectively...
January 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/26437452/nanoparticulate-carbon-black-in-cigarette-smoke-induces-dna-cleavage-and-th17-mediated-emphysema
#8
Ran You, Wen Lu, Ming Shan, Jacob M Berlin, Errol Lg Samuel, Daniela C Marcano, Zhengzong Sun, William Ka Sikkema, Xiaoyi Yuan, Lizhen Song, Amanda Y Hendrix, James M Tour, David B Corry, Farrah Kheradmand
Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less known. In this study, we show that insoluble nanoparticulate carbon black (nCB) accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c(+) lung antigen presenting cells (APC) of mice exposed to smoke. Likewise, nCB intranasal administration induced emphysema in mouse lungs...
October 5, 2015: ELife
https://www.readbyqxmd.com/read/26266827/role-of-b-cell-activating-factor-in-chronic-obstructive-pulmonary-disease
#9
Leen J M Seys, Fien M Verhamme, Anja Schinwald, Hamida Hammad, Danen Mootoosamy Cunoosamy, Claudie Bantsimba-Malanda, Alan Sabirsh, Eileen McCall, Liz Flavell, Ronald Herbst, Sharen Provoost, Bart N Lambrecht, Guy F Joos, Guy G Brusselle, Ken R Bracke
RATIONALE: B cell-activating factor (BAFF) plays a major role in activation of B cells and in adaptive humoral immune responses. In chronic obstructive pulmonary disease (COPD), lymphoid follicles have been associated with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of patients with severe COPD. OBJECTIVES: To investigate expression and localization of BAFF in the lungs of patients with COPD and to study the role of BAFF in COPD by antagonizing BAFF in a mouse model of chronic cigarette smoke (CS) exposure...
September 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26169828/extracts-from-presumed-reduced-harm-cigarettes-induce-equivalent-or-greater-toxicity-in-antigen-presenting-cells
#10
COMPARATIVE STUDY
Robert Vassallo, Lei Wang, Yoshimi Hirano, Paula Walters, Diane Grill
The tobacco industry has promoted certain cigarette products with claims that their use may be less harmful to the smoker as they purportedly deliver lower amounts of toxic chemicals compared to conventional cigarettes. This study was designed to compare the relative antigen presenting cellular toxicity of Eclipse, a presumed reduced exposure product (PREP) cigarette, when compared with the reference research 3R4F cigarettes (Kentucky University). Utilizing a murine macrophage cell line, murine bone marrow derived dendritic cells (DCs) and human monocyte-derived DCs incubated with extracts generated from Eclipse and Kentucky reference 3R4F cigarettes, we determined the relative toxic effects of the different cigarette smoke extracts on cellular viability, oxidative stress, T-helper-1 (Th-1) polarizing cytokine production and general gene expression...
September 1, 2015: Toxicology
https://www.readbyqxmd.com/read/26109638/tgf-%C3%AE-dependent-dendritic-cell-chemokinesis-in-murine-models-of-airway-disease
#11
Mitsuo Hashimoto, Haruhiko Yanagisawa, Shunsuke Minagawa, Debasish Sen, Royce Ma, Lynne A Murray, Ping Tsui, Jianlong Lou, James D Marks, Jody L Baron, Matthew F Krummel, Stephen L Nishimura
Small airway chronic inflammation is a major pathologic feature of chronic obstructive pulmonary disease (COPD) and is refractory to current treatments. Dendritic cells (DCs) accumulate around small airways in COPD. DCs are critical mediators of Ag surveillance and Ag presentation and amplify adaptive immune responses. How DCs accumulate around airways remains largely unknown. We use 2-photon DC imaging of living murine lung sections to directly visualize the dynamic movement of living DCs around airways in response to either soluble mediators (IL-1β) or environmental stimuli (cigarette smoke or TLR3 ligands) implicated in COPD pathogenesis...
August 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/25507640/-pathogenesis-of-rheumatoid-arthritis
#12
Branimir Anić, Miroslav Mayer
Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA patients there is no clear predisposing factor present. Environmental factors involved in RA pathogenesis are cigarette smoke, industrial pollutants like silica crystals, disturbances of intestinal, lung, and oral microbiota and some specific bacterial and viral infectious agents and their components...
2014: Reumatizam
https://www.readbyqxmd.com/read/25465103/activation-of-c3a-receptor-is-required-in-cigarette-smoke-mediated-emphysema
#13
X Yuan, M Shan, R You, M V Frazier, M J Hong, R A Wetsel, S Drouin, A Seryshev, L-Z Song, L Cornwell, R D Rossen, D B Corry, F Kheradmand
Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1) and Th17 cells in the emphysematous lungs. Consumption of complement proteins increases in acute inflammation, but the contribution of complement protein 3 (C3) to chronic cigarette smoke-induced immune responses in the lung is not clear. Here, we show that following chronic exposure to cigarette smoke, C3-deficient (C3(-/-)) mice develop less emphysema and have fewer CD11b(+)CD11c(+) mDCs infiltrating the lungs as compared with wild-type mice...
July 2015: Mucosal Immunology
https://www.readbyqxmd.com/read/25427390/-pathogenesis-of-rheumatoid-arthritis
#14
REVIEW
Branimir Anić, Miroslav Mayer
Rheumatoid arthritis (RA) is an autoimmune systemic disease that primarily affects joints. Etiology and the pathogenesis of RA are complex, involving many types of cells, among others macrophages, T and B cells, fibro- blasts, chondrocytes and dendritic cells. Despite well documented role of many genes and epigenetic modifications in the development and evolution of the disease, in most RA patients there is no clear predisposing factor present. Environmental factors involved in RA pathogenesis are cigarette smoke, industrial pollutants like silica crystals, disturbances of intestinal, lung, and oral microbiota and some specific bacterial and viral infectious agents and their components...
2014: Reumatizam
https://www.readbyqxmd.com/read/25351656/establishment-of-a-langerhans-cell-histiocytosis-lesion-cell-line-with-dermal-dendritic-cell-characteristics
#15
Ichiro Murakami, Jean Gogusev, Francis Jaubert, Michiko Matsushita, Kazuhiko Hayashi, Ikuo Miura, Takehiro Tanaka, Takashi Oka, Tadashi Yoshino
A cell line named PRU-1, derived from a Langerhans cell (LC) histiocytosis (LCH) skull lesion of a 7-year-old boy, was established and characterized. PRU-1 is an adherent spindle-shaped cell line that shows no Birbeck granules on electron microscopy. Flow cytometric analysis of cells collected from the early seventh passage showed no LC phenotypes of CD1a and S100 protein. Immunostaining of PRU-1 cells also revealed no expression of LC markers but showed expression of CD11c, CD54 (ICAM-1) and CD68, which was also observed in some peripherally located cells of the original LCH lesion...
January 2015: Oncology Reports
https://www.readbyqxmd.com/read/25338516/cigarette-smoke-affects-dendritic-cell-maturation-in-the-small-airways-of-patients-with-chronic-obstructive-pulmonary-disease
#16
Shi-Xia Liao, Ting Ding, Xi-Min Rao, De-Sheng Sun, Peng-Peng Sun, Ya-Jun Wang, Dan-Dan Fu, Xiao-Li Liu, Yao Ou-Yang
The aim of the present study was to characterize and quantify the numbers and expression levels of cells markers associated with dendritic cell (DC) maturation in small airways in current smokers and non-smokers with or without chronic obstructive pulmonary disease (COPD). Lung tissues from the following 32 patients were obtained during resection for lung cancer: Eight smokers with COPD, eight non-smokers with COPD, eight current smokers without COPD and eight non-smokers without COPD, serving as a control...
January 2015: Molecular Medicine Reports
https://www.readbyqxmd.com/read/25172546/effect-of-smoking-on-immunity-in-human-chronic-periodontitis
#17
Giovanna Ribeiro Souto, Celso Martins Queiroz-Junior, Fernando Oliveira Costa, Ricardo Alves Mesquita
AIM: Evaluate the effects of smoking on dendritic cells (DCs), cytokines, clinical periodontal parameters, and number of teeth in samples of human chronic periodontitis (CP). MATERIAL AND METHODS: Gingival samples were obtained from 24 smokers and 21 non-smokers with CP. Periodontal examination was carried out. Immunohistochemical staining was performed to identify Factor XIIIa+ immature, CD1a+ immature, and CD83+ mature DCs. The inflammatory infiltrate was counted, and IL-2, IL-10, IL-4, IL-6, IFN-γ, TNF-α, and IL-17A were measured using the cytometric bead array (CBA)...
December 2014: Immunobiology
https://www.readbyqxmd.com/read/25171864/allergens-and-the-airway-epithelium-response-gateway-to-allergic-sensitization
#18
REVIEW
Bart N Lambrecht, Hamida Hammad
Allergic sensitization to inhaled antigens is common but poorly understood. Although lung epithelial cells were initially merely regarded as a passive barrier impeding allergen penetrance, we now realize that they recognize allergens through expression of pattern recognition receptors and mount an innate immune response driven by activation of nuclear factor κB. On allergen recognition, epithelial cells release cytokines, such as IL-1, IL-25, IL-33, thymic stromal lymphopoietin, and GM-CSF, and endogenous danger signals, such as high-mobility group box 1, uric acid, and ATP, that activate the dendritic cell network and other innate immune cells, such as basophils and type 2 innate lymphoid cells...
September 2014: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/24909166/smoking-accelerates-pancreatic-cancer-progression-by-promoting-differentiation-of-mdscs-and-inducing-hb-egf-expression-in-macrophages
#19
S Kumar, M P Torres, S Kaur, S Rachagani, S Joshi, S L Johansson, N Momi, M J Baine, C E Gilling, L M Smith, T A Wyatt, M Jain, S S Joshi, S K Batra
Smoking is an established risk factor for pancreatic cancer (PC), but late diagnosis limits the evaluation of its mechanistic role in the progression of PC. We used a well-established genetically engineered mouse model (LSL-K-ras(G12D)) of PC to elucidate the role of smoking during initiation and development of pancreatic intraepithelial neoplasia (PanIN). The 10-week-old floxed mice (K-ras(G12D); Pdx-1cre) and their control unfloxed (LSL-K-ras(G12D)) littermates were exposed to cigarette smoke (total suspended particles: 150 mg/m(3)) for 20 weeks...
April 16, 2015: Oncogene
https://www.readbyqxmd.com/read/24886748/vorinostat-positively-regulates-synaptic-plasticity-genes-expression-and-spine-density-in-hiv-infected-neurons-role-of-nicotine-in-progression-of-hiv-associated-neurocognitive-disorder
#20
Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Thangavel Samikkannu, Vidya Sagar, Kesava Rao Venkata Kurapati, Shailendra K Saxena, Adriana Yndart, Andrea Raymond, Hong Ding, Oscar Hernandez, Madhavan P N Nair
BACKGROUND: HIV-associated neurocognitive disorder (HAND) is characterized by development of cognitive, behavioral and motor abnormalities, and occurs in approximately 50% of HIV infected individuals. In the United States, the prevalence of cigarette smoking ranges from 35-70% in HIV-infected individuals compared to 20% in general population. Cognitive impairment in heavy cigarette smokers has been well reported. However, the synergistic effects of nicotine and HIV infection and the underlying mechanisms in the development of HAND are unknown...
2014: Molecular Brain
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