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https://www.readbyqxmd.com/read/28782709/mic-distribution-among-wild-type-strains-of-legionella-pneumophila-identifies-a-subpopulation-with-reduced-susceptibility-to-macrolides-owing-to-efflux-pump-genes
#1
Marine Vandewalle-Capo, Clémence Massip, Ghislaine Descours, Joséphine Charavit, Joelle Chastang, Pierre Alain Billy, Sandrine Boisset, Gerard Lina, Christophe Gilbert, Max Maurin, Sophie Jarraud, Christophe Ginevra
Legionnaires' disease is a severe pneumonia mainly caused by Legionella pneumophila, and which is treated by antibiotics. The purpose of this study was to describe the susceptibility of clinical strains of Legionella pneumophila to seven antibiotics used for legionellosis treatment. The minimum inhibitory concentrations (MICs) of 109 well-characterized clinical strains of L. pneumophila serogroup-1 were determined using a broth microdilution method without charcoal and compared to antibiotic-resistant strains selected in vitro...
August 4, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28695408/a-gyrb-oligonucleotide-microarray-for-the-specific-detection-of-pathogenic-legionella-and-three-legionella-pneumophila-subsp
#2
Daoyi Xi, Yan Dou, Wei Ren, Shuang Yang, Lu Feng, Boyang Cao, Lei Wang
Among the 50 species and 70 serogroups of Legionella identified, Legionella pneumophila, comprising three subsp. (subsp. pneumophila, subsp. fraseri, and subsp. pasculleii), is recognized as the major cause of epidemic legionellosis. Rapid and reliable assays to identify pathogenic Legionella spp., and the three L. pneumophila subsp. in particular, are in great demand. In this study, we analyzed the gyrB genes of eleven Legionella spp. and subsp., comprising L. anisa, L. bozemanii, L. dumoffii, L. feeleii, L...
July 10, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28674045/digital-pcr-for-detection-and-quantification-of-fluoroquinolone-resistance-in-legionella-pneumophila
#3
Aurélie Hennebique, Marie Bidart, Sophie Jarraud, Laëtitia Beraud, Carole Schwebel, Max Maurin, Sandrine Boisset
The emergence of fluoroquinolone (FQ)-resistant mutants of Legionella pneumophila in infected humans has been previously reported using a next-generation DNA sequencing (NGS) approach. This finding could explain part of the therapeutic failures observed in legionellosis patients treated with these antibiotics. The aim of this study was to develop digital PCR (dPCR) assays allowing rapid and accurate detection and quantification of these resistant mutants in respiratory samples, especially when the proportion of mutants in a wild-type background is low...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28664708/legionella-risk-assessment-in-cruise-ships-and-ferries
#4
Pasqualina Laganà, Maria Elsa Gambuzza, Santi Delia
<b>Introduction.</b> The increasing development of marine traffic has led to a rise in the incidence of legionellosis among travellers. It occurs in similar environments, especially closed and crowded, and aboard ships Legionella survives and multiplies easily in water pipes, spreading into the environment through air conditioning systems and water distribution points. Although in recent years in the construction of cruise ships preventive measures aimed at curbing the proliferation of Legionella (design, materials, focus on the operation and maintenance of the water system), have been taken account, little or no attention has been paid to small ships which, in many cases, are old and not well maintained...
June 12, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28640202/evaluation-of-legionella-air-contamination-in-healthcare-facilities-by-different-sampling-methods-an-italian-multicenter-study
#5
Maria Teresa Montagna, Osvalda De Giglio, Maria Luisa Cristina, Christian Napoli, Claudia Pacifico, Antonella Agodi, Tatjana Baldovin, Beatrice Casini, Maria Anna Coniglio, Marcello Mario D'Errico, Santi Antonino Delia, Maria Grazia Deriu, Marco Guida, Pasqualina Laganà, Giorgio Liguori, Matteo Moro, Ida Mura, Francesca Pennino, Gaetano Privitera, Vincenzo Romano Spica, Silvia Sembeni, Anna Maria Spagnolo, Stefano Tardivo, Ida Torre, Federica Valeriani, Roberto Albertini, Cesira Pasquarella
Healthcare facilities (HF) represent an at-risk environment for legionellosis transmission occurring after inhalation of contaminated aerosols. In general, the control of water is preferred to that of air because, to date, there are no standardized sampling protocols. Legionella air contamination was investigated in the bathrooms of 11 HF by active sampling (Surface Air System and Coriolis(®)μ) and passive sampling using settling plates. During the 8-hour sampling, hot tap water was sampled three times. All air samples were evaluated using culture-based methods, whereas liquid samples collected using the Coriolis(®)μ were also analyzed by real-time PCR...
June 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28625225/legionella-longbeachae-detected-in-an-industrial-cooling-tower-linked-to-a-legionellosis-outbreak-new-zealand-2015-possible-waterborne-transmission
#6
C N Thornley, D J Harte, R P Weir, L J Allen, K J Knightbridge, P R T Wood
A legionellosis outbreak at an industrial site was investigated to identify and control the source. Cases were identified from disease notifications, workplace illness records, and from clinicians. Cases were interviewed for symptoms and risk factors and tested for legionellosis. Implicated environmental sources were sampled and tested for legionella. We identified six cases with Legionnaires' disease and seven with Pontiac fever; all had been exposed to aerosols from the cooling towers on the site. Nine cases had evidence of infection with either Legionella pneumophila serogroup (sg) 1 or Legionella longbeachae sg1; these organisms were also isolated from the cooling towers...
June 19, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28622629/bacterial-community-dynamics-in-a-cooling-tower-with-emphasis-on-pathogenic-bacteria-and-legionella-species-using-universal-and-genus-specific-deep-sequencing
#7
Rui P A Pereira, Jörg Peplies, Manfred G Höfle, Ingrid Brettar
Cooling towers are the major source of outbreaks of legionellosis in Europe and worldwide. These outbreaks are mostly associated with Legionella species, primarily L. pneumophila, and its surveillance in cooling tower environments is of high relevance to public health. In this study, a combined NGS-based approach was used to study the whole bacterial community, specific waterborne and water-based bacterial pathogens, especially Legionella species, targeting the 16S rRNA gene. This approach was applied to water from a cooling tower obtained by monthly sampling during two years...
June 6, 2017: Water Research
https://www.readbyqxmd.com/read/28602386/respiratory-infections-associated-with-anti-tnf%C3%AE-agents
#8
REVIEW
E Blanchard, M-E Truchetet, I Machelart, J Séneschal, C Raherison-Semjen
Anti-TNFα agents have proved effective in the treatment of various inflammatory, rheumatologic, dermatologic, and gastrointestinal diseases. Severe respiratory tract infections of bacterial or fungal origin have emerged as important complications in patients receiving such treatments. The risk of infection due to anti-TNFα therapy is difficult to assess in these patients who are immunocompromised because of the underlying disease itself and of previous or concomitant immunosuppressive drugs. This excessive infection risk seems real, particularly in the first six months following treatment initiation, and higher for patients receiving anti-TNFα monoclonal antibodies than for those receiving soluble TNFα receptor...
June 8, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28598344/occurrence-of-legionella-in-showers-at-recreational-facilities
#9
Patrizia De Filippis, Cinzia Mozzetti, Massimo Amicosante, Gian Loreto D'Alò, Alessandra Messina, Donatella Varrenti, Roberto Giammattei, Floriana Di Giorgio, Stefania Corradi, Alberto D'Auria, Roberta Fraietta, Rosanna Gabrieli
Critical environments, including water systems in recreational settings, represent an important source of Legionella pneumophila infection in humans. In order to assess the potential risk for legionellosis, we analyzed Legionella contamination of water distribution systems in 36 recreational facilities equipped with swimming pools. One hundred and sixty water samples were analyzed from shower heads or taps located in locker rooms or in bathrooms. By culture method and polymerase chain reaction, 41/160 samples were positive for Legionella from 12/36 recreational centers...
June 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28529020/nosocomial-legionellosis-and-invasive-aspergillosis-in-a-child-with-t-lymphoblastic-leukemia
#10
Rhoikos Furtwängler, Uwe Schlotthauer, Barbara Gärtner, Norbert Graf, Arne Simon
Invasive aspergillosis of the lungs and the central nervous system and Legionella pneumophilia serotype 1 infection of the lungs were diagnosed in a 22-month old child during inpatient induction treatment for T-lymphoblastic leukemia. Environmental investigations i.e. samples from the hospital water system did not reveal any Legionella. The patient may have been exposed to waterborne pathogens despite terminal water filtration due to a technical device to release residual tap water from the hose after showering...
May 13, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28497871/vital-signs-deficiencies-in-environmental-control-identified-in-outbreaks-of-legionnaires-disease-north-america-2000-2014
#11
EDITORIAL
L E Garrison, J M Kunz, L A Cooley, M R Moore, C Lucas, S Schrag, J Sarisky, C G Whitney
BACKGROUND: The number of reported cases of Legionnaires' disease, a severe pneumonia caused by the bacterium Legionella, is increasing in the United States. During 2000-2014, the rate of reported legionellosis cases increased from 0.42 to 1.62 per 100 000 persons; 4% of reported cases were outbreak-associated. Legionella is transmitted through aerosolization of contaminated water. A new industry standard for prevention of Legionella growth and transmission in water systems in buildings was published in 2015...
October 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/28494478/survival-of-legionella-in-earthquake-induced-soil-disturbance-liquefaction-in-residential-areas-christchurch-new-zealand-implications-for-disease
#12
Frances F Graham, David Jg Harte
AIM: To investigate a possible link between liquefaction dust exposure and the noticeable increase in legionellosis cases in response to major earthquakes in 2010 and 2011 that resulted in widespread soil disturbance (liquefaction) in parts of Christchurch, New Zealand. METHOD: We culture tested liquefaction-affected soil for Legionella spp. in the six months following the first earthquake in 2010. Thirty silt samples were collected randomly from locations within Christchurch's metropolitan area that were affected by liquefaction...
May 12, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28465870/is-legionellosis-present-and-important-in-colombia-an-analyses-of-cases-from-2009-to-2013
#13
Andrés Mauricio Patiño-Barbosa, Andrés Felipe Gil-Restrepo, Valentina Restrepo-Montoya, Wilmer E Villamil-Gomez, Jaime A Cardona-Ospina, Alfonso J Rodriguez-Morales
Infection due to Legionella pneumophila has been not studied in Colombia, although it is present. The observational, retrospective study in which the incidence of legionellosis in Colombia, 2009-2013, was estimated based on data extracted from the personal health records system (Registro Individual de Prestación de Servicios, RIPS) using the ICD-10 codes A48.1 (Legionnaires' disease) and A48.2 (Pontiac Fever). Using official population estimates of the National Administrative Department of Statistics (DANE), crude and adjusted incidence rates were estimated (cases / 100,000 pop)...
March 28, 2017: Curēus
https://www.readbyqxmd.com/read/28448459/viability-of-legionella-pneumophila-in-water-samples-a-comparison-of-propidium-monoazide-pma-treatment-on-membrane-filters-and-in-liquid
#14
Sara Bonetta, Cristina Pignata, Silvia Bonetta, Lorenza Meucci, Donatella Giacosa, Elena Marino, Giorgio Gilli, Elisabetta Carraro
Legionella pneumophila is a ubiquitous microorganism widely distributed in aquatic environments and can cause Legionellosis in humans. A promising approach to detect viable cells in water samples involves the use of quantitative polymerase chain reaction (qPCR) in combination with photoactivatable DNA intercalator propidium monoazide (PMA). However, the PMA efficiency could be different depending on the experimental conditions used. The aim of this study was to compare two PMA exposure protocols: (A) directly on the membrane filter or (B) in liquid after filter washing...
April 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28418314/population-genomics-of-legionella-longbeachae-and-hidden-complexities-of-infection-source-attribution
#15
Rodrigo Bacigalupe, Diane Lindsay, Giles Edwards, J Ross Fitzgerald
Legionella longbeachae is the primary cause of legionellosis in Australasia and Southeast Asia and an emerging pathogen in Europe and the United States; however, our understanding of the population diversity of L. longbeachae from patient and environmental sources is limited. We analyzed the genomes of 64 L. longbeachae isolates, of which 29 were from a cluster of legionellosis cases linked to commercial growing media in Scotland in 2013 and 35 were non-outbreak-associated isolates from Scotland and other countries...
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28353109/exploring-the-legionella-pneumophila-positivity-rate-in-hotel-water-samples-from-antalya-turkey
#16
Nevgün Sepin Özen, Şenay Tuğlu Ataman, Mestan Emek
The genus Legionella is a fastidious Gram-negative bacteria widely distributed in natural waters and man made water supply systems. Legionella pneumophila is the aetiological agent of approximately 90% of reported Legionellosis cases, and serogroup 1 is the most frequent cause of infections. Legionnaires' disease is often associated with travel and continues to be a public health concern at present. The correct water management quality practices and rapid methods for analyzing Legionella species in environmental water is a key point for the prevention of Legionnaires' disease outbreaks...
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28250292/discrimination-between-legionnaires-disease-and-pneumococcal-pneumonia-based-on-the-clinical-and-laboratory-features-a-quantitative-approach-using-the-modified-winthrop-university-hospital-weighted-point-system
#17
Hiroki Yamakuchi, Yohei Hamada, Tosiharu Urakami, Yosuke Aoki
Objective Legionnaires' disease (LD) is a common form of lobar pneumonia, but the optimum diagnostic modality has long been a subject of debate due to incomplete sensitivity and specificity. A delay in the initiation of specific therapy for LD is associated with increased mortality. The decision to treat a patient for Legionella must be made quickly. The purpose of this study was to evaluate the ability of the modified Winthrop-University Hospital WUH system to identify LD while discriminating against pneumococcal pneumonia at the time of hospitalization for community-acquired pneumonia...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28228245/legionellosis-acquired-through-a-dental-unit-a-case-study
#18
C Schönning, C Jernberg, D Klingenberg, S Andersson, A Pääjärvi, E Alm, E Tano, B Lytsy
In 2012, an elderly immunocompromised man died from legionellosis at a hospital in Uppsala, Sweden. The patient had visited a dental ward at the hospital during the incubation period. Legionella spp. at a concentration of 2000 colony-forming units/L were isolated from the cupfiller outlet providing water for oral rinsing. Isolates from the patient and the dental unit were Legionella pneumophila serogroup 1, subgroup Knoxville and ST9. Pulsed-field gel electrophoresis and whole-genome sequencing strongly suggested that the isolates were of common origin...
January 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28188095/prevalence-of-legionella-species-isolated-from-shower-water-in-public-bath-facilities-in-toyama-prefecture-japan
#19
Jun-Ichi Kanatani, Junko Isobe, Shiho Norimoto, Keiko Kimata, Chieko Mitsui, Junko Amemura-Maekawa, Fumiaki Kura, Tetsutaro Sata, Masanori Watahiki
AIMS: We investigated the prevalence of Legionella spp. isolated from shower water in public bath facilities in Toyama Prefecture, Japan. In addition, we analyzed the genetic diversity among Legionella pneumophila isolates from shower water as well as the genetic relationship between isolates from shower water and from stock strains previously analyzed from sputum specimens. METHODS: The isolates were characterized using serogrouping, 16S rRNA gene sequencing, and sequence-based typing...
May 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28166862/legionella-prevalence-and-risk-of-legionellosis-in-japanese-households
#20
T Kuroki, Y Watanabe, H Teranishi, S Izumiyama, J Amemura-Maekawa, F Kura
This study determined the occurrence of legionellae in private houses for which there were no available data on aquatic environments other than the water supply system. From June 2013 to November 2014, we collected 138 water and 90 swab samples from aquatic environments in 19 houses. Legionella DNA was detected via a loop-mediated isothermal amplification assay in 66 (47·8%) water and 17 (18·9%) swab samples. High Legionella DNA detection rates were observed in water samples from washing machines and aquariums...
May 2017: Epidemiology and Infection
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