keyword
MENU ▼
Read by QxMD icon Read
search

Karl Friston

keyword
https://www.readbyqxmd.com/read/28338892/embodiment-and-schizophrenia-a-review-of-implications-and-applications
#1
Wolfgang Tschacher, Anne Giersch, Karl Friston
In recent decades, embodiment has become an influential concept in psychology and cognitive neuroscience. Embodiment denotes the study of the reciprocal (causal) relationships between mind and body, with the mind not only affecting the body but also vice versa. Embodied cognition comes to the fore in sensorimotor coupling, predictive coding, and nonverbal behavior. Additionally, the embodiment of the mind constitutes the basis of social interaction and communication, as evident in research on nonverbal synchrony and mimicry...
March 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28334138/working-memory-modulation-of-frontoparietal-network-connectivity-in-first-episode-schizophrenia
#2
Jesper Duemose Nielsen, Kristoffer H Madsen, Zheng Wang, Zhening Liu, Karl J Friston, Yuan Zhou
Working memory (WM) impairment is regarded as a core aspect of schizophrenia. However, the neural mechanisms behind this cognitive deficit remain unclear. The connectivity of a frontoparietal network is known to be important for subserving WM. Using functional magnetic resonance imaging, the current study investigated whether WM-dependent modulation of effective connectivity in this network is affected in a group of first-episode schizophrenia (FES) patients compared with similarly performing healthy participants during a verbal n-back task...
February 25, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28323165/on-the-importance-of-modeling-fmri-transients-when-estimating-effective-connectivity-a-dynamic-causal-modeling-study-using-asl-data
#3
Martin Havlicek, Alard Roebroeck, Karl J Friston, Anna Gardumi, Dimo Ivanov, Kamil Uludag
Effective connectivity is commonly assessed using blood oxygenation level-dependent (BOLD) signals. In (Havlicek et al., 2015), we presented a novel, physiologically informed dynamic causal model (P-DCM) that extends current generative models. We demonstrated the improvements afforded by P-DCM in terms of the ability to model commonly observed neuronal and vascular transients in single regions. Here, we assess the ability of the novel and previous DCM variants to estimate effective connectivity among a network of five ROIs driven by a visuo-motor task...
March 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28316456/functional-connectivity-of-the-pedunculopontine-nucleus-and-surrounding-region-in-parkinson-s-disease
#4
Ashwani Jha, Vladimir Litvak, Samu Taulu, Wesley Thevathasan, Jonathan A Hyam, Tom Foltynie, Patricia Limousin, Marko Bogdanovic, Ludvic Zrinzo, Alexander L Green, Tipu Z Aziz, Karl Friston, Peter Brown
Deep brain stimulation of the pedunculopontine nucleus and surrounding region (PPNR) is a novel treatment strategy for gait freezing in Parkinson's disease (PD). However, clinical results have been variable, in part because of the paucity of functional information that might help guide selection of the optimal surgical target. In this study, we use simultaneous magnetoencephalography and local field recordings from the PPNR in seven PD patients, to characterize functional connectivity with distant brain areas at rest...
January 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28266640/corrigendum-perceptual-learning-to-discriminate-the-intensity-and-spatial-location-of-nociceptive-stimuli
#5
Flavia Mancini, Karina Dolgilevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D Iannetti
No abstract text is available yet for this article.
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259780/regression-dcm-for-fmri
#6
Stefan Frässle, Ekaterina I Lomakina, Adeel Razi, Karl J Friston, Joachim M Buhmann, Klaas E Stephan
The development of large-scale network models that infer the effective (directed) connectivity among neuronal populations from neuroimaging data represents a key challenge for computational neuroscience. Dynamic causal models (DCMs) of neuroimaging and electrophysiological data are frequently used for inferring effective connectivity but are presently restricted to small graphs (typically up to 10 regions) in order to keep model inversion computationally feasible. Here, we present a novel variant of DCM for functional magnetic resonance imaging (fMRI) data that is suited to assess effective connectivity in large (whole-brain) networks...
March 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28240422/cerebellar-lobules-and-dentate-nuclei-mirror-cortical-force-related-bold-responses-beyond-all-linear-expectations
#7
Adnan A S Alahmadi, Matteo Pardini, Rebecca S Samson, Karl J Friston, Ahmed T Toosy, Egidio D'Angelo, Claudia A M Gandini Wheeler-Kingshott
The relationship between the BOLD response and an applied force was quantified in the cerebellum using a power grip task. To investigate whether the cerebellum responds in an on/off way to motor demands or contributes to motor responses in a parametric fashion, similarly to the cortex, five grip force levels were investigated under visual feedback. Functional MRI data were acquired in 13 healthy volunteers and their responses were analyzed using a cerebellum-optimized pipeline. This allowed us to evaluate, within the cerebellum, voxelwise linear and non-linear associations between cerebellar activations and forces...
February 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28226255/action-perception-as-hypothesis-testing
#8
Francesco Donnarumma, Marcello Costantini, Ettore Ambrosini, Karl Friston, Giovanni Pezzulo
We present a novel computational model that describes action perception as an active inferential process that combines motor prediction (the reuse of our own motor system to predict perceived movements) and hypothesis testing (the use of eye movements to disambiguate amongst hypotheses). The system uses a generative model of how (arm and hand) actions are performed to generate hypothesis-specific visual predictions, and directs saccades to the most informative places of the visual scene to test these predictions - and underlying hypotheses...
January 31, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28224285/abnormal-effective-connectivity-in-the-brain-is-involved-in-auditory-verbal-hallucinations-in-schizophrenia
#9
Baojuan Li, Long-Biao Cui, Yi-Bin Xi, Karl J Friston, Fan Guo, Hua-Ning Wang, Lin-Chuan Zhang, Yuan-Han Bai, Qing-Rong Tan, Hong Yin, Hongbing Lu
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations (AVHs) in schizophrenia (SZ) remains unclear. In this study, we used stochastic dynamic causal modeling (sDCM) to quantify connections among the left dorsolateral prefrontal cortex (inner speech monitoring), auditory cortex (auditory processing), hippocampus (memory retrieval), thalamus (information filtering), and Broca's area (language production) in 17 first-episode drug-naïve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging...
February 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28161288/the-depressed-brain-an-evolutionary-systems-theory
#10
REVIEW
Paul B Badcock, Christopher G Davey, Sarah Whittle, Nicholas B Allen, Karl J Friston
Major depression is a debilitating condition characterised by diverse neurocognitive and behavioural deficits. Nevertheless, our species-typical capacity for depressed mood implies that it serves an adaptive function. Here we apply an interdisciplinary theory of brain function to explain depressed mood and its clinical manifestations. Combining insights from the free-energy principle (FEP) with evolutionary theorising in psychology, we argue that depression reflects an adaptive response to perceived threats of aversive social outcomes (e...
February 1, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28081125/the-neural-representation-of-prospective-choice-during-spatial-planning-and-decisions
#11
Raphael Kaplan, John King, Raphael Koster, William D Penny, Neil Burgess, Karl J Friston
We are remarkably adept at inferring the consequences of our actions, yet the neuronal mechanisms that allow us to plan a sequence of novel choices remain unclear. We used functional magnetic resonance imaging (fMRI) to investigate how the human brain plans the shortest path to a goal in novel mazes with one (shallow maze) or two (deep maze) choice points. We observed two distinct anterior prefrontal responses to demanding choices at the second choice point: one in rostrodorsal medial prefrontal cortex (rd-mPFC)/superior frontal gyrus (SFG) that was also sensitive to (deactivated by) demanding initial choices and another in lateral frontopolar cortex (lFPC), which was only engaged by demanding choices at the second choice point...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28080966/active-interoceptive-inference-and-the-emotional-brain
#12
REVIEW
Anil K Seth, Karl J Friston
We review a recent shift in conceptions of interoception and its relationship to hierarchical inference in the brain. The notion of interoceptive inference means that bodily states are regulated by autonomic reflexes that are enslaved by descending predictions from deep generative models of our internal and external milieu. This re-conceptualization illuminates several issues in cognitive and clinical neuroscience with implications for experiences of selfhood and emotion. We first contextualize interoception in terms of active (Bayesian) inference in the brain, highlighting its enactivist (embodied) aspects...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28044016/is-predictability-salient-a-study-of-attentional-capture-by-auditory-patterns
#13
Rosy Southwell, Anna Baumann, Cécile Gal, Nicolas Barascud, Karl Friston, Maria Chait
In this series of behavioural and electroencephalography (EEG) experiments, we investigate the extent to which repeating patterns of sounds capture attention. Work in the visual domain has revealed attentional capture by statistically predictable stimuli, consistent with predictive coding accounts which suggest that attention is drawn to sensory regularities. Here, stimuli comprised rapid sequences of tone pips, arranged in regular (REG) or random (RAND) patterns. EEG data demonstrate that the brain rapidly recognizes predictable patterns manifested as a rapid increase in responses to REG relative to RAND sequences...
February 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28018185/life-and-understanding-the-origins-of-understanding-in-self-organizing-nervous-systems
#14
REVIEW
Yan M Yufik, Karl Friston
This article is motivated by a formulation of biotic self-organization in Friston (2013), where the emergence of "life" in coupled material entities (e.g., macromolecules) was predicated on bounded subsets that maintain a degree of statistical independence from the rest of the network. Boundary elements in such systems constitute a Markov blanket; separating the internal states of a system from its surrounding states. In this article, we ask whether Markov blankets operate in the nervous system and underlie the development of intelligence, enabling a progression from the ability to sense the environment to the ability to understand it...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28007997/stimulating-at-the-right-time-phase-specific-deep-brain-stimulation
#15
Hayriye Cagnan, David Pedrosa, Simon Little, Alek Pogosyan, Binith Cheeran, Tipu Aziz, Alexander Green, James Fitzgerald, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Marwan Hariz, Karl J Friston, Timothy Denison, Peter Brown
SEE MOLL AND ENGEL DOI101093/AWW308 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Brain regions dynamically engage and disengage with one another to execute everyday actions from movement to decision making. Pathologies such as Parkinson's disease and tremor emerge when brain regions controlling movement cannot readily decouple, compromising motor function. Here, we propose a novel stimulation strategy that selectively regulates neural synchrony through phase-specific stimulation. We demonstrate for the first time the therapeutic potential of such a stimulation strategy for the treatment of patients with pathological tremor...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27996022/perceptual-learning-to-discriminate-the-intensity-and-spatial-location-of-nociceptive-stimuli
#16
Flavia Mancini, Karina Dolgevica, James Steckelmacher, Patrick Haggard, Karl Friston, Giandomenico D Iannetti
Accurate discrimination of the intensity and spatial location of nociceptive stimuli is essential to guide appropriate behaviour. The ability to discriminate the attributes of sensory stimuli is continuously refined by practice, even throughout adulthood - a phenomenon called perceptual learning. In the visual domain, perceptual learning to discriminate one of the features that define a visual stimulus (e.g., its orientation) can transfer to a different feature of the same stimulus (e.g., its contrast). Here, we performed two experiments on 48 volunteers to characterize perceptual learning in nociception, which has been rarely studied...
December 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27913429/heritability-of-the-effective-connectivity-in-the-resting-state-default-mode-network
#17
Junhai Xu, Xuntao Yin, Haitao Ge, Yan Han, Zengchang Pang, Baolin Liu, Shuwei Liu, Karl Friston
The default mode network (DMN) is thought to reflect endogenous neural activity, which is considered as one of the most intriguing phenomena in cognitive neuroscience. Previous studies have found that key regions within the DMN are highly interconnected. Here, we characterized the genetic influences on causal or directed information flow within the DMN during the resting state. In this study, we recruited 46 pairs of twins and collected fMRI imaging data using a 3.0 T scanner. Dynamic causal modeling was conducted for each participant, and a structural equation model was used to calculate the heritability of DMN in terms of its effective connectivity...
November 23, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27871729/an-integrative-tinnitus-model-based-on-sensory-precision
#18
REVIEW
William Sedley, Karl J Friston, Phillip E Gander, Sukhbinder Kumar, Timothy D Griffiths
Tinnitus is a common disorder that often complicates hearing loss. Its mechanisms are incompletely understood. Current theories proposing pathophysiology from the ear to the cortex cannot individually - or collectively - explain the range of experimental evidence available. We propose a new framework, based on predictive coding, in which spontaneous activity in the subcortical auditory pathway constitutes a 'tinnitus precursor' which is normally ignored as imprecise evidence against the prevailing percept of 'silence'...
December 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27870614/active-inference-a-process-theory
#19
Karl Friston, Thomas FitzGerald, Francesco Rigoli, Philipp Schwartenbeck, Giovanni Pezzulo
This article describes a process theory based on active inference and belief propagation. Starting from the premise that all neuronal processing (and action selection) can be explained by maximizing Bayesian model evidence-or minimizing variational free energy-we ask whether neuronal responses can be described as a gradient descent on variational free energy. Using a standard (Markov decision process) generative model, we derive the neuronal dynamics implicit in this description and reproduce a remarkable range of well-characterized neuronal phenomena...
January 2017: Neural Computation
https://www.readbyqxmd.com/read/27718099/bayesian-modelling-of-induced-responses-and-neuronal-rhythms
#20
Dimitris A Pinotsis, Roman Loonis, Andre M Bastos, Earl K Miller, Karl J Friston
Neural rhythms or oscillations are ubiquitous in neuroimaging data. These spectral responses have been linked to several cognitive processes; including working memory, attention, perceptual binding and neuronal coordination. In this paper, we show how Bayesian methods can be used to finesse the ill-posed problem of reconstructing-and explaining-oscillatory responses. We offer an overview of recent developments in this field, focusing on (i) the use of MEG data and Empirical Bayes to build hierarchical models for group analyses-and the identification of important sources of inter-subject variability and (ii) the construction of novel dynamic causal models of intralaminar recordings to explain layer-specific activity...
October 7, 2016: Brain Topography
keyword
keyword
90340
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"