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JOURNAL ARTICLE
Ingridi Camboim Franceschi, Rubem Augusto da Paixão Dornas, Isabel Salgueiro Lermen, Artur Vicente Pfeifer Coelho, Ademir Henrique Vilas Boas, Adriano Garcia Chiarello, Adriano Pereira Paglia, Agnis Cristiane de Souza, Alana Rafaela Borsekowsky, Alessandro Rocha, Alex Bager, Alexander Zaidan de Souza, Alexandre Martins Costa Lopes, Aloysio Souza de Moura, Aluane Silva Ferreira, Alvaro García-Olaechea, Ana Cláudia Delciellos, Ana Elisa de Faria Bacellar, Ana Kellen Nogueira Campelo, Ana Maria Oliveira Paschoal, Anderson Claudino Rolim, André Luiz Ferreira da Silva, Andre Monnerat Lanna, André Pereira da Silva, Andresa Guimarães, Ângela Cardoso, Angelica Soligo Cassol, Anna Ludmilla da Costa-Pinto, Ariel Guilherme Santos do Nascimento, Arthur Soares Fernandes, Aryanne Clyvia, Aureo Banhos Dos Santos, Barbara Lima-Silva, Beatriz de Mello Beisiegel, Beatriz Fernandes Lima Luciano, Bernardo de Faria Leopoldo, Bruna Nunes Krobel, Bruno Busnello Kubiak, Bruno Henrique Saranholi, Bruno Senna Correa, Caio Sant Anna Teixeira, Camila Rezende Ayroza, Camila Righetto Cassano, Camilo Benitez-Riveros, Carla Cristina Gestich, Carla Denise Tedesco, Carla Gheler-Costa, Carla Grasiele Zanin Hegel, Carlito da Silva Evangelista Junior, Carlos Eduardo Morando Faria Ferreira, Carlos Eduardo Viveiros Grelle, Carolina Franco Esteves, Caroline da Costa Espinosa, Caroline Leuchtenberger, Catalina Sanchéz-Lalinde, Cauanne Iglesias Campos Machado, Cecilia Andreazzi, Cecília Bueno, Cecilia Cronemberger de Faria, Claudio Novaes, Cynthia Elisa Widmer, Cyntia Cavalcante Santos, Daniel da Silva Ferraz, Daniel Galiano, Daniela Aparecida Savariz Bôlla, Daniela Behs, Daniele Pereira Rodrigues, Danielle Picão de Melo, Déborah Maria Soares Ramos, Denise Lidório de Mattia, Diego Dias Pavei, Diogo Loretto, Douglas da Silva Huning, Douglas de Matos Dias, Éder Ricardo Paetzhold, Elaine Rios, Eleonore Zulnara Freire Setz, Eliana Cazetta, Emanuel Giovani Cafofo Silva, Emanuelle Pasa, Erica Naomi Saito, Erick Francisco Silva de Aguiar, Érika Paula Castro, Ernesto Bastos Viveiros de Castro, Ezequiel Pedó, Fabiane de Aguiar Pereira, Fábio Bolzan, Fábio de Oliveira Roque, Fábio Dias Mazim, Fábio Henrique Comin, Fábio Maffei, Felipe Bortolotto Peters, Felipe Moreli Fantacini, Felipe Pessoa da Silva, Felipe Santana Machado, Felipe Vélez-Garcia, Fernanda Stussi Duarte Lage, Fernando Araújo Perini, Fernando Camargo Passos, Fernando Carvalho, Fernando Cesar Cascelli de Azevedo, Fernando Ferreira, Fernando Ferreira de Pinho, Flávia Guimarães Chaves, Flavia Regina Miranda, Flavio Henrique Guimarães Rodrigues, Flávio Kulaif Ubaid, Francisco Homem Gabriel, Franco Leandro de Souza, Fred Victor de Oliveira, Gabriel Cupolillo, Gabriela de Araújo Pires Moreira, Gabriela Mette, Gabriela Teixeira Duarte, Gabrielle Beca, Gilberto Corso, Gilmar Perbiche-Neves, Glauber Henrique Borges de Oliveira Souto, Glenda Jéssica da Silva Vilarroel, Graziele O Batista, Guilherme Braga Ferreira, Gustavo Alves da Costa Toledo, Gustavo Senger, Helena de Godoy Bergallo, Hellen Cristina Pinheiro Dos Santos, Humberto Angelo Gazola, Isabel Melo, Ismael Verrastro Brack, Iuri Veríssimo, Ivan Réus Viana, Izabela Costa Laurentino, Jaime Luis Diehl, Jairo José Zocche, Jimi Martins-Silva, João Paulo Gava Just, Jorge José Cherem, Jorge Luiz Nascimento, Jorge Reppold Marinho, José Oliveira Dantas, Jose Roberto de Matos, José Salatiel Rodrigues Pires, Josi Fernanda Cerveira, Juan Ruiz-Esparza, Juliana Paulo da Silva, Juliano André Bogoni, Karina Theodoro Molina, Karla Dayane de Lima Pereira, Karoline Ceron, Kristel de Vleeschouwer, Laís Lautenschlager, Larissa Bailey, Larissa Fornitano, Lilian Elaine Rampim, Lorena Sforza, Luan Gonçalves Bissa, Luca Mattos Santucci, Lucas Gonçalves da Silva, Lucas Neves Perillo, Lucas Ribeiro Correa, Ludmila Hufnagel, Luis Fernando Alberti, Luis Jose Recalde Mello, Luis Renato Rezende Bernardo, Luiz Gustavo Rodrigues Oliveira-Santos, Luiza Neves Guimarães, Maíra Benchimol, Manuela Catharina Twardowschy, Marcela Ferreira-Riveros, Marcelo da Silva, Márcia Maria de Assis Jardim, Marco Aurélio Leite Fontes, Marcos Adriano Tortato, Marcos Tadeu do Nascimento, Margareth Lumy Sekiama, Maria Clara Nascimento-Costa, Maria Ester Bueno Dos Santos, Maria Santina de Castro Morini, Mariana Baldy Nagy-Reis, Mariane da Cruz Kaizer, Mariano José Ribeiro da Silva Sant'Anna, Marilia Teresinha Hartmann, Marina Ochoa Favarini, Marina Oliveira Olivo, Martín Alejandro Montes, Martin Roberto Del Valle Alvaréz, Matheus Feldstein Haddad, Maurício Djalles Costa, Maurício Eduardo Graipel, Mauricio Quoos Konzen, Mauro Galetti, Meyline de Oliveira Souza Almeida, Michel Barros Faria, Micheli Ribeiro Luiz, Michelle Noronha da Matta Baptista, Miguel Ângelo Marini, Milton Cezar Ribeiro, Natalie Olifiers, Natasha Moraes de Albuquerque, Nicolás Cantero, Nivaldo Peroni, Noeli Zanella, Olívia Mendonça-Furtado, Olivier Pays, Orlando Ednei Ferretti, Oscar Rocha-Barbosa, Paloma Marques Santos, Patrícia Menegaz de Farias, Patrício Adriano da Rocha, Paul François Colas-Rosas, Paula Ribeiro-Souza, Paula Ferracioli, Paulo Afonso Hartmann, Paulo de Tarso Zuquim Antas, Paulo Ribeiro, Paulo Tomasi Sarti, Paulo Ivo Mônico, Pedro Volkmer de Castilho, Peônia Brito de Moraes Pereira, Peter Gransden Crawshaw, Pierre-Cyril Renaud, Rafael Spilere Romagna, Rafael Turíbio Moraes de Sousa, Raíssa Soares Spagnol, Raone Beltrão-Mendes, Ravi Fernandes Mariano, Renata Reinoso Rocha, Renata Sousa-Lima, Renata Valls Pagotto, Rhayssa Terra de Faria, Ricardo Corassa Arrais, Ricardo Moratelli, Ricardo Sartorello, Rita de Cassia Bianchi, Roberto de Carvalho Guimarães, Rodrigo Lima Massara, Romulo Theodoro Costa, Rosane Vera Marques, Ruan Márcio Ruas Nunes, Sandra Maria Hartz, Saulo Meneses Silvestre de Sousa, Saulo Ramos Lima, Sergio Lutz Barbosa, Silvia Neri Godoy, Stephen Francis Ferrari, Talita Guimarães de Araújo-Piovezan, Talita Laura Góes, Tatiane Campos Trigo, Thales R O de Freitas, Thiago Bernardes Maccarini, Thiago Marcial de Castro, Thiago Ribas Bella, Tonny Marques de Oliveira Junior, Uslaine Maciel Cunha, Vanessa Tavares Kanaan, Vera Pfannerstill, Victor Siqueira Pimentel, Vilmar Picinatto Filho, Vinícius Nunes Alves, Viviana Rojas-Bonzi, Viviane Mottin, Vlamir José Rocha, Andreas Kindel, Igor Pfeifer Coelho
Camera traps became the main observational method of a myriad of species over large areas. Data sets from camera traps can be used to describe the patterns and monitor the occupancy, abundance, and richness of wildlife, essential information for conservation in times of rapid climate and land-cover changes. Habitat loss and poaching are responsible for historical population losses of mammals in the Atlantic Forest biodiversity hotspot, especially for medium to large-sized species. Here we present a data set from camera trap surveys of medium to large-sized native mammals (>1 kg) across the Atlantic Forest...
April 12, 2024: Ecology
#2
JOURNAL ARTICLE
Pyungwon Kang, Philippe N Tobler, Peter Dayan
We and other animals learn because there is some aspect of the world about which we are uncertain. This uncertainty arises from initial ignorance, and from changes in the world that we do not perfectly know; the uncertainty often becomes evident when our predictions about the world are found to be erroneous. The Rescorla-Wagner learning rule, which specifies one way that prediction errors can occasion learning, has been hugely influential as a characterization of Pavlovian conditioning and, through its equivalence to the delta rule in engineering, in a much wider class of learning problems...
April 3, 2024: Neurobiology of Learning and Memory
#3
David B Kastner, Greer Williams, Cristofer Holobetz, Joseph P Romano, Peter Dayan
Behavior contains rich structure across many timescales, but there is a dearth of methods to identify relevant components, especially over the longer periods required for learning and decision-making. Inspired by the goals and techniques of genome-wide association studies, we present a data-driven method-the choice-wide behavioral association study: CBAS-that systematically identifies such behavioral features. CBAS uses powerful, resampling-based, methods of multiple comparisons correction 1-3 to identify sequences of actions or choices that either differ significantly between groups or significantly correlate with a covariate of interest...
February 28, 2024: bioRxiv
#4
JOURNAL ARTICLE
Seth R Batten, Dan Bang, Brian H Kopell, Arianna N Davis, Matthew Heflin, Qixiu Fu, Ofer Perl, Kimia Ziafat, Alice Hashemi, Ignacio Saez, Leonardo S Barbosa, Thomas Twomey, Terry Lohrenz, Jason P White, Peter Dayan, Alexander W Charney, Martijn Figee, Helen S Mayberg, Kenneth T Kishida, Xiaosi Gu, P Read Montague
Dopamine and serotonin are hypothesized to guide social behaviours. In humans, however, we have not yet been able to study neuromodulator dynamics as social interaction unfolds. Here, we obtained subsecond estimates of dopamine and serotonin from human substantia nigra pars reticulata during the ultimatum game. Participants, who were patients with Parkinson's disease undergoing awake brain surgery, had to accept or reject monetary offers of varying fairness from human and computer players. They rejected more offers in the human than the computer condition, an effect of social context associated with higher overall levels of dopamine but not serotonin...
February 26, 2024: Nature Human Behaviour
#5
JOURNAL ARTICLE
Daniel S Tsze, Christian Thiele, Gerrit Hirschfeld, Peter S Dayan
OBJECTIVES: Changes in pain scores that represent clinically significant differences in children with headaches are necessary for study design and interpretation of findings reported in studies. We aimed to determine changes in pain scores associated with a minimum clinically significant difference (MCSD), ideal clinically significant difference (ICSD), and patient-perceived adequate analgesia (PPAA) in this population. METHODS: We performed a secondary analysis of two prospective studies of children with headaches presenting to an emergency department...
February 23, 2024: Academic Emergency Medicine
#6
JOURNAL ARTICLE
N G R Dayan Elshan, Karen C Wolff, Laura Riva, Ashley K Woods, Gennadii Grabovyi, Katy Wilson, James Pedroarena, Sourav Ghorai, Armen Nazarian, Frank Weiss, Yuyin Liu, Wrickban Mazumdar, Lirui Song, Neechi Okwor, Jacqueline Malvin, Malina A Bakowski, Nathan Beutler, Melanie G Kirkpatrick, Amal Gebara-Lamb, Edward Huang, Vân T B Nguyen-Tran, Victor Chi, Shuangwei Li, Thomas F Rogers, Case W McNamara, Anil Kumar Gupta, Alireza Rahimi, Jian Jeffrey Chen, Sean B Joseph, Peter G Schultz, Arnab K Chatterjee
There remains a need to develop novel SARS-CoV-2 therapeutic options that improve upon existing therapies by an increased robustness of response, fewer safety liabilities, and global-ready accessibility. Functionally critical viral main protease (Mpro , 3CLpro ) of SARS-CoV-2 is an attractive target due to its homology within the coronaviral family, and lack thereof toward human proteases. In this disclosure, we outline the advent of a novel SARS-CoV-2 3CLpro inhibitor, CMX990 , bearing an unprecedented trifluoromethoxymethyl ketone warhead...
February 9, 2024: Journal of Medicinal Chemistry
#7
JOURNAL ARTICLE
Timothy H Muller, James L Butler, Sebastijan Veselic, Bruno Miranda, Joni D Wallis, Peter Dayan, Timothy E J Behrens, Zeb Kurth-Nelson, Steven W Kennerley
The prefrontal cortex is crucial for learning and decision-making. Classic reinforcement learning (RL) theories center on learning the expectation of potential rewarding outcomes and explain a wealth of neural data in the prefrontal cortex. Distributional RL, on the other hand, learns the full distribution of rewarding outcomes and better explains dopamine responses. In the present study, we show that distributional RL also better explains macaque anterior cingulate cortex neuronal responses, suggesting that it is a common mechanism for reward-guided learning...
January 10, 2024: Nature Neuroscience
#8
JOURNAL ARTICLE
Michelle Coriddi, Leslie Kim, Kathryn Haglich, Jonas A Nelson, Farooq Shahzad, Joseph H Dayan, Joe Disa, Babak Mehrara, Peter G Cordeiro, Colleen M McCarthy
INTRODUCTION: Prior studies have shown an increased risk of complications and flap loss with the use of vein grafts in microsurgery. We hypothesize that indication for use of a vein graft can affect flap complications and loss rates. METHODS: We performed a retrospective review of all patients at our institution from 2010-2020 who underwent free flap reconstruction and required use of a vein graft. Indications for vein grafting included: salvage of flap during primary operation after microvascular compromise; augmentation of flow during primary operation; lengthening of the flap pedicle during the primary operation; and salvage of the flap during a secondary salvage operation after microvascular compromise...
January 8, 2024: Journal of Reconstructive Microsurgery
#9
JOURNAL ARTICLE
Poornima Kumar, Peter Dayan, Thomas Wolfers
No abstract text is available yet for this article.
February 1, 2024: JAMA Psychiatry
#10
JOURNAL ARTICLE
Aenne A Brielmann, Max Berentelg, Peter Dayan
Listening to music, watching a sunset-many sensory experiences are valuable to us, to a degree that differs significantly between individuals, and within an individual over time. We have theorized (Brielmann & Dayan 2022 Psychol. Rev . 129 , 1319-1337 (doi:10.1037/rev0000337))) that these idiosyncratic values derive from the task of using experiences to tune the sensory-cognitive system to current and likely future input. We tested the theory using participants' ( n = 59) ratings of a set of dog images ( n = 55) created using the NeuralCrossbreed morphing algorithm...
January 29, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
#11
JOURNAL ARTICLE
Vincent Duron, Nicholas Schmoke, Rika Ichinose, Steven Stylianos, Steven G Kernie, Peter S Dayan, Mark B Slidell, Casey Stulce, Grace Chong, Regan F Williams, Ankush Gosain, Nicholas P Morin, Isam W Nasr, Sapna R Kudchadkar, Jeff Bolstridge, Jose M Prince, Chethan Sathya, Todd Sweberg, N Valerio Dorrello
INTRODUCTION: While intravenous fluid therapy is essential to re-establishing volume status in children who have experienced trauma, aggressive resuscitation can lead to various complications. There remains a lack of consensus on whether pediatric trauma patients will benefit from a liberal or restrictive crystalloid resuscitation approach and how to optimally identify and transition between fluid phases. METHODS: A panel was comprised of physicians with expertise in pediatric trauma, critical care, and emergency medicine...
December 9, 2023: Journal of Surgical Research
#12
JOURNAL ARTICLE
Vikki Neville, Michael Mendl, Elizabeth S Paul, Peggy Seriès, Peter Dayan
Objective measures of animal emotion-like and mood-like states are essential for preclinical studies of affective disorders and for assessing the welfare of laboratory and other animals. However, the development and validation of measures of these affective states poses a challenge partly because the relationships between affect and its behavioural, physiological and cognitive signatures are complex. Here, we suggest that the crisp characterisations offered by computational modelling of the underlying, but unobservable, processes that mediate these signatures should provide better insights...
November 30, 2023: Cognitive, Affective & Behavioral Neuroscience
#13
REVIEW
Lakdasa D Premawardhana, Peter Nicholas Taylor, Onyebuchi E Okosieme, Mohamed A Adlan, Emmanuel K Obuobie, Colin Mark Dayan
Approximately 10%-15% of subjects with hypothyroidism on L-thyroxine (LT4) alone have persistent symptoms affecting their quality of life (QoL). Although the cause is unclear, there is evidence that "tissue T3 lack" may be responsible. If so, combining liothyronine (LT3) with LT4 would be helpful. However, randomized controlled trials (RCT), have not established greater efficacy for the LT3 + LT4 combination in these subjects than for LT4 alone. While the trial design may have been responsible, the use of unphysiological, short-acting LT3 preparations and non-thyroid-specific patient-reported outcome measures (PROMs) may have contributed...
2023: Frontiers in Endocrinology
#14
JOURNAL ARTICLE
Daniel S Tsze, Nathan Kuppermann, T Charles Casper, Bradley J Barney, Lawrence P Richer, Danica B Liberman, Pamela J Okada, Claudia R Morris, Sage R Myers, Jane K Soung, Rakesh D Mistry, Lynn Babcock, Sandra P Spencer, Michael D Johnson, Eileen J Klein, Kimberly S Quayle, Dale W Steele, Andrea T Cruz, Alexander J Rogers, Danny G Thomas, Jacqueline M Grupp-Phelan, Tiffani J Johnson, Peter S Dayan
INTRODUCTION: Headache is a common chief complaint of children presenting to emergency departments (EDs). Approximately 0.5%-1% will have emergent intracranial abnormalities (EIAs) such as brain tumours or strokes. However, more than one-third undergo emergent neuroimaging in the ED, resulting in a large number of children unnecessarily exposed to radiation. The overuse of neuroimaging in children with headaches in the ED is driven by clinician concern for life-threatening EIAs and lack of clarity regarding which clinical characteristics accurately identify children with EIAs...
November 22, 2023: BMJ Open
#15
JOURNAL ARTICLE
Peter N Taylor, Kimberly S Collins, Anna Lam, Stephen R Karpen, Brianna Greeno, Frank Walker, Alejandro Lozano, Elnaz Atabakhsh, Simi T Ahmed, Marjana Marinac, Esther Latres, Peter A Senior, Mark Rigby, Peter A Gottlieb, Colin M Dayan
BACKGROUND: Metabolic outcomes in type 1 diabetes remain suboptimal. Disease modifying therapy to prevent β-cell loss presents an alternative treatment framework but the effect on metabolic outcomes is unclear. We, therefore, aimed to define the relationship between insulin C-peptide as a marker of β-cell function and metabolic outcomes in new-onset type 1 diabetes. METHODS: 21 trials of disease-modifying interventions within 100 days of type 1 diabetes diagnosis comprising 1315 adults (ie, those 18 years and older) and 1396 children (ie, those younger than 18 years) were combined...
December 2023: Lancet Diabetes & Endocrinology
#16
JOURNAL ARTICLE
Marc Guitart-Masip, Amy Walsh, Peter Dayan, Andreas Olsson
Unavoidable stress can lead to perceived lack of control and learned helplessness, a risk factor for depression. Avoiding punishment and gaining rewards involve updating the values of actions based on experience. Such updating is however useful only if action values are sufficiently stable, something that a lack of control may impair. We examined whether self-reported stress uncontrollability during the first wave of the COVID-19 pandemic predicted impaired reward-learning. In a preregistered study during the first-wave of the COVID-19 pandemic, we used self-reported measures of depression, anxiety, uncontrollable stress, and COVID-19 risk from 427 online participants to predict performance in a three-armed-bandit probabilistic reward learning task...
October 27, 2023: Scientific Reports
#17
JOURNAL ARTICLE
Kevin Lloyd, Peter Dayan
Pavlovian influences notoriously interfere with operant behaviour. Evidence suggests this interference sometimes coincides with the release of the neuromodulator dopamine in the nucleus accumbens. Suppressing such interference is one of the targets of cognitive control. Here, using the examples of active avoidance and omission behaviour, we examine the possibility that direct manipulation of the dopamine signal is an instrument of control itself. In particular, when instrumental and Pavlovian influences come into conflict, dopamine levels might be affected by the controlled deployment of a reframing mechanism that recasts the prospect of possible punishment as an opportunity to approach safety, and the prospect of future reward in terms of a possible loss of that reward...
October 2023: PLoS Computational Biology
#18
JOURNAL ARTICLE
Stijn Vanstraelen, Manjit S Bains, Joe Dycoco, Prasad S Adusumilli, Matthew J Bott, Robert J Downey, James Huang, James M Isbell, Daniela Molena, Bernard J Park, Valerie W Rusch, Smita Sihag, Robert J Allen, Peter G Cordeiro, Michelle R Coriddi, Joseph H Dayan, Joseph J Disa, Evan Matros, Colleen M McCarthy, Jonas A Nelson, Carrie Stern, Farooq Shahzad, Babak Mehrara, David R Jones, Gaetano Rocco
OBJECTIVES: To compare postoperative outcomes between biologic and synthetic reconstructions after chest wall resection in a matched cohort. METHODS: All patients who underwent reconstruction after full-thickness chest wall resection from 2000 to 2022 were reviewed and stratified by prosthesis type (biologic or synthetic). Biologic prostheses were of biologic origin or were fully absorbable and incorporable. Integer matching was performed to reduce confounding. The study endpoint was surgical site complications requiring reoperation...
October 16, 2023: European Journal of Cardio-thoracic Surgery
#19
JOURNAL ARTICLE
Nitay Alon, Lion Schulz, Jeffrey S Rosenschein, Peter Dayan
In complex situations involving communication, agents might attempt to mask their intentions, exploiting Shannon's theory of information as a theory of misinformation. Here, we introduce and analyze a simple multiagent reinforcement learning task where a buyer sends signals to a seller via its actions, and in which both agents are endowed with a recursive theory of mind. We show that this theory of mind, coupled with pure reward-maximization, gives rise to agents that selectively distort messages and become skeptical towards one another...
2023: Open Mind: Discoveries in Cognitive Science
#20
JOURNAL ARTICLE
Todd A Florin, Octavio Ramilo, Russell K Banks, David Schnadower, Kimberly S Quayle, Elizabeth C Powell, Michelle L Pickett, Lise E Nigrovic, Rakesh Mistry, Aaron N Leetch, Robert W Hickey, Eric W Glissmeyer, Peter S Dayan, Andrea T Cruz, Daniel M Cohen, Amanda Bogie, Fran Balamuth, Shireen M Atabaki, John M VanBuren, Prashant Mahajan, Nathan Kuppermann
OBJECTIVE: The lack of evidence-based criteria to guide chest radiograph (CXR) use in young febrile infants results in variation in its use with resultant suboptimal quality of care. We sought to describe the features associated with radiographic pneumonias in young febrile infants. STUDY DESIGN: Secondary analysis of a prospective cohort study in 18 emergency departments (EDs) in the Pediatric Emergency Care Applied Research Network from 2016 to 2019. Febrile (≥38°C) infants aged ≤60 days who received CXRs were included...
December 22, 2023: Emergency Medicine Journal: EMJ
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