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https://www.readbyqxmd.com/read/28338878/risk-of-diabetes-after-hysterectomy-with-or-without-oophorectomy-in-postmenopausal-women
#1
Juhua Luo, JoAnn E Manson, Rachel Peragallo Urrutia, Michael Hendryx, Erin S LeBlanc, Karen L Margolis
The aim of this study was to determine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence of diabetes in postmenopausal women participating in the Women's Health Initiative (WHI), a series of trials conducted in the United States, during the period 1993-1998. A total of 67,130 postmenopausal women aged 50-79 years were followed for a mean of 13.4 years. Among them, 7,430 cases of diabetes were diagnosed. Multivariable Cox proportional hazards models were used to assess the association between hysterectomy/oophorectomy status and diabetes incidence...
March 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28337524/quantitative-analysis-of-efficacy-and-associated-factors-of-calcium-intake-on-bone-mineral-density-in-postmenopausal-women
#2
J Wu, L Xu, Y Lv, L Dong, Q Zheng, L Li
A model-based meta-analysis method was performed to quantitatively analyze the efficacy characteristics of calcium intake in BMD increase among postmenopausal women. We found that age and calcium intake dose were key factors affecting the efficiency and onset of BMD change, and daily 1200 mg calcium was suggested to be a beneficial dosage. INTRODUCTION: This paper aims to quantify the efficacy of calcium intake in preventing bone mineral density (BMD) decrease among postmenopausal women and to investigate the factors that may affect the efficacy...
March 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28336831/-calcilytic-drugs-feature-and-future
#3
Itsuro Endo
Calcium-sensing receptor(CaSR)is highly expressed in parathyroid, kidney, bone, and small and large intestines to regulate Ca homeostasis. Calcilytics are allosteric antagonists of CaSR, and stimulate endogenous PTH release. Several calcilytics have been evaluated as anabolic therapies for postmenopausal osteoporosis but clinical development of all of them has been abandoned because the lacked clinical efficacy. Calcilytics might be repurposed for new indications like autosomal dominant hypocalcemia or other disorders...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28336582/high-mammographic-density-in-long-term-night-shift-workers-ddm-spain-var-ddm
#4
Ana Maria Pedraza-Flechas, Virginia Lope, Carmen Sánchez-Contador, Carmen Santamariña, Carmen Pedraz-Pingarrón, Pilar Moreo, María Ederra, Josefa Miranda-García, Carmen Vidal, Rafael Llobet, Nuria Aragonés, Dolores Salas-Trejo, Marina Pollán, Beatriz Pérez-Gómez
Background:Night-shift work (NSW) has been suggested as a possible cause of breast cancer (BC), and its association with mammographic density (MD), one of the strongest risk factors for BC, has been scarcely addressed. This study examined NSW and MD in Spanish women. Methods:The study covered 2752 women aged 45-68 years recruited in 2007-2008 in 7 population-based public BC screening centers, which included 243 women who had performed NSW for at least one year. Occupational data and information on potential confounders was collected by personal interview...
March 23, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28335442/in-vitro-and-in-vivo-effects-of-gracilaria-verrucosa-extracts-on-osteoclast-differentiation
#5
Kwang-Jin Kim, Yong-Jin Lee, Yun-Ho Hwang, Kyung-Yun Kang, Sung-Tae Yee, Young-Jin Son
Bone remodeling, a physiological process characterized by bone formation by osteoblasts and bone resorption by osteoclasts, is important for the maintenance of healthy bone in adult humans. Osteoclasts play a critical role in bone erosion and osteoporosis and are bone-specific multinucleated cells generated through differentiation of monocyte/macrophage lineage precursors. Receptor activator of NF-κB ligand (RANKL) has been reported to induce osteoclast differentiation. In this study, we explored whether Gracilaria verrucosa extracts (GE) could affect RANKL-mediated osteoclast differentiation...
March 14, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28333238/clustering-of-pcos-like-traits-in-naturally-hyperandrogenic-female-rhesus-monkeys
#6
D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine
STUDY QUESTION: Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28332870/changes-in-the-level-of-immunoglobulins-and-cd4-cd8-ratio-in-young-and-aged-mice-with-estradiol-deficiency
#7
Ming-Jun Shao, Yi-Jun Zhu, Ying-Er Qiu, Min Hu, Yun-Qin He
Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice with surgical or medical variectomy and aged C57BL/6N mice with the common feature of E2 deficiency following Con A stimulation. We observed inverted CD4/CD8 ratios in the aged group and apparent reduced production of serum immunoglobin (Ig)G, IgA, and IgM in the surgical group, whereas changes in immune parameters in the medical group were moderate...
April 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28332508/prolactin-as-a-predictor-of-endothelial-dysfunction-and-arterial-stiffness-progression-in-menopause
#8
G Georgiopoulos, I Lambrinoudaki, F Athanasouli, E Armeni, A Koliviras, A Augoulea, D Rizos, C Papamichael, A Protogerou, K Stellos, K Stamatelopoulos
Postmenopausal women are at increased risk for progression of arteriosclerosis and hypertension. Recent cross-sectional evidence suggests that high normal circulating prolactin levels may accelerate vascular ageing in menopause. Postmenopausal women (n=201) were consecutively recruited from a Menopause Clinic and re-evaluated in at least one follow-up visit within the next 3 years. Baseline circulating prolactin levels were measured while both baseline and follow-up vascular and biochemical measurements were performed...
March 23, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28332358/perceptions-of-postmenopausal-symptoms-and-treatment-options-among-middle-aged-korean-women
#9
Min Kyoung Kim, Seok Kyo Seo, Hee Dong Chae, Kyung Joo Hwang, Tak Kim, Byung Koo Yoon, Byung Seok Lee
PURPOSE: To investigate the perceptions of postmenopausal symptoms and treatment options among middle-aged Korean women. MATERIALS AND METHODS: This cross-sectional study included 2330 Korean women. The women were administered a structured questionnaire to collect sociodemographic data and information regarding menopause and its treatment. RESULTS: More than half (65%) of the participants perceived menopause as a disease, and 66.8% knew hormone therapy (HT) is available for menopausal symptom treatment...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28332172/quantitative-ultrasound-and-dxa-measurements-in-aromatase-inhibitor-treated-breast-cancer-women-receiving-denosumab
#10
A Catalano, A Gaudio, N Morabito, G Basile, R M Agostino, A Xourafa, M Atteritano, E Morini, G Natale, A Lasco
PURPOSE: Denosumab has been proven to reduce fracture risk in breast cancer (BC) women under aromatase inhibitors (AIs). Quantitative ultrasound (QUS) provides information on the structure and elastic properties of bone. Our aim was to assess bone health by phalangeal QUS and by dual-energy X-ray absorptiometry (DXA), and to evaluate bone turnover in AIs-treated BC women receiving denosumab. METHODS: 35 Postmenopausal BC women on AIs were recruited (mean age 61...
March 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28331747/the-relationship-between-bone-mineral-density-and-estrogen-receptor-positivity-in-patients-with-breast-cancer
#11
Zeynep Erdoğan İyigün, Kezban Nur Pilancı, Fatmagül Kuşku Çabuk, Serkan İlgün, Çetin Ordu, Tomris Duymaz, Gül Alço, Filiz Çelebi, Dauren Sarsenov, Filiz İzci, Alper Öztürk, Filiz Ağaçayak, Ülkühan İner Köksal, Fatma Aktepe, Yeşim Eralp, Vahit Özmen
OBJECTIVE: The effect of estrogen on bone mineral density (BMD) and breast cancer has been known for a long time. The aim of this study was to compare of the BMD of patients with breast cancer and healthy individuals, and to investigate the degree of correlation of estrogen receptor (ER) with BMD. MATERIALS AND METHODS: Seventy-one patients with postmenopausal breast cancer and 79 healthy dividuals were included in the study. The patient demographics (age, menopause age, body mass index, number of children, BMD, Z scores, and estrogen status for breast cancer patients) were taken from hospital records...
July 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28331735/metaplastic-breast-carcinoma-analysis-of-clinical-and-pathologic-characteristics-a-case-series
#12
Semra Salimoğlu, İsmail Sert, Mustafa Emiroğlu, Cem Karaali, Dilek Kuzukıran, Yasemin Akyüz Kırmızı, Gülden Diniz, Cengiz Aydın
OBJECTIVE: Metaplastic breast cancer (MBC) is a rare type of breast cancer that is considered to be clinically aggressive. The clinical significance and prognostic risk factors of MBC are limited. This study comprises a retrospective analysis of the clinical and pathologic findings of a series of patients treated for MBC. MATERIALS AND METHODS: The files of 657 patients who underwent surgery because of breast cancer at our clinic were examined and the data found on 11 patients who were diagnosed as having MBC were analyzed...
April 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28329549/frontal-fibrosing-alopecia-in-a-46-year-old-man
#13
Forrest White, Shields Callahan, Randie H Kim, Shane A Meehan, Jennifer Stein
Frontal fibrosing alopecia is a scarring alopecia thatis characterized by recession of the frontotemporalhairline with the frequent loss of eyebrows. Itpredominantly affects postmenopausal womenand only rarely affects men. We report the caseof a 46-year-old man with a ten-year history of anerythematous patch with perifollicular erythemaat the superior aspect of the forehead andfrontotemporal hairline. A skin biopsy specimenshowed a perivascular, lymphocytic infiltrate withperiinfundibular fibrosis. These findings establisheda diagnosis of frontal fibrosing alopecia...
December 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328803/incident-acute-pseudogout-and-prior-bisphosphonate-use-matched-case-control-study-in-the-uk-clinical-practice-research-datalink
#14
Edward Roddy, Sara Muller, Zoe Paskins, Samantha L Hider, Milisa Blagojevic-Bucknall, Christian D Mallen
Oral bisphosphonates are the most commonly used drugs to treat postmenopausal osteoporosis. Acute pseudogout is anecdotally reported to occur following bisphosphonate initiation but empirical data are lacking. We investigated whether treatment with oral bisphosphonates is a risk factor for incident acute pseudogout.A matched case-control study was undertaken using data from the UK-Clinical Practice Research Datalink. Adults who consulted for incident acute pseudogout between 1987 and 2012 were each matched for gender, age at pseudogout diagnosis, and general practice to up to 4 control subjects without pseudogout...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28328386/walking-training-and-cortisol-to-dhea-s-ratio-in-postmenopause-an-intervention-study
#15
Andrea Di Blasio, Pascal Izzicupo, Angela Di Baldassarre, Sabina Gallina, Ines Bucci, Cesidio Giuliani, Serena Di Santo, Angelo Di Iorio, Patrizio Ripari, Giorgio Napolitano
The literature indicates that the plasma cortisol-to-dihydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogens and DHEA-S, and an increase in cortisol occur. An increase in the cortisol-to-DHEA-S ratio has been positively correlated with metabolic syndrome, all-cause mortality, cancer and other diseases. The aim of this study was to investigate the effects of a walking program on the plasma cortisol-to-DHEA-S ratio in postmenopausal women. Fifty-one postmenopausal women participated in a 13-week supervised walking program, in the metropolitan area of Pescara (Italy), from June to September 2013...
March 22, 2017: Women & Health
https://www.readbyqxmd.com/read/28326899/prevalence-and-predictors-of-complementary-and-alternative-medicine-non-pharmacological-interventions-use-for-menopausal-symptoms-within-the-uk-collaborative-trial-of-ovarian-cancer-screening
#16
A Gentry-Maharaj, C Karpinskyj, C Glazer, M Burnell, K Bailey, S Apostolidou, A Ryan, A Lanceley, L Fraser, I Jacobs, M S Hunter, U Menon
OBJECTIVES: The negative publicity about menopausal hormone therapy (MHT) has led to increased use of complementary and alternative medicines (CAM) and non-pharmacological interventions (NPI) for menopausal symptom relief. We report on the prevalence and predictors of CAM/NPI among UK postmenopausal women. METHOD: Postmenopausal women aged 50-74 years were invited to participate in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). A total of 202 638 women were recruited and completed a baseline questionnaire...
March 22, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28326829/endogenous-sex-hormone-levels-and-coronary-heart-disease-risk-in-postmenopausal-women-a-meta-analysis-of-prospective-studies
#17
Haihui Wang, Yuehua Li, Xinlu Wang, Jianhong Bu, Guoliang Yan, Danfei Lou
Background Low testosterone levels have been associated with coronary heart disease (CHD) morbidity and mortality in men, but the influence of hormones in postmenopausal women is unclear. This meta-analysis aimed to examine whether there is an association between endogenous sex hormones and CHD risk in postmenopausal women. Methods A systematic search of the PubMed and EMBASE databases from 1966 to 30 November 2016 was performed for prospective studies that reported an association between endogenous sex hormones and CHD in postmenopausal women...
April 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28326633/bias-from-depletion-of-susceptibles-the-example-of-hormone-replacement-therapy-and-the-risk-of-venous-thromboembolism
#18
Christel Renoux, Sophie Dell'Aniello, Benjamin Brenner, Samy Suissa
PURPOSE: The data on the association between hormone replacement therapy and the increased risk of venous thromboembolism (VTE) in postmenopausal women are conflicting. The observed differences between oral estrogen and oral estrogen-progestogen combination formulations may be the result of bias from depletion of susceptibles. METHODS: We used United Kingdom's Clinical Practice Research Datalink to identify the cohort of all women aged 50 to 79 during 1987-2008, with all incident cases of VTE occurring during the study period identified...
March 22, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28326520/transdermal-hormone-replacement-therapy-with-nanostructured-medicines
#19
Fatemeh Abdi, Tayebeh Darooneh, Maryam Ghorbani, Farzaneh Banihashemi, Nasibeh Roozbeh
OBJECTIVES: Due to hormonal changes during the menopause, women experience a variety of perimenopause and postmenopause symptoms. This review examines the various aspects of nanostructured hormone therapy and its application in the treatments of menopausal symptoms. MATERIAL AND METHODS: Excerpta Medica DataBase, Medical Literature Analysis and Retrieval System Online, Web of Science, and Google Scholar were searched basing on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28326507/objectively-measured-sedentary-behavior-and-quality-of-life-among-survivors-of-early-stage-breast-cancer
#20
Sheri J Hartman, Catherine R Marinac, John Bellettiere, Suneeta Godbole, Loki Natarajan, Ruth E Patterson, Jacqueline Kerr
PURPOSE: This study examined relationships between sedentary behavior accumulated in different bout durations and quality of life (QoL) among breast cancer survivors. METHODS: Postmenopausal breast cancer survivors completed the Short Form Health Survey to assess QoL and wore an accelerometer to measure sedentary behavior and physical activity between August 2011 and May 2013. RESULTS: Participants (n = 134) averaged 509.7 min/day in sedentary time with 285...
March 22, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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