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Wei-Hsuan Lo-Ciganic, Walid F Gellad, Haiden A Huskamp, Niteesh K Choudhry, Chung-Chou H Chang, Ruoxin Zhang, Bobby L Jones, Hasan Guclu, Seth Richards-Shubik, Julie M Donohue
BACKGROUND: Variation in physician adoption of new medications is poorly understood. Traditional approaches (eg, measuring time to first prescription) may mask substantial heterogeneity in technology adoption. OBJECTIVE: Apply group-based trajectory models to examine the physician adoption of dabigratran, a novel anticoagulant. METHODS: A retrospective cohort study using prescribing data from IMS Xponent™ on all Pennsylvania physicians regularly prescribing anticoagulants (n=3911) and data on their characteristics from the American Medical Association Masterfile...
July 2016: Medical Care
Eric T Alexander, Allyson R Minton, Candace S Hayes, Ashley Goss, Joanne Van Ryn, Susan K Gilmour
Cancer is often associated with an increased risk of thrombotic events which are exacerbated by treatment with chemotherapeutics such as cyclosphosphamide (CP). Evidence suggests that thrombin can stimulate tumor progression via formation of fibrin and activation of protease-activated receptors (PARs) and platelets. We examined the effect of co-treatment with CP and dabigatran etexilate, a direct inhibitor of thrombin, using the murine orthotopic 4T1 tumor model. Mice receiving co-treatment with both low dose CP and dabigatran etexilate had significantly smaller mammary tumors and fewer lung metastases than mice treated with CP or dabigratran etexilate alone...
2015: Cancer Biology & Therapy
Noa Zemer-Wassercug, Moti Haim, Dorit Leshem-Lev, Katia L Orvin, Muthiah Vaduganathan, Ariel Gutstein, Ehud Kadmon, Aviv Mager, Ran Kornowski, Eli I Lev, Eli L Lev
The new oral anticoagulants (NOACs) reduce stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF), but dabigatran may increase risk of coronary ischemic events for unclear reasons. Thus, this study assessed the effects of dabigatran and rivaroxaban on platelet reactivity and inflammatory markers in patients with non-valvular AF. Patients with non-valvular AF planned to begin treatment with NOACs were included. Seventeen patients were prescribed dabigatran and ten rivaroxaban. Platelet function (as assessed by multiple-electrode aggregometry, Impact-R shear-induced platelet deposition, P-selectin expression and plasma RANTES levels) and high-sensitivity C-reactive protein (hs-CRP) were measured at enrollment (prior to initiation of NOAC treatment) and at least 7 days into treatment with either dabigratran or rivaroxaban...
October 2015: Journal of Thrombosis and Thrombolysis
Cindy Huang, Michele Siu, Lily Vu, Soo Wong, Jaekyu Shin
RATIONALE, AIMS AND OBJECTIVES: This study was designed to examine the factors that influence doctors' decision in initiating or switching from warfarin to dabigratran. METHOD: A survey questionnaire was sent to 181 doctors who were most likely to prescribe dabigatran (e.g. cardiologists and general internists) at the University of California, San Francisco Medical Center between November 2011 and February 2012. Survey participants were asked to complete an electronic or a paper version of the questionnaire, which consisted of 17 multiple-choice questions...
October 2013: Journal of Evaluation in Clinical Practice
Bénédicte Dumont, Dorothée Faille, Nadine Ajzenberg
For years, prevention and treatment of thromboembolic events have been restricted to the use of heparins and vitamin K antagonists. These treatments, in spite of their unquestioned efficacy, present numerous limits (hemorrhagic risk, need for regular laboratory controls). These limits call for the development of new antithrombotic drugs. This review briefly reports on three new molecules, in very advanced phases of clinical research: dabigatran (Pradaxa®), rivaroxaban (Xarelto®) and apixaban. These molecules represent new oral anticoagulants, which directly inhibit a coagulation factor (thrombin for dabigatran, factor Xa for rivaroxaban and apixaban) and do not need regular anticoagulant monitoring or dose adjustment...
May 2011: Médecine Sciences: M/S
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