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https://www.readbyqxmd.com/read/27900799/tissue-sources-for-accurate-measurement-of-germline-dna-genotypes-in-prostate-cancer-patients-treated-with-radical-prostatectomy
#1
Nima C Emami, Lancelote Leong, Eunice Wan, Erin L Van Blarigan, Matthew R Cooperberg, Imelda Tenggara, Peter R Carroll, June M Chan, John S Witte, Jeffry P Simko
BACKGROUND: Benign tissue from a tumor-containing organ is commonly the only available source for obtaining a patient's unmutated genome for use in cancer research. While it is critical to identify histologically normal tissue that is independent of the tumor lineage, few additional considerations are applied to the choice of this material for such measurements. METHODS: Normal formalin-fixed, paraffin-embedded seminal vesicle, and urethral tissues, in addition to whole blood, were collected from 31 prostate cancer patients having undergone radical prostatectomy...
November 30, 2016: Prostate
https://www.readbyqxmd.com/read/27895686/successful-treatment-of-a-67-year-old-woman-with-urethral-adenocarcinoma-with-the-use-of-external-beam-radiotherapy-and-image-guided-adaptive-interstitial-brachytherapy
#2
Jasmin Mujkanovic, Kari Tanderup, Mads Agerbæk, Ulla Bisgaard, Søren Høyer, Jacob Christian Lindegaard, Lars Fokdal
Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27895678/prostate-brachytherapy-in-ghana-our-initial-experience
#3
James Edward Mensah, Joel Yarney, Verna Vanderpuye, Evans Akpakli, Samuel Tagoe, Evans Sasu
PURPOSE: This study presents the experience of a brachytherapy team in Ghana with a focus on technology transfer and outcome. The team was initially proctored by experienced physicians from Europe and South Africa. MATERIAL AND METHODS: A total of 90 consecutive patients underwent either brachytherapy alone or brachytherapy in combination with external beam radiotherapy for prostate carcinoma between July 2008 and February 2014 at Korle Bu Teaching Hospital, Accra, Ghana...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27887943/magnetic-resonance-imaging-for-membranous-urethral-length-assessment-prior-to-radical-prostatectomy-can-it-really-improve-prostate-cancer-management
#4
EDITORIAL
Manuela Tutolo, Nicola Fossati, Frank Van der Aa, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti
No abstract text is available yet for this article.
November 22, 2016: European Urology
https://www.readbyqxmd.com/read/27879443/skeletal-metastasis-of-canine-urothelial-carcinoma-pathologic-and-computed-tomographic-features
#5
V A Charney, M A Miller, H G Heng, H Y Weng, D W Knapp
Invasive urothelial (transitional cell) carcinoma (UC) is the most common cancer in the canine urinary tract. Prolonged survival of dogs with UC due to better management of the primary tumor and prevention of urethral obstruction might have contributed to an apparent increase in distant metastasis. Metastasis to bone is particularly concerning because the ensuing pain often leads to euthanasia; however, little is known of the frequency, site, or nature of UC skeletal metastasis. In a retrospective analysis, 17 (9%) of 188 canine UC cases had histologically confirmed skeletal metastasis, mainly to the vertebrae...
November 22, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27867812/comparisons-of-oncological-and-functional-outcomes-among-radical-retropubic-prostatectomy-high-dose-rate-brachytherapy-cryoablation-and-high-intensity-focused-ultrasound-for-localized-prostate-cancer
#6
Po Hui Chiang, Yi Yang Liu
PURPOSE: To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. METHODS: We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and HIFU respectively for localized prostate cancer from May 2008 to December 2013. PSA biochemical recurrence, salvage treatment-free rate, metastasis-free rate, and biochemical recurrence-free survival were analyzed for oncological outcomes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27862230/penile-compression-clamps-a-model-of-the-internal-mechanical-state-of-penile-soft-tissues
#7
Ayelet Levy, Mandy Fader, Daniel Bader, Amit Gefen
AIMS: Prostate cancer is the most frequently diagnosed male cancer and urinary incontinence represents a major consequence following surgery. Penile compression clamps (PCCs) which externally occlude the urethra may be used to manage the incontinence. Despite potential complication of PCCs, such as deformation-inflicted tissue damage, to date, there are no reported biomechanical criteria for design of PCCs, in terms of quantitative parameters for evaluating the safety-versus-efficacy of existing or future designs...
November 15, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27847917/predictors-of-urgency-improvement-after-holmium-laser-enucleation-of-the-prostate-in-men-with-benign-prostatic-hyperplasia
#8
Won Sok Hur, Joon Chul Kim, Hyo Sin Kim, Jun Sung Koh, Sang Hoon Kim, Hyun Woo Kim, Su Yeon Cho, Kang Jun Cho
PURPOSE: To investigate the change in urinary urgency and predictors of urgency improvement after holmium laser enucleation of the prostate (HoLEP) in men with benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: We retrospectively analyzed the medical records of patients who were treated with HoLEP for BPH and had preoperative urgency measuring ≥3 on a 5-point urinary sensation scale. Those with prostate cancer diagnosed prior to or after HoLEP, a history of other prostatic and/or urethral surgery, moderate to severe postoperative complications, and neurogenic causes were excluded...
November 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27846935/-ccafu-french-national-guidelines-2016-2018-on-bladder-cancer
#9
M Rouprêt, Y Neuzillet, A Masson-Lecomte, P Colin, E Compérat, F Dubosq, N Houédé, S Larré, G Pignot, P Puech, M Roumiguié, E Xylinas, A Méjean
OBJECTIVE: The purpose of the guidelines national committee CCAFU on bladder cancer was to propose updated french guidelines for non-muscle invasive (NMIBC) and invasive (MIBC) bladder cancers. METHODS: A Medline search was achieved between 2013 and 2016, as regards diagnosis, options of treatment and follow-up of bladder cancer, to evaluate different references with levels of evidence. RESULTS: Diagnosis of NMIBC (Ta, T1, CIS) is based on a complete deep resection of the tumour...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27824258/full-neurovascular-sparing-extraperitoneal-robotic-radical-prostatectomy-our-experience-with-perusia-tecnique
#10
Giovanni Cochetti, Andrea Boni, Francesco Barillaro, Solajd Pohja, Roberto Cirocchi, Ettore Mearini
INTRODUCTION: Primary aim of this study was to investigate the feasibility and the safety of P.E.R.U.S.I.A. (Posterior, Extraperitoneal, Robotic, Under Santorini, Intrafascial, Anterograde) Radical Prostatectomy. Secondary aim was to evaluate oncologic and functional results. The main intent of PERUSIA is to reduce injury of the NVB and to preserve peri-urethral anterior structures. This is the first reported prospective cohort study about our technique. MATERIALS AND METHODS: We collected prospective data of a cohort of 210 patients who had undergone PERUSIA radical prostatectomy between January 2013 and May 2015...
November 8, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27818715/optical-fibre-sensors-their-role-in-in-vivo-dosimetry-for-prostate-cancer-radiotherapy
#11
REVIEW
P Woulfe, F J Sullivan, S O'Keeffe
Review is made of dosimetric studies of current optical fibre technology in radiotherapy for therapeutic applications, focusing particularly on in vivo dosimetry for prostate radiotherapy. We present the various sensor designs along with the main advantages and disadvantages associated with this technology. Optical fibres are ideally placed for applications in radiotherapy dosimetry; due to their small size they are lightweight and immune to electromagnetic interferences. The small dimensions of optical fibres allows it to be easily guided within existing brachytherapy equipment; for example, within the seed implantation needle for direct tumour dose analysis, in the urinary catheter to monitor urethral dose, or within the biopsy needle holder of the transrectal ultrasound probe to monitor rectal wall dose...
2016: Cancer Nanotechnology
https://www.readbyqxmd.com/read/27783117/-urethral-stricture-after-radiation-therapy
#12
C M Rosenbaum, O Engel, M Fisch, L A Kluth
Radiation-induced urethral stricture occurs most often due to radiation for prostate cancer. It is one of the most common side effects of radiotherapy. Stricture rates are lowest in patients undergoing external beam radiation therapy, occur more frequently in those who require brachytherapy and show highest stricture rates in patients receiving a combination of external beam radiation and brachytherapy. Strictures are mostly located at the bulbomembranous part of the urethra. Diagnostic work-up should include basic urologic work-up, ultrasound, uroflowmetric assessment, urethroscopy, retrograde urethrogram and voiding cystourethrography...
October 25, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27748126/simple-diagrammatic-method-to-delineate-male-urethra-in-prostate-cancer-radiotherapy-an-mri-based-approach
#13
Tejinder Kataria, Deepak Gupta, Shikha Goyal, Shyam S Bisht, Ravi Chaudhary, Kushal Narang, Susovan Banerjee, Trinanjan Basu, Ashu Abhishek, Sasikumar Sambasivam, Nisha T Vishnu
Stereotactic body radiotherapy (SBRT) is being increasingly utilized in the treatment of prostate cancer. With the advent of high-precision radiosurgery systems, it is possible to obtain dose distributions akin to high-dose rate brachytherapy with SBRT. However, urethral toxicity has a significant impact on the quality of life in patients with prostate cancer. Contouring the male urethra on a CT scan is difficult in the absence of an indwelling catheter. In this pictorial essay, we have used the MRI obtained for radiotherapy planning to aid in the delineation of the male urethra and have attempted to define guidelines for the same...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27733065/photoselective-vaporization-of-the-prostate-long-term-outcomes-and-safety-during-10-years-of-follow-up
#14
Yasushi Yamada, Jun Furusawa, Yoshiki Sugimura, Isao Kuromatsu
PURPOSE: To evaluate the long-term outcomes and safety photoselective vaporization of the prostate (PVP). PATIENTS AND METHODS: From April 2005 to December 2015, a total of 1154 patients with benign prostatic hyperplasia underwent PVP. The type of Green Light laser was an 80 W potassium-titanyl-phosphate laser and later a 120 W lithium triborate laser. Before and after surgery, the International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post-voiding volume of residual urine (PVR), prostate-specific antigen (PSA) level, and prostate volume were assessed regularly...
December 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27732566/extralevator-abdominoperineal-excision-for-rectal-cancer-with-biological-mesh-for-pelvic-floor-reconstruction
#15
Wei Ge, Song-Song Jiang, Wang Qi, Hao Chen, Li-Ming Zheng, Gang Chen
GOAL: To share our experience of extra-levator abdominoperineal excision (ELAPE) for low rectal cancer, focusing on perineal repair with biological mesh. METHODS: We retrospectively analyzed medical records of all patients with low rectal cancer who underwent the ELAPE procedure using biological mesh for perineal repair at the Gastrointestinal Surgery of Nanjing Drum Power Hospital between January 2013 and September 2015. All patients were closely followed up to now...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27721660/primary-metastatic-squamous-cell-carcinoma-of-the-male-urethra-presenting-with-scrotal-abscess-and-subsequent-development-of-fournier-s-gangrene
#16
Sarah J Moore, Omid Rashidipour, Ronald B Moore
This male patient presented with a scrotal abscess and urinary obstruction. The patient's history included a perineal abscess and the development of urethrocutaneous fistulae (watering-can perineum). He underwent multiple debridement procedures without resolution. During the fifth debridement for Fournier's gangrene, a biopsy revealed invasive squamous cell carcinoma. The patient was bedridden because of the large mass, a wide en bloc resection with lymphadenectomy and reconstruction was performed revealing a large (22 cm) squamous cell carcinoma originating from the urethra...
2016: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/27720774/outcomes-and-prognostic-factors-of-primary-urethral-cancer
#17
Wilson Sui, Arindam RoyChoudry, Sven Wenske, Guarionex J Decastro, James M McKiernan, Christopher B Anderson
OBJECTIVE: To identify prognostic and treatment factors for primary urethral cancer using a nationwide database. MATERIALS AND METHODS: The National Cancer Database (NCDB) was queried for all cases of primary urethral cancer from 2004-2013. Patients with other cancer diagnoses, metastasis or diagnosis on autopsy we excluded. Proportional hazards regression was used to identify independent predictors of overall survival in patients with primary urethral cancer. Because we hypothesized that predictors may covary by sex, we also performed regression analysis stratified by sex...
October 5, 2016: Urology
https://www.readbyqxmd.com/read/27720536/pathophysiology-and-contributing-factors-in-postprostatectomy-incontinence-a-review
#18
John Heesakkers, Fawzy Farag, Ricarda M Bauer, Jaspreet Sandhu, Dirk De Ridder, Arnulf Stenzl
CONTEXT: The incidence and awareness of postprostatectomy incontinence (PPI) has increased during the past few years, probably because of an increase in prostate cancer surgery. Many theories have been postulated to explain the pathophysiology of PPI. OBJECTIVE: The current review scrutinizes various pathophysiologic mechanisms underlying the occurrence of PPI. EVIDENCE ACQUISITION: A search was conducted on PubMed and EMBASE for publications on PPI...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27720534/systematic-review-on-the-fate-of-the-remnant-urothelium-after-radical-cystectomy
#19
Georgios Gakis, Peter C Black, Bernard H Bochner, Stephen A Boorjian, Arnulf Stenzl, George N Thalmann, Wassim Kassouf
CONTEXT: Urothelial carcinoma is considered a pan-urothelial disease. As such, the remnant urothelium in the upper urinary tract and urethra following radical cystectomy (RC) remains at risk for secondary urothelial tumors (SUTs). OBJECTIVE: To describe the incidence, diagnosis, treatment, and outcomes of patients with SUTs after RC. EVIDENCE ACQUISITION: A systematic search was conducted using PubMed database according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to identify studies between 1970 and 2016 reporting on malignant diseases of the urothelium after RC for bladder cancer...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27717442/penile-urethral-and-scrotal-cancer
#20
Philippe E Spiess
No abstract text is available yet for this article.
November 2016: Urologic Clinics of North America
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